SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2cz2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1B02_A_C2FA281_0
(PROTEIN (THYMIDYLATE
SYNTHASE))		 2cz2 MALEYLACETOACETATE
ISOMERASE
(Mus
musculus) 		5 / 11 ALA A 150
THR A 149
ILE A 102
LEU A  73
LEU A 166
 None
 1.06A 1b02A-2cz2A:
undetectable		 1b02A-2cz2A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_G_REAG501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2cz2 MALEYLACETOACETATE
ISOMERASE
(Mus
musculus) 		5 / 12 ILE A 106
ILE A 135
PHE A 139
LEU A 142
ALA A 141
 None
 0.95A 2aclG-2cz2A:
undetectable		 2aclG-2cz2A:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_B_MTXB164_2
(DIHYDROFOLATE
REDUCTASE)		 2cz2 MALEYLACETOACETATE
ISOMERASE
(Mus
musculus) 		4 / 4 PHE A  50
LYS A  57
ILE A  36
THR A  68
 None
 1.43A 3ia4B-2cz2A:
undetectable		 3ia4B-2cz2A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 2cz2 MALEYLACETOACETATE
ISOMERASE
(Mus
musculus) 		4 / 6 PHE A 176
ALA A 131
LEU A 119
VAL A 118
 None
 0.93A 4dubB-2cz2A:
undetectable		 4dubB-2cz2A:
20.99