SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2czd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_A_MK1A401_1
(HIV-II PROTEASE)		 2czd OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Pyrococcus
horikoshii) 		6 / 12 GLY A  76
ALA A  77
ASP A  41
ILE A  42
ILE A  70
ILE A  43
 None
 1.35A 1hshA-2czdA:
undetectable		 1hshA-2czdA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 2czd OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Pyrococcus
horikoshii) 		3 / 3 ILE A 103
ASP A  80
PHE A  75
 None
 0.53A 1uwjB-2czdA:
undetectable		 1uwjB-2czdA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q5K_A_AB1A201_2
(PROTEASE)		 2czd OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A  78
ALA A  79
ASP A  80
ILE A  55
ILE A  42
 None
 0.94A 2q5kB-2czdA:
undetectable		 2q5kB-2czdA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKG_B_AB1B501_1
(PROTEASE RETROPEPSIN)		 2czd OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Pyrococcus
horikoshii) 		6 / 12 GLY A  76
ALA A  77
ASP A  41
ILE A  42
ILE A  70
ILE A  43
 None
 1.30A 2rkgA-2czdA:
undetectable		 2rkgA-2czdA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL9_A_DR7A100_2
(PROTEASE)		 2czd OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Pyrococcus
horikoshii) 		5 / 10 GLY A  78
ALA A  79
ASP A  80
ILE A  55
ILE A  42
 None
 1.02A 3el9B-2czdA:
undetectable		 3el9B-2czdA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDW_A_RITA100_1
(PROTEASE)		 2czd OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A  76
ALA A  77
ILE A  70
VAL A  30
ILE A  43
 None
 1.06A 3ndwA-2czdA:
undetectable		 3ndwA-2czdA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U6T_A_KANA4699_1
(RIBOSOME
INACTIVATING PROTEIN)		 2czd OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Pyrococcus
horikoshii) 		5 / 10 TYR A  24
ILE A 201
SER A  26
ILE A 188
ALA A 197
 None
 1.44A 3u6tA-2czdA:
undetectable		 3u6tA-2czdA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2czd OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Pyrococcus
horikoshii) 		5 / 10 ILE A  54
VAL A  52
ILE A 183
ILE A  55
THR A  50
 None
None
DTT  A 501 ( 4.6A)
None
None
 1.06A 3um5A-2czdA:
undetectable		 3um5A-2czdA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2czd OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Pyrococcus
horikoshii) 		5 / 10 ILE A  54
VAL A  52
ILE A 183
ILE A  55
THR A  50
 None
None
DTT  A 501 ( 4.6A)
None
None
 1.11A 3um5B-2czdA:
undetectable		 3um5B-2czdA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2czd OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Pyrococcus
horikoshii) 		5 / 9 ALA A 174
ALA A 177
ILE A 183
GLY A 163
ALA A 161
 None
None
DTT  A 501 ( 4.6A)
None
None
 1.18A 4qvqK-2czdA:
undetectable
4qvqL-2czdA:
undetectable		 4qvqK-2czdA:
20.43
4qvqL-2czdA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2czd OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Pyrococcus
horikoshii) 		5 / 9 ALA A 174
ALA A 177
ILE A 183
GLY A 163
ALA A 161
 None
None
DTT  A 501 ( 4.6A)
None
None
 1.18A 4qvqY-2czdA:
undetectable
4qvqZ-2czdA:
undetectable		 4qvqY-2czdA:
20.43
4qvqZ-2czdA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_B_RBFB201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2czd OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Pyrococcus
horikoshii) 		4 / 8 ILE A  63
LEU A  99
VAL A  84
LEU A  60
 None
 0.91A 4r38B-2czdA:
undetectable		 4r38B-2czdA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2czd OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Pyrococcus
horikoshii) 		4 / 8 ILE A  63
LEU A  99
VAL A  84
LEU A  60
 None
 0.84A 4r38D-2czdA:
undetectable		 4r38D-2czdA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2czd OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Pyrococcus
horikoshii) 		3 / 3 PHE A  87
ILE A 117
ASP A 122
 None
 0.70A 5cswB-2czdA:
undetectable		 5cswB-2czdA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2czd OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Pyrococcus
horikoshii) 		5 / 8 ILE A  25
VAL A   3
ILE A  70
ILE A  35
ASP A  57
 None
None
None
None
DTT  A 501 ( 4.4A)
 1.50A 5hi2A-2czdA:
undetectable		 5hi2A-2czdA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ1_B_AB1B201_1
(HIV-1 PROTEASE)		 2czd OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A  78
ALA A  79
ASP A  80
ILE A  55
ILE A  42
 None
 0.96A 6dj1B-2czdA:
undetectable		 6dj1B-2czdA:
21.05