SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2d0v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBR_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 2d0v METHANOL
DEHYDROGENASE LARGE
SUBUNIT
(Hyphomicrobium
denitrificans) 		5 / 12 PHE A 562
LEU A 556
ALA A 558
ALA A 561
PRO A 440
 None
 1.25A 1cbrA-2d0vA:
undetectable		 1cbrA-2d0vA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBR_B_REAB200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 2d0v METHANOL
DEHYDROGENASE LARGE
SUBUNIT
(Hyphomicrobium
denitrificans) 		5 / 12 PHE A 562
LEU A 556
ALA A 558
ALA A 561
PRO A 440
 None
 1.25A 1cbrB-2d0vA:
undetectable		 1cbrB-2d0vA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1873_0
(FPRA)		 2d0v METHANOL
DEHYDROGENASE LARGE
SUBUNIT
(Hyphomicrobium
denitrificans) 		3 / 3 ASP A 502
ASP A 401
LYS A 466
 None
 1.12A 1lqtB-2d0vA:
undetectable		 1lqtB-2d0vA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1430_0
(FPRA)		 2d0v METHANOL
DEHYDROGENASE LARGE
SUBUNIT
(Hyphomicrobium
denitrificans) 		3 / 3 ASP A 502
ASP A 401
LYS A 466
 None
 1.13A 1lquB-2d0vA:
undetectable		 1lquB-2d0vA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEI_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 2d0v METHANOL
DEHYDROGENASE LARGE
SUBUNIT
(Hyphomicrobium
denitrificans) 		4 / 8 SER A  69
SER A  70
ASN A 108
GLY A 536
 None
 0.81A 1meiA-2d0vA:
undetectable		 1meiA-2d0vA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA732_1
(ALPHA AMYLASE)		 2d0v METHANOL
DEHYDROGENASE LARGE
SUBUNIT
(Hyphomicrobium
denitrificans) 		5 / 9 GLY A 573
GLU A  55
GLY A  53
GLY A 518
GLY A  56
 None
PQQ  A 601 (-2.7A)
None
None
None
 1.07A 1mxdA-2d0vA:
undetectable		 1mxdA-2d0vA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA442_1
(ALPHA AMYLASE)		 2d0v METHANOL
DEHYDROGENASE LARGE
SUBUNIT
(Hyphomicrobium
denitrificans) 		5 / 11 GLY A 573
GLU A  55
GLY A  53
GLY A 518
GLY A  56
 None
PQQ  A 601 (-2.7A)
None
None
None
 1.05A 1mxgA-2d0vA:
undetectable		 1mxgA-2d0vA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA6_B_STRB402_1
(MINERALOCORTICOID
RECEPTOR)		 2d0v METHANOL
DEHYDROGENASE LARGE
SUBUNIT
(Hyphomicrobium
denitrificans) 		5 / 12 ALA A  43
LEU A  80
MET A 521
MET A  65
LEU A 575
 None
 1.44A 2aa6B-2d0vA:
undetectable		 2aa6B-2d0vA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPM_A_SAMA300_0
(PROTEIN
(ADENINE-SPECIFIC
METHYLTRANSFERASE
DPNII 1))		 2d0v METHANOL
DEHYDROGENASE LARGE
SUBUNIT
(Hyphomicrobium
denitrificans) 		5 / 12 GLY A  56
GLY A 478
GLY A 477
PHE A 408
PHE A 407
 None
 1.13A 2dpmA-2d0vA:
undetectable		 2dpmA-2d0vA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_B_ACTB1004_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 2d0v METHANOL
DEHYDROGENASE LARGE
SUBUNIT
(Hyphomicrobium
denitrificans) 		4 / 4 HIS A 525
PRO A 585
ASN A 584
TYR A 523
 None
 1.41A 2f7aB-2d0vA:
0.0		 2f7aB-2d0vA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HKK_A_ALEA300_1
(CARBONIC ANHYDRASE 2)		 2d0v METHANOL
DEHYDROGENASE LARGE
SUBUNIT
(Hyphomicrobium
denitrificans) 		4 / 6 ASN A  24
ASN A  20
ILE A   5
THR A  28
 None
 1.26A 2hkkA-2d0vA:
undetectable		 2hkkA-2d0vA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 2d0v METHANOL
DEHYDROGENASE LARGE
SUBUNIT
(Hyphomicrobium
denitrificans) 		3 / 3 ARG A 109
ASP A 330
ASN A 394
 PQQ  A 601 (-3.2A)
None
PQQ  A 601 (-3.5A)
 0.83A 2zzmA-2d0vA:
undetectable		 2zzmA-2d0vA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_2
(PHOSPHOLIPASE A2)		 2d0v METHANOL
DEHYDROGENASE LARGE
SUBUNIT
METHANOL
DEHYDROGENASE SMALL
SUBUNIT
(Hyphomicrobium
denitrificans) 		4 / 6 VAL A 184
GLN A 194
GLY A 192
ARG B  54
 None
 1.01A 3bjwE-2d0vA:
undetectable		 3bjwE-2d0vA:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2d0v METHANOL
DEHYDROGENASE LARGE
SUBUNIT
(Hyphomicrobium
denitrificans) 		3 / 3 GLY A 518
GLY A 396
GLY A 477
 None
 0.43A 3bogC-2d0vA:
undetectable		 3bogC-2d0vA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2d0v METHANOL
DEHYDROGENASE LARGE
SUBUNIT
(Hyphomicrobium
denitrificans) 		3 / 3 GLY A 518
GLY A 396
GLY A 477
 None
 0.42A 3bogD-2d0vA:
undetectable		 3bogD-2d0vA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FSU_A_C2FA995_0
(5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE)		 2d0v METHANOL
DEHYDROGENASE LARGE
SUBUNIT
(Hyphomicrobium
denitrificans) 		5 / 12 LEU A 111
SER A  69
ASN A  73
GLN A 128
TYR A  66
 None
 1.38A 3fsuA-2d0vA:
undetectable		 3fsuA-2d0vA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_0
(PCZA361.24)		 2d0v METHANOL
DEHYDROGENASE LARGE
SUBUNIT
(Hyphomicrobium
denitrificans) 		5 / 12 ALA A 558
GLY A 560
LEU A 549
LEU A 436
GLY A 542
 None
 1.02A 3g2oA-2d0vA:
undetectable		 3g2oA-2d0vA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LD6_B_KKKB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2d0v METHANOL
DEHYDROGENASE LARGE
SUBUNIT
(Hyphomicrobium
denitrificans) 		5 / 12 PHE A 358
TRP A 302
GLY A 555
ALA A 558
ILE A 414
 None
 1.24A 3ld6B-2d0vA:
undetectable		 3ld6B-2d0vA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEK_A_SAMA510_0
(SET AND MYND
DOMAIN-CONTAINING
PROTEIN 3)		 2d0v METHANOL
DEHYDROGENASE LARGE
SUBUNIT
METHANOL
DEHYDROGENASE SMALL
SUBUNIT
(Hyphomicrobium
denitrificans;
Hyphomicrobium
denitrificans) 		5 / 12 GLY A 131
ASN A 149
TYR A 187
GLU B  47
TYR B  66
 None
 1.45A 3mekA-2d0vA:
undetectable		 3mekA-2d0vA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 2d0v METHANOL
DEHYDROGENASE LARGE
SUBUNIT
(Hyphomicrobium
denitrificans) 		3 / 3 GLY A 478
TRP A 245
VAL A 309
 None
 0.50A 3n62B-2d0vA:
undetectable		 3n62B-2d0vA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N65_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 2d0v METHANOL
DEHYDROGENASE LARGE
SUBUNIT
(Hyphomicrobium
denitrificans) 		3 / 3 GLY A 478
TRP A 245
VAL A 309
 None
 0.49A 3n65B-2d0vA:
undetectable		 3n65B-2d0vA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 2d0v METHANOL
DEHYDROGENASE LARGE
SUBUNIT
(Hyphomicrobium
denitrificans) 		3 / 3 GLY A 478
TRP A 245
VAL A 309
 None
 0.49A 3n66B-2d0vA:
undetectable		 3n66B-2d0vA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3M_A_DLUA398_1
(PFV INTEGRASE)		 2d0v METHANOL
DEHYDROGENASE LARGE
SUBUNIT
(Hyphomicrobium
denitrificans) 		4 / 8 ASP A 303
GLY A 306
GLU A 177
ARG A 109
 CA  A 775 ( 3.4A)
None
CA  A 775 ( 2.1A)
PQQ  A 601 (-3.2A)
 0.94A 3s3mA-2d0vA:
undetectable		 3s3mA-2d0vA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SGL_A_SAMA692_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 2d0v METHANOL
DEHYDROGENASE LARGE
SUBUNIT
(Hyphomicrobium
denitrificans) 		5 / 12 GLY A 518
GLY A 478
THR A 479
LEU A 480
GLY A  56
 None
 1.10A 3sglA-2d0vA:
undetectable		 3sglA-2d0vA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		 2d0v METHANOL
DEHYDROGENASE LARGE
SUBUNIT
(Hyphomicrobium
denitrificans) 		5 / 12 ASN A 108
GLY A 539
ALA A 176
GLY A 175
ASN A 261
 None
PQQ  A 601 (-3.4A)
PQQ  A 601 (-3.3A)
PQQ  A 601 (-3.2A)
CA  A 775 (-2.8A)
 1.20A 3v3oA-2d0vA:
undetectable		 3v3oA-2d0vA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		 2d0v METHANOL
DEHYDROGENASE LARGE
SUBUNIT
(Hyphomicrobium
denitrificans) 		5 / 12 ASN A 394
HIS A 393
GLY A 410
ALA A  57
GLY A  56
 PQQ  A 601 (-3.5A)
None
None
None
None
 1.18A 3v3oA-2d0vA:
undetectable		 3v3oA-2d0vA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		 2d0v METHANOL
DEHYDROGENASE LARGE
SUBUNIT
METHANOL
DEHYDROGENASE SMALL
SUBUNIT
(Hyphomicrobium
denitrificans) 		5 / 12 HIS A 183
GLY A 150
ALA B  52
GLU B  56
ASN B  53
 None
 1.25A 3v3oB-2d0vA:
undetectable		 3v3oB-2d0vA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_1
(MNMC2)		 2d0v METHANOL
DEHYDROGENASE LARGE
SUBUNIT
(Hyphomicrobium
denitrificans) 		4 / 6 GLY A 375
GLU A 301
ASP A 273
ASP A 371
 None
 0.91A 3vywC-2d0vA:
undetectable		 3vywC-2d0vA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AF0_A_MOAA1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 2d0v METHANOL
DEHYDROGENASE LARGE
SUBUNIT
(Hyphomicrobium
denitrificans) 		4 / 8 SER A  69
SER A  70
ASN A 108
GLY A 536
 None
 0.88A 4af0A-2d0vA:
undetectable		 4af0A-2d0vA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DXU_A_ACAA711_1
(LACTOTRANSFERRIN)		 2d0v METHANOL
DEHYDROGENASE LARGE
SUBUNIT
(Hyphomicrobium
denitrificans) 		4 / 6 GLY A 518
VAL A 516
GLY A 410
GLU A 471
 None
 0.82A 4dxuA-2d0vA:
undetectable		 4dxuA-2d0vA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2d0v METHANOL
DEHYDROGENASE LARGE
SUBUNIT
(Hyphomicrobium
denitrificans) 		5 / 11 ALA A 176
GLY A 239
GLY A 258
ASN A 261
TRP A 243
 PQQ  A 601 (-3.3A)
None
None
CA  A 775 (-2.8A)
PQQ  A 601 (-3.3A)
 1.24A 4e47A-2d0vA:
undetectable		 4e47A-2d0vA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_B_SAMB800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2d0v METHANOL
DEHYDROGENASE LARGE
SUBUNIT
(Hyphomicrobium
denitrificans) 		5 / 11 ALA A 176
GLY A 239
GLY A 258
ASN A 261
TRP A 243
 PQQ  A 601 (-3.3A)
None
None
CA  A 775 (-2.8A)
PQQ  A 601 (-3.3A)
 1.28A 4e47B-2d0vA:
undetectable		 4e47B-2d0vA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_C_SAMC800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2d0v METHANOL
DEHYDROGENASE LARGE
SUBUNIT
(Hyphomicrobium
denitrificans) 		5 / 11 ALA A 176
GLY A 239
GLY A 258
ASN A 261
TRP A 243
 PQQ  A 601 (-3.3A)
None
None
CA  A 775 (-2.8A)
PQQ  A 601 (-3.3A)
 1.29A 4e47C-2d0vA:
undetectable		 4e47C-2d0vA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_C_VK3C202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 2d0v METHANOL
DEHYDROGENASE LARGE
SUBUNIT
(Hyphomicrobium
denitrificans) 		4 / 7 TYR A 256
LEU A 326
ASN A 342
TYR A 220
 None
 1.38A 4f8yC-2d0vA:
undetectable
4f8yD-2d0vA:
undetectable		 4f8yC-2d0vA:
16.17
4f8yD-2d0vA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 2d0v METHANOL
DEHYDROGENASE LARGE
SUBUNIT
(Hyphomicrobium
denitrificans) 		4 / 8 SER A  69
SER A  70
ASN A 108
GLY A 536
 None
 0.86A 4fo4A-2d0vA:
undetectable		 4fo4A-2d0vA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 2d0v METHANOL
DEHYDROGENASE LARGE
SUBUNIT
(Hyphomicrobium
denitrificans) 		4 / 8 SER A  69
SER A  70
ASN A 108
GLY A 536
 None
 0.85A 4fo4B-2d0vA:
undetectable		 4fo4B-2d0vA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H2F_A_ADNA601_1
(5'-NUCLEOTIDASE)		 2d0v METHANOL
DEHYDROGENASE LARGE
SUBUNIT
(Hyphomicrobium
denitrificans) 		5 / 9 GLY A 542
GLY A 544
GLY A 538
PHE A 547
ASP A 105
 None
 1.17A 4h2fA-2d0vA:
undetectable		 4h2fA-2d0vA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H2G_A_ADNA603_1
(5'-NUCLEOTIDASE)		 2d0v METHANOL
DEHYDROGENASE LARGE
SUBUNIT
(Hyphomicrobium
denitrificans) 		5 / 9 GLY A 542
GLY A 544
GLY A 538
PHE A 547
ASP A 105
 None
 1.17A 4h2gA-2d0vA:
undetectable		 4h2gA-2d0vA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2d0v METHANOL
DEHYDROGENASE LARGE
SUBUNIT
(Hyphomicrobium
denitrificans) 		5 / 11 ALA A 176
GLY A 239
GLY A 258
ASN A 261
TRP A 243
 PQQ  A 601 (-3.3A)
None
None
CA  A 775 (-2.8A)
PQQ  A 601 (-3.3A)
 1.25A 4jdsA-2d0vA:
undetectable		 4jdsA-2d0vA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_B_SAMB401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2d0v METHANOL
DEHYDROGENASE LARGE
SUBUNIT
(Hyphomicrobium
denitrificans) 		5 / 11 ALA A 176
GLY A 239
GLY A 258
ASN A 261
TRP A 243
 PQQ  A 601 (-3.3A)
None
None
CA  A 775 (-2.8A)
PQQ  A 601 (-3.3A)
 1.23A 4jdsB-2d0vA:
undetectable		 4jdsB-2d0vA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_C_SAMC401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2d0v METHANOL
DEHYDROGENASE LARGE
SUBUNIT
(Hyphomicrobium
denitrificans) 		5 / 11 ALA A 176
GLY A 239
GLY A 258
ASN A 261
TRP A 243
 PQQ  A 601 (-3.3A)
None
None
CA  A 775 (-2.8A)
PQQ  A 601 (-3.3A)
 1.31A 4jdsC-2d0vA:
undetectable		 4jdsC-2d0vA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLG_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2d0v METHANOL
DEHYDROGENASE LARGE
SUBUNIT
(Hyphomicrobium
denitrificans) 		5 / 12 ALA A 176
GLY A 239
GLY A 258
ASN A 261
TRP A 243
 PQQ  A 601 (-3.3A)
None
None
CA  A 775 (-2.8A)
PQQ  A 601 (-3.3A)
 1.17A 4jlgA-2d0vA:
undetectable		 4jlgA-2d0vA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 2d0v METHANOL
DEHYDROGENASE LARGE
SUBUNIT
METHANOL
DEHYDROGENASE SMALL
SUBUNIT
(Hyphomicrobium
denitrificans;
Hyphomicrobium
denitrificans) 		4 / 5 TYR B   1
LYS B  16
PRO B  17
GLU A 267
 None
 1.33A 4w5tA-2d0vB:
undetectable		 4w5tA-2d0vB:
6.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_D_QDND602_1
(CYTOCHROME P450 2D6)		 2d0v METHANOL
DEHYDROGENASE LARGE
SUBUNIT
(Hyphomicrobium
denitrificans) 		5 / 10 GLY A 428
GLN A 429
PHE A 430
SER A 100
ALA A  97
 None
 1.36A 4wnuD-2d0vA:
undetectable		 4wnuD-2d0vA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 2d0v METHANOL
DEHYDROGENASE LARGE
SUBUNIT
METHANOL
DEHYDROGENASE SMALL
SUBUNIT
(Hyphomicrobium
denitrificans;
Hyphomicrobium
denitrificans) 		4 / 6 TYR B   1
LYS B  16
PRO B  17
GLU A 267
 None
 1.34A 4z4cA-2d0vB:
undetectable		 4z4cA-2d0vB:
6.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 2d0v METHANOL
DEHYDROGENASE LARGE
SUBUNIT
METHANOL
DEHYDROGENASE SMALL
SUBUNIT
(Hyphomicrobium
denitrificans;
Hyphomicrobium
denitrificans) 		4 / 6 TYR B   1
LYS B  16
PRO B  17
GLU A 267
 None
 1.31A 4z4gA-2d0vB:
undetectable		 4z4gA-2d0vB:
6.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CCM_A_SAMA504_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SMYD3)		 2d0v METHANOL
DEHYDROGENASE LARGE
SUBUNIT
METHANOL
DEHYDROGENASE SMALL
SUBUNIT
(Hyphomicrobium
denitrificans;
Hyphomicrobium
denitrificans) 		5 / 12 GLY A 131
ASN A 149
TYR A 187
GLU B  47
TYR B  66
 None
 1.42A 5ccmA-2d0vA:
undetectable		 5ccmA-2d0vA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_A_BEZA301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 2d0v METHANOL
DEHYDROGENASE LARGE
SUBUNIT
(Hyphomicrobium
denitrificans) 		5 / 10 GLY A 451
GLY A 453
SER A 474
LEU A 452
TYR A 392
 None
 1.40A 5hwkA-2d0vA:
undetectable		 5hwkA-2d0vA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_B_BEZB301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 2d0v METHANOL
DEHYDROGENASE LARGE
SUBUNIT
(Hyphomicrobium
denitrificans) 		5 / 10 GLY A 451
GLY A 453
SER A 474
LEU A 452
TYR A 392
 None
 1.41A 5hwkB-2d0vA:
undetectable		 5hwkB-2d0vA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2d0v METHANOL
DEHYDROGENASE LARGE
SUBUNIT
METHANOL
DEHYDROGENASE SMALL
SUBUNIT
(Hyphomicrobium
denitrificans) 		4 / 5 TYR B   1
GLY B   3
THR B   4
GLY A 182
 None
 0.79A 5jlcA-2d0vB:
undetectable		 5jlcA-2d0vB:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 2d0v METHANOL
DEHYDROGENASE LARGE
SUBUNIT
(Hyphomicrobium
denitrificans) 		4 / 8 ARG A 472
ILE A 414
GLY A 560
PHE A 562
 None
 0.88A 5nooD-2d0vA:
undetectable		 5nooD-2d0vA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2d0v METHANOL
DEHYDROGENASE LARGE
SUBUNIT
(Hyphomicrobium
denitrificans) 		3 / 3 TYR A 294
ALA A 348
TYR A 336
 None
 0.83A 5uunB-2d0vA:
0.0		 5uunB-2d0vA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2d0v METHANOL
DEHYDROGENASE LARGE
SUBUNIT
(Hyphomicrobium
denitrificans) 		5 / 12 GLY A 238
LYS A 236
ASP A 300
GLY A 306
SER A 259
 None
 1.09A 5vooA-2d0vA:
undetectable		 5vooA-2d0vA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_ACTB804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2d0v METHANOL
DEHYDROGENASE LARGE
SUBUNIT
(Hyphomicrobium
denitrificans) 		3 / 3 GLY A 478
TRP A 245
VAL A 309
 None
 0.50A 5vuoB-2d0vA:
undetectable		 5vuoB-2d0vA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXD_A_SAMA501_0
(SMYD3
METHYLTRANSFERASE)		 2d0v METHANOL
DEHYDROGENASE LARGE
SUBUNIT
METHANOL
DEHYDROGENASE SMALL
SUBUNIT
(Hyphomicrobium
denitrificans;
Hyphomicrobium
denitrificans) 		5 / 12 GLY A 131
ASN A 149
TYR A 187
GLU B  47
TYR B  66
 None
 1.42A 5xxdA-2d0vA:
undetectable		 5xxdA-2d0vA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJO_A_SAMA505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SMYD3)		 2d0v METHANOL
DEHYDROGENASE LARGE
SUBUNIT
METHANOL
DEHYDROGENASE SMALL
SUBUNIT
(Hyphomicrobium
denitrificans;
Hyphomicrobium
denitrificans) 		5 / 12 GLY A 131
ASN A 149
TYR A 187
GLU B  47
TYR B  66
 None
 1.43A 5yjoA-2d0vA:
undetectable		 5yjoA-2d0vA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA411_0
(UNCHARACTERIZED
PROTEIN KDOO)		 2d0v METHANOL
DEHYDROGENASE LARGE
SUBUNIT
(Hyphomicrobium
denitrificans) 		3 / 3 LYS A 497
LEU A 506
ARG A 499
 None
 0.86A 5yw0A-2d0vA:
undetectable		 5yw0A-2d0vA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 2d0v METHANOL
DEHYDROGENASE LARGE
SUBUNIT
(Hyphomicrobium
denitrificans) 		3 / 3 LYS A 126
ASN A  73
SER A  69
 None
 1.01A 5yw0A-2d0vA:
undetectable		 5yw0A-2d0vA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0G_B_DAHB98_0
(MELC
TYROSINASE)		 2d0v METHANOL
DEHYDROGENASE LARGE
SUBUNIT
(Hyphomicrobium
denitrificans) 		5 / 11 ILE A 280
HIS A 328
ASN A 332
SER A 259
PRO A 368
 None
 1.47A 5z0gA-2d0vA:
undetectable
5z0gB-2d0vA:
undetectable		 5z0gA-2d0vA:
11.18
5z0gB-2d0vA:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0I_B_DAHB98_0
(MELC
TYROSINASE)		 2d0v METHANOL
DEHYDROGENASE LARGE
SUBUNIT
(Hyphomicrobium
denitrificans) 		5 / 11 ILE A 280
HIS A 328
ASN A 332
SER A 259
PRO A 368
 None
 1.47A 5z0iA-2d0vA:
undetectable
5z0iB-2d0vA:
undetectable		 5z0iA-2d0vA:
11.18
5z0iB-2d0vA:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2d0v METHANOL
DEHYDROGENASE LARGE
SUBUNIT
(Hyphomicrobium
denitrificans) 		3 / 3 MET A 278
ASP A 303
ARG A 109
 None
CA  A 775 ( 3.4A)
PQQ  A 601 (-3.2A)
 1.22A 5z6kA-2d0vA:
undetectable		 5z6kA-2d0vA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E8Q_A_X2NA602_0
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2d0v METHANOL
DEHYDROGENASE LARGE
SUBUNIT
(Hyphomicrobium
denitrificans) 		5 / 12 GLY A 131
TYR A 246
ILE A 310
GLY A 306
THR A 157
 None
 1.21A 6e8qA-2d0vA:
undetectable		 6e8qA-2d0vA:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HZP_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 2d0v METHANOL
DEHYDROGENASE LARGE
SUBUNIT
(Hyphomicrobium
denitrificans) 		4 / 8 VAL A 528
GLN A  39
ASN A  36
ILE A  32
 None
 1.09A 6hzpA-2d0vA:
undetectable		 6hzpA-2d0vA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I5Z_D_SAMD401_0
(O-METHYLTRANSFERASE
1)		 2d0v METHANOL
DEHYDROGENASE LARGE
SUBUNIT
(Hyphomicrobium
denitrificans) 		5 / 11 GLY A 557
GLY A 555
VAL A 543
MET A 438
ASP A 303
 None
None
None
None
CA  A 775 ( 3.4A)
 1.07A 6i5zD-2d0vA:
undetectable		 6i5zD-2d0vA:
19.24