SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2cya'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 2cya TYROSYL-TRNA
SYNTHETASE
(Aeropyrum
pernix) 		5 / 8 VAL A 197
TYR A 165
SER A 171
ILE A 173
LEU A 193
 None
 1.16A 1igxA-2cyaA:
undetectable		 1igxA-2cyaA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_1
(TRANSTHYRETIN)		 2cya TYROSYL-TRNA
SYNTHETASE
(Aeropyrum
pernix) 		4 / 6 LEU A  84
GLU A  43
LEU A  90
VAL A  98
 None
 1.20A 1sn5A-2cyaA:
undetectable		 1sn5A-2cyaA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_B_BEZB12_0
(CES1 PROTEIN)		 2cya TYROSYL-TRNA
SYNTHETASE
(Aeropyrum
pernix) 		4 / 4 GLY A  28
SER A  32
VAL A   6
LEU A  26
 None
 1.30A 1yajB-2cyaA:
2.0		 1yajB-2cyaA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_B_ADNB1502_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 2cya TYROSYL-TRNA
SYNTHETASE
(Aeropyrum
pernix) 		4 / 7 ARG A  92
GLU A  73
PRO A  44
ALA A  78
 None
 1.26A 2ejgB-2cyaA:
undetectable		 2ejgB-2cyaA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO5_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 2cya TYROSYL-TRNA
SYNTHETASE
(Aeropyrum
pernix) 		5 / 9 TYR A  57
LEU A  53
VAL A 101
ALA A 105
LEU A 284
 None
 1.42A 2qo5A-2cyaA:
0.0		 2qo5A-2cyaA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_1
(N,N-DIMETHYLTRANSFER
ASE)		 2cya TYROSYL-TRNA
SYNTHETASE
(Aeropyrum
pernix) 		3 / 3 TYR A  39
GLU A  43
ASP A  82
 None
 0.78A 3bxoB-2cyaA:
3.4		 3bxoB-2cyaA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2cya TYROSYL-TRNA
SYNTHETASE
(Aeropyrum
pernix) 		4 / 8 GLY A  41
HIS A  77
ASP A 172
ILE A 173
 None
 0.54A 3fi0B-2cyaA:
20.7		 3fi0B-2cyaA:
25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2cya TYROSYL-TRNA
SYNTHETASE
(Aeropyrum
pernix) 		4 / 8 HIS A  77
ASP A 172
ILE A 173
GLN A 187
 None
None
None
SO4  A1003 (-3.9A)
 0.55A 3fi0B-2cyaA:
20.7		 3fi0B-2cyaA:
25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2cya TYROSYL-TRNA
SYNTHETASE
(Aeropyrum
pernix) 		4 / 7 GLY A  41
HIS A  77
ASP A 172
ILE A 173
 None
 0.45A 3fi0E-2cyaA:
19.7		 3fi0E-2cyaA:
25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_G_TRPG1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2cya TYROSYL-TRNA
SYNTHETASE
(Aeropyrum
pernix) 		4 / 8 GLY A  41
HIS A  77
ASP A 172
ILE A 173
 None
 0.51A 3fi0G-2cyaA:
21.3		 3fi0G-2cyaA:
25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_G_TRPG1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2cya TYROSYL-TRNA
SYNTHETASE
(Aeropyrum
pernix) 		4 / 8 HIS A  77
ASP A 172
ILE A 173
GLN A 187
 None
None
None
SO4  A1003 (-3.9A)
 0.54A 3fi0G-2cyaA:
21.3		 3fi0G-2cyaA:
25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_I_TRPI1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2cya TYROSYL-TRNA
SYNTHETASE
(Aeropyrum
pernix) 		4 / 8 GLY A  41
HIS A  77
ASP A 172
ILE A 173
 None
 0.44A 3fi0I-2cyaA:
6.1		 3fi0I-2cyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_I_TRPI1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2cya TYROSYL-TRNA
SYNTHETASE
(Aeropyrum
pernix) 		4 / 8 HIS A  77
ASP A 172
ILE A 173
GLN A 187
 None
None
None
SO4  A1003 (-3.9A)
 0.59A 3fi0I-2cyaA:
6.1		 3fi0I-2cyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_P_TRPP1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2cya TYROSYL-TRNA
SYNTHETASE
(Aeropyrum
pernix) 		4 / 7 GLY A  41
HIS A  77
ASP A 172
ILE A 173
 None
 0.53A 3fi0P-2cyaA:
20.4		 3fi0P-2cyaA:
25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_P_TRPP1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2cya TYROSYL-TRNA
SYNTHETASE
(Aeropyrum
pernix) 		4 / 7 HIS A  77
ASP A 172
ILE A 173
GLN A 187
 None
None
None
SO4  A1003 (-3.9A)
 0.64A 3fi0P-2cyaA:
20.4		 3fi0P-2cyaA:
25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_Q_TRPQ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2cya TYROSYL-TRNA
SYNTHETASE
(Aeropyrum
pernix) 		4 / 8 GLY A  41
HIS A  77
ASP A 172
ILE A 173
 None
 0.47A 3fi0Q-2cyaA:
20.8		 3fi0Q-2cyaA:
25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KZ7_A_RAPA225_1
(FK506-BINDING
PROTEIN 3)		 2cya TYROSYL-TRNA
SYNTHETASE
(Aeropyrum
pernix) 		5 / 10 TYR A 309
LEU A 277
LYS A 327
VAL A 330
PHE A 285
 None
 1.25A 3kz7A-2cyaA:
undetectable		 3kz7A-2cyaA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 2cya TYROSYL-TRNA
SYNTHETASE
(Aeropyrum
pernix) 		4 / 6 LEU A  62
PHE A  69
ILE A  40
THR A 211
 None
 1.07A 3mdrA-2cyaA:
undetectable		 3mdrA-2cyaA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0S_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 2cya TYROSYL-TRNA
SYNTHETASE
(Aeropyrum
pernix) 		5 / 12 VAL A 330
LEU A  53
ILE A 283
ILE A 214
VAL A 250
 None
 0.98A 4y0sA-2cyaA:
undetectable		 4y0sA-2cyaA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_B_DESB600_1
(ESTROGEN RECEPTOR)		 2cya TYROSYL-TRNA
SYNTHETASE
(Aeropyrum
pernix) 		5 / 11 LEU A 355
ALA A 357
LEU A  84
LEU A  90
ARG A  96
 None
 1.33A 4zn7B-2cyaA:
undetectable		 4zn7B-2cyaA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_1
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 2cya TYROSYL-TRNA
SYNTHETASE
(Aeropyrum
pernix) 		3 / 3 ARG A  12
LYS A  60
GLU A  64
 None
 0.81A 5d0yA-2cyaA:
undetectable		 5d0yA-2cyaA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JI0_D_BRLD501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2cya TYROSYL-TRNA
SYNTHETASE
(Aeropyrum
pernix) 		5 / 12 GLY A  41
GLN A 169
TYR A 126
LEU A 120
MET A 176
 None
 1.36A 5ji0D-2cyaA:
0.4		 5ji0D-2cyaA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 2cya TYROSYL-TRNA
SYNTHETASE
(Aeropyrum
pernix) 		5 / 12 SER A 138
ASP A 159
VAL A 158
ALA A 145
LEU A 146
 None
 1.02A 5kocA-2cyaA:
undetectable		 5kocA-2cyaA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_2
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 2cya TYROSYL-TRNA
SYNTHETASE
(Aeropyrum
pernix) 		3 / 3 VAL A  59
ARG A  92
PRO A  44
 None
 0.62A 5koxA-2cyaA:
undetectable		 5koxA-2cyaA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUM_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 2cya TYROSYL-TRNA
SYNTHETASE
(Aeropyrum
pernix) 		5 / 8 VAL A  67
ILE A  13
LEU A  62
ILE A 209
ILE A  20
 None
 1.50A 5numA-2cyaA:
undetectable		 5numA-2cyaA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2cya TYROSYL-TRNA
SYNTHETASE
(Aeropyrum
pernix) 		3 / 3 LEU A 120
ALA A 121
LEU A  72
 None
 0.50A 5uunB-2cyaA:
undetectable		 5uunB-2cyaA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2cya TYROSYL-TRNA
SYNTHETASE
(Aeropyrum
pernix) 		3 / 3 GLY A 219
THR A 317
PRO A 267
 None
 0.61A 5v5zA-2cyaA:
undetectable		 5v5zA-2cyaA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_D_BEZD502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 2cya TYROSYL-TRNA
SYNTHETASE
(Aeropyrum
pernix) 		4 / 6 PHE A 285
VAL A 330
LEU A 321
LEU A 312
 None
 1.00A 6e43D-2cyaA:
undetectable		 6e43D-2cyaA:
23.01