SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2cyb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		 2cyb TYROSYL-TRNA
SYNTHETASE
(Archaeoglobus
fulgidus) 		4 / 4 HIS A 184
LEU A  56
LEU A  59
LEU A  26
 None
 1.22A 1a4lD-2cybA:
undetectable		 1a4lD-2cybA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_2
(ESTROGEN RECEPTOR)		 2cyb TYROSYL-TRNA
SYNTHETASE
(Archaeoglobus
fulgidus) 		4 / 6 LEU A  70
ASP A 165
LEU A 102
HIS A  49
 None
 1.26A 1errB-2cybA:
undetectable		 1errB-2cybA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 2cyb TYROSYL-TRNA
SYNTHETASE
(Archaeoglobus
fulgidus) 		6 / 11 GLY A  38
HIS A  46
HIS A  49
GLY A 177
ASP A 179
GLN A 180
 None
 0.66A 1jzsA-2cybA:
undetectable		 1jzsA-2cybA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K6C_B_MK1B902_1
(POL POLYPROTEIN)		 2cyb TYROSYL-TRNA
SYNTHETASE
(Archaeoglobus
fulgidus) 		5 / 10 LEU A  23
ALA A  14
ILE A 178
GLY A 177
GLY A 176
 None
 0.92A 1k6cA-2cybA:
undetectable		 1k6cA-2cybA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PG2_A_ADNA552_1
(METHIONYL-TRNA
SYNTHETASE)		 2cyb TYROSYL-TRNA
SYNTHETASE
(Archaeoglobus
fulgidus) 		5 / 11 HIS A  46
GLY A  48
HIS A  49
GLY A 177
ASP A 179
 None
 0.73A 1pg2A-2cybA:
10.8		 1pg2A-2cybA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q72_H_COCH401_1
(FAB M82G2, HEAVY
CHAIN
FAB M82G2, LIGHT
CHAIN)		 2cyb TYROSYL-TRNA
SYNTHETASE
(Archaeoglobus
fulgidus) 		5 / 10 VAL A  37
GLN A 162
GLY A 176
HIS A  46
PHE A  97
 None
 1.48A 1q72H-2cybA:
0.0
1q72L-2cybA:
0.0		 1q72H-2cybA:
22.36
1q72L-2cybA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 2cyb TYROSYL-TRNA
SYNTHETASE
(Archaeoglobus
fulgidus) 		5 / 12 GLY A  48
HIS A  49
GLY A 177
ASP A 179
GLN A 180
 None
 0.60A 1qu2A-2cybA:
3.3		 1qu2A-2cybA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA502_1
(YKOF)		 2cyb TYROSYL-TRNA
SYNTHETASE
(Archaeoglobus
fulgidus) 		4 / 6 ALA A 305
LEU A 308
ILE A 254
CYH A 241
 None
 1.01A 1sbrA-2cybA:
undetectable
1sbrB-2cybA:
undetectable		 1sbrA-2cybA:
20.61
1sbrB-2cybA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDV_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 2cyb TYROSYL-TRNA
SYNTHETASE
(Archaeoglobus
fulgidus) 		5 / 10 LEU A  23
ALA A  14
ILE A 178
GLY A 177
GLY A 176
 None
 0.89A 1sdvA-2cybA:
undetectable		 1sdvA-2cybA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_2
(ESTROGEN RECEPTOR)		 2cyb TYROSYL-TRNA
SYNTHETASE
(Archaeoglobus
fulgidus) 		4 / 5 LEU A  70
ASP A 165
LEU A 102
HIS A  49
 None
 1.14A 2jfaA-2cybA:
undetectable		 2jfaA-2cybA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2cyb TYROSYL-TRNA
SYNTHETASE
(Archaeoglobus
fulgidus) 		3 / 3 THR A 133
ASP A 142
SER A 145
 None
 0.80A 2nxeB-2cybA:
3.6		 2nxeB-2cybA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_2
(ESTROGEN RECEPTOR)		 2cyb TYROSYL-TRNA
SYNTHETASE
(Archaeoglobus
fulgidus) 		4 / 5 LEU A  70
ASP A 165
LEU A 102
HIS A  49
 None
 1.20A 2qxsA-2cybA:
undetectable		 2qxsA-2cybA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_2
(ESTROGEN RECEPTOR)		 2cyb TYROSYL-TRNA
SYNTHETASE
(Archaeoglobus
fulgidus) 		4 / 5 LEU A  70
ASP A 165
LEU A 102
HIS A  49
 None
 1.22A 2qxsB-2cybA:
undetectable		 2qxsB-2cybA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W03_A_ADNA1588_1
(ACSD)		 2cyb TYROSYL-TRNA
SYNTHETASE
(Archaeoglobus
fulgidus) 		5 / 10 LEU A 111
PRO A  41
ILE A  67
HIS A  74
GLN A 116
 None
 1.46A 2w03A-2cybA:
0.0		 2w03A-2cybA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_A_ADNA601_1
(METHIONYL-TRNA
SYNTHETASE)		 2cyb TYROSYL-TRNA
SYNTHETASE
(Archaeoglobus
fulgidus) 		5 / 11 HIS A  46
GLY A  48
HIS A  49
GLY A 177
ASP A 179
 None
 0.65A 2x1lA-2cybA:
5.8		 2x1lA-2cybA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_B_ADNB601_1
(METHIONYL-TRNA
SYNTHETASE)		 2cyb TYROSYL-TRNA
SYNTHETASE
(Archaeoglobus
fulgidus) 		5 / 12 HIS A  46
GLY A  48
HIS A  49
GLY A 177
ASP A 179
 None
 0.66A 2x1lB-2cybA:
7.4		 2x1lB-2cybA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_B_ADNB601_1
(METHIONYL-TRNA
SYNTHETASE)		 2cyb TYROSYL-TRNA
SYNTHETASE
(Archaeoglobus
fulgidus) 		5 / 12 HIS A  46
GLY A  48
HIS A  49
GLY A 177
LEU A 207
 None
 0.65A 2x1lB-2cybA:
7.4		 2x1lB-2cybA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_C_ADNC601_1
(METHIONYL-TRNA
SYNTHETASE)		 2cyb TYROSYL-TRNA
SYNTHETASE
(Archaeoglobus
fulgidus) 		5 / 11 HIS A  46
GLY A  48
HIS A  49
GLY A 177
ASP A 179
 None
 0.68A 2x1lC-2cybA:
7.2		 2x1lC-2cybA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2cyb TYROSYL-TRNA
SYNTHETASE
(Archaeoglobus
fulgidus) 		5 / 10 GLY A  38
HIS A  74
ASP A 165
ILE A 166
GLN A 180
 None
 0.74A 3fhjA-2cybA:
20.5		 3fhjA-2cybA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2cyb TYROSYL-TRNA
SYNTHETASE
(Archaeoglobus
fulgidus) 		5 / 10 GLY A  38
HIS A  74
ASP A 165
ILE A 166
GLN A 180
 None
 0.73A 3fhjB-2cybA:
19.6		 3fhjB-2cybA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2cyb TYROSYL-TRNA
SYNTHETASE
(Archaeoglobus
fulgidus) 		5 / 10 GLY A  38
HIS A  74
ASP A 165
ILE A 166
GLN A 180
 None
 0.73A 3fhjC-2cybA:
19.0		 3fhjC-2cybA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_D_TRPD1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2cyb TYROSYL-TRNA
SYNTHETASE
(Archaeoglobus
fulgidus) 		5 / 9 GLY A  38
HIS A  74
ASP A 165
ILE A 166
GLN A 180
 None
 0.74A 3fhjD-2cybA:
3.0		 3fhjD-2cybA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2cyb TYROSYL-TRNA
SYNTHETASE
(Archaeoglobus
fulgidus) 		5 / 10 GLY A  38
HIS A  74
ASP A 165
ILE A 166
GLN A 180
 None
 0.73A 3fhjE-2cybA:
20.4		 3fhjE-2cybA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_F_TRPF1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2cyb TYROSYL-TRNA
SYNTHETASE
(Archaeoglobus
fulgidus) 		5 / 9 GLY A  38
HIS A  74
ASP A 165
ILE A 166
GLN A 180
 None
 0.73A 3fhjF-2cybA:
21.5		 3fhjF-2cybA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2cyb TYROSYL-TRNA
SYNTHETASE
(Archaeoglobus
fulgidus) 		5 / 9 GLY A  38
HIS A  74
ASP A 165
ILE A 166
GLN A 180
 None
 0.75A 3fi0A-2cybA:
20.5		 3fi0A-2cybA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2cyb TYROSYL-TRNA
SYNTHETASE
(Archaeoglobus
fulgidus) 		4 / 8 GLY A  38
HIS A  74
ASP A 165
GLN A 180
 None
 0.70A 3fi0B-2cybA:
20.2		 3fi0B-2cybA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2cyb TYROSYL-TRNA
SYNTHETASE
(Archaeoglobus
fulgidus) 		5 / 9 GLY A  38
HIS A  74
ASP A 165
ILE A 166
GLN A 180
 None
 0.73A 3fi0C-2cybA:
20.7		 3fi0C-2cybA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_D_TRPD1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2cyb TYROSYL-TRNA
SYNTHETASE
(Archaeoglobus
fulgidus) 		5 / 9 GLY A  38
HIS A  74
ASP A 165
ILE A 166
GLN A 180
 None
 0.74A 3fi0D-2cybA:
20.5		 3fi0D-2cybA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2cyb TYROSYL-TRNA
SYNTHETASE
(Archaeoglobus
fulgidus) 		4 / 7 GLY A  38
HIS A  74
ASP A 165
ILE A 166
 None
 0.56A 3fi0E-2cybA:
19.4		 3fi0E-2cybA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2cyb TYROSYL-TRNA
SYNTHETASE
(Archaeoglobus
fulgidus) 		4 / 7 HIS A  74
ASP A 165
ILE A 166
GLN A 180
 None
 0.46A 3fi0E-2cybA:
19.4		 3fi0E-2cybA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_F_TRPF1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2cyb TYROSYL-TRNA
SYNTHETASE
(Archaeoglobus
fulgidus) 		5 / 9 GLY A  38
HIS A  74
ASP A 165
ILE A 166
GLN A 180
 None
 0.72A 3fi0F-2cybA:
14.4		 3fi0F-2cybA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_G_TRPG1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2cyb TYROSYL-TRNA
SYNTHETASE
(Archaeoglobus
fulgidus) 		5 / 8 GLY A  38
HIS A  74
ASP A 165
ILE A 166
GLN A 180
 None
 0.81A 3fi0G-2cybA:
20.8		 3fi0G-2cybA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_H_TRPH1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2cyb TYROSYL-TRNA
SYNTHETASE
(Archaeoglobus
fulgidus) 		5 / 9 GLY A  38
HIS A  74
ASP A 165
ILE A 166
GLN A 180
 None
 0.80A 3fi0H-2cybA:
20.2		 3fi0H-2cybA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_I_TRPI1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2cyb TYROSYL-TRNA
SYNTHETASE
(Archaeoglobus
fulgidus) 		5 / 8 GLY A  38
HIS A  74
ASP A 165
ILE A 166
GLN A 180
 None
 0.78A 3fi0I-2cybA:
20.2		 3fi0I-2cybA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_J_TRPJ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2cyb TYROSYL-TRNA
SYNTHETASE
(Archaeoglobus
fulgidus) 		5 / 9 GLY A  38
HIS A  74
ASP A 165
ILE A 166
GLN A 180
 None
 0.76A 3fi0J-2cybA:
13.9		 3fi0J-2cybA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_K_TRPK1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2cyb TYROSYL-TRNA
SYNTHETASE
(Archaeoglobus
fulgidus) 		5 / 9 GLY A  38
HIS A  74
ASP A 165
ILE A 166
GLN A 180
 None
 0.76A 3fi0K-2cybA:
19.5		 3fi0K-2cybA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_L_TRPL1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2cyb TYROSYL-TRNA
SYNTHETASE
(Archaeoglobus
fulgidus) 		5 / 9 GLY A  38
HIS A  74
ASP A 165
ILE A 166
GLN A 180
 None
 0.72A 3fi0L-2cybA:
19.9		 3fi0L-2cybA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_M_TRPM1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2cyb TYROSYL-TRNA
SYNTHETASE
(Archaeoglobus
fulgidus) 		5 / 9 GLY A  38
HIS A  74
ASP A 165
ILE A 166
GLN A 180
 None
 0.77A 3fi0M-2cybA:
20.1		 3fi0M-2cybA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_N_TRPN1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2cyb TYROSYL-TRNA
SYNTHETASE
(Archaeoglobus
fulgidus) 		5 / 9 GLY A  38
HIS A  74
ASP A 165
ILE A 166
GLN A 180
 None
 0.80A 3fi0N-2cybA:
20.5		 3fi0N-2cybA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_O_TRPO1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2cyb TYROSYL-TRNA
SYNTHETASE
(Archaeoglobus
fulgidus) 		5 / 9 GLY A  38
HIS A  74
ASP A 165
ILE A 166
GLN A 180
 None
 0.81A 3fi0O-2cybA:
20.3		 3fi0O-2cybA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_P_TRPP1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2cyb TYROSYL-TRNA
SYNTHETASE
(Archaeoglobus
fulgidus) 		5 / 7 GLY A  38
HIS A  74
ASP A 165
ILE A 166
GLN A 180
 None
 0.81A 3fi0P-2cybA:
19.8		 3fi0P-2cybA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_Q_TRPQ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2cyb TYROSYL-TRNA
SYNTHETASE
(Archaeoglobus
fulgidus) 		4 / 8 GLY A  38
HIS A  74
ASP A 165
ILE A 166
 None
 0.59A 3fi0Q-2cybA:
20.2		 3fi0Q-2cybA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_R_TRPR1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2cyb TYROSYL-TRNA
SYNTHETASE
(Archaeoglobus
fulgidus) 		5 / 9 GLY A  38
HIS A  74
ASP A 165
ILE A 166
GLN A 180
 None
 0.77A 3fi0R-2cybA:
19.7		 3fi0R-2cybA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_F_TOPF200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2cyb TYROSYL-TRNA
SYNTHETASE
(Archaeoglobus
fulgidus) 		5 / 10 LEU A   7
GLU A  20
VAL A  17
ALA A  62
LEU A 173
 None
 1.22A 3fl9F-2cybA:
undetectable		 3fl9F-2cybA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA800_0
(GLUTAMATE RECEPTOR 2)		 2cyb TYROSYL-TRNA
SYNTHETASE
(Archaeoglobus
fulgidus) 		4 / 7 ASN A 249
LEU A 252
ASP A 253
LYS A 256
 None
 1.41A 3lslA-2cybA:
undetectable
3lslD-2cybA:
undetectable		 3lslA-2cybA:
23.78
3lslD-2cybA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID800_0
(GLUTAMATE RECEPTOR 2)		 2cyb TYROSYL-TRNA
SYNTHETASE
(Archaeoglobus
fulgidus) 		4 / 7 ASN A 249
LEU A 252
ASP A 253
LYS A 256
 None
 1.37A 3lslA-2cybA:
undetectable
3lslD-2cybA:
undetectable		 3lslA-2cybA:
23.78
3lslD-2cybA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 2cyb TYROSYL-TRNA
SYNTHETASE
(Archaeoglobus
fulgidus) 		3 / 3 TYR A 307
LEU A 319
LYS A 317
 None
 0.49A 3sueD-2cybA:
undetectable		 3sueD-2cybA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HAJ_A_DXCA75_0
(PPCA)		 2cyb TYROSYL-TRNA
SYNTHETASE
(Archaeoglobus
fulgidus) 		4 / 7 ILE A 236
LEU A 308
MET A  51
GLY A  48
 None
 1.00A 4hajA-2cybA:
undetectable		 4hajA-2cybA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L78_A_ACTA1327_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 2cyb TYROSYL-TRNA
SYNTHETASE
(Archaeoglobus
fulgidus) 		4 / 4 VAL A  17
THR A  19
GLU A  20
GLU A  21
 None
 1.18A 4l78A-2cybA:
undetectable		 4l78A-2cybA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJB_A_198A1001_1
(ANDROGEN RECEPTOR)		 2cyb TYROSYL-TRNA
SYNTHETASE
(Archaeoglobus
fulgidus) 		5 / 12 LEU A 186
LEU A 194
MET A 128
VAL A 125
HIS A 168
 None
 1.10A 4ojbA-2cybA:
undetectable		 4ojbA-2cybA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_1
(ANDROGEN RECEPTOR)		 2cyb TYROSYL-TRNA
SYNTHETASE
(Archaeoglobus
fulgidus) 		5 / 12 LEU A 186
LEU A 194
MET A 128
VAL A 125
HIS A 168
 None
 1.16A 4okbA-2cybA:
undetectable		 4okbA-2cybA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_1
(ANDROGEN RECEPTOR)		 2cyb TYROSYL-TRNA
SYNTHETASE
(Archaeoglobus
fulgidus) 		5 / 12 LEU A 186
LEU A 194
MET A 128
VAL A 125
HIS A 168
 None
 1.16A 4okxA-2cybA:
undetectable		 4okxA-2cybA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_1
(ANDROGEN RECEPTOR)		 2cyb TYROSYL-TRNA
SYNTHETASE
(Archaeoglobus
fulgidus) 		5 / 12 LEU A 186
LEU A 194
MET A 128
VAL A 125
HIS A 168
 None
 1.24A 4olmA-2cybA:
undetectable		 4olmA-2cybA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_B_RBFB201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2cyb TYROSYL-TRNA
SYNTHETASE
(Archaeoglobus
fulgidus) 		4 / 8 GLU A  15
LEU A 252
VAL A 208
LEU A 207
 None
 0.96A 4r38B-2cybA:
undetectable		 4r38B-2cybA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_B_RBFB201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2cyb TYROSYL-TRNA
SYNTHETASE
(Archaeoglobus
fulgidus) 		4 / 8 GLU A  15
VAL A 208
LEU A 207
MET A  51
 None
 0.82A 4r38B-2cybA:
undetectable		 4r38B-2cybA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0I_A_TRPA402_0
(TRYPTOPHAN--TRNA
LIGASE)		 2cyb TYROSYL-TRNA
SYNTHETASE
(Archaeoglobus
fulgidus) 		5 / 9 GLY A  38
HIS A  74
ASP A 165
ILE A 166
GLN A 180
 None
 0.68A 5v0iA-2cybA:
20.6		 5v0iA-2cybA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0I_B_TRPB402_0
(TRYPTOPHAN--TRNA
LIGASE)		 2cyb TYROSYL-TRNA
SYNTHETASE
(Archaeoglobus
fulgidus) 		5 / 9 GLY A  38
HIS A  74
ASP A 165
ILE A 166
GLN A 180
 None
 0.65A 5v0iB-2cybA:
21.2		 5v0iB-2cybA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2cyb TYROSYL-TRNA
SYNTHETASE
(Archaeoglobus
fulgidus) 		5 / 12 GLY A  63
GLN A  60
LEU A 173
ILE A  27
LEU A 102
 None
 1.12A 5y2tA-2cybA:
undetectable		 5y2tA-2cybA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_C_CHDC401_0
(BILE SALT HYDROLASE)		 2cyb TYROSYL-TRNA
SYNTHETASE
(Archaeoglobus
fulgidus) 		4 / 8 LEU A 308
LEU A 319
ALA A 315
LEU A 100
 None
 0.72A 5y7pC-2cybA:
undetectable		 5y7pC-2cybA:
24.05