SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2czc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQP_A_803A311_1
(ANTIGEN CD11A (P180))		 2czc GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Pyrococcus
horikoshii) 		5 / 10 LEU A 246
VAL A 278
ILE A 283
TYR A 292
LEU A 229
 None
 1.00A 1cqpA-2czcA:
2.8
1cqpB-2czcA:
undetectable		 1cqpA-2czcA:
18.52
1cqpB-2czcA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		 2czc GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Pyrococcus
horikoshii) 		5 / 12 ILE A 260
ASP A 265
ILE A 259
ALA A 295
ARG A 264
 None
 1.06A 1kijB-2czcA:
undetectable		 1kijB-2czcA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_1
(PROTEASE)		 2czc GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Pyrococcus
horikoshii) 		4 / 7 ASN A 306
ASP A  85
GLY A  11
ALA A  20
 None
None
NAD  A 501 (-3.3A)
None
 0.77A 1n49A-2czcA:
undetectable		 1n49A-2czcA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X1A_A_SAMA4264_0
(CRTF-RELATED PROTEIN)		 2czc GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Pyrococcus
horikoshii) 		5 / 12 ALA A  44
GLY A   6
GLY A  31
ILE A  83
TYR A  99
 None
 0.95A 1x1aA-2czcA:
4.6		 1x1aA-2czcA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X1A_A_SAMA4264_0
(CRTF-RELATED PROTEIN)		 2czc GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Pyrococcus
horikoshii) 		5 / 12 ALA A  44
GLY A  11
ILE A  32
ILE A 303
TYR A 274
 None
NAD  A 501 (-3.3A)
None
None
None
 1.11A 1x1aA-2czcA:
4.6		 1x1aA-2czcA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_A_BEZA1222_0
(PEROXIREDOXIN 6)		 2czc GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Pyrococcus
horikoshii) 		4 / 8 THR A 326
SER A 322
GLU A 305
ALA A 123
 None
 0.96A 2v32A-2czcA:
undetectable
2v32B-2czcA:
undetectable		 2v32A-2czcA:
19.54
2v32B-2czcA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_B_BEZB1220_0
(PEROXIREDOXIN 6)		 2czc GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Pyrococcus
horikoshii) 		4 / 8 THR A 326
SER A 322
GLU A 305
ALA A 123
 None
 0.96A 2v32A-2czcA:
undetectable
2v32B-2czcA:
undetectable		 2v32A-2czcA:
19.54
2v32B-2czcA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_G_BEZG1222_0
(PEROXIREDOXIN 6.)		 2czc GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Pyrococcus
horikoshii) 		4 / 8 THR A 326
SER A 322
GLU A 305
ALA A 123
 None
 0.90A 2v41G-2czcA:
undetectable
2v41H-2czcA:
undetectable		 2v41G-2czcA:
19.54
2v41H-2czcA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FAK_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 2czc GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Pyrococcus
horikoshii) 		5 / 10 LEU A  77
ILE A  83
GLY A   6
GLY A  31
SER A  55
 None
 0.99A 4fakA-2czcA:
undetectable		 4fakA-2czcA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUH_A_ACTA610_0
(SERUM ALBUMIN)		 2czc GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Pyrococcus
horikoshii) 		3 / 3 VAL A 139
SER A 140
THR A 143
 None
PO4  A 601 (-2.5A)
None
 0.47A 4luhA-2czcA:
undetectable		 4luhA-2czcA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2czc GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A  29
ALA A  20
GLY A  14
ALA A 309
ILE A 307
 None
 1.07A 4nkxC-2czcA:
undetectable		 4nkxC-2czcA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2czc GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A  29
ALA A  20
GLY A  14
ALA A 309
ILE A 307
 None
 1.07A 4nkxD-2czcA:
undetectable		 4nkxD-2czcA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2czc GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Pyrococcus
horikoshii) 		3 / 3 ASP A  26
LYS A  23
LEU A 330
 None
 1.03A 4ptjA-2czcA:
undetectable		 4ptjA-2czcA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 2czc GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Pyrococcus
horikoshii) 		3 / 3 ASP A 195
ASN A 142
PHE A 108
 None
PO4  A 601 (-3.3A)
None
 0.65A 5jglB-2czcA:
4.1		 5jglB-2czcA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 2czc GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Pyrococcus
horikoshii) 		4 / 5 TYR A 156
SER A 151
ALA A 152
THR A 241
 None
 1.34A 5n0wB-2czcA:
1.5		 5n0wB-2czcA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 2czc GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Pyrococcus
horikoshii) 		4 / 5 TYR A 156
SER A 151
ALA A 152
THR A 241
 None
 1.28A 5n4iA-2czcA:
undetectable		 5n4iA-2czcA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UTU_H_ADNH503_2
(ADENOSYLHOMOCYSTEINA
SE)		 2czc GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Pyrococcus
horikoshii) 		4 / 5 GLU A 205
THR A 206
HIS A 219
LEU A 150
 None
 1.33A 5utuH-2czcA:
5.6		 5utuH-2czcA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_B_SAMB301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 2czc GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Pyrococcus
horikoshii) 		5 / 12 ILE A 237
ILE A 235
VAL A 221
VAL A 223
ILE A 153
 None
 1.06A 6emuB-2czcA:
4.8		 6emuB-2czcA:
18.24