SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2d1p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4003_1
(SERUM ALBUMIN)		 2d1p HYPOTHETICAL PROTEIN
YHEL
(Escherichia
coli) 		5 / 9 ILE C  74
VAL C  34
GLY C  33
ALA C  56
LEU C  61
 None
 1.19A 1e7bA-2d1pC:
undetectable		 1e7bA-2d1pC:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2d1p HYPOTHETICAL UPF0163
PROTEIN YHEN
(Escherichia
coli) 		4 / 5 SER A  18
SER A  19
VAL A   7
PHE A 128
 None
 1.03A 1oipA-2d1pA:
undetectable		 1oipA-2d1pA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2d1p HYPOTHETICAL UPF0163
PROTEIN YHEN
(Escherichia
coli) 		5 / 10 VAL A  73
GLY A  72
THR A 108
ASN A  76
VAL A  37
 None
 1.08A 1pwyE-2d1pA:
undetectable		 1pwyE-2d1pA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_B_VIAB902_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2d1p HYPOTHETICAL PROTEIN
YHEL
(Escherichia
coli) 		5 / 12 ALA C  63
ILE C  62
VAL C  34
ALA C  37
ILE C  70
 None
 1.11A 2h42B-2d1pC:
undetectable		 2h42B-2d1pC:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA702_0
(FERROCHELATASE)		 2d1p HYPOTHETICAL UPF0116
PROTEIN YHEM
HYPOTHETICAL PROTEIN
YHEL
(Escherichia
coli;
Escherichia
coli) 		4 / 7 MET C   1
ARG C  19
LEU B 106
VAL B   7
 None
 1.11A 2hrcA-2d1pC:
undetectable		 2hrcA-2d1pC:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_C_AZZC1211_1
(DEOXYNUCLEOSIDE
KINASE)		 2d1p HYPOTHETICAL UPF0163
PROTEIN YHEN
(Escherichia
coli) 		5 / 12 VAL A  73
LEU A  75
PHE A  39
ALA A  20
PHE A  21
 None
 1.41A 2jj8C-2d1pA:
undetectable		 2jj8C-2d1pA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I9J_B_NCAB302_0
(ADP-RIBOSYL CYCLASE)		 2d1p HYPOTHETICAL PROTEIN
YHEL
(Escherichia
coli) 		4 / 6 LEU C  44
GLU C  45
ASN C  49
SER C  71
 None
 1.03A 3i9jB-2d1pC:
undetectable		 3i9jB-2d1pC:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB1_A_IMNA701_1
(LACTOTRANSFERRIN)		 2d1p HYPOTHETICAL UPF0163
PROTEIN YHEN
(Escherichia
coli) 		4 / 4 PRO A  53
THR A  51
GLY A  43
THR A   8
 None
 1.15A 3ib1A-2d1pA:
undetectable		 3ib1A-2d1pA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 2d1p HYPOTHETICAL PROTEIN
YHEL
(Escherichia
coli) 		3 / 3 ARG C  48
ASP C  39
ASP C  73
 None
 0.55A 3jayA-2d1pC:
undetectable		 3jayA-2d1pC:
6.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 2d1p HYPOTHETICAL PROTEIN
YHEL
(Escherichia
coli) 		3 / 3 ARG C  48
ASP C  39
ASP C  73
 None
 0.46A 3jb2A-2d1pC:
undetectable		 3jb2A-2d1pC:
6.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_B_9PLB1_1
(CYTOCHROME P450 2A13)		 2d1p HYPOTHETICAL PROTEIN
YHEL
HYPOTHETICAL UPF0163
PROTEIN YHEN
(Escherichia
coli) 		4 / 6 PHE A   3
PHE A  23
ALA A  26
THR C  80
 None
 1.12A 3t3sB-2d1pA:
undetectable		 3t3sB-2d1pA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_F_9PLF1_1
(CYTOCHROME P450 2A13)		 2d1p HYPOTHETICAL UPF0116
PROTEIN YHEM
(Escherichia
coli) 		4 / 8 PHE B 119
PHE B   8
PHE B   6
ALA B   5
 None
 0.94A 3t3sF-2d1pB:
undetectable		 3t3sF-2d1pB:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_B_SVRB516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 2d1p HYPOTHETICAL UPF0116
PROTEIN YHEM
(Escherichia
coli) 		4 / 7 PRO B  12
GLY B  18
ASP B  60
ARG B  59
 None
 0.82A 3ur0B-2d1pB:
undetectable		 3ur0B-2d1pB:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T44A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 2d1p HYPOTHETICAL PROTEIN
YHEL
HYPOTHETICAL UPF0163
PROTEIN YHEN
(Escherichia
coli) 		4 / 6 GLN A  15
VAL C  34
THR C  35
ARG C  64
 None
 1.25A 4lnxA-2d1pA:
undetectable		 4lnxA-2d1pA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_1
(CYTOCHROME P450 2D6)		 2d1p HYPOTHETICAL UPF0163
PROTEIN YHEN
(Escherichia
coli) 		6 / 12 PHE A  58
LEU A  60
LEU A  34
GLN A  25
VAL A  73
VAL A   7
 None
 1.48A 4wnwB-2d1pA:
undetectable		 4wnwB-2d1pA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_A_9KLA402_0
(EST-Y29)		 2d1p HYPOTHETICAL UPF0163
PROTEIN YHEN
HYPOTHETICAL UPF0116
PROTEIN YHEM
(Escherichia
coli;
Escherichia
coli) 		5 / 12 PHE B   6
LEU B  35
GLY A 113
ALA A 116
LEU A 120
 None
 1.07A 5zwrA-2d1pB:
undetectable		 5zwrA-2d1pB:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2d1p HYPOTHETICAL PROTEIN
YHEL
(Escherichia
coli) 		3 / 3 LEU C  18
ASN C  41
LEU C  29
 None
 0.76A 6exiD-2d1pC:
undetectable		 6exiD-2d1pC:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FK2_A_SORA302_0
(GALECTIN-3)		 2d1p HYPOTHETICAL UPF0163
PROTEIN YHEN
HYPOTHETICAL UPF0116
PROTEIN YHEM
(Escherichia
coli;
Escherichia
coli) 		4 / 4 ARG A  41
GLU B  20
GLU A  42
ARG A  85
 None
 0.81A 6fk2A-2d1pA:
undetectable		 6fk2A-2d1pA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FK2_A_SORA302_0
(GALECTIN-3)		 2d1p HYPOTHETICAL UPF0163
PROTEIN YHEN
HYPOTHETICAL UPF0116
PROTEIN YHEM
(Escherichia
coli;
Escherichia
coli) 		4 / 4 ARG A  85
GLU A  42
GLU B  20
ARG A  41
 None
 1.25A 6fk2A-2d1pA:
undetectable		 6fk2A-2d1pA:
19.33