SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2d2i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DSS_G_CCSG149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 2d2i GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(Synechococcus
sp.) 		4 / 7 ASN A 318
TYR A 322
ASN A 158
TYR A 316
 NAP  A1341 (-3.9A)
NAP  A1341 (-3.7A)
None
None
 0.90A 1dssG-2d2iA:
49.0		 1dssG-2d2iA:
42.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DSS_G_CCSG149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 2d2i GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(Synechococcus
sp.) 		7 / 7 SER A 154
THR A 156
ASN A 158
CYH A 159
TYR A 316
ASN A 318
TYR A 322
 SO4  A1339 (-2.9A)
SO4  A1339 ( 4.3A)
None
None
None
NAP  A1341 (-3.9A)
NAP  A1341 (-3.7A)
 0.24A 1dssG-2d2iA:
49.0		 1dssG-2d2iA:
42.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DSS_R_CCSR149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 2d2i GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(Synechococcus
sp.) 		4 / 8 ASN A 318
TYR A 322
ASN A 158
TYR A 316
 NAP  A1341 (-3.9A)
NAP  A1341 (-3.7A)
None
None
 0.90A 1dssR-2d2iA:
48.9		 1dssR-2d2iA:
42.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DSS_R_CCSR149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 2d2i GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(Synechococcus
sp.) 		8 / 8 SER A 154
THR A 156
ASN A 158
CYH A 159
HIS A 182
TYR A 316
ASN A 318
TYR A 322
 SO4  A1339 (-2.9A)
SO4  A1339 ( 4.3A)
None
None
None
None
NAP  A1341 (-3.9A)
NAP  A1341 (-3.7A)
 0.37A 1dssR-2d2iA:
48.9		 1dssR-2d2iA:
42.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_2
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 2d2i GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(Synechococcus
sp.) 		4 / 4 THR A 156
LEU A 160
VAL A 163
LEU A 167
 SO4  A1339 ( 4.3A)
None
None
None
 0.78A 1fbmD-2d2iA:
undetectable		 1fbmD-2d2iA:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_3
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 2d2i GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(Synechococcus
sp.) 		4 / 5 THR A 156
LEU A 160
VAL A 163
LEU A 167
 SO4  A1339 ( 4.3A)
None
None
None
 0.61A 1fbmE-2d2iA:
undetectable		 1fbmE-2d2iA:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2d2i GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(Synechococcus
sp.) 		3 / 3 THR A 156
LEU A 160
VAL A 163
 SO4  A1339 ( 4.3A)
None
None
 0.64A 1mz9E-2d2iA:
undetectable		 1mz9E-2d2iA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 2d2i GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(Synechococcus
sp.) 		4 / 7 LEU A  29
ILE A 150
VAL A   5
ILE A   3
 None
 0.79A 2aojB-2d2iA:
undetectable		 2aojB-2d2iA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_A_ACTA1121_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 2d2i GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(Synechococcus
sp.) 		4 / 5 SER A 183
VAL A 237
SER A 285
VAL A 242
 None
 1.37A 2j9cA-2d2iA:
2.0
2j9cB-2d2iA:
1.6
2j9cC-2d2iA:
1.9		 2j9cA-2d2iA:
16.90
2j9cB-2d2iA:
16.90
2j9cC-2d2iA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NO0_A_GEOA302_1
(DEOXYCYTIDINE KINASE)		 2d2i GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(Synechococcus
sp.) 		5 / 12 ILE A  67
VAL A  31
TRP A  21
LEU A  18
PHE A  22
 None
 1.48A 2no0A-2d2iA:
2.9		 2no0A-2d2iA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NO0_B_GEOB302_1
(DEOXYCYTIDINE KINASE)		 2d2i GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(Synechococcus
sp.) 		5 / 12 ILE A  67
VAL A  31
TRP A  21
LEU A  18
PHE A  22
 None
 1.50A 2no0B-2d2iA:
1.2		 2no0B-2d2iA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_B_ACTB1463_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 2d2i GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(Synechococcus
sp.) 		4 / 7 ILE A 296
VAL A 242
GLY A 290
THR A 291
 None
 0.76A 2xrzB-2d2iA:
undetectable		 2xrzB-2d2iA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA1_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 2d2i GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(Synechococcus
sp.) 		3 / 3 GLY A 136
ASP A 139
SER A 140
 None
 0.66A 3brfA-2d2iA:
undetectable		 3brfA-2d2iA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BUR_A_TESA339_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 2d2i GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(Synechococcus
sp.) 		5 / 10 ILE A  67
SER A  98
ASN A   8
VAL A  95
VAL A   5
 None
None
NAP  A1341 ( 4.3A)
None
None
 1.45A 3burA-2d2iA:
undetectable		 3burA-2d2iA:
21.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DMT_C_CCSC166_0
(GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
GLYCOSOMAL)		 2d2i GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(Synechococcus
sp.) 		4 / 8 ASN A 318
TYR A 322
ASN A 158
TYR A 316
 NAP  A1341 (-3.9A)
NAP  A1341 (-3.7A)
None
None
 0.91A 3dmtC-2d2iA:
49.3		 3dmtC-2d2iA:
47.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DMT_C_CCSC166_0
(GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
GLYCOSOMAL)		 2d2i GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(Synechococcus
sp.) 		8 / 8 SER A 154
THR A 156
ASN A 158
CYH A 159
HIS A 182
TYR A 316
ASN A 318
TYR A 322
 SO4  A1339 (-2.9A)
SO4  A1339 ( 4.3A)
None
None
None
None
NAP  A1341 (-3.9A)
NAP  A1341 (-3.7A)
 0.32A 3dmtC-2d2iA:
49.3		 3dmtC-2d2iA:
47.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2d2i GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(Synechococcus
sp.) 		5 / 8 THR A 255
ASN A 261
LEU A 167
LEU A 303
GLY A 307
 None
 1.48A 4r3aA-2d2iA:
2.3		 4r3aA-2d2iA:
26.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UGL_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 2d2i GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(Synechococcus
sp.) 		3 / 3 ARG A  24
THR A 291
TRP A 320
 None
 1.25A 4uglA-2d2iA:
undetectable		 4uglA-2d2iA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_B_SAMB1548_0
(CYSTATHIONINE
BETA-SYNTHASE)		 2d2i GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(Synechococcus
sp.) 		5 / 11 SER A 154
LEU A 160
PRO A 162
VAL A 134
THR A 132
 SO4  A1339 (-2.9A)
None
None
None
None
 1.17A 4uuuB-2d2iA:
undetectable		 4uuuB-2d2iA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2d2i GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(Synechococcus
sp.) 		4 / 5 VAL A 101
TYR A 316
ILE A 296
THR A 239
 NAP  A1341 (-4.9A)
None
None
None
 1.27A 4ze1A-2d2iA:
undetectable		 4ze1A-2d2iA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERS_A_ACTA803_0
(GEPHYRIN)		 2d2i GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(Synechococcus
sp.) 		3 / 3 THR A 157
ALA A 153
ASN A 158
 None
 0.60A 5ersA-2d2iA:
undetectable		 5ersA-2d2iA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2d2i GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(Synechococcus
sp.) 		5 / 12 ILE A 223
ASN A 138
ALA A 153
ILE A 276
MET A 272
 None
 0.97A 5igyA-2d2iA:
1.1		 5igyA-2d2iA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2d2i GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(Synechococcus
sp.) 		5 / 12 ILE A 223
ASN A 138
ALA A 153
ILE A 276
MET A 272
 None
 1.03A 5ih0A-2d2iA:
undetectable		 5ih0A-2d2iA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_A_9SCA601_1
(SERUM ALBUMIN)		 2d2i GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(Synechococcus
sp.) 		4 / 5 ASN A  36
VAL A   5
LEU A  94
SER A  98
 NAP  A1341 (-4.2A)
None
None
None
 1.31A 6a7pA-2d2iA:
undetectable		 6a7pA-2d2iA:
20.00