SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2d0i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_2
(HIV-1 PROTEASE)		 2d0i DEHYDROGENASE
(Pyrococcus
horikoshii) 		3 / 3 ARG A 236
THR A 259
VAL A 261
 None
 0.99A 1hxbA-2d0iA:
undetectable		 1hxbA-2d0iA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R55_A_097A518_1
(ADAM 33)		 2d0i DEHYDROGENASE
(Pyrococcus
horikoshii) 		5 / 10 ALA A 258
THR A 259
HIS A 284
GLU A 265
ALA A 286
 None
 1.13A 1r55A-2d0iA:
undetectable		 1r55A-2d0iA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT6_A_DESA129_1
(TRANSTHYRETIN)		 2d0i DEHYDROGENASE
(Pyrococcus
horikoshii) 		4 / 4 LYS A  66
LEU A 308
LEU A 304
SER A  69
 None
 1.28A 1tt6A-2d0iA:
undetectable		 1tt6A-2d0iA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1414_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 2d0i DEHYDROGENASE
(Pyrococcus
horikoshii) 		4 / 8 LEU A 272
ILE A 249
THR A 259
LEU A 281
 None
 0.80A 2xfhA-2d0iA:
undetectable		 2xfhA-2d0iA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XUD_A_DMEA1544_1
(ACETYLCHOLINESTERASE)		 2d0i DEHYDROGENASE
(Pyrococcus
horikoshii) 		4 / 6 TYR A 118
TRP A 128
TRP A 277
HIS A 131
 None
 1.13A 2xudA-2d0iA:
0.0		 2xudA-2d0iA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7V_A_SAMA992_0
(METHYLORNITHINE
SYNTHASE PYLB)		 2d0i DEHYDROGENASE
(Pyrococcus
horikoshii) 		5 / 12 THR A 259
GLY A 237
GLY A 235
LEU A 198
VAL A 245
 None
 1.19A 3t7vA-2d0iA:
undetectable		 3t7vA-2d0iA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 2d0i DEHYDROGENASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A 153
GLY A 155
ILE A 161
LEU A 208
PRO A 209
 None
 0.98A 4gc9A-2d0iA:
4.8		 4gc9A-2d0iA:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 2d0i DEHYDROGENASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A 153
GLY A 158
ILE A 205
LEU A 208
PRO A 209
 None
 0.85A 4gc9A-2d0iA:
4.8		 4gc9A-2d0iA:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2V_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		 2d0i DEHYDROGENASE
(Pyrococcus
horikoshii) 		3 / 3 HIS A 216
VAL A 204
LEU A 206
 None
 0.75A 4m2vA-2d0iA:
undetectable		 4m2vA-2d0iA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD4_C_AOQC4003_1
(CYTOCHROME B)		 2d0i DEHYDROGENASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A  38
VAL A  39
ILE A  40
LEU A   8
ILE A  78
 None
 1.08A 4pd4C-2d0iA:
undetectable		 4pd4C-2d0iA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2d0i DEHYDROGENASE
(Pyrococcus
horikoshii) 		3 / 3 ASP A  76
LYS A  92
LEU A  97
 None
 1.01A 4ptjA-2d0iA:
undetectable		 4ptjA-2d0iA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_A_SALA801_1
(PROTEIN POLYBROMO-1)		 2d0i DEHYDROGENASE
(Pyrococcus
horikoshii) 		4 / 7 ILE A 157
LEU A  97
ALA A 286
ILE A 234
 None
 0.86A 4y03A-2d0iA:
undetectable		 4y03A-2d0iA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2d0i DEHYDROGENASE
(Pyrococcus
horikoshii) 		5 / 12 SER A  94
ALA A 100
VAL A 296
GLY A 297
ALA A 300
 None
 1.03A 5kirB-2d0iA:
0.0		 5kirB-2d0iA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUM_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 2d0i DEHYDROGENASE
(Pyrococcus
horikoshii) 		4 / 8 ILE A  88
LEU A  65
ILE A  68
ILE A  78
 None
 0.66A 5numA-2d0iA:
undetectable		 5numA-2d0iA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_2
(TUBULIN BETA CHAIN)		 2d0i DEHYDROGENASE
(Pyrococcus
horikoshii) 		5 / 12 ALA A  73
ALA A 102
ILE A 234
ALA A 286
ILE A 161
 None
 1.10A 5xiwD-2d0iA:
2.1		 5xiwD-2d0iA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_G_CHDG401_0
(BILE SALT HYDROLASE)		 2d0i DEHYDROGENASE
(Pyrococcus
horikoshii) 		5 / 10 ILE A 205
LEU A 165
LEU A 187
ALA A 189
GLU A 196
 None
 1.02A 5y7pG-2d0iA:
undetectable		 5y7pG-2d0iA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_G_CHDG401_0
(BILE SALT HYDROLASE)		 2d0i DEHYDROGENASE
(Pyrococcus
horikoshii) 		5 / 10 LEU A 197
LEU A 165
LEU A 187
ALA A 189
GLU A 196
 None
 1.17A 5y7pG-2d0iA:
undetectable		 5y7pG-2d0iA:
22.29