SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2d0j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_A_TESA325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 2d0j GALACTOSYLGALACTOSYL
XYLOSYLPROTEIN
3-BETA-GLUCURONOSYLT
RANSFERASE 2
(Homo
sapiens) 		4 / 7 LEU A 167
TYR A  83
HIS A 171
THR A 201
 None
 1.26A 1afsA-2d0jA:
undetectable		 1afsA-2d0jA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_B_TESB325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 2d0j GALACTOSYLGALACTOSYL
XYLOSYLPROTEIN
3-BETA-GLUCURONOSYLT
RANSFERASE 2
(Homo
sapiens) 		4 / 7 LEU A 167
TYR A  83
HIS A 171
THR A 201
 None
 1.26A 1afsB-2d0jA:
undetectable		 1afsB-2d0jA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F86_B_T44B528_1
(TRANSTHYRETIN
THR119MET VARIANT)		 2d0j GALACTOSYLGALACTOSYL
XYLOSYLPROTEIN
3-BETA-GLUCURONOSYLT
RANSFERASE 2
(Homo
sapiens) 		4 / 4 LYS A 295
LEU A 297
ALA A 290
LEU A 194
 None
 1.48A 1f86B-2d0jA:
undetectable		 1f86B-2d0jA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_A_NCAA1501_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 2d0j GALACTOSYLGALACTOSYL
XYLOSYLPROTEIN
3-BETA-GLUCURONOSYLT
RANSFERASE 2
(Homo
sapiens) 		4 / 7 ASP A 185
ALA A 156
ARG A 155
ASP A 186
 None
 1.09A 2e5dA-2d0jA:
undetectable
2e5dB-2d0jA:
undetectable		 2e5dA-2d0jA:
18.81
2e5dB-2d0jA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_D_ADND904_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 2d0j GALACTOSYLGALACTOSYL
XYLOSYLPROTEIN
3-BETA-GLUCURONOSYLT
RANSFERASE 2
(Homo
sapiens) 		5 / 12 PHE A 183
ASN A 161
ILE A  85
THR A 157
VAL A 249
 None
 1.24A 2gl0D-2d0jA:
undetectable
2gl0E-2d0jA:
undetectable		 2gl0D-2d0jA:
22.57
2gl0E-2d0jA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_E_ADNE905_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 2d0j GALACTOSYLGALACTOSYL
XYLOSYLPROTEIN
3-BETA-GLUCURONOSYLT
RANSFERASE 2
(Homo
sapiens) 		5 / 11 PHE A 183
ASN A 161
ILE A  85
THR A 157
VAL A 249
 None
 1.24A 2gl0E-2d0jA:
0.0
2gl0F-2d0jA:
0.3		 2gl0E-2d0jA:
22.57
2gl0F-2d0jA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2d0j GALACTOSYLGALACTOSYL
XYLOSYLPROTEIN
3-BETA-GLUCURONOSYLT
RANSFERASE 2
(Homo
sapiens) 		4 / 8 LEU A 181
LEU A 277
ILE A  85
PHE A 183
 None
 0.95A 3ln1A-2d0jA:
undetectable		 3ln1A-2d0jA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2d0j GALACTOSYLGALACTOSYL
XYLOSYLPROTEIN
3-BETA-GLUCURONOSYLT
RANSFERASE 2
(Homo
sapiens) 		4 / 7 LEU A 181
LEU A 277
ILE A  85
PHE A 183
 None
 0.95A 3ln1B-2d0jA:
undetectable		 3ln1B-2d0jA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NAI_C_URFC521_1
(RNA DEPENDENT RNA
POLYMERASE)		 2d0j GALACTOSYLGALACTOSYL
XYLOSYLPROTEIN
3-BETA-GLUCURONOSYLT
RANSFERASE 2
(Homo
sapiens) 		4 / 5 ASP A 187
ASP A 186
ASP A 185
ARG A 155
 None
 1.30A 3naiC-2d0jA:
0.0		 3naiC-2d0jA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_A_ACTA1002_0
(PUTATIVE
OXIDOREDUCTASE)		 2d0j GALACTOSYLGALACTOSYL
XYLOSYLPROTEIN
3-BETA-GLUCURONOSYLT
RANSFERASE 2
(Homo
sapiens) 		4 / 6 ASP A 243
GLY A 213
VAL A 212
THR A 232
 None
 1.03A 3vqrA-2d0jA:
undetectable		 3vqrA-2d0jA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_B_ACTB1002_0
(PUTATIVE
OXIDOREDUCTASE)		 2d0j GALACTOSYLGALACTOSYL
XYLOSYLPROTEIN
3-BETA-GLUCURONOSYLT
RANSFERASE 2
(Homo
sapiens) 		4 / 5 ASP A 243
GLY A 213
VAL A 212
THR A 232
 None
 1.00A 3vqrB-2d0jA:
undetectable		 3vqrB-2d0jA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_0
(PUTATIVE REGULATORY
PROTEIN)		 2d0j GALACTOSYLGALACTOSYL
XYLOSYLPROTEIN
3-BETA-GLUCURONOSYLT
RANSFERASE 2
(Homo
sapiens) 		5 / 12 LEU A 164
THR A 281
ILE A 280
ILE A  85
ALA A 184
 None
 1.05A 3vw1D-2d0jA:
undetectable		 3vw1D-2d0jA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2d0j GALACTOSYLGALACTOSYL
XYLOSYLPROTEIN
3-BETA-GLUCURONOSYLT
RANSFERASE 2
(Homo
sapiens) 		4 / 7 MET A 244
ARG A 168
VAL A 204
MET A 198
 None
 1.33A 4f4dA-2d0jA:
undetectable		 4f4dA-2d0jA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_A_ACTA403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 2d0j GALACTOSYLGALACTOSYL
XYLOSYLPROTEIN
3-BETA-GLUCURONOSYLT
RANSFERASE 2
(Homo
sapiens) 		3 / 3 VAL A 204
LEU A 286
VAL A 206
 None
 0.59A 4wq4A-2d0jA:
undetectable		 4wq4A-2d0jA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH614_0
(NADH DEHYDROGENASE,
PUTATIVE)		 2d0j GALACTOSYLGALACTOSYL
XYLOSYLPROTEIN
3-BETA-GLUCURONOSYLT
RANSFERASE 2
(Homo
sapiens) 		4 / 6 ILE A 242
VAL A 227
VAL A 206
TRP A 230
 None
 0.74A 5jwaH-2d0jA:
undetectable		 5jwaH-2d0jA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_A_7V7A201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 2d0j GALACTOSYLGALACTOSYL
XYLOSYLPROTEIN
3-BETA-GLUCURONOSYLT
RANSFERASE 2
(Homo
sapiens) 		4 / 8 THR A 189
TYR A 190
THR A 104
GLN A 107
 None
 1.16A 5tzoA-2d0jA:
undetectable		 5tzoA-2d0jA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 2d0j GALACTOSYLGALACTOSYL
XYLOSYLPROTEIN
3-BETA-GLUCURONOSYLT
RANSFERASE 2
(Homo
sapiens) 		4 / 8 THR A 189
TYR A 190
THR A 104
GLN A 107
 None
 1.16A 5tzoB-2d0jA:
undetectable		 5tzoB-2d0jA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_C_7V7C202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 2d0j GALACTOSYLGALACTOSYL
XYLOSYLPROTEIN
3-BETA-GLUCURONOSYLT
RANSFERASE 2
(Homo
sapiens) 		4 / 8 THR A 189
TYR A 190
THR A 104
GLN A 107
 None
 1.13A 5tzoC-2d0jA:
undetectable		 5tzoC-2d0jA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_2
(RIFAMPIN
MONOOXYGENASE)		 2d0j GALACTOSYLGALACTOSYL
XYLOSYLPROTEIN
3-BETA-GLUCURONOSYLT
RANSFERASE 2
(Homo
sapiens) 		4 / 6 GLN A 279
VAL A 249
ARG A 235
PRO A 239
 None
 1.18A 6brdB-2d0jA:
undetectable		 6brdB-2d0jA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_B_STRB502_1
(CYTOCHROME P450
CYP260A1)		 2d0j GALACTOSYLGALACTOSYL
XYLOSYLPROTEIN
3-BETA-GLUCURONOSYLT
RANSFERASE 2
(Homo
sapiens) 		4 / 6 LEU A 135
ALA A 133
SER A 137
THR A  86
 None
 0.88A 6f88B-2d0jA:
undetectable		 6f88B-2d0jA:
15.10