SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2d16'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_1
(PROTEASE)		 2d16 HYPOTHETICAL PROTEIN
PH1918
(Pyrococcus
horikoshii) 		4 / 7 ASP A   8
ILE A   4
ALA A  79
ILE A  77
 None
 0.72A 1n49A-2d16A:
undetectable		 1n49A-2d16A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA140_0
(LYSOZYME C)		 2d16 HYPOTHETICAL PROTEIN
PH1918
(Pyrococcus
horikoshii) 		3 / 3 ASN A  73
ALA A  48
ASN A  50
 None
 0.76A 1n4fA-2d16A:
undetectable		 1n4fA-2d16A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2d16 HYPOTHETICAL PROTEIN
PH1918
(Pyrococcus
horikoshii) 		5 / 12 ALA A 104
PRO A 103
VAL A 105
ILE A  99
PHE A  83
 None
 1.12A 2v95A-2d16A:
undetectable		 2v95A-2d16A:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_F_SAMF228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 2d16 HYPOTHETICAL PROTEIN
PH1918
(Pyrococcus
horikoshii) 		5 / 12 GLY A  46
ALA A  70
ASP A  30
ALA A  33
ASP A  63
 None
 1.31A 3nmuA-2d16A:
undetectable
3nmuF-2d16A:
undetectable		 3nmuA-2d16A:
18.02
3nmuF-2d16A:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_I_SAMI228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2d16 HYPOTHETICAL PROTEIN
PH1918
(Pyrococcus
horikoshii) 		5 / 12 GLY A  46
ILE A  47
ASP A  30
ALA A  33
ASP A  63
 None
 1.14A 3nvkI-2d16A:
undetectable		 3nvkI-2d16A:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA502_0
(RNA POLYMERASE
3D-POL)		 2d16 HYPOTHETICAL PROTEIN
PH1918
(Pyrococcus
horikoshii) 		3 / 3 ARG A 151
LYS A 148
LYS A 147
 None
 1.40A 4k50A-2d16A:
2.9		 4k50A-2d16A:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE502_0
(RNA POLYMERASE
3D-POL)		 2d16 HYPOTHETICAL PROTEIN
PH1918
(Pyrococcus
horikoshii) 		3 / 3 ARG A 151
LYS A 148
LYS A 147
 None
 1.26A 4k50E-2d16A:
undetectable		 4k50E-2d16A:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI506_0
(RNA POLYMERASE
3D-POL)		 2d16 HYPOTHETICAL PROTEIN
PH1918
(Pyrococcus
horikoshii) 		3 / 3 ARG A 151
LYS A 148
LYS A 147
 None
 1.32A 4k50I-2d16A:
3.0		 4k50I-2d16A:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NPT_A_017A401_1
(PROTEASE)		 2d16 HYPOTHETICAL PROTEIN
PH1918
(Pyrococcus
horikoshii) 		5 / 9 ALA A  79
ILE A  19
GLY A  20
ILE A 130
VAL A 120
 None
None
None
NA  A1001 (-4.8A)
None
 1.04A 4nptA-2d16A:
undetectable		 4nptA-2d16A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2d16 HYPOTHETICAL PROTEIN
PH1918
(Pyrococcus
horikoshii) 		4 / 7 HIS A  81
ASP A  31
THR A  28
LEU A  36
 None
 0.99A 6nmfA-2d16A:
undetectable
6nmfC-2d16A:
undetectable
6nmfP-2d16A:
undetectable		 6nmfA-2d16A:
13.84
6nmfC-2d16A:
18.25
6nmfP-2d16A:
18.25