SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2cyc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 2cyc TYROSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		6 / 12 HIS A  47
GLY A  49
GLY A 187
ASP A 189
GLN A 190
HIS A 223
 None
None
None
None
TYR  A 701 (-3.3A)
None
 0.66A 1ffyA-2cycA:
4.6		 1ffyA-2cycA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 2cyc TYROSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 11 GLY A  39
HIS A  47
GLY A 187
ASP A 189
GLN A 190
 TYR  A 701 (-3.4A)
None
None
None
TYR  A 701 (-3.3A)
 0.62A 1jzsA-2cycA:
3.0		 1jzsA-2cycA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS6_A_DXCA75_0
(PPCA)		 2cyc TYROSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 8 ILE A 263
LEU A  52
LYS A 114
GLY A 110
 None
 0.94A 1os6A-2cycA:
undetectable		 1os6A-2cycA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PG2_A_ADNA552_1
(METHIONYL-TRNA
SYNTHETASE)		 2cyc TYROSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 11 GLY A  49
HIS A  47
GLY A 187
ASP A 189
HIS A 223
 None
 1.17A 1pg2A-2cycA:
8.9		 1pg2A-2cycA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PG2_A_ADNA552_1
(METHIONYL-TRNA
SYNTHETASE)		 2cyc TYROSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 11 HIS A  47
GLY A  49
GLY A 187
ASP A 189
HIS A 223
 None
 0.59A 1pg2A-2cycA:
8.9		 1pg2A-2cycA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 2cyc TYROSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A  49
HIS A  47
GLY A 187
ASP A 189
HIS A 223
 None
 1.11A 1qu2A-2cycA:
4.6		 1qu2A-2cycA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 2cyc TYROSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		6 / 12 HIS A  47
GLY A  49
GLY A 187
ASP A 189
GLN A 190
HIS A 223
 None
None
None
None
TYR  A 701 (-3.3A)
None
 0.66A 1qu2A-2cycA:
4.6		 1qu2A-2cycA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU3_A_MRCA993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 2cyc TYROSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 HIS A  47
GLY A  49
ASP A 189
GLN A 190
HIS A 223
 None
None
None
TYR  A 701 (-3.3A)
None
 0.68A 1qu3A-2cycA:
undetectable		 1qu3A-2cycA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2cyc TYROSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 10 ALA A 174
LEU A 125
ILE A  79
ILE A 167
THR A 133
 None
 1.21A 1rb3A-2cycA:
undetectable		 1rb3A-2cycA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_C_DESC129_1
(TRANSTHYRETIN)		 2cyc TYROSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 6 LYS A 244
ALA A 248
LEU A 225
SER A 253
 None
 0.92A 1tz8C-2cycA:
undetectable
1tz8D-2cycA:
undetectable		 1tz8C-2cycA:
15.80
1tz8D-2cycA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_A_ADNA601_1
(METHIONYL-TRNA
SYNTHETASE)		 2cyc TYROSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 11 GLY A  49
HIS A  47
GLY A 187
ASP A 189
HIS A 223
 None
 1.11A 2x1lA-2cycA:
9.9		 2x1lA-2cycA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_A_ADNA601_1
(METHIONYL-TRNA
SYNTHETASE)		 2cyc TYROSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 11 HIS A  47
GLY A  49
GLY A 187
ASP A 189
HIS A 223
 None
 0.63A 2x1lA-2cycA:
9.9		 2x1lA-2cycA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_B_ADNB601_1
(METHIONYL-TRNA
SYNTHETASE)		 2cyc TYROSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		6 / 12 HIS A  47
GLY A  49
GLY A 187
ASP A 189
HIS A 223
LEU A 226
 None
 0.78A 2x1lB-2cycA:
3.7		 2x1lB-2cycA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_C_ADNC601_1
(METHIONYL-TRNA
SYNTHETASE)		 2cyc TYROSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 11 GLY A  49
HIS A  47
GLY A 187
ASP A 189
HIS A 223
 None
 1.10A 2x1lC-2cycA:
2.6		 2x1lC-2cycA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_C_ADNC601_1
(METHIONYL-TRNA
SYNTHETASE)		 2cyc TYROSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 11 HIS A  47
GLY A  49
GLY A 187
ASP A 189
HIS A 223
 None
 0.57A 2x1lC-2cycA:
2.6		 2x1lC-2cycA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_1
(N,N-DIMETHYLTRANSFER
ASE)		 2cyc TYROSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		3 / 3 TYR A  37
GLU A  41
ASP A  81
 TYR  A 701 (-4.6A)
TYR  A 701 ( 4.3A)
None
 0.87A 3bxoA-2cycA:
2.6		 3bxoA-2cycA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_1
(N,N-DIMETHYLTRANSFER
ASE)		 2cyc TYROSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		3 / 3 TYR A  37
GLU A  41
ASP A  81
 TYR  A 701 (-4.6A)
TYR  A 701 ( 4.3A)
None
 0.82A 3bxoB-2cycA:
undetectable		 3bxoB-2cycA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2cyc TYROSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 10 GLY A  39
HIS A  76
ASP A 175
ILE A 176
GLN A 190
 TYR  A 701 (-3.4A)
TYR  A 701 (-3.7A)
TYR  A 701 (-3.4A)
None
TYR  A 701 (-3.3A)
 1.01A 3fhjA-2cycA:
19.2		 3fhjA-2cycA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2cyc TYROSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 10 GLY A  39
HIS A  76
ASP A 175
ILE A 176
GLN A 190
 TYR  A 701 (-3.4A)
TYR  A 701 (-3.7A)
TYR  A 701 (-3.4A)
None
TYR  A 701 (-3.3A)
 1.01A 3fhjB-2cycA:
18.2		 3fhjB-2cycA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2cyc TYROSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 10 GLY A  39
HIS A  76
ASP A 175
ILE A 176
GLN A 190
 TYR  A 701 (-3.4A)
TYR  A 701 (-3.7A)
TYR  A 701 (-3.4A)
None
TYR  A 701 (-3.3A)
 1.01A 3fhjC-2cycA:
17.6		 3fhjC-2cycA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_D_TRPD1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2cyc TYROSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 9 GLY A  39
HIS A  76
ASP A 175
ILE A 176
GLN A 190
 TYR  A 701 (-3.4A)
TYR  A 701 (-3.7A)
TYR  A 701 (-3.4A)
None
TYR  A 701 (-3.3A)
 1.01A 3fhjD-2cycA:
2.2		 3fhjD-2cycA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2cyc TYROSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 10 GLY A  39
HIS A  76
ASP A 175
ILE A 176
GLN A 190
 TYR  A 701 (-3.4A)
TYR  A 701 (-3.7A)
TYR  A 701 (-3.4A)
None
TYR  A 701 (-3.3A)
 1.00A 3fhjE-2cycA:
2.3		 3fhjE-2cycA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_F_TRPF1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2cyc TYROSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 9 GLY A  39
HIS A  76
ASP A 175
ILE A 176
GLN A 190
 TYR  A 701 (-3.4A)
TYR  A 701 (-3.7A)
TYR  A 701 (-3.4A)
None
TYR  A 701 (-3.3A)
 1.01A 3fhjF-2cycA:
19.9		 3fhjF-2cycA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2cyc TYROSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 9 GLY A  39
HIS A  76
ASP A 175
ILE A 176
GLN A 190
 TYR  A 701 (-3.4A)
TYR  A 701 (-3.7A)
TYR  A 701 (-3.4A)
None
TYR  A 701 (-3.3A)
 1.00A 3fi0A-2cycA:
19.3		 3fi0A-2cycA:
25.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2cyc TYROSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 9 GLY A  39
HIS A  76
ASP A 175
ILE A 176
GLN A 190
 TYR  A 701 (-3.4A)
TYR  A 701 (-3.7A)
TYR  A 701 (-3.4A)
None
TYR  A 701 (-3.3A)
 0.98A 3fi0C-2cycA:
19.4		 3fi0C-2cycA:
25.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_D_TRPD1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2cyc TYROSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 9 GLY A  39
HIS A  76
ASP A 175
ILE A 176
GLN A 190
 TYR  A 701 (-3.4A)
TYR  A 701 (-3.7A)
TYR  A 701 (-3.4A)
None
TYR  A 701 (-3.3A)
 1.01A 3fi0D-2cycA:
19.4		 3fi0D-2cycA:
25.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2cyc TYROSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 7 GLY A  39
HIS A  76
ASP A 175
ILE A 176
 TYR  A 701 (-3.4A)
TYR  A 701 (-3.7A)
TYR  A 701 (-3.4A)
None
 0.87A 3fi0E-2cycA:
18.1		 3fi0E-2cycA:
25.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_F_TRPF1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2cyc TYROSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 9 GLY A  39
HIS A  76
ASP A 175
ILE A 176
GLN A 190
 TYR  A 701 (-3.4A)
TYR  A 701 (-3.7A)
TYR  A 701 (-3.4A)
None
TYR  A 701 (-3.3A)
 0.95A 3fi0F-2cycA:
12.0		 3fi0F-2cycA:
25.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_I_TRPI1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2cyc TYROSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 8 GLY A  39
HIS A  76
ASP A 175
ILE A 176
GLN A 190
 TYR  A 701 (-3.4A)
TYR  A 701 (-3.7A)
TYR  A 701 (-3.4A)
None
TYR  A 701 (-3.3A)
 1.02A 3fi0I-2cycA:
18.9		 3fi0I-2cycA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_J_TRPJ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2cyc TYROSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 9 GLY A  39
HIS A  76
ASP A 175
ILE A 176
GLN A 190
 TYR  A 701 (-3.4A)
TYR  A 701 (-3.7A)
TYR  A 701 (-3.4A)
None
TYR  A 701 (-3.3A)
 1.00A 3fi0J-2cycA:
19.2		 3fi0J-2cycA:
25.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_K_TRPK1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2cyc TYROSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 9 GLY A  39
HIS A  76
ASP A 175
ILE A 176
GLN A 190
 TYR  A 701 (-3.4A)
TYR  A 701 (-3.7A)
TYR  A 701 (-3.4A)
None
TYR  A 701 (-3.3A)
 1.01A 3fi0K-2cycA:
18.3		 3fi0K-2cycA:
25.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_L_TRPL1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2cyc TYROSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 9 GLY A  39
HIS A  76
ASP A 175
ILE A 176
GLN A 190
 TYR  A 701 (-3.4A)
TYR  A 701 (-3.7A)
TYR  A 701 (-3.4A)
None
TYR  A 701 (-3.3A)
 0.97A 3fi0L-2cycA:
6.8		 3fi0L-2cycA:
25.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_M_TRPM1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2cyc TYROSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 9 GLY A  39
HIS A  76
ASP A 175
ILE A 176
GLN A 190
 TYR  A 701 (-3.4A)
TYR  A 701 (-3.7A)
TYR  A 701 (-3.4A)
None
TYR  A 701 (-3.3A)
 1.00A 3fi0M-2cycA:
19.1		 3fi0M-2cycA:
25.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_O_TRPO1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2cyc TYROSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 9 GLY A  39
HIS A  76
ASP A 175
ILE A 176
GLN A 190
 TYR  A 701 (-3.4A)
TYR  A 701 (-3.7A)
TYR  A 701 (-3.4A)
None
TYR  A 701 (-3.3A)
 1.04A 3fi0O-2cycA:
19.2		 3fi0O-2cycA:
25.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_P_TRPP1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2cyc TYROSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 7 GLY A  39
ASP A 175
ILE A 176
GLN A 190
 TYR  A 701 (-3.4A)
TYR  A 701 (-3.4A)
None
TYR  A 701 (-3.3A)
 0.82A 3fi0P-2cycA:
18.7		 3fi0P-2cycA:
25.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_P_TRPP1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2cyc TYROSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 7 GLY A  39
HIS A  76
ASP A 175
ILE A 176
 TYR  A 701 (-3.4A)
TYR  A 701 (-3.7A)
TYR  A 701 (-3.4A)
None
 0.90A 3fi0P-2cycA:
18.7		 3fi0P-2cycA:
25.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWW_A_SFXA801_1
(TRANSPORTER)		 2cyc TYROSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A  48
GLY A  49
LEU A  52
ILE A 296
ALA A  56
 None
 1.09A 3gwwA-2cycA:
undetectable		 3gwwA-2cycA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_B_KKKB413_1
(FLAVOHEMOGLOBIN)		 2cyc TYROSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 HIS A  76
ALA A 193
HIS A 185
LEU A 225
ILE A 137
 TYR  A 701 (-3.7A)
None
None
None
None
 1.14A 3ozwB-2cycA:
undetectable		 3ozwB-2cycA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL3_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2cyc TYROSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 ALA A 174
LEU A 125
ILE A  79
ILE A 167
THR A 133
 None
 1.22A 3ql3A-2cycA:
undetectable		 3ql3A-2cycA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_B_ROCB203_1
(PROTEASE)		 2cyc TYROSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 7 LEU A  48
LEU A 347
GLU A 269
PRO A 267
ILE A 270
 None
 1.42A 3s56B-2cycA:
undetectable		 3s56B-2cycA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SEL_X_DXCX75_0
(CYTOCHROME C7)		 2cyc TYROSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 8 ILE A 263
LEU A  52
LYS A 114
GLY A 110
 None
 1.03A 3selX-2cycA:
undetectable		 3selX-2cycA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ4_X_DXCX75_0
(CYTOCHROME C7)		 2cyc TYROSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 9 ILE A 270
LEU A 351
ILE A 297
MET A  53
GLY A  49
 None
 1.19A 3sj4X-2cycA:
undetectable		 3sj4X-2cycA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_1
(PUTATIVE REGULATORY
PROTEIN)		 2cyc TYROSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		3 / 3 TYR A  97
MET A 109
LEU A  48
 None
 0.80A 3vw1D-2cycA:
undetectable		 3vw1D-2cycA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_A_PXLA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 2cyc TYROSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 7 GLY A  51
GLY A  55
MET A 102
HIS A  36
 None
 0.89A 4c5nA-2cycA:
2.0		 4c5nA-2cycA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HAJ_A_DXCA75_0
(PPCA)		 2cyc TYROSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 7 ILE A 270
LEU A 351
MET A  53
GLY A  49
 None
 0.94A 4hajA-2cycA:
undetectable		 4hajA-2cycA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB6_A_DXCA75_0
(PPCA)		 2cyc TYROSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 8 ILE A 270
LEU A 351
MET A  53
GLY A  49
 None
 0.89A 4hb6A-2cycA:
undetectable		 4hb6A-2cycA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB8_A_DXCA75_0
(PPCA)		 2cyc TYROSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 8 ILE A 270
LEU A 351
ILE A 297
MET A  53
GLY A  49
 None
 1.17A 4hb8A-2cycA:
undetectable		 4hb8A-2cycA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2cyc TYROSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 8 ILE A 246
GLU A 242
GLU A 245
GLN A 249
 None
 0.95A 4mj8A-2cycA:
undetectable		 4mj8A-2cycA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		 2cyc TYROSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 6 ASP A 175
VAL A 134
ALA A 121
PHE A  71
 TYR  A 701 (-3.4A)
None
None
TYR  A 701 (-4.4A)
 1.17A 4nedA-2cycA:
undetectable		 4nedA-2cycA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YFB_C_PACC601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 2cyc TYROSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 PRO A 218
PHE A 177
ILE A 176
HIS A 194
VAL A 195
 None
 1.48A 4yfbC-2cycA:
undetectable		 4yfbC-2cycA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YFB_F_PACF601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 2cyc TYROSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 PRO A 218
PHE A 177
ILE A 176
HIS A 194
VAL A 195
 None
 1.48A 4yfbF-2cycA:
undetectable		 4yfbF-2cycA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YFB_I_PACI601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 2cyc TYROSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 PRO A 218
PHE A 177
ILE A 176
HIS A 194
VAL A 195
 None
 1.47A 4yfbI-2cycA:
undetectable		 4yfbI-2cycA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YFB_L_PACL601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 2cyc TYROSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 PRO A 218
PHE A 177
ILE A 176
HIS A 194
VAL A 195
 None
 1.48A 4yfbL-2cycA:
0.0		 4yfbL-2cycA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11802_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
UL4
RIBOSOMAL PROTEIN
UL15
RIBOSOMAL PROTEIN
EL15)		 2cyc TYROSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		3 / 3 ARG A 145
LYS A 203
ARG A 148
 None
 1.43A 6az3C-2cycA:
0.0
6az3L-2cycA:
0.0
6az3M-2cycA:
undetectable		 6az3C-2cycA:
11.35
6az3L-2cycA:
11.35
6az3M-2cycA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_A_BEZA502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 2cyc TYROSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 6 PHE A 298
VAL A 343
LEU A 334
LEU A 325
 None
 0.97A 6e43A-2cycA:
undetectable		 6e43A-2cycA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_B_BEZB502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 2cyc TYROSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 6 PHE A 298
VAL A 343
LEU A 334
LEU A 325
 None
 0.97A 6e43B-2cycA:
undetectable		 6e43B-2cycA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_C_BEZC502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 2cyc TYROSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 6 PHE A 298
VAL A 343
LEU A 334
LEU A 325
 None
 0.97A 6e43C-2cycA:
undetectable		 6e43C-2cycA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_D_BEZD502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 2cyc TYROSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 6 PHE A 298
VAL A 343
LEU A 334
LEU A 325
 None
 0.91A 6e43D-2cycA:
undetectable		 6e43D-2cycA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G2P_A_TRPA502_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 2cyc TYROSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 7 TYR A  97
LEU A  83
TYR A  45
VAL A 371
 None
 1.36A 6g2pA-2cycA:
1.2		 6g2pA-2cycA:
22.86