SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2d2e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_A_DVAA6_0
(MINI-GRAMICIDIN A)		 2d2e SUFC PROTEIN
(Thermus
thermophilus) 		3 / 3 ALA A 183
VAL A 181
TRP A 131
 None
 0.87A 1kqeA-2d2eA:
undetectable
1kqeE-2d2eA:
undetectable		 1kqeA-2d2eA:
10.26
1kqeE-2d2eA:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MIC_A_DVAA6_0
(GRAMICIDIN A)		 2d2e SUFC PROTEIN
(Thermus
thermophilus) 		3 / 3 ALA A 183
VAL A 181
TRP A 131
 None
 0.86A 1micA-2d2eA:
undetectable
1micB-2d2eA:
undetectable		 1micA-2d2eA:
9.23
1micB-2d2eA:
9.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_B_CTCB1385_0
(TETX2 PROTEIN)		 2d2e SUFC PROTEIN
(Thermus
thermophilus) 		4 / 8 MET A 189
PHE A 194
GLY A  29
GLY A  81
 None
 0.93A 2y6rB-2d2eA:
undetectable		 2y6rB-2d2eA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZU_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2d2e SUFC PROTEIN
(Thermus
thermophilus) 		5 / 12 ILE A  62
GLN A   3
LEU A  63
VAL A  57
LEU A  45
 None
 0.99A 3dzuA-2d2eA:
undetectable		 3dzuA-2d2eA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZOW_A_CLMA500_0
(MULTIDRUG
TRANSPORTER MDFA)		 2d2e SUFC PROTEIN
(Thermus
thermophilus) 		5 / 11 LEU A 167
LEU A 158
LEU A 157
ILE A 154
LEU A 128
 None
 1.04A 4zowA-2d2eA:
undetectable		 4zowA-2d2eA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 2d2e SUFC PROTEIN
(Thermus
thermophilus) 		5 / 9 LEU A  19
VAL A 223
ARG A 221
MET A 218
ALA A  40
 None
 1.46A 5g44A-2d2eA:
undetectable		 5g44A-2d2eA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_B_ADNB401_1
(ADENOSINE KINASE)		 2d2e SUFC PROTEIN
(Thermus
thermophilus) 		5 / 12 GLY A  46
VAL A 166
ILE A   6
GLY A  51
ILE A  62
 None
None
None
GOL  A 801 (-3.8A)
None
 0.91A 5kb6B-2d2eA:
undetectable		 5kb6B-2d2eA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_B_REAB601_1
(RETINOIC ACID
RECEPTOR)		 2d2e SUFC PROTEIN
(Thermus
thermophilus) 		5 / 10 VAL A 198
LEU A 197
LEU A 157
GLY A 185
VAL A 182
 None
 1.01A 6eu9B-2d2eA:
undetectable		 6eu9B-2d2eA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_2
(-)		 2d2e SUFC PROTEIN
(Thermus
thermophilus) 		4 / 8 VAL A 198
ASN A 207
TYR A 208
GLU A 235
 None
 1.29A 6gneB-2d2eA:
undetectable		 6gneB-2d2eA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2d2e SUFC PROTEIN
(Thermus
thermophilus) 		4 / 7 ILE A 205
MET A 189
GLY A 191
ALA A 196
 None
 0.90A 6hd6B-2d2eA:
undetectable		 6hd6B-2d2eA:
15.45