SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2d0d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_A_FLPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)
2d0d 2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE

(Pseudomonas
fluorescens)
5 / 12 VAL A 120
VAL A  82
ILE A  31
GLY A 106
ALA A 109
None
0.99A 1eqhA-2d0dA:
undetectable
1eqhA-2d0dA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_B_FLPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)
2d0d 2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE

(Pseudomonas
fluorescens)
5 / 12 VAL A 120
VAL A  82
ILE A  31
GLY A 106
ALA A 109
None
0.99A 1eqhB-2d0dA:
undetectable
1eqhB-2d0dA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))
2d0d 2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE

(Pseudomonas
fluorescens)
4 / 7 PHE A 191
PHE A  65
VAL A 129
HIS A 252
None
0.95A 1lh6A-2d0dA:
undetectable
1lh6A-2d0dA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHV_A_NOGA301_1
(SEX HORMONE-BINDING
GLOBULIN)
2d0d 2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE

(Pseudomonas
fluorescens)
4 / 8 SER A 164
THR A 259
ASP A 260
LEU A 165
None
1.08A 1lhvA-2d0dA:
undetectable
1lhvA-2d0dA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OLT_A_SAMA502_0
(OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE)
2d0d 2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE

(Pseudomonas
fluorescens)
5 / 9 GLY A 248
PHE A 262
GLN A 258
LEU A 265
ILE A 219
None
1.45A 1oltA-2d0dA:
0.5
1oltA-2d0dA:
20.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UKB_A_BEZA1300_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)
2d0d 2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE

(Pseudomonas
fluorescens)
5 / 11 GLY A  33
ALA A 128
VAL A 226
VAL A 227
HIS A 252
CL  A 400 ( 4.2A)
None
None
None
None
1.10A 1ukbA-2d0dA:
51.6
1ukbA-2d0dA:
99.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UKB_A_BEZA1300_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)
2d0d 2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE

(Pseudomonas
fluorescens)
9 / 11 GLY A  33
SER A  34
PHE A 104
PHE A 133
TRP A 143
LEU A 202
VAL A 226
VAL A 227
HIS A 252
CL  A 400 ( 4.2A)
CL  A 400 (-2.8A)
None
None
None
None
None
None
None
0.29A 1ukbA-2d0dA:
51.6
1ukbA-2d0dA:
99.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UKB_A_BEZA1300_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)
2d0d 2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE

(Pseudomonas
fluorescens)
7 / 11 GLY A  33
SER A  34
PHE A 104
TRP A 143
LEU A 202
VAL A 226
HIS A 252
CL  A 400 ( 4.2A)
CL  A 400 (-2.8A)
None
None
None
None
None
1.43A 1ukbA-2d0dA:
51.6
1ukbA-2d0dA:
99.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UKB_A_BEZA1301_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)
2d0d 2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE

(Pseudomonas
fluorescens)
4 / 6 LEU A 156
PHE A 159
ALA A 160
LEU A 170
None
0.28A 1ukbA-2d0dA:
51.6
1ukbA-2d0dA:
99.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UKB_A_BEZA1302_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)
2d0d 2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE

(Pseudomonas
fluorescens)
5 / 5 SER A  77
LYS A  78
TRP A  81
TRP A 198
ALA A 201
None
0.29A 1ukbA-2d0dA:
51.6
1ukbA-2d0dA:
99.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_A_URFA999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)
2d0d 2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE

(Pseudomonas
fluorescens)
4 / 5 ALA A  91
TYR A  19
ILE A  88
ASP A  21
None
1.25A 1upfA-2d0dA:
undetectable
1upfA-2d0dA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)
2d0d 2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE

(Pseudomonas
fluorescens)
4 / 5 PHE A 104
PHE A 191
MET A 190
SER A 186
None
1.04A 1wrkB-2d0dA:
0.2
1wrkB-2d0dA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_A_NCAA1252_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)
2d0d 2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE

(Pseudomonas
fluorescens)
4 / 7 SER A  39
PHE A 183
ARG A  70
GLN A 180
None
1.16A 2c8aA-2d0dA:
undetectable
2c8aA-2d0dA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_C_NCAC1252_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)
2d0d 2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE

(Pseudomonas
fluorescens)
4 / 6 SER A  39
PHE A 183
ARG A  70
GLU A   5
None
1.46A 2c8aC-2d0dA:
undetectable
2c8aC-2d0dA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_B_SAMB1400_0
(UPF0088 PROTEIN
AQ_165)
2d0d 2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE

(Pseudomonas
fluorescens)
5 / 12 VAL A 227
GLY A 221
LEU A 235
LEU A 125
ALA A 128
None
1.02A 2egvB-2d0dA:
undetectable
2egvB-2d0dA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXD_A_DR7A102_2
(POL PROTEIN)
2d0d 2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE

(Pseudomonas
fluorescens)
4 / 7 ALA A 201
ASP A 200
GLY A 130
ILE A 110
None
0.89A 2fxdB-2d0dA:
undetectable
2fxdB-2d0dA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_A_J01A1249_1
(CLAVALDEHYDE
DEHYDROGENASE)
2d0d 2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE

(Pseudomonas
fluorescens)
5 / 12 LEU A 212
ALA A 109
VAL A 120
ALA A 113
LEU A 235
None
1.14A 2japA-2d0dA:
5.4
2japA-2d0dA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_B_J01B1249_1
(CLAVALDEHYDE
DEHYDROGENASE)
2d0d 2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE

(Pseudomonas
fluorescens)
5 / 12 LEU A 212
ALA A 109
VAL A 120
ALA A 113
LEU A 235
None
1.16A 2japB-2d0dA:
5.7
2japB-2d0dA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_C_J01C1249_1
(CLAVALDEHYDE
DEHYDROGENASE)
2d0d 2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE

(Pseudomonas
fluorescens)
5 / 12 LEU A 212
ALA A 109
VAL A 120
ALA A 113
LEU A 235
None
1.13A 2japC-2d0dA:
5.5
2japC-2d0dA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_D_J01D1249_1
(CLAVALDEHYDE
DEHYDROGENASE)
2d0d 2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE

(Pseudomonas
fluorescens)
5 / 12 LEU A 212
ALA A 109
VAL A 120
ALA A 113
LEU A 235
None
1.13A 2japD-2d0dA:
5.4
2japD-2d0dA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJM_B_BJMB2_1
(DIPEPTIDYL PEPTIDASE
4)
2d0d 2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE

(Pseudomonas
fluorescens)
5 / 12 PHE A 187
SER A 103
VAL A 129
VAL A 227
HIS A 252
None
CL  A 400 (-2.9A)
None
None
None
1.15A 3bjmB-2d0dA:
16.6
3bjmB-2d0dA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_B_478B200_1
(PROTEASE)
2d0d 2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE

(Pseudomonas
fluorescens)
5 / 8 LEU A 114
GLY A 107
ALA A 109
VAL A 120
ILE A 218
None
1.20A 3ekpA-2d0dA:
undetectable
3ekpA-2d0dA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)
2d0d 2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE

(Pseudomonas
fluorescens)
3 / 3 GLY A  33
TRP A 143
VAL A 142
CL  A 400 ( 4.2A)
None
None
0.76A 3n62B-2d0dA:
undetectable
3n62B-2d0dA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N65_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)
2d0d 2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE

(Pseudomonas
fluorescens)
3 / 3 GLY A  33
TRP A 143
VAL A 142
CL  A 400 ( 4.2A)
None
None
0.73A 3n65B-2d0dA:
undetectable
3n65B-2d0dA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)
2d0d 2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE

(Pseudomonas
fluorescens)
3 / 3 GLY A  33
TRP A 143
VAL A 142
CL  A 400 ( 4.2A)
None
None
0.76A 3n66B-2d0dA:
undetectable
3n66B-2d0dA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)
2d0d 2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE

(Pseudomonas
fluorescens)
3 / 3 TYR A 175
LEU A 165
ARG A 174
None
0.67A 3sufB-2d0dA:
undetectable
3sufB-2d0dA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6D_A_SAMA1350_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)
2d0d 2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE

(Pseudomonas
fluorescens)
5 / 12 GLY A  37
GLY A  35
PHE A 183
ALA A  42
ASP A  61
None
1.16A 4a6dA-2d0dA:
undetectable
4a6dA-2d0dA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB6_C_VLBC503_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)
2d0d 2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE

(Pseudomonas
fluorescens)
5 / 12 THR A  17
PRO A  60
ILE A  48
VAL A  57
ILE A  29
None
1.44A 4eb6B-2d0dA:
undetectable
4eb6C-2d0dA:
3.2
4eb6B-2d0dA:
23.41
4eb6C-2d0dA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_2
(CYTOCHROME P450
21-HYDROXYLASE)
2d0d 2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE

(Pseudomonas
fluorescens)
3 / 3 LEU A 233
VAL A 227
ASP A 224
None
0.63A 4y8wC-2d0dA:
undetectable
4y8wC-2d0dA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_B_PAUB601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)
2d0d 2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE

(Pseudomonas
fluorescens)
4 / 7 ALA A 177
GLY A  37
SER A  39
GLY A  66
None
0.88A 5e26A-2d0dA:
undetectable
5e26B-2d0dA:
undetectable
5e26A-2d0dA:
21.24
5e26B-2d0dA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_K_BO2K305_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-1)
2d0d 2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE

(Pseudomonas
fluorescens)
5 / 11 ALA A 111
THR A 112
ALA A 113
GLY A 105
GLY A 106
None
0.95A 5lf3K-2d0dA:
undetectable
5lf3L-2d0dA:
undetectable
5lf3K-2d0dA:
19.73
5lf3L-2d0dA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_Y_BO2Y305_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-1)
2d0d 2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE

(Pseudomonas
fluorescens)
5 / 11 ALA A 111
THR A 112
ALA A 113
GLY A 105
GLY A 106
None
0.94A 5lf3Y-2d0dA:
undetectable
5lf3Z-2d0dA:
undetectable
5lf3Y-2d0dA:
19.73
5lf3Z-2d0dA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_K_6V8K305_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)
2d0d 2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE

(Pseudomonas
fluorescens)
5 / 11 ALA A 111
THR A 112
ALA A 113
GLY A 105
GLY A 106
None
0.93A 5lf7K-2d0dA:
undetectable
5lf7L-2d0dA:
undetectable
5lf7K-2d0dA:
19.73
5lf7L-2d0dA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_Y_6V8Y306_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)
2d0d 2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE

(Pseudomonas
fluorescens)
5 / 11 ALA A 111
THR A 112
ALA A 113
GLY A 105
GLY A 106
None
0.94A 5lf7Y-2d0dA:
undetectable
5lf7Z-2d0dA:
undetectable
5lf7Y-2d0dA:
19.73
5lf7Z-2d0dA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)
2d0d 2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE

(Pseudomonas
fluorescens)
4 / 4 LEU A 108
LEU A 202
SER A  77
ALA A 201
None
1.02A 5uunA-2d0dA:
undetectable
5uunA-2d0dA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)
2d0d 2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE

(Pseudomonas
fluorescens)
5 / 7 GLY A 101
LEU A 125
LEU A 233
ILE A 110
GLY A 107
None
1.39A 5vkqA-2d0dA:
undetectable
5vkqB-2d0dA:
undetectable
5vkqA-2d0dA:
10.69
5vkqB-2d0dA:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VM8_B_SAMB301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)
2d0d 2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE

(Pseudomonas
fluorescens)
5 / 10 VAL A 100
GLY A 101
GLY A 106
ILE A 218
LEU A 217
None
1.02A 5vm8B-2d0dA:
undetectable
5vm8B-2d0dA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_ACTB804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)
2d0d 2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE

(Pseudomonas
fluorescens)
3 / 3 GLY A  33
TRP A 143
VAL A 142
CL  A 400 ( 4.2A)
None
None
0.70A 5vuoB-2d0dA:
undetectable
5vuoB-2d0dA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_C_EU7C101_0
(MATRIX PROTEIN 2)
2d0d 2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE

(Pseudomonas
fluorescens)
5 / 9 SER A  80
VAL A  15
ALA A  13
VAL A  63
GLY A  87
None
1.23A 6bklA-2d0dA:
undetectable
6bklB-2d0dA:
undetectable
6bklC-2d0dA:
undetectable
6bklD-2d0dA:
undetectable
6bklA-2d0dA:
8.47
6bklB-2d0dA:
8.47
6bklC-2d0dA:
8.47
6bklD-2d0dA:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)
2d0d 2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE

(Pseudomonas
fluorescens)
5 / 10 LEU A 235
ASP A 224
ILE A 110
SER A 103
GLY A 107
None
None
None
CL  A 400 (-2.9A)
None
1.33A 6dlzA-2d0dA:
3.6
6dlzD-2d0dA:
3.5
6dlzA-2d0dA:
15.47
6dlzD-2d0dA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)
2d0d 2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE

(Pseudomonas
fluorescens)
5 / 10 ILE A 110
SER A 103
GLY A 107
LEU A 235
ASP A 224
None
CL  A 400 (-2.9A)
None
None
None
1.33A 6dlzB-2d0dA:
3.6
6dlzC-2d0dA:
undetectable
6dlzB-2d0dA:
15.47
6dlzC-2d0dA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)
2d0d 2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE

(Pseudomonas
fluorescens)
5 / 10 LEU A 235
ASP A 224
ILE A 110
SER A 103
GLY A 107
None
None
None
CL  A 400 (-2.9A)
None
1.34A 6dm1A-2d0dA:
undetectable
6dm1D-2d0dA:
3.5
6dm1A-2d0dA:
15.47
6dm1D-2d0dA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)
2d0d 2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE

(Pseudomonas
fluorescens)
5 / 10 ILE A 110
SER A 103
GLY A 107
LEU A 235
ASP A 224
None
CL  A 400 (-2.9A)
None
None
None
1.34A 6dm1B-2d0dA:
undetectable
6dm1C-2d0dA:
undetectable
6dm1B-2d0dA:
15.47
6dm1C-2d0dA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_B_STRB502_1
(CYTOCHROME P450
CYP260A1)
2d0d 2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE

(Pseudomonas
fluorescens)
4 / 6 LEU A 212
ALA A 113
LEU A 235
SER A 204
None
0.96A 6f88B-2d0dA:
undetectable
6f88B-2d0dA:
13.81