SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2d1c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2d1c ISOCITRATE
DEHYDROGENASE
(Thermus
thermophilus) 		3 / 3 ILE A 461
LEU A 464
VAL A 468
 None
 0.18A 1mz9B-2d1cA:
undetectable		 1mz9B-2d1cA:
7.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2d1c ISOCITRATE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 4 ALA A 226
VAL A 223
ALA A 189
HIS A 187
 None
 1.21A 1q23K-2d1cA:
undetectable		 1q23K-2d1cA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 2d1c ISOCITRATE
DEHYDROGENASE
(Thermus
thermophilus) 		3 / 3 ASP A 393
LYS A 421
ARG A 419
 None
 1.20A 1ra8A-2d1cA:
undetectable		 1ra8A-2d1cA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V2X_A_SAMA400_0
(TRNA (GM18)
METHYLTRANSFERASE)		 2d1c ISOCITRATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 LEU A  84
GLY A  31
GLY A  86
SER A 300
LEU A 298
 None
 1.03A 1v2xA-2d1cA:
undetectable		 1v2xA-2d1cA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_B_ACTB294_0
(GLYCINE
N-METHYLTRANSFERASE)		 2d1c ISOCITRATE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 6 ALA A 404
TYR A 444
ILE A 423
LEU A 400
 None
 0.96A 1xvaA-2d1cA:
undetectable
1xvaB-2d1cA:
undetectable		 1xvaA-2d1cA:
21.47
1xvaB-2d1cA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		 2d1c ISOCITRATE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 6 ARG A 104
ASP A 252
SER A 251
SER A 266
 CIT  A1585 (-3.1A)
None
None
None
 0.96A 2j2pA-2d1cA:
undetectable
2j2pC-2d1cA:
undetectable		 2j2pA-2d1cA:
17.55
2j2pC-2d1cA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)		 2d1c ISOCITRATE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 6 ARG A 104
ASP A 252
SER A 251
SER A 266
 CIT  A1585 (-3.1A)
None
None
None
 0.96A 2j2pD-2d1cA:
undetectable
2j2pF-2d1cA:
undetectable		 2j2pD-2d1cA:
17.55
2j2pF-2d1cA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIQ_A_STIA1001_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2d1c ISOCITRATE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 5 LEU A 401
VAL A 392
LEU A 477
ARG A 467
 None
 1.12A 2oiqA-2d1cA:
undetectable		 2oiqA-2d1cA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQ5_B_LDPB1197_1
(S-NORCOCLAURINE
SYNTHASE)		 2d1c ISOCITRATE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 7 LEU A 325
LEU A 321
LEU A 331
PRO A 294
 None
 0.86A 2vq5B-2d1cA:
undetectable		 2vq5B-2d1cA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		 2d1c ISOCITRATE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 8 LEU A 133
LEU A 250
LEU A 257
ARG A 114
 None
None
None
CIT  A1585 (-3.1A)
 1.15A 2xn3A-2d1cA:
undetectable
2xn3B-2d1cA:
undetectable		 2xn3A-2d1cA:
20.52
2xn3B-2d1cA:
6.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZTH_A_SAMA305_1
(CATECHOL
O-METHYLTRANSFERASE)		 2d1c ISOCITRATE
DEHYDROGENASE
(Thermus
thermophilus) 		3 / 3 SER A 251
GLU A 277
ASP A 248
 None
NAP  A1002 (-3.5A)
CIT  A1585 (-3.2A)
 0.84A 2zthA-2d1cA:
2.4		 2zthA-2d1cA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 2d1c ISOCITRATE
DEHYDROGENASE
(Thermus
thermophilus) 		3 / 3 SER A 251
GLU A 277
ASP A 248
 None
NAP  A1002 (-3.5A)
CIT  A1585 (-3.2A)
 0.83A 3bwmA-2d1cA:
undetectable		 3bwmA-2d1cA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2d1c ISOCITRATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 THR A  38
VAL A  41
VAL A  82
ILE A  22
TYR A  51
 None
 1.46A 3elzC-2d1cA:
undetectable		 3elzC-2d1cA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWI_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 2d1c ISOCITRATE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 7 TYR A 347
THR A 295
LEU A 321
THR A 362
 None
 1.02A 3fwiA-2d1cA:
undetectable		 3fwiA-2d1cA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_2
(DIHYDROFOLATE
REDUCTASE)		 2d1c ISOCITRATE
DEHYDROGENASE
(Thermus
thermophilus) 		3 / 3 ARG A 104
ILE A  25
THR A  38
 CIT  A1585 (-3.1A)
None
None
 0.67A 3ia4D-2d1cA:
1.5		 3ia4D-2d1cA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_B_PZIB802_0
(GLUTAMATE RECEPTOR 2)		 2d1c ISOCITRATE
DEHYDROGENASE
(Thermus
thermophilus) 		3 / 3 SER A 154
ASP A 442
ASN A 399
 None
 0.97A 3lsfB-2d1cA:
undetectable
3lsfE-2d1cA:
undetectable		 3lsfB-2d1cA:
19.68
3lsfE-2d1cA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_E_PZIE802_0
(GLUTAMATE RECEPTOR 2)		 2d1c ISOCITRATE
DEHYDROGENASE
(Thermus
thermophilus) 		3 / 3 ASP A 442
ASN A 399
SER A 154
 None
 0.92A 3lsfB-2d1cA:
undetectable
3lsfE-2d1cA:
undetectable		 3lsfB-2d1cA:
19.68
3lsfE-2d1cA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EOH_A_TEPA402_1
(PYRIDOXAL KINASE)		 2d1c ISOCITRATE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 5 GLY A  27
THR A  73
VAL A  60
ASP A  28
 None
 1.05A 4eohA-2d1cA:
undetectable		 4eohA-2d1cA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4II8_A_010A210_0
(LYSOZYME C)		 2d1c ISOCITRATE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 7 GLU A 199
ASP A 142
ASN A 244
ILE A 170
 None
 1.22A 4ii8A-2d1cA:
undetectable		 4ii8A-2d1cA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2d1c ISOCITRATE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 8 SER A  59
VAL A  60
ARG A  63
GLY A  86
 None
 0.69A 4mk4A-2d1cA:
4.0		 4mk4A-2d1cA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XR4_B_AG2B511_1
(HOMOSPERMIDINE
SYNTHASE)		 2d1c ISOCITRATE
DEHYDROGENASE
(Thermus
thermophilus) 		3 / 3 VAL A 219
PHE A 237
ARG A 233
 None
 0.90A 4xr4B-2d1cA:
4.8		 4xr4B-2d1cA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 2d1c ISOCITRATE
DEHYDROGENASE
(Thermus
thermophilus) 		3 / 3 SER A 251
GLU A 277
ASP A 248
 None
NAP  A1002 (-3.5A)
CIT  A1585 (-3.2A)
 0.80A 4xudA-2d1cA:
2.5		 4xudA-2d1cA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_2
(TUBULIN BETA-2B
CHAIN)		 2d1c ISOCITRATE
DEHYDROGENASE
(Thermus
thermophilus) 		3 / 3 LEU A 462
LEU A 477
ARG A 471
 None
 0.66A 5hnzB-2d1cA:
undetectable		 5hnzB-2d1cA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_2
(CDL2.3B)		 2d1c ISOCITRATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 9 ILE A 317
VAL A  24
LEU A  84
ILE A  22
LEU A 321
 None
 1.41A 5iepA-2d1cA:
undetectable		 5iepA-2d1cA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMF_A_6U9A1301_1
(ION TRANSPORT
PROTEIN)		 2d1c ISOCITRATE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 6 THR A 152
GLU A 397
PHE A 395
ILE A 423
 None
 0.96A 5kmfA-2d1cA:
undetectable
5kmfC-2d1cA:
undetectable		 5kmfA-2d1cA:
20.52
5kmfC-2d1cA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 2d1c ISOCITRATE
DEHYDROGENASE
(Thermus
thermophilus) 		3 / 3 THR A  90
SER A  98
ASP A 248
 CIT  A1585 ( 3.4A)
CIT  A1585 (-2.6A)
CIT  A1585 (-3.2A)
 0.83A 5kvaA-2d1cA:
2.2		 5kvaA-2d1cA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 2d1c ISOCITRATE
DEHYDROGENASE
(Thermus
thermophilus) 		3 / 3 THR A  90
SER A  98
ASP A 248
 CIT  A1585 ( 3.4A)
CIT  A1585 (-2.6A)
CIT  A1585 (-3.2A)
 0.83A 5kvaB-2d1cA:
2.5		 5kvaB-2d1cA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_0
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 2d1c ISOCITRATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 ALA A 274
GLY A 270
LYS A  10
LEU A 308
ASN A 268
 None
 1.16A 5ybbA-2d1cA:
undetectable		 5ybbA-2d1cA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZSF_A_6T0A910_0
(TOLL-LIKE RECEPTOR 7)		 2d1c ISOCITRATE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 7 THR A  80
ILE A  74
THR A  73
PHE A 107
 None
 0.95A 5zsfA-2d1cA:
undetectable
5zsfB-2d1cA:
undetectable		 5zsfA-2d1cA:
10.83
5zsfB-2d1cA:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CB4_A_BEZA501_0
(CANAVALIN)		 2d1c ISOCITRATE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 8 LEU A 257
VAL A 135
LEU A 133
ILE A 240
 None
 0.66A 6cb4A-2d1cA:
undetectable		 6cb4A-2d1cA:
22.53