SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2czq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DY5_A_ACTA600_0
(RIBONUCLEASE A)		 2czq CUTINASE-LIKE
PROTEIN
(Cryptococcus
sp.
S-2) 		4 / 4 HIS A 119
VAL A 127
ASN A 126
THR A 135
 None
 1.28A 1dy5A-2czqA:
undetectable		 1dy5A-2czqA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_F_BEZF5023_0
(CES1 PROTEIN)		 2czq CUTINASE-LIKE
PROTEIN
(Cryptococcus
sp.
S-2) 		4 / 6 GLY A  16
SER A  85
ILE A 176
HIS A 180
 EDO  A 602 (-3.4A)
EDO  A 602 ( 3.9A)
EDO  A 602 ( 4.9A)
EDO  A 602 ( 4.8A)
 0.84A 1yajF-2czqA:
3.8		 1yajF-2czqA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_J_BEZJ5041_0
(CES1 PROTEIN)		 2czq CUTINASE-LIKE
PROTEIN
(Cryptococcus
sp.
S-2) 		4 / 4 GLY A  16
SER A  85
ILE A 176
HIS A 180
 EDO  A 602 (-3.4A)
EDO  A 602 ( 3.9A)
EDO  A 602 ( 4.9A)
EDO  A 602 ( 4.8A)
 0.82A 1yajJ-2czqA:
3.3		 1yajJ-2czqA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_B_ACTB1004_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 2czq CUTINASE-LIKE
PROTEIN
(Cryptococcus
sp.
S-2) 		4 / 4 HIS A 180
PRO A 117
ASN A 116
TYR A 183
 EDO  A 602 ( 4.8A)
None
None
None
 1.47A 2f7aB-2czqA:
2.2		 2f7aB-2czqA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 2czq CUTINASE-LIKE
PROTEIN
(Cryptococcus
sp.
S-2) 		5 / 12 TYR A  84
ALA A  89
GLY A  83
SER A  56
PRO A 117
 EDO  A 602 (-4.2A)
None
None
None
None
 1.18A 2okcB-2czqA:
2.6		 2okcB-2czqA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UZ2_A_ACTA1123_0
(XENAVIDIN)		 2czq CUTINASE-LIKE
PROTEIN
(Cryptococcus
sp.
S-2) 		4 / 7 ASN A 126
LEU A 123
THR A 157
VAL A 154
 None
 1.03A 2uz2A-2czqA:
undetectable		 2uz2A-2czqA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HAV_A_SRYA403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 2czq CUTINASE-LIKE
PROTEIN
(Cryptococcus
sp.
S-2) 		4 / 8 ASP A 186
SER A 182
ASP A 165
ASP A 159
 None
 1.08A 3havA-2czqA:
undetectable		 3havA-2czqA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECLB600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2czq CUTINASE-LIKE
PROTEIN
(Cryptococcus
sp.
S-2) 		4 / 8 LEU A  81
GLY A 193
THR A  35
ILE A  43
 None
 0.80A 3jusB-2czqA:
undetectable		 3jusB-2czqA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_A_VIBA223_1
(THIAMINE
PYROPHOSPHOKINASE)		 2czq CUTINASE-LIKE
PROTEIN
(Cryptococcus
sp.
S-2) 		4 / 7 LEU A 113
LEU A  95
SER A 151
THR A 100
 None
 1.00A 3lm8A-2czqA:
2.7
3lm8C-2czqA:
undetectable		 3lm8A-2czqA:
21.54
3lm8C-2czqA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_A_RBFA190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 2czq CUTINASE-LIKE
PROTEIN
(Cryptococcus
sp.
S-2) 		5 / 12 THR A 191
ALA A 197
LEU A  11
LEU A 158
ASN A  31
 None
 0.99A 3p5nA-2czqA:
undetectable		 3p5nA-2czqA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_B_RBFB190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 2czq CUTINASE-LIKE
PROTEIN
(Cryptococcus
sp.
S-2) 		5 / 12 THR A 191
ALA A 197
LEU A  11
LEU A 158
ASN A  31
 None
 0.99A 3p5nB-2czqA:
undetectable		 3p5nB-2czqA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_A_9PLA1_1
(CYTOCHROME P450 2A13)		 2czq CUTINASE-LIKE
PROTEIN
(Cryptococcus
sp.
S-2) 		5 / 9 ALA A 205
PHE A 112
ASN A 199
PHE A 196
ALA A 197
 None
 1.48A 3t3sA-2czqA:
undetectable		 3t3sA-2czqA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_E_9PLE1_1
(CYTOCHROME P450 2A13)		 2czq CUTINASE-LIKE
PROTEIN
(Cryptococcus
sp.
S-2) 		5 / 8 ALA A 205
PHE A 112
ASN A 199
PHE A 196
ALA A 197
 None
 1.38A 3t3sE-2czqA:
undetectable		 3t3sE-2czqA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEG_A_DAHA416_1
(PHENYLALANYL-TRNA
SYNTHETASE,
MITOCHONDRIAL)		 2czq CUTINASE-LIKE
PROTEIN
(Cryptococcus
sp.
S-2) 		6 / 12 SER A  24
GLU A  19
PHE A  27
GLY A  87
GLY A 115
GLY A  16
 None
None
None
None
None
EDO  A 602 (-3.4A)
 1.29A 3tegA-2czqA:
undetectable		 3tegA-2czqA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_C_ECNC403_1
(FLAVOHEMOGLOBIN)		 2czq CUTINASE-LIKE
PROTEIN
(Cryptococcus
sp.
S-2) 		5 / 9 ILE A  63
LEU A  81
VAL A 108
VAL A 149
LEU A  95
 None
 1.00A 4g1bC-2czqA:
3.0		 4g1bC-2czqA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_A_SAMA401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 2czq CUTINASE-LIKE
PROTEIN
(Cryptococcus
sp.
S-2) 		5 / 11 GLY A 164
GLY A 173
ASP A 169
VAL A 138
ASP A 128
 None
 1.00A 4pghA-2czqA:
undetectable		 4pghA-2czqA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_A_URFA302_1
(URIDINE
PHOSPHORYLASE)		 2czq CUTINASE-LIKE
PROTEIN
(Cryptococcus
sp.
S-2) 		4 / 7 GLY A 193
GLN A 190
ALA A 197
ILE A  34
 None
 0.72A 4txnA-2czqA:
2.3		 4txnA-2czqA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_B_URFB302_1
(URIDINE
PHOSPHORYLASE)		 2czq CUTINASE-LIKE
PROTEIN
(Cryptococcus
sp.
S-2) 		4 / 7 GLY A 193
GLN A 190
ALA A 197
ILE A  34
 None
 0.73A 4txnB-2czqA:
3.7		 4txnB-2czqA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_C_URFC302_1
(URIDINE
PHOSPHORYLASE)		 2czq CUTINASE-LIKE
PROTEIN
(Cryptococcus
sp.
S-2) 		4 / 7 GLY A 193
GLN A 190
ALA A 197
ILE A  34
 None
 0.71A 4txnC-2czqA:
3.7		 4txnC-2czqA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_D_URFD302_1
(URIDINE
PHOSPHORYLASE)		 2czq CUTINASE-LIKE
PROTEIN
(Cryptococcus
sp.
S-2) 		4 / 7 GLY A 193
GLN A 190
ALA A 197
ILE A  34
 None
 0.73A 4txnD-2czqA:
3.3		 4txnD-2czqA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2czq CUTINASE-LIKE
PROTEIN
(Cryptococcus
sp.
S-2) 		5 / 8 LEU A 201
GLY A 202
VAL A 198
LEU A  11
GLY A  40
 None
 1.02A 4zauA-2czqA:
undetectable		 4zauA-2czqA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2czq CUTINASE-LIKE
PROTEIN
(Cryptococcus
sp.
S-2) 		5 / 8 LEU A 201
GLY A 203
VAL A 198
LEU A  11
GLY A  40
 None
 1.11A 4zauA-2czqA:
undetectable		 4zauA-2czqA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FUQ_A_ACTA1278_0
(NAD(P)H
DEHYDROGENASE
[QUINONE] 1)		 2czq CUTINASE-LIKE
PROTEIN
(Cryptococcus
sp.
S-2) 		4 / 5 SER A  24
GLN A 190
ILE A 114
TYR A 183
 None
 1.12A 5fuqA-2czqA:
4.9
5fuqB-2czqA:
4.4		 5fuqA-2czqA:
20.88
5fuqB-2czqA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_2
(CYTOCHROME P450 3A4)		 2czq CUTINASE-LIKE
PROTEIN
(Cryptococcus
sp.
S-2) 		4 / 6 ARG A  65
ARG A  66
ILE A  43
THR A  42
 None
CIT  A 501 (-3.7A)
None
CIT  A 501 (-3.3A)
 1.11A 5vceA-2czqA:
undetectable		 5vceA-2czqA:
16.12