SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2czr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_A_TESA903_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 2czr TBP-INTERACTING
PROTEIN
(Thermococcus
kodakarensis) 		4 / 6 TYR A 147
TRP A 102
VAL A 119
LEU A 172
 None
 1.31A 1j96A-2czrA:
undetectable		 1j96A-2czrA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_2
(ESTROGEN RECEPTOR
BETA)		 2czr TBP-INTERACTING
PROTEIN
(Thermococcus
kodakarensis) 		3 / 3 ASP A  21
LEU A  19
HIS A 130
 None
 0.74A 1qknA-2czrA:
undetectable		 1qknA-2czrA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_1
(POL POLYPROTEIN)		 2czr TBP-INTERACTING
PROTEIN
(Thermococcus
kodakarensis) 		5 / 8 ASP A  45
ILE A  26
ILE A  31
GLY A  33
ILE A  34
 None
 1.26A 1sh9A-2czrA:
undetectable		 1sh9A-2czrA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7I_A_017A200_2
(POL POLYPROTEIN)		 2czr TBP-INTERACTING
PROTEIN
(Thermococcus
kodakarensis) 		4 / 7 ALA A  47
ASP A  45
GLY A   8
THR A  85
 None
 0.77A 1t7iB-2czrA:
undetectable		 1t7iB-2czrA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7J_A_478A200_2
(POL POLYPROTEIN)		 2czr TBP-INTERACTING
PROTEIN
(Thermococcus
kodakarensis) 		4 / 7 ALA A  47
ASP A  45
GLY A   8
THR A  85
 None
 0.80A 1t7jB-2czrA:
undetectable		 1t7jB-2czrA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_D_TOPD1158_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 2czr TBP-INTERACTING
PROTEIN
(Thermococcus
kodakarensis) 		5 / 10 ALA A  91
ASP A  95
LEU A 127
ILE A 131
PHE A  75
 None
 1.10A 2w9sD-2czrA:
undetectable		 2w9sD-2czrA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_F_TOPF1159_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 2czr TBP-INTERACTING
PROTEIN
(Thermococcus
kodakarensis) 		5 / 10 ALA A  91
ASP A  95
LEU A 127
ILE A 131
PHE A  75
 None
 1.10A 2w9sF-2czrA:
undetectable		 2w9sF-2czrA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP9_D_SPMD230_1
(LS-24)		 2czr TBP-INTERACTING
PROTEIN
(Thermococcus
kodakarensis) 		3 / 3 GLU A 211
GLU A 159
ASN A 160
 None
 0.76A 3lp9B-2czrA:
undetectable
3lp9D-2czrA:
undetectable		 3lp9B-2czrA:
21.37
3lp9D-2czrA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1C_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 2czr TBP-INTERACTING
PROTEIN
(Thermococcus
kodakarensis) 		5 / 10 ILE A  66
PHE A  82
ILE A  64
ASP A  95
LEU A 127
 None
GOL  A1001 ( 4.8A)
None
None
None
 1.24A 3o1cA-2czrA:
undetectable		 3o1cA-2czrA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGZ_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 2czr TBP-INTERACTING
PROTEIN
(Thermococcus
kodakarensis) 		5 / 10 ILE A  66
PHE A  82
ILE A  64
ASP A  95
LEU A 127
 None
GOL  A1001 ( 4.8A)
None
None
None
 1.24A 3qgzA-2czrA:
undetectable		 3qgzA-2czrA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2czr TBP-INTERACTING
PROTEIN
(Thermococcus
kodakarensis) 		4 / 7 GLU A 151
ILE A 170
TYR A 147
HIS A 179
 None
 1.07A 4a97D-2czrA:
undetectable		 4a97D-2czrA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2czr TBP-INTERACTING
PROTEIN
(Thermococcus
kodakarensis) 		4 / 6 GLU A 151
ILE A 170
TYR A 147
HIS A 179
 None
 1.11A 4a97I-2czrA:
undetectable		 4a97I-2czrA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_B_0HKB1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 2czr TBP-INTERACTING
PROTEIN
(Thermococcus
kodakarensis) 		3 / 3 ASP A  60
ASN A  79
PHE A  82
 None
None
GOL  A1001 ( 4.8A)
 0.79A 5dsgB-2czrA:
undetectable		 5dsgB-2czrA:
20.33