SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2cy7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_A_ESTA1_1
(ESTROGEN RECEPTOR)		 2cy7 CYSTEINE PROTEASE
APG4B
(Homo
sapiens) 		5 / 10 ALA A  86
LEU A 164
LEU A 222
ILE A 168
LEU A 152
 None
 1.18A 1a52A-2cy7A:
undetectable		 1a52A-2cy7A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_B_ESTB2_1
(ESTROGEN RECEPTOR)		 2cy7 CYSTEINE PROTEASE
APG4B
(Homo
sapiens) 		5 / 10 ALA A  86
LEU A 164
LEU A 222
ILE A 168
LEU A 152
 None
 1.18A 1a52B-2cy7A:
undetectable		 1a52B-2cy7A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_B_SAMB105_0
(PROTEIN (MET
REPRESSOR))		 2cy7 CYSTEINE PROTEASE
APG4B
(Homo
sapiens) 		5 / 11 LEU A  76
HIS A 280
HIS A 264
ALA A 263
GLY A 258
 None
 1.06A 1cmaA-2cy7A:
undetectable
1cmaB-2cy7A:
0.1		 1cmaA-2cy7A:
13.05
1cmaB-2cy7A:
13.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_GLYA1292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2cy7 CYSTEINE PROTEASE
APG4B
(Homo
sapiens) 		4 / 8 SER A 262
HIS A 280
TYR A 276
PHE A 266
 None
 0.97A 1eqbA-2cy7A:
undetectable
1eqbB-2cy7A:
undetectable		 1eqbA-2cy7A:
20.50
1eqbB-2cy7A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_GLYB2292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2cy7 CYSTEINE PROTEASE
APG4B
(Homo
sapiens) 		4 / 8 TYR A 276
PHE A 266
SER A 262
HIS A 280
 None
 0.95A 1eqbA-2cy7A:
undetectable
1eqbB-2cy7A:
undetectable		 1eqbA-2cy7A:
20.50
1eqbB-2cy7A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_GLYC3292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2cy7 CYSTEINE PROTEASE
APG4B
(Homo
sapiens) 		4 / 8 SER A 262
HIS A 280
TYR A 276
PHE A 266
 None
 0.97A 1eqbC-2cy7A:
undetectable
1eqbD-2cy7A:
undetectable		 1eqbC-2cy7A:
20.50
1eqbD-2cy7A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_GLYD4292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2cy7 CYSTEINE PROTEASE
APG4B
(Homo
sapiens) 		4 / 8 TYR A 276
PHE A 266
SER A 262
HIS A 280
 None
 0.95A 1eqbC-2cy7A:
undetectable
1eqbD-2cy7A:
undetectable		 1eqbC-2cy7A:
20.50
1eqbD-2cy7A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_A_ESTA600_1
(ESTROGEN RECEPTOR)		 2cy7 CYSTEINE PROTEASE
APG4B
(Homo
sapiens) 		5 / 9 ALA A  86
LEU A 164
LEU A 222
ILE A 168
LEU A 152
 None
 1.19A 1ereA-2cy7A:
undetectable		 1ereA-2cy7A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_B_ESTB600_1
(ESTROGEN RECEPTOR)		 2cy7 CYSTEINE PROTEASE
APG4B
(Homo
sapiens) 		5 / 9 ALA A  86
LEU A 164
LEU A 222
ILE A 168
LEU A 152
 None
 1.20A 1ereB-2cy7A:
undetectable		 1ereB-2cy7A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_C_ESTC600_1
(ESTROGEN RECEPTOR)		 2cy7 CYSTEINE PROTEASE
APG4B
(Homo
sapiens) 		5 / 9 ALA A  86
LEU A 164
LEU A 222
ILE A 168
LEU A 152
 None
 1.18A 1ereC-2cy7A:
undetectable		 1ereC-2cy7A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_D_ESTD600_1
(ESTROGEN RECEPTOR)		 2cy7 CYSTEINE PROTEASE
APG4B
(Homo
sapiens) 		5 / 9 ALA A  86
LEU A 164
LEU A 222
ILE A 168
LEU A 152
 None
 1.21A 1ereD-2cy7A:
undetectable		 1ereD-2cy7A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2200_0
(PROTEIN (METHIONINE
REPRESSOR))		 2cy7 CYSTEINE PROTEASE
APG4B
(Homo
sapiens) 		5 / 12 HIS A 264
ALA A 263
GLY A 258
LEU A  76
HIS A 280
 None
 1.16A 1mj2A-2cy7A:
undetectable
1mj2B-2cy7A:
undetectable		 1mj2A-2cy7A:
13.05
1mj2B-2cy7A:
13.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC2199_0
(PROTEIN (METHIONINE
REPRESSOR))		 2cy7 CYSTEINE PROTEASE
APG4B
(Homo
sapiens) 		5 / 12 HIS A 264
ALA A 263
GLY A 258
LEU A  76
HIS A 280
 None
 1.14A 1mj2C-2cy7A:
undetectable
1mj2D-2cy7A:
undetectable		 1mj2C-2cy7A:
13.05
1mj2D-2cy7A:
13.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_C_SAMC200_0
(METHIONINE REPRESSOR)		 2cy7 CYSTEINE PROTEASE
APG4B
(Homo
sapiens) 		5 / 12 HIS A 264
ALA A 263
GLY A 258
LEU A  76
HIS A 280
 None
 1.12A 1mjoC-2cy7A:
undetectable
1mjoD-2cy7A:
undetectable		 1mjoC-2cy7A:
13.05
1mjoD-2cy7A:
13.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_A_SAMA200_0
(METHIONINE REPRESSOR)		 2cy7 CYSTEINE PROTEASE
APG4B
(Homo
sapiens) 		5 / 11 LEU A  76
HIS A 280
HIS A 264
ALA A 263
GLY A 258
 None
 1.13A 1mjqA-2cy7A:
0.1
1mjqB-2cy7A:
undetectable		 1mjqA-2cy7A:
13.05
1mjqB-2cy7A:
13.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 2cy7 CYSTEINE PROTEASE
APG4B
(Homo
sapiens) 		4 / 6 ARG A  55
ILE A 294
PHE A 299
GLU A 297
 None
 1.29A 1nsiA-2cy7A:
undetectable
1nsiB-2cy7A:
undetectable		 1nsiA-2cy7A:
22.50
1nsiB-2cy7A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 2cy7 CYSTEINE PROTEASE
APG4B
(Homo
sapiens) 		4 / 6 PHE A 299
GLU A 297
ARG A  55
ILE A 294
 None
 1.34A 1nsiA-2cy7A:
undetectable
1nsiB-2cy7A:
undetectable		 1nsiA-2cy7A:
22.50
1nsiB-2cy7A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_C_H4BC602_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 2cy7 CYSTEINE PROTEASE
APG4B
(Homo
sapiens) 		4 / 6 ARG A  55
ILE A 294
PHE A 299
GLU A 297
 None
 1.33A 1nsiC-2cy7A:
undetectable
1nsiD-2cy7A:
undetectable		 1nsiC-2cy7A:
22.50
1nsiD-2cy7A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_D_H4BD603_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 2cy7 CYSTEINE PROTEASE
APG4B
(Homo
sapiens) 		4 / 6 PHE A 299
GLU A 297
ARG A  55
ILE A 294
 None
 1.36A 1nsiC-2cy7A:
undetectable
1nsiD-2cy7A:
undetectable		 1nsiC-2cy7A:
22.50
1nsiD-2cy7A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_A_ESTA600_1
(ESTRADIOL RECEPTOR)		 2cy7 CYSTEINE PROTEASE
APG4B
(Homo
sapiens) 		5 / 10 ALA A  86
LEU A 164
LEU A 222
ILE A 168
LEU A 152
 None
 1.22A 1qkuA-2cy7A:
undetectable		 1qkuA-2cy7A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_B_ESTB600_1
(ESTRADIOL RECEPTOR)		 2cy7 CYSTEINE PROTEASE
APG4B
(Homo
sapiens) 		5 / 10 ALA A  86
LEU A 164
LEU A 222
ILE A 168
LEU A 152
 None
 1.21A 1qkuB-2cy7A:
undetectable		 1qkuB-2cy7A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_C_ESTC600_1
(ESTRADIOL RECEPTOR)		 2cy7 CYSTEINE PROTEASE
APG4B
(Homo
sapiens) 		5 / 10 ALA A  86
LEU A 164
LEU A 222
ILE A 168
LEU A 152
 None
 1.21A 1qkuC-2cy7A:
undetectable		 1qkuC-2cy7A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 2cy7 CYSTEINE PROTEASE
APG4B
(Homo
sapiens) 		4 / 7 ARG A  55
ILE A 294
PHE A 299
GLU A 297
 None
 1.31A 2nsiA-2cy7A:
undetectable
2nsiB-2cy7A:
undetectable		 2nsiA-2cy7A:
22.50
2nsiB-2cy7A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 2cy7 CYSTEINE PROTEASE
APG4B
(Homo
sapiens) 		4 / 7 PHE A 299
GLU A 297
ARG A  55
ILE A 294
 None
 1.29A 2nsiA-2cy7A:
undetectable
2nsiB-2cy7A:
undetectable		 2nsiA-2cy7A:
22.50
2nsiB-2cy7A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_C_H4BC602_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 2cy7 CYSTEINE PROTEASE
APG4B
(Homo
sapiens) 		4 / 7 ARG A  55
ILE A 294
PHE A 299
GLU A 297
 None
 1.32A 2nsiC-2cy7A:
undetectable
2nsiD-2cy7A:
undetectable		 2nsiC-2cy7A:
22.50
2nsiD-2cy7A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_D_H4BD603_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 2cy7 CYSTEINE PROTEASE
APG4B
(Homo
sapiens) 		4 / 7 PHE A 299
GLU A 297
ARG A  55
ILE A 294
 None
 1.32A 2nsiC-2cy7A:
undetectable
2nsiD-2cy7A:
undetectable		 2nsiC-2cy7A:
22.50
2nsiD-2cy7A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA802_1
(PROSTAGLANDIN
REDUCTASE 1)		 2cy7 CYSTEINE PROTEASE
APG4B
(Homo
sapiens) 		4 / 7 TYR A 269
ARG A 307
VAL A 240
ASP A 314
 None
 0.92A 2y05A-2cy7A:
undetectable
2y05B-2cy7A:
undetectable		 2y05A-2cy7A:
19.70
2y05B-2cy7A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2cy7 CYSTEINE PROTEASE
APG4B
(Homo
sapiens) 		4 / 7 ARG A  55
ILE A 294
PHE A 299
GLU A 297
 None
 1.30A 3e7gA-2cy7A:
undetectable
3e7gB-2cy7A:
undetectable		 3e7gA-2cy7A:
22.39
3e7gB-2cy7A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_B_H4BB1902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2cy7 CYSTEINE PROTEASE
APG4B
(Homo
sapiens) 		4 / 7 PHE A 299
GLU A 297
ARG A  55
ILE A 294
 None
 1.33A 3e7gA-2cy7A:
undetectable
3e7gB-2cy7A:
undetectable		 3e7gA-2cy7A:
22.39
3e7gB-2cy7A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_C_H4BC2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2cy7 CYSTEINE PROTEASE
APG4B
(Homo
sapiens) 		4 / 7 ARG A  55
ILE A 294
PHE A 299
GLU A 297
 None
 1.26A 3e7gC-2cy7A:
undetectable
3e7gD-2cy7A:
undetectable		 3e7gC-2cy7A:
22.39
3e7gD-2cy7A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_D_H4BD3902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2cy7 CYSTEINE PROTEASE
APG4B
(Homo
sapiens) 		4 / 8 PHE A 299
GLU A 297
ARG A  55
ILE A 294
 None
 1.28A 3e7gC-2cy7A:
undetectable
3e7gD-2cy7A:
undetectable		 3e7gC-2cy7A:
22.39
3e7gD-2cy7A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2cy7 CYSTEINE PROTEASE
APG4B
(Homo
sapiens) 		5 / 6 VAL A 255
LEU A  76
MET A  75
ILE A 310
ILE A 317
 None
 1.38A 3gcsA-2cy7A:
undetectable		 3gcsA-2cy7A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_A_CYZA266_2
(GLUTAMATE RECEPTOR 2)		 2cy7 CYSTEINE PROTEASE
APG4B
(Homo
sapiens) 		4 / 5 ILE A 256
PRO A 145
SER A 262
GLY A 257
 None
 1.02A 3tkdB-2cy7A:
undetectable		 3tkdB-2cy7A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_B_CYZB267_1
(GLUTAMATE RECEPTOR 2)		 2cy7 CYSTEINE PROTEASE
APG4B
(Homo
sapiens) 		4 / 5 ILE A 256
PRO A 145
SER A 262
GLY A 257
 None
 1.03A 3tkdA-2cy7A:
undetectable		 3tkdA-2cy7A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2cy7 CYSTEINE PROTEASE
APG4B
(Homo
sapiens) 		3 / 3 PHE A  16
CYH A 306
HIS A 303
 None
 1.10A 3u9fF-2cy7A:
undetectable		 3u9fF-2cy7A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2cy7 CYSTEINE PROTEASE
APG4B
(Homo
sapiens) 		3 / 3 PHE A  16
CYH A 306
HIS A 303
 None
 1.14A 3u9fG-2cy7A:
undetectable		 3u9fG-2cy7A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_K_CLMK221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2cy7 CYSTEINE PROTEASE
APG4B
(Homo
sapiens) 		3 / 3 PHE A  16
CYH A 306
HIS A 303
 None
 1.11A 3u9fL-2cy7A:
undetectable		 3u9fL-2cy7A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_R_CLMR221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2cy7 CYSTEINE PROTEASE
APG4B
(Homo
sapiens) 		3 / 3 PHE A  16
CYH A 306
HIS A 303
 None
 1.09A 3u9fS-2cy7A:
undetectable		 3u9fS-2cy7A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2cy7 CYSTEINE PROTEASE
APG4B
(Homo
sapiens) 		4 / 8 PHE A 299
GLU A 297
ARG A  55
ILE A 294
 None
 1.33A 4cx7A-2cy7A:
undetectable
4cx7B-2cy7A:
undetectable		 4cx7A-2cy7A:
22.50
4cx7B-2cy7A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_D_H4BD600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2cy7 CYSTEINE PROTEASE
APG4B
(Homo
sapiens) 		4 / 7 PHE A 299
GLU A 297
ARG A  55
ILE A 294
 None
 1.30A 4cx7C-2cy7A:
undetectable
4cx7D-2cy7A:
undetectable		 4cx7C-2cy7A:
22.50
4cx7D-2cy7A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVQ_A_ACTA904_0
(TYROSINE-PROTEIN
KINASE JAK2)		 2cy7 CYSTEINE PROTEASE
APG4B
(Homo
sapiens) 		3 / 3 PHE A  19
VAL A 270
GLU A 273
 None
 0.84A 4fvqA-2cy7A:
undetectable		 4fvqA-2cy7A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_B_H4BB1011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 2cy7 CYSTEINE PROTEASE
APG4B
(Homo
sapiens) 		4 / 7 PHE A 299
GLU A 297
ARG A  55
ILE A 294
 None
 1.36A 4nosA-2cy7A:
undetectable
4nosB-2cy7A:
undetectable		 4nosA-2cy7A:
22.25
4nosB-2cy7A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_C_H4BC2011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 2cy7 CYSTEINE PROTEASE
APG4B
(Homo
sapiens) 		4 / 7 ARG A  55
ILE A 294
PHE A 299
GLU A 297
 None
 1.33A 4nosC-2cy7A:
undetectable
4nosD-2cy7A:
undetectable		 4nosC-2cy7A:
22.25
4nosD-2cy7A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_D_H4BD3011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 2cy7 CYSTEINE PROTEASE
APG4B
(Homo
sapiens) 		4 / 6 PHE A 299
GLU A 297
ARG A  55
ILE A 294
 None
 1.36A 4nosC-2cy7A:
undetectable
4nosD-2cy7A:
undetectable		 4nosC-2cy7A:
22.25
4nosD-2cy7A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 2cy7 CYSTEINE PROTEASE
APG4B
(Homo
sapiens) 		3 / 3 SER A 316
ALA A 318
VAL A 319
 None
 0.54A 4x20C-2cy7A:
undetectable		 4x20C-2cy7A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_B_ESTB601_1
(ESTROGEN RECEPTOR)		 2cy7 CYSTEINE PROTEASE
APG4B
(Homo
sapiens) 		5 / 11 ALA A  86
LEU A 164
LEU A 222
ILE A 168
LEU A 152
 None
 1.17A 5dxbB-2cy7A:
undetectable		 5dxbB-2cy7A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2cy7 CYSTEINE PROTEASE
APG4B
(Homo
sapiens) 		4 / 8 ALA A  47
HIS A 303
PRO A 305
LEU A 277
 None
 1.10A 5dzkF-2cy7A:
undetectable
5dzkT-2cy7A:
undetectable		 5dzkF-2cy7A:
20.33
5dzkT-2cy7A:
0.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMD_C_6UBC1304_1
(ION TRANSPORT
PROTEIN)		 2cy7 CYSTEINE PROTEASE
APG4B
(Homo
sapiens) 		4 / 5 TYR A 265
ILE A 256
LEU A  87
PHE A  83
 None
 0.81A 5kmdC-2cy7A:
undetectable
5kmdD-2cy7A:
undetectable		 5kmdC-2cy7A:
19.95
5kmdD-2cy7A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_A_08JA602_1
(CYTOCHROME P450 3A4)		 2cy7 CYSTEINE PROTEASE
APG4B
(Homo
sapiens) 		4 / 7 SER A 162
LEU A  87
ALA A 114
LEU A  50
 None
 1.05A 5te8A-2cy7A:
undetectable		 5te8A-2cy7A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_C_08JC602_1
(CYTOCHROME P450 3A4)		 2cy7 CYSTEINE PROTEASE
APG4B
(Homo
sapiens) 		4 / 7 SER A 162
LEU A  87
ALA A 114
LEU A  50
 None
 0.97A 5te8C-2cy7A:
undetectable		 5te8C-2cy7A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_2
(PROTEASE)		 2cy7 CYSTEINE PROTEASE
APG4B
(Homo
sapiens) 		3 / 3 GLY A 257
ASP A 314
ILE A 235
 None
 0.58A 6dgxB-2cy7A:
undetectable		 6dgxB-2cy7A:
13.75