SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2d1g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_2
(PROTEIN (HIV-1
PROTEASE))		 2d1g ACID PHOSPHATASE
(Francisella
tularensis) 		4 / 8 ALA A  25
GLY A 312
ILE A 311
VAL A  38
 None
 0.64A 1d4yB-2d1gA:
undetectable		 1d4yB-2d1gA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE1_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 2d1g ACID PHOSPHATASE
(Francisella
tularensis) 		3 / 3 ASP A 389
HIS A 350
HIS A 106
 None
VO4  A 801 (-3.8A)
VO4  A 801 (-3.8A)
 0.66A 1oe1A-2d1gA:
undetectable		 1oe1A-2d1gA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE3_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 2d1g ACID PHOSPHATASE
(Francisella
tularensis) 		3 / 3 ASP A 389
HIS A 350
HIS A 106
 None
VO4  A 801 (-3.8A)
VO4  A 801 (-3.8A)
 0.68A 1oe3A-2d1gA:
undetectable		 1oe3A-2d1gA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2d1g ACID PHOSPHATASE
(Francisella
tularensis) 		4 / 8 SER A 281
ASN A 275
GLN A 347
ASP A 283
 None
None
ETX  A1006 (-3.5A)
None
 1.30A 1p6kA-2d1gA:
undetectable		 1p6kA-2d1gA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2d1g ACID PHOSPHATASE
(Francisella
tularensis) 		4 / 8 SER A 281
ASN A 275
GLN A 347
ASP A 283
 None
None
ETX  A1006 (-3.5A)
None
 1.27A 1p6kB-2d1gA:
undetectable		 1p6kB-2d1gA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_B_C2FB802_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 2d1g ACID PHOSPHATASE
(Francisella
tularensis) 		5 / 12 GLU A 111
GLY A 128
ASP A 207
SER A 388
ASN A  44
 None
None
None
None
VO4  A 801 ( 2.1A)
 0.90A 1q8jB-2d1gA:
undetectable		 1q8jB-2d1gA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2d1g ACID PHOSPHATASE
(Francisella
tularensis) 		4 / 8 SER A 281
ASN A 275
GLN A 347
ASP A 283
 None
None
ETX  A1006 (-3.5A)
None
 1.34A 1rs6A-2d1gA:
undetectable		 1rs6A-2d1gA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2d1g ACID PHOSPHATASE
(Francisella
tularensis) 		4 / 8 SER A 281
ASN A 275
GLN A 347
ASP A 283
 None
None
ETX  A1006 (-3.5A)
None
 1.32A 1rs6B-2d1gA:
undetectable		 1rs6B-2d1gA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2d1g ACID PHOSPHATASE
(Francisella
tularensis) 		4 / 8 SER A 281
ASN A 275
GLN A 347
ASP A 283
 None
None
ETX  A1006 (-3.5A)
None
 1.30A 1rs7B-2d1gA:
undetectable		 1rs7B-2d1gA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2d1g ACID PHOSPHATASE
(Francisella
tularensis) 		4 / 8 SER A 281
ASN A 275
GLN A 347
ASP A 283
 None
None
ETX  A1006 (-3.5A)
None
 1.30A 1zzqA-2d1gA:
undetectable		 1zzqA-2d1gA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2d1g ACID PHOSPHATASE
(Francisella
tularensis) 		4 / 8 SER A 281
ASN A 275
GLN A 347
ASP A 283
 None
None
ETX  A1006 (-3.5A)
None
 1.28A 1zzqB-2d1gA:
undetectable		 1zzqB-2d1gA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2d1g ACID PHOSPHATASE
(Francisella
tularensis) 		4 / 8 SER A 281
ASN A 275
GLN A 347
ASP A 283
 None
None
ETX  A1006 (-3.5A)
None
 1.28A 1zzuA-2d1gA:
0.5		 1zzuA-2d1gA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2d1g ACID PHOSPHATASE
(Francisella
tularensis) 		4 / 8 SER A 281
ASN A 275
GLN A 347
ASP A 283
 None
None
ETX  A1006 (-3.5A)
None
 1.28A 1zzuB-2d1gA:
undetectable		 1zzuB-2d1gA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_A_SALA2006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2d1g ACID PHOSPHATASE
(Francisella
tularensis) 		4 / 6 ARG A  94
THR A 150
VAL A 151
ALA A  57
 None
 1.05A 2e1qA-2d1gA:
undetectable		 2e1qA-2d1gA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_C_SALC4006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2d1g ACID PHOSPHATASE
(Francisella
tularensis) 		4 / 6 ARG A  94
THR A 150
VAL A 151
ALA A  57
 None
 0.97A 2e1qC-2d1gA:
undetectable		 2e1qC-2d1gA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH8_A_VIBA1_1
(MAJOR PRION PROTEIN)		 2d1g ACID PHOSPHATASE
(Francisella
tularensis) 		4 / 6 PRO A 209
ASP A 215
ASP A 214
TYR A 293
 None
 1.30A 2lh8A-2d1gA:
undetectable		 2lh8A-2d1gA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 2d1g ACID PHOSPHATASE
(Francisella
tularensis) 		4 / 4 SER A 192
GLY A 195
HIS A 287
ASP A 387
 None
None
VO4  A 801 (-3.6A)
UNX  A 601 ( 2.6A)
 1.22A 2oxtC-2d1gA:
undetectable		 2oxtC-2d1gA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_B_J01B600_1
(ORF12)		 2d1g ACID PHOSPHATASE
(Francisella
tularensis) 		5 / 11 ALA A 437
SER A 461
GLY A 185
SER A 456
PHE A 402
 None
 1.49A 2xfsB-2d1gA:
0.0		 2xfsB-2d1gA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_A_CUA1338_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 2d1g ACID PHOSPHATASE
(Francisella
tularensis) 		3 / 3 ASP A 389
HIS A 350
HIS A 106
 None
VO4  A 801 (-3.8A)
VO4  A 801 (-3.8A)
 0.68A 2xxgA-2d1gA:
undetectable		 2xxgA-2d1gA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_C_CUC1339_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 2d1g ACID PHOSPHATASE
(Francisella
tularensis) 		3 / 3 ASP A 389
HIS A 350
HIS A 106
 None
VO4  A 801 (-3.8A)
VO4  A 801 (-3.8A)
 0.66A 2xxgC-2d1gA:
undetectable		 2xxgC-2d1gA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_D_TC9D1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2d1g ACID PHOSPHATASE
(Francisella
tularensis) 		4 / 8 TYR A 385
GLN A 436
ILE A 384
ASP A 387
 None
None
None
UNX  A 601 ( 2.6A)
 0.90A 2xytE-2d1gA:
undetectable		 2xytE-2d1gA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_G_TC9G1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2d1g ACID PHOSPHATASE
(Francisella
tularensis) 		4 / 8 TYR A 385
GLN A 436
ILE A 384
ASP A 387
 None
None
None
UNX  A 601 ( 2.6A)
 0.93A 2xytH-2d1gA:
undetectable		 2xytH-2d1gA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_H_TC9H1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2d1g ACID PHOSPHATASE
(Francisella
tularensis) 		4 / 7 TYR A 385
GLN A 436
ILE A 384
ASP A 387
 None
None
None
UNX  A 601 ( 2.6A)
 0.97A 2xytI-2d1gA:
undetectable		 2xytI-2d1gA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1303_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2d1g ACID PHOSPHATASE
(Francisella
tularensis) 		4 / 7 PHE A  41
ILE A 384
PRO A 177
GLY A 178
 None
 0.78A 2y7kA-2d1gA:
undetectable		 2y7kA-2d1gA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_A_SAMA301_1
(HYPOTHETICAL PROTEIN
TTHA0223)		 2d1g ACID PHOSPHATASE
(Francisella
tularensis) 		4 / 5 GLU A 359
ARG A  49
ASP A 348
ASP A 283
 None
 1.08A 2yqzA-2d1gA:
0.8		 2yqzA-2d1gA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_B_SAMB401_1
(HYPOTHETICAL PROTEIN
TTHA0223)		 2d1g ACID PHOSPHATASE
(Francisella
tularensis) 		4 / 5 GLU A 359
ARG A  49
ASP A 348
ASP A 283
 None
 1.11A 2yqzB-2d1gA:
undetectable		 2yqzB-2d1gA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX7_A_SALA1336_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2d1g ACID PHOSPHATASE
(Francisella
tularensis) 		4 / 8 ARG A  94
THR A 150
VAL A 151
ALA A  57
 None
 0.99A 3ax7A-2d1gA:
undetectable		 3ax7A-2d1gA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_2
(PHOSPHOLIPASE A2)		 2d1g ACID PHOSPHATASE
(Francisella
tularensis) 		4 / 8 TYR A 353
PRO A 290
PHE A 291
TRP A 252
 None
 1.39A 3bjwD-2d1gA:
undetectable		 3bjwD-2d1gA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGG_A_CHDA211_0
(CMER)		 2d1g ACID PHOSPHATASE
(Francisella
tularensis) 		4 / 7 PHE A 172
PHE A 115
PHE A 168
TYR A 411
 None
 0.95A 3hggA-2d1gA:
undetectable		 3hggA-2d1gA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KL3_A_DHIA403_0
(GLUCURONOXYLANASE
XYNC)		 2d1g ACID PHOSPHATASE
(Francisella
tularensis) 		4 / 4 GLY A 188
TYR A 455
GLY A 236
ASP A 235
 None
 1.13A 3kl3A-2d1gA:
undetectable		 3kl3A-2d1gA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_H_TFPH202_1
(PROTEIN S100-A4)		 2d1g ACID PHOSPHATASE
(Francisella
tularensis) 		5 / 12 ASP A 375
SER A 339
ILE A 381
PHE A 326
PHE A 253
 None
 1.32A 3ko0G-2d1gA:
undetectable
3ko0H-2d1gA:
undetectable
3ko0I-2d1gA:
undetectable
3ko0J-2d1gA:
undetectable		 3ko0G-2d1gA:
11.51
3ko0H-2d1gA:
11.51
3ko0I-2d1gA:
11.51
3ko0J-2d1gA:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_R_TFPR202_1
(PROTEIN S100-A4)		 2d1g ACID PHOSPHATASE
(Francisella
tularensis) 		5 / 11 ASP A 375
SER A 339
ILE A 381
PHE A 326
PHE A 253
 None
 1.35A 3ko0Q-2d1gA:
undetectable
3ko0R-2d1gA:
undetectable
3ko0S-2d1gA:
undetectable
3ko0T-2d1gA:
undetectable		 3ko0Q-2d1gA:
11.51
3ko0R-2d1gA:
11.51
3ko0S-2d1gA:
11.51
3ko0T-2d1gA:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LD6_A_KKKA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2d1g ACID PHOSPHATASE
(Francisella
tularensis) 		5 / 12 GLY A 345
ALA A 343
ILE A  40
ILE A 382
MET A 417
 None
 1.28A 3ld6A-2d1gA:
undetectable		 3ld6A-2d1gA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_1
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT)		 2d1g ACID PHOSPHATASE
(Francisella
tularensis) 		5 / 10 VAL A 452
LEU A 440
SER A 453
TYR A 455
GLY A 240
 None
 1.00A 3ls4H-2d1gA:
undetectable		 3ls4H-2d1gA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU9_A_478A401_1
(PROTEASE)		 2d1g ACID PHOSPHATASE
(Francisella
tularensis) 		4 / 8 ALA A  25
GLY A 312
ILE A 311
VAL A  38
 None
 0.70A 3nu9A-2d1gA:
undetectable		 3nu9A-2d1gA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_A_SALA1344_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2d1g ACID PHOSPHATASE
(Francisella
tularensis) 		4 / 7 ARG A  94
THR A 150
VAL A 151
ALA A  57
 None
 0.95A 3uniA-2d1gA:
undetectable		 3uniA-2d1gA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GRQ_C_AVLC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 2d1g ACID PHOSPHATASE
(Francisella
tularensis) 		4 / 7 PHE A  41
PRO A 416
GLN A  42
TYR A 385
 None
 1.38A 4grqA-2d1gA:
undetectable
4grqC-2d1gA:
undetectable		 4grqA-2d1gA:
13.76
4grqC-2d1gA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 2d1g ACID PHOSPHATASE
(Francisella
tularensis) 		5 / 8 HIS A 106
PRO A 174
ASP A 387
SER A 175
ASP A 208
 VO4  A 801 (-3.8A)
VO4  A 801 (-4.1A)
UNX  A 601 ( 2.6A)
UNX  A 601 ( 1.8A)
VO4  A 801 (-2.6A)
 1.47A 4k0bB-2d1gA:
undetectable		 4k0bB-2d1gA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_B_ACTB701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 2d1g ACID PHOSPHATASE
(Francisella
tularensis) 		3 / 3 HIS A 109
GLY A 407
ILE A 206
 None
 0.63A 4k50A-2d1gA:
undetectable		 4k50A-2d1gA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_J_ACTJ701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 2d1g ACID PHOSPHATASE
(Francisella
tularensis) 		3 / 3 HIS A 109
GLY A 407
ILE A 206
 None
 0.61A 4k50I-2d1gA:
undetectable		 4k50I-2d1gA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K7G_B_ACTB902_0
(3-HYDROXYPROLINE
DEHYDRATSE)		 2d1g ACID PHOSPHATASE
(Francisella
tularensis) 		4 / 7 ASP A 389
ASP A 387
SER A 175
HIS A 350
 None
UNX  A 601 ( 2.6A)
UNX  A 601 ( 1.8A)
VO4  A 801 (-3.8A)
 1.17A 4k7gB-2d1gA:
undetectable		 4k7gB-2d1gA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTV_C_ADNC403_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2d1g ACID PHOSPHATASE
(Francisella
tularensis) 		5 / 11 HIS A 106
PRO A 174
ASP A 387
ASP A 208
ILE A 285
 VO4  A 801 (-3.8A)
VO4  A 801 (-4.1A)
UNX  A 601 ( 2.6A)
VO4  A 801 (-2.6A)
None
 1.38A 4ktvC-2d1gA:
undetectable
4ktvD-2d1gA:
undetectable		 4ktvC-2d1gA:
21.97
4ktvD-2d1gA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 2d1g ACID PHOSPHATASE
(Francisella
tularensis) 		5 / 8 HIS A 106
PRO A 174
ASP A 387
SER A 175
ASP A 208
 VO4  A 801 (-3.8A)
VO4  A 801 (-4.1A)
UNX  A 601 ( 2.6A)
UNX  A 601 ( 1.8A)
VO4  A 801 (-2.6A)
 1.44A 4l7iB-2d1gA:
undetectable		 4l7iB-2d1gA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_1
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 2d1g ACID PHOSPHATASE
(Francisella
tularensis) 		3 / 3 ARG A 282
ASN A 210
ASP A 207
 None
 0.61A 5gwxA-2d1gA:
undetectable		 5gwxA-2d1gA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		 2d1g ACID PHOSPHATASE
(Francisella
tularensis) 		4 / 7 PRO A 259
TYR A 262
SER A 298
ASN A 299
 None
 1.24A 5l1fC-2d1gA:
undetectable		 5l1fC-2d1gA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIY_A_OAQA302_0
(SULFOTRANSFERASE)		 2d1g ACID PHOSPHATASE
(Francisella
tularensis) 		5 / 11 ILE A 200
VAL A 230
SER A 194
LEU A 180
THR A 176
 None
 1.45A 5tiyA-2d1gA:
undetectable		 5tiyA-2d1gA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_2
(PROTEIN CYP51)		 2d1g ACID PHOSPHATASE
(Francisella
tularensis) 		4 / 6 TYR A  54
LEU A 415
PHE A  47
LEU A 418
 None
 1.19A 5tl8A-2d1gA:
undetectable		 5tl8A-2d1gA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1804_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2d1g ACID PHOSPHATASE
(Francisella
tularensis) 		5 / 8 VAL A 439
ILE A 239
GLY A 240
LEU A 243
ILE A  34
 None
 1.20A 5vkqB-2d1gA:
undetectable
5vkqC-2d1gA:
undetectable		 5vkqB-2d1gA:
13.88
5vkqC-2d1gA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_1
(REGULATORY PROTEIN
TETR)		 2d1g ACID PHOSPHATASE
(Francisella
tularensis) 		4 / 7 GLN A 100
GLY A 351
GLN A 254
TYR A 385
 None
 1.04A 5vlmC-2d1gA:
undetectable		 5vlmC-2d1gA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_H_BEZH201_0
(NS3 PROTEASE)		 2d1g ACID PHOSPHATASE
(Francisella
tularensis) 		4 / 5 HIS A 106
SER A 103
GLY A 351
TYR A 353
 VO4  A 801 (-3.8A)
None
None
None
 1.16A 5yodH-2d1gA:
undetectable		 5yodH-2d1gA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA608_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 2d1g ACID PHOSPHATASE
(Francisella
tularensis) 		3 / 3 GLY A 240
THR A 297
GLU A 296
 None
 0.65A 6b58A-2d1gA:
undetectable		 6b58A-2d1gA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_A_SAMA501_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 2d1g ACID PHOSPHATASE
(Francisella
tularensis) 		5 / 12 LEU A 243
ILE A 248
GLY A 247
ILE A 239
VAL A 452
 None
 0.97A 6emuA-2d1gA:
undetectable		 6emuA-2d1gA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBP_B_ADNB404_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2d1g ACID PHOSPHATASE
(Francisella
tularensis) 		5 / 12 ILE A 285
HIS A 106
PRO A 174
ASP A 387
ASP A 208
 None
VO4  A 801 (-3.8A)
VO4  A 801 (-4.1A)
UNX  A 601 ( 2.6A)
VO4  A 801 (-2.6A)
 1.44A 6fbpA-2d1gA:
undetectable
6fbpB-2d1gA:
undetectable		 6fbpA-2d1gA:
10.13
6fbpB-2d1gA:
10.13