SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2d1f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		 2d1f THREONINE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 5 TYR A 204
PRO A 188
LEU A 184
THR A  39
 None
 1.34A 1i2wA-2d1fA:
undetectable		 1i2wA-2d1fA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIN_A_KTNA801_1
(CYTOCHROME P450
107A1)		 2d1f THREONINE SYNTHASE
(Mycobacterium
tuberculosis) 		6 / 11 ALA A  44
THR A  51
LEU A 286
ALA A 283
ALA A 300
LEU A  57
 None
 1.44A 1jinA-2d1fA:
undetectable		 1jinA-2d1fA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5K_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2d1f THREONINE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 9 THR A  39
GLY A  37
GLY A 327
GLU A  60
GLY A  66
 None
None
PLP  A 500 ( 3.8A)
None
None
 1.22A 1l5kA-2d1fA:
undetectable		 1l5kA-2d1fA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_0
(MODIFICATION
METHYLASE RSRI)		 2d1f THREONINE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 12 ASP A 182
THR A  74
GLY A 172
VAL A 168
ALA A 176
 None
 1.23A 1nw5A-2d1fA:
undetectable		 1nw5A-2d1fA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M2O_B_DHIB24_0
(INSULIN B CHAIN)		 2d1f THREONINE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 6 ARG A 169
GLY A  72
LYS A 174
THR A 175
 None
 1.14A 2m2oB-2d1fA:
undetectable		 2m2oB-2d1fA:
6.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 2d1f THREONINE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 7 VAL A 325
GLY A 327
LEU A  62
SER A 299
 None
PLP  A 500 ( 3.8A)
None
PLP  A 500 ( 4.3A)
 0.74A 2wekB-2d1fA:
2.6		 2wekB-2d1fA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECLB600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2d1f THREONINE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 8 LEU A 273
GLY A 196
THR A 245
ILE A 280
 None
PLP  A 500 (-3.6A)
None
None
 0.82A 3jusB-2d1fA:
undetectable		 3jusB-2d1fA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 2d1f THREONINE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 5 PHE A  68
ILE A  42
LEU A  57
LYS A  58
 PLP  A 500 (-4.7A)
None
None
None
 1.23A 3sueC-2d1fA:
undetectable		 3sueC-2d1fA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_A_SAMA258_0
(PUTATIVE
METHYLTRANSFERASE)		 2d1f THREONINE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  72
GLU A 171
ALA A 203
TYR A 204
ASN A 200
 None
None
None
None
PLP  A 500 (-4.9A)
 1.25A 3sxjA-2d1fA:
undetectable		 3sxjA-2d1fA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_B_SAMB258_0
(PUTATIVE
METHYLTRANSFERASE)		 2d1f THREONINE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  72
GLU A 171
ALA A 203
TYR A 204
ASN A 200
 None
None
None
None
PLP  A 500 (-4.9A)
 1.25A 3sxjB-2d1fA:
undetectable		 3sxjB-2d1fA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_C_SAMC300_0
(PUTATIVE
METHYLTRANSFERASE)		 2d1f THREONINE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  72
GLU A 171
ALA A 203
TYR A 204
ASN A 200
 None
None
None
None
PLP  A 500 (-4.9A)
 1.28A 3t7sC-2d1fA:
undetectable		 3t7sC-2d1fA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5J_A_08HA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2d1f THREONINE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 7 PRO A 243
LEU A 146
ASN A 197
ILE A 252
 None
None
PLP  A 500 (-4.8A)
None
 1.02A 3u5jA-2d1fA:
undetectable		 3u5jA-2d1fA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA506_0
(RNA POLYMERASE
3D-POL)		 2d1f THREONINE SYNTHASE
(Mycobacterium
tuberculosis) 		3 / 3 VAL A 129
GLY A 132
LYS A 134
 None
 0.60A 4k50A-2d1fA:
undetectable		 4k50A-2d1fA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE504_0
(RNA POLYMERASE
3D-POL)		 2d1f THREONINE SYNTHASE
(Mycobacterium
tuberculosis) 		3 / 3 VAL A 129
GLY A 132
LYS A 134
 None
 0.54A 4k50E-2d1fA:
undetectable		 4k50E-2d1fA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI504_0
(RNA POLYMERASE
3D-POL)		 2d1f THREONINE SYNTHASE
(Mycobacterium
tuberculosis) 		3 / 3 VAL A 129
GLY A 132
LYS A 134
 None
 0.62A 4k50I-2d1fA:
undetectable		 4k50I-2d1fA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K7A_A_MXDA1002_1
(ANDROGEN RECEPTOR)		 2d1f THREONINE SYNTHASE
(Mycobacterium
tuberculosis) 		3 / 3 GLU A 179
TRP A  12
LYS A 174
 None
 1.43A 4k7aA-2d1fA:
undetectable		 4k7aA-2d1fA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_B_DB8B800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 2d1f THREONINE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 10 ALA A 275
GLY A 225
LEU A 224
ALA A 309
ASP A 312
 None
 1.29A 5ajqB-2d1fA:
undetectable		 5ajqB-2d1fA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CU6_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 2d1f THREONINE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 6 TYR A 103
ILE A 109
VAL A  32
ALA A 107
 None
 0.91A 5cu6A-2d1fA:
undetectable		 5cu6A-2d1fA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 2d1f THREONINE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 9 ALA A 301
ALA A 283
ALA A 304
ALA A 247
ASP A 277
 None
 1.11A 5l5zK-2d1fA:
undetectable
5l5zL-2d1fA:
undetectable		 5l5zK-2d1fA:
22.55
5l5zL-2d1fA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 2d1f THREONINE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 9 ALA A 301
ALA A 283
ALA A 304
ALA A 247
ASP A 277
 None
 1.11A 5l5zY-2d1fA:
undetectable
5l5zZ-2d1fA:
undetectable		 5l5zY-2d1fA:
22.55
5l5zZ-2d1fA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 2d1f THREONINE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  81
ALA A  80
SER A 160
THR A  33
GLY A 172
 None
 1.14A 5m5cB-2d1fA:
undetectable		 5m5cB-2d1fA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OH1_C_9UQC202_0
(CEREBLON ISOFORM 4)		 2d1f THREONINE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 8 ASN A  95
GLU A  60
PHE A  68
TYR A 103
 PLP  A 500 (-3.9A)
None
PLP  A 500 (-4.7A)
None
 1.49A 5oh1C-2d1fA:
undetectable		 5oh1C-2d1fA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_1
(CYTOCHROME P450 2C9)		 2d1f THREONINE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 112
VAL A  77
GLY A 108
ALA A 107
LEU A  34
 None
 1.03A 5xxiA-2d1fA:
undetectable		 5xxiA-2d1fA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_B_REAB601_1
(RETINOIC ACID
RECEPTOR)		 2d1f THREONINE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 10 VAL A 235
LEU A 234
LEU A 224
GLY A 230
GLY A 305
 None
 0.97A 6eu9B-2d1fA:
undetectable		 6eu9B-2d1fA:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_D_READ601_1
(RETINOIC ACID
RECEPTOR)		 2d1f THREONINE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 7 VAL A 235
LEU A 224
GLY A 230
GLY A 305
 None
 0.67A 6eu9D-2d1fA:
undetectable		 6eu9D-2d1fA:
12.12