SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2d1y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZ4_A_BEZA784_0
(MALT REGULATORY
PROTEIN)		 2d1y HYPOTHETICAL PROTEIN
TT0321
(Thermus
thermophilus) 		4 / 6 LEU A 118
LEU A 115
PRO A 112
MET A 113
 None
 0.96A 1hz4A-2d1yA:
undetectable		 1hz4A-2d1yA:
23.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UAY_A_ADNA1001_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 2d1y HYPOTHETICAL PROTEIN
TT0321
(Thermus
thermophilus) 		7 / 11 GLY A  13
ALA A  15
ASP A  37
LEU A  38
ASP A  57
ALA A  85
VAL A 107
 NAD  A1001 (-3.5A)
NAD  A1001 ( 4.0A)
NAD  A1001 (-2.8A)
NAD  A1001 (-4.2A)
NAD  A1001 (-4.3A)
NAD  A1001 (-3.6A)
NAD  A1001 ( 4.6A)
 0.78A 1uayA-2d1yA:
30.1		 1uayA-2d1yA:
37.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UAY_B_ADNB1002_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 2d1y HYPOTHETICAL PROTEIN
TT0321
(Thermus
thermophilus) 		7 / 10 GLY A  13
ALA A  15
ASP A  37
LEU A  38
ASP A  57
ALA A  85
VAL A 107
 NAD  A1001 (-3.5A)
NAD  A1001 ( 4.0A)
NAD  A1001 (-2.8A)
NAD  A1001 (-4.2A)
NAD  A1001 (-4.3A)
NAD  A1001 (-3.6A)
NAD  A1001 ( 4.6A)
 0.86A 1uayB-2d1yA:
30.4		 1uayB-2d1yA:
37.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_4
(POL POLYPROTEIN)		 2d1y HYPOTHETICAL PROTEIN
TT0321
(Thermus
thermophilus) 		3 / 3 ARG A  28
VAL A  45
GLY A  13
 None
None
NAD  A1001 (-3.5A)
 0.62A 2avvE-2d1yA:
undetectable		 2avvE-2d1yA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2d1y HYPOTHETICAL PROTEIN
TT0321
(Thermus
thermophilus) 		5 / 12 GLY A  13
ASP A  37
ASP A  57
ASN A  84
ALA A  85
 NAD  A1001 (-3.5A)
NAD  A1001 (-2.8A)
NAD  A1001 (-4.3A)
NAD  A1001 (-3.3A)
NAD  A1001 (-3.6A)
 0.99A 2bm9E-2d1yA:
5.6		 2bm9E-2d1yA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_B_SAMB401_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 2d1y HYPOTHETICAL PROTEIN
TT0321
(Thermus
thermophilus) 		6 / 12 GLY A  13
ILE A  22
ALA A  71
VAL A  82
LEU A  10
LEU A 115
 NAD  A1001 (-3.5A)
None
None
None
None
None
 1.39A 2yqzB-2d1yA:
6.4		 2yqzB-2d1yA:
27.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXZ_A_ADNA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 2d1y HYPOTHETICAL PROTEIN
TT0321
(Thermus
thermophilus) 		5 / 12 LEU A  35
GLY A  13
ILE A  49
GLY A  19
GLY A  14
 None
NAD  A1001 (-3.5A)
None
None
None
 0.95A 3axzA-2d1yA:
undetectable		 3axzA-2d1yA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2d1y HYPOTHETICAL PROTEIN
TT0321
(Thermus
thermophilus) 		4 / 4 LEU A 109
PRO A 112
LEU A 159
ARG A 161
 None
 1.38A 3hcoA-2d1yA:
3.3		 3hcoA-2d1yA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q87_B_SAMB300_0
(N6 ADENINE SPECIFIC
DNA METHYLASE)		 2d1y HYPOTHETICAL PROTEIN
TT0321
(Thermus
thermophilus) 		5 / 12 GLY A  13
ILE A  22
ASP A  37
LEU A  38
ASP A  57
 NAD  A1001 (-3.5A)
None
NAD  A1001 (-2.8A)
NAD  A1001 (-4.2A)
NAD  A1001 (-4.3A)
 0.48A 3q87B-2d1yA:
7.0		 3q87B-2d1yA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q87_B_SAMB300_0
(N6 ADENINE SPECIFIC
DNA METHYLASE)		 2d1y HYPOTHETICAL PROTEIN
TT0321
(Thermus
thermophilus) 		6 / 12 THR A 184
GLY A  13
ILE A  18
ASP A  37
LEU A  38
ASP A  57
 NAD  A1001 (-2.8A)
NAD  A1001 (-3.5A)
NAD  A1001 (-4.0A)
NAD  A1001 (-2.8A)
NAD  A1001 (-4.2A)
NAD  A1001 (-4.3A)
 1.49A 3q87B-2d1yA:
7.0		 3q87B-2d1yA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_B_DXCB1473_0
(MJ0495-LIKE PROTEIN)		 2d1y HYPOTHETICAL PROTEIN
TT0321
(Thermus
thermophilus) 		5 / 11 ILE A  22
ILE A  18
GLY A  17
VAL A 241
GLY A 214
 None
NAD  A1001 (-4.0A)
NAD  A1001 (-3.4A)
None
None
 0.94A 4ac9B-2d1yA:
6.3
4ac9C-2d1yA:
5.1		 4ac9B-2d1yA:
21.37
4ac9C-2d1yA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_A_SAMA401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 2d1y HYPOTHETICAL PROTEIN
TT0321
(Thermus
thermophilus) 		5 / 11 GLY A  13
GLY A  14
ASP A  37
LEU A  38
ASP A  57
 NAD  A1001 (-3.5A)
None
NAD  A1001 (-2.8A)
NAD  A1001 (-4.2A)
NAD  A1001 (-4.3A)
 0.97A 4pghA-2d1yA:
6.3		 4pghA-2d1yA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_C_RBFC201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2d1y HYPOTHETICAL PROTEIN
TT0321
(Thermus
thermophilus) 		5 / 9 ILE A  22
ASN A  83
VAL A 174
ILE A 172
PHE A  26
 None
 1.34A 4r38C-2d1yA:
undetectable		 4r38C-2d1yA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2d1y HYPOTHETICAL PROTEIN
TT0321
(Thermus
thermophilus) 		5 / 8 ILE A  22
ASN A  83
VAL A 174
ILE A 172
PHE A  26
 None
 1.31A 4r38D-2d1yA:
undetectable		 4r38D-2d1yA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_E_SPME202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2d1y HYPOTHETICAL PROTEIN
TT0321
(Thermus
thermophilus) 		4 / 5 GLU A  61
GLU A  63
GLU A 106
GLU A  59
 None
 1.36A 4r87E-2d1yA:
0.6		 4r87E-2d1yA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDR_A_ADNA402_1
(FAD:PROTEIN FMN
TRANSFERASE)		 2d1y HYPOTHETICAL PROTEIN
TT0321
(Thermus
thermophilus) 		5 / 12 LEU A  38
ASP A  37
GLY A  13
ALA A  85
ILE A  87
 NAD  A1001 (-4.2A)
NAD  A1001 (-2.8A)
NAD  A1001 (-3.5A)
NAD  A1001 (-3.6A)
NAD  A1001 (-4.3A)
 0.89A 4xdrA-2d1yA:
undetectable		 4xdrA-2d1yA:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_A_PZAA1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 2d1y HYPOTHETICAL PROTEIN
TT0321
(Thermus
thermophilus) 		4 / 7 ALA A 178
GLY A 139
VAL A 157
ARG A 161
 None
 0.90A 5fpdA-2d1yA:
undetectable		 5fpdA-2d1yA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_B_PZAB1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 2d1y HYPOTHETICAL PROTEIN
TT0321
(Thermus
thermophilus) 		4 / 7 ALA A 178
GLY A 139
VAL A 157
ARG A 161
 None
 0.89A 5fpdB-2d1yA:
1.7		 5fpdB-2d1yA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_D_EVPD101_1
()		 2d1y HYPOTHETICAL PROTEIN
TT0321
(Thermus
thermophilus) 		4 / 5 GLY A  13
ASP A  37
ARG A  16
GLN A  24
 NAD  A1001 (-3.5A)
NAD  A1001 (-2.8A)
NAD  A1001 (-3.8A)
None
 1.15A 5zrfB-2d1yA:
2.4		 5zrfB-2d1yA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CB4_A_BEZA501_0
(CANAVALIN)		 2d1y HYPOTHETICAL PROTEIN
TT0321
(Thermus
thermophilus) 		4 / 8 ASN A 133
VAL A 174
LEU A 167
ILE A 131
 None
 0.73A 6cb4A-2d1yA:
undetectable		 6cb4A-2d1yA:
20.27