SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2cyg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U70_A_MTXA187_2
(DIHYDROFOLATE
REDUCTASE)		 2cyg BETA-1, 3-GLUCANANSE
(Musa
acuminata) 		4 / 4 SER A 215
ILE A 214
VAL A 228
THR A 296
 None
 0.98A 1u70A-2cygA:
undetectable		 1u70A-2cygA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A15_A_NCAA1001_0
(HYPOTHETICAL PROTEIN
RV0760C)		 2cyg BETA-1, 3-GLUCANANSE
(Musa
acuminata) 		5 / 11 VAL A 159
ILE A 124
LEU A 183
LEU A 190
MET A 137
 None
 1.23A 2a15A-2cygA:
undetectable		 2a15A-2cygA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_A_PNXA1435_1
(CHITINASE)		 2cyg BETA-1, 3-GLUCANANSE
(Musa
acuminata) 		4 / 6 TYR A  50
GLY A 266
PHE A 309
SER A 265
 None
 1.25A 2a3cA-2cygA:
8.0		 2a3cA-2cygA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2434_1
(CHITINASE)		 2cyg BETA-1, 3-GLUCANANSE
(Musa
acuminata) 		4 / 6 TYR A  50
GLY A 266
PHE A 309
SER A 265
 None
 1.25A 2a3cB-2cygA:
11.1		 2a3cB-2cygA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2cyg BETA-1, 3-GLUCANANSE
(Musa
acuminata) 		3 / 3 LYS A 317
ASP A  62
ASP A  86
 None
 1.17A 2br4A-2cygA:
undetectable		 2br4A-2cygA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACHB603_0
(ACETYLCHOLINESTERASE)		 2cyg BETA-1, 3-GLUCANANSE
(Musa
acuminata) 		4 / 7 TYR A 202
GLU A 314
TYR A  61
GLY A  34
 None
 1.23A 2ha4B-2cygA:
undetectable		 2ha4B-2cygA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UZ2_A_ACTA1123_0
(XENAVIDIN)		 2cyg BETA-1, 3-GLUCANANSE
(Musa
acuminata) 		4 / 7 ASN A 324
SER A 269
THR A 278
VAL A 335
 None
 1.14A 2uz2A-2cygA:
undetectable		 2uz2A-2cygA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL5_B_1UNB201_1
(PROTEASE)		 2cyg BETA-1, 3-GLUCANANSE
(Musa
acuminata) 		5 / 10 LEU A 129
ALA A  91
VAL A 119
ILE A 140
PRO A  83
 None
 1.07A 3el5A-2cygA:
undetectable		 3el5A-2cygA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_A_SAMA220_0
(16S RRNA METHYLASE)		 2cyg BETA-1, 3-GLUCANANSE
(Musa
acuminata) 		5 / 12 VAL A 253
ALA A 248
ALA A 245
THR A 166
LEU A 164
 None
 1.02A 3mteA-2cygA:
undetectable		 3mteA-2cygA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_B_SAMB220_0
(16S RRNA METHYLASE)		 2cyg BETA-1, 3-GLUCANANSE
(Musa
acuminata) 		5 / 12 VAL A 253
ALA A 248
ALA A 245
THR A 166
LEU A 164
 None
 1.03A 3mteB-2cygA:
undetectable		 3mteB-2cygA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFT_D_QMRD301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2cyg BETA-1, 3-GLUCANANSE
(Musa
acuminata) 		4 / 8 TYR A 116
VAL A 260
TYR A 307
VAL A 243
 None
 1.07A 4aftD-2cygA:
undetectable
4aftE-2cygA:
undetectable		 4aftD-2cygA:
22.26
4aftE-2cygA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DCM_A_SAMA401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G)		 2cyg BETA-1, 3-GLUCANANSE
(Musa
acuminata) 		5 / 11 ALA A 136
GLY A  98
ILE A 140
ASP A  99
ASN A 139
 None
 0.96A 4dcmA-2cygA:
undetectable		 4dcmA-2cygA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_A_RKEA401_1
(PROTON-GATED ION
CHANNEL)		 2cyg BETA-1, 3-GLUCANANSE
(Musa
acuminata) 		4 / 8 ASP A 160
VAL A 260
PHE A 175
LEU A 183
 None
 1.06A 4f8hA-2cygA:
undetectable
4f8hB-2cygA:
undetectable		 4f8hA-2cygA:
21.89
4f8hB-2cygA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_B_RKEB401_1
(PROTON-GATED ION
CHANNEL)		 2cyg BETA-1, 3-GLUCANANSE
(Musa
acuminata) 		4 / 8 ASP A 160
VAL A 260
PHE A 175
LEU A 183
 None
 1.09A 4f8hB-2cygA:
undetectable
4f8hC-2cygA:
undetectable		 4f8hB-2cygA:
21.89
4f8hC-2cygA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_C_RKEC401_1
(PROTON-GATED ION
CHANNEL)		 2cyg BETA-1, 3-GLUCANANSE
(Musa
acuminata) 		4 / 8 ASP A 160
VAL A 260
PHE A 175
LEU A 183
 None
 1.08A 4f8hC-2cygA:
undetectable
4f8hD-2cygA:
undetectable		 4f8hC-2cygA:
21.89
4f8hD-2cygA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_D_RKED401_1
(PROTON-GATED ION
CHANNEL)		 2cyg BETA-1, 3-GLUCANANSE
(Musa
acuminata) 		4 / 8 ASP A 160
VAL A 260
PHE A 175
LEU A 183
 None
 1.07A 4f8hD-2cygA:
undetectable
4f8hE-2cygA:
undetectable		 4f8hD-2cygA:
21.89
4f8hE-2cygA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_E_RKEE401_1
(PROTON-GATED ION
CHANNEL)		 2cyg BETA-1, 3-GLUCANANSE
(Musa
acuminata) 		4 / 8 VAL A 260
PHE A 175
LEU A 183
ASP A 160
 None
 1.09A 4f8hA-2cygA:
undetectable
4f8hE-2cygA:
undetectable		 4f8hA-2cygA:
21.89
4f8hE-2cygA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2cyg BETA-1, 3-GLUCANANSE
(Musa
acuminata) 		5 / 11 ILE A 186
ARG A 138
LEU A 134
VAL A 159
LEU A 250
 None
 1.17A 4nqaA-2cygA:
undetectable		 4nqaA-2cygA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L94_A_TESA502_1
(CYTOCHROME P450)		 2cyg BETA-1, 3-GLUCANANSE
(Musa
acuminata) 		5 / 8 VAL A 201
ILE A 242
ALA A 245
VAL A 260
VAL A 199
 None
 1.39A 5l94A-2cygA:
undetectable		 5l94A-2cygA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 2cyg BETA-1, 3-GLUCANANSE
(Musa
acuminata) 		5 / 12 VAL A 262
SER A 263
PHE A 239
GLY A 266
VAL A 159
 None
 1.15A 6drzA-2cygA:
undetectable		 6drzA-2cygA:
21.90