SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2cyj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RE7_A_FOLA161_0 (DIHYDROFOLATE REDUCTASE)	2cyj	HYPOTHETICAL PROTEIN PH1505 (Pyrococcus horikoshii)	5 / 12	ILE A 22 ASP A 19 PHE A 18 LYS A 12 ILE A 30	None	1.04A	1re7A-2cyjA: undetectable	1re7A-2cyjA: 21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2BXM_A_IMNA2002_1 (SERUM ALBUMIN)	2cyj	HYPOTHETICAL PROTEIN PH1505 (Pyrococcus horikoshii)	5 / 11	ARG A 32 ILE A 24 LEU A 101 ARG A 33 GLY A 67	None	1.21A	2bxmA-2cyjA: undetectable	2bxmA-2cyjA: 11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2PGR_A_DCFA501_2 (ADENOSINE DEAMINASE)	2cyj	HYPOTHETICAL PROTEIN PH1505 (Pyrococcus horikoshii)	3 / 3	LEU A 57 LEU A 48 PHE A 61	None	0.61A	2pgrA-2cyjA: undetectable	2pgrA-2cyjA: 18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3PWW_A_ROCA1001_1 (ENDOTHIAPEPSIN)	2cyj	HYPOTHETICAL PROTEIN PH1505 (Pyrococcus horikoshii)	5 / 12	ASP A 19 GLY A 15 LEU A 10 ILE A 24 ILE A 30	None	1.02A	3pwwA-2cyjA: undetectable	3pwwA-2cyjA: 13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4JLT_A_8PRA505_1 (CYTOCHROME P450 2B4)	2cyj	HYPOTHETICAL PROTEIN PH1505 (Pyrococcus horikoshii)	5 / 8	ILE A 13 ILE A 114 GLU A 4 ALA A 97 VAL A 6	None	1.31A	4jltA-2cyjA: undetectable	4jltA-2cyjA: 14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5N0S_B_SAMB501_0 (PEPTIDE N-METHYLTRANSFERASE)	2cyj	HYPOTHETICAL PROTEIN PH1505 (Pyrococcus horikoshii)	5 / 12	ILE A 113 VAL A 84 PHE A 61 TYR A 25 ILE A 24	None	1.13A	5n0sB-2cyjA: undetectable	5n0sB-2cyjA: 15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5N0W_B_SAMB501_0 (PEPTIDE N-METHYLTRANSFERASE)	2cyj	HYPOTHETICAL PROTEIN PH1505 (Pyrococcus horikoshii)	5 / 12	ILE A 113 VAL A 84 PHE A 61 TYR A 25 ILE A 24	None	1.08A	5n0wB-2cyjA: 2.6	5n0wB-2cyjA: 15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5N4I_A_SAMA501_0 (PEPTIDE N-METHYLTRANSFERASE)	2cyj	HYPOTHETICAL PROTEIN PH1505 (Pyrococcus horikoshii)	5 / 12	ILE A 113 VAL A 84 PHE A 61 TYR A 25 ILE A 24	None	1.08A	5n4iA-2cyjA: undetectable	5n4iA-2cyjA: 15.82

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1RE7_A_FOLA161_0","DIHYDROFOLATE REDUCTASE","2cyj","HYPOTHETICAL PROTEIN PH1505","Pyrococcus horikoshii",5,"ILE A  22;ASP A  19;PHE A  18;LYS A  12;ILE A  30","None","1.04A","1re7A-2cyjA:undetectable","1re7A-2cyjA:21.29"],["2BXM_A_IMNA2002_1","SERUM ALBUMIN","2cyj","HYPOTHETICAL PROTEIN PH1505","Pyrococcus horikoshii",5,"ARG A  32;ILE A  24;LEU A 101;ARG A  33;GLY A  67","None","1.21A","2bxmA-2cyjA:undetectable","2bxmA-2cyjA:11.93"],["2PGR_A_DCFA501_2","ADENOSINE DEAMINASE","2cyj","HYPOTHETICAL PROTEIN PH1505","Pyrococcus horikoshii",3,"LEU A  57;LEU A  48;PHE A  61","None","0.61A","2pgrA-2cyjA:undetectable","2pgrA-2cyjA:18.10"],["3PWW_A_ROCA1001_1","ENDOTHIAPEPSIN","2cyj","HYPOTHETICAL PROTEIN PH1505","Pyrococcus horikoshii",5,"ASP A  19;GLY A  15;LEU A  10;ILE A  24;ILE A  30","None","1.02A","3pwwA-2cyjA:undetectable","3pwwA-2cyjA:13.00"],["4JLT_A_8PRA505_1","CYTOCHROME P450 2B4","2cyj","HYPOTHETICAL PROTEIN PH1505","Pyrococcus horikoshii",5,"ILE A  13;ILE A 114;GLU A   4;ALA A  97;VAL A   6","None","1.31A","4jltA-2cyjA:undetectable","4jltA-2cyjA:14.26"],["5N0S_B_SAMB501_0","PEPTIDE N-METHYLTRANSFERASE","2cyj","HYPOTHETICAL PROTEIN PH1505","Pyrococcus horikoshii",5,"ILE A 113;VAL A  84;PHE A  61;TYR A  25;ILE A  24","None","1.13A","5n0sB-2cyjA:undetectable","5n0sB-2cyjA:15.82"],["5N0W_B_SAMB501_0","PEPTIDE N-METHYLTRANSFERASE","2cyj","HYPOTHETICAL PROTEIN PH1505","Pyrococcus horikoshii",5,"ILE A 113;VAL A  84;PHE A  61;TYR A  25;ILE A  24","None","1.08A","5n0wB-2cyjA:2.6","5n0wB-2cyjA:15.82"],["5N4I_A_SAMA501_0","PEPTIDE N-METHYLTRANSFERASE","2cyj","HYPOTHETICAL PROTEIN PH1505","Pyrococcus horikoshii",5,"ILE A 113;VAL A  84;PHE A  61;TYR A  25;ILE A  24","None","1.08A","5n4iA-2cyjA:undetectable","5n4iA-2cyjA:15.82"]]