SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2d2n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2d2n GIANT HEMOGLOBIN,
A2(A5) GLOBIN CHAIN
(Oligobrachia
mashikoi) 		5 / 10 THR B 118
ALA B 117
ALA B  17
LEU B  67
VAL B  66
 None
None
None
None
HEM  B 200 ( 3.9A)
 1.29A 1claA-2d2nB:
undetectable		 1claA-2d2nB:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_1
(VITAMIN D NUCLEAR
RECEPTOR)		 2d2n GIANT HEMOGLOBIN,
A2(A5) GLOBIN CHAIN
(Oligobrachia
mashikoi) 		5 / 12 LEU B  70
LEU B  67
VAL B  66
SER B  63
HIS B  94
 HEM  B 200 (-3.8A)
None
HEM  B 200 ( 3.9A)
None
HEM  B 200 (-3.2A)
 1.10A 1db1A-2d2nB:
undetectable		 1db1A-2d2nB:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_A_ESTA351_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 2d2n GIANT HEMOGLOBIN,
B2(C) GLOBIN CHAIN
(Oligobrachia
mashikoi) 		5 / 12 VAL C  70
GLY C  73
LEU C  94
LEU C 147
SER C 144
 HEM  C 200 ( 3.7A)
HEM  C 200 ( 4.2A)
HEM  C 200 ( 4.7A)
None
None
 1.11A 1fduA-2d2nC:
undetectable		 1fduA-2d2nC:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_C_T44C128_1
(TRANSTHYRETIN)		 2d2n GIANT HEMOGLOBIN,
A2(A5) GLOBIN CHAIN
(Oligobrachia
mashikoi) 		5 / 11 LEU B  35
ALA B 111
LEU B  70
LEU B  67
SER B  63
 None
None
HEM  B 200 (-3.8A)
None
None
 1.18A 1ictA-2d2nB:
undetectable
1ictC-2d2nB:
undetectable		 1ictA-2d2nB:
20.26
1ictC-2d2nB:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE9_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 2d2n GIANT HEMOGLOBIN,
A2(A5) GLOBIN CHAIN
(Oligobrachia
mashikoi) 		5 / 12 LEU B  70
LEU B  67
VAL B  66
SER B  63
HIS B  94
 HEM  B 200 (-3.8A)
None
HEM  B 200 ( 3.9A)
None
HEM  B 200 (-3.2A)
 1.09A 1ie9A-2d2nB:
undetectable		 1ie9A-2d2nB:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1868_0
(FPRA)		 2d2n GIANT HEMOGLOBIN,
B2(C) GLOBIN CHAIN
(Oligobrachia
mashikoi) 		3 / 3 ALA C 107
HIS C 108
VAL C 111
 None
HEM  C 200 (-3.9A)
None
 0.45A 1lqtB-2d2nC:
undetectable		 1lqtB-2d2nC:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1425_0
(FPRA)		 2d2n GIANT HEMOGLOBIN,
B2(C) GLOBIN CHAIN
(Oligobrachia
mashikoi) 		3 / 3 ALA C 107
HIS C 108
VAL C 111
 None
HEM  C 200 (-3.9A)
None
 0.44A 1lquB-2d2nC:
undetectable		 1lquB-2d2nC:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_B_DESB128_1
(TRANSTHYRETIN)		 2d2n GIANT HEMOGLOBIN,
A2(A5) GLOBIN CHAIN
(Oligobrachia
mashikoi) 		5 / 11 LEU B  35
ALA B 111
LEU B  70
LEU B  67
SER B  63
 None
None
HEM  B 200 (-3.8A)
None
None
 1.08A 1tz8A-2d2nB:
undetectable
1tz8B-2d2nB:
undetectable		 1tz8A-2d2nB:
20.26
1tz8B-2d2nB:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_B_DESB128_1
(TRANSTHYRETIN)		 2d2n GIANT HEMOGLOBIN,
A2(A5) GLOBIN CHAIN
(Oligobrachia
mashikoi) 		5 / 11 LEU B  70
LEU B  67
SER B  63
LEU B  35
ALA B 111
 HEM  B 200 (-3.8A)
None
None
None
None
 1.08A 1tz8A-2d2nB:
undetectable
1tz8B-2d2nB:
undetectable		 1tz8A-2d2nB:
20.26
1tz8B-2d2nB:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2d2n GIANT HEMOGLOBIN,
B2(C) GLOBIN CHAIN
(Oligobrachia
mashikoi) 		4 / 7 LEU C  94
PHE C 116
MET C 112
VAL C 111
 HEM  C 200 ( 4.7A)
None
HEM  C 200 (-4.6A)
None
 1.06A 1wrlA-2d2nC:
1.0
1wrlB-2d2nC:
undetectable		 1wrlA-2d2nC:
17.04
1wrlB-2d2nC:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IYF_B_ERYB1399_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 2d2n GIANT HEMOGLOBIN,
A2(A5) GLOBIN CHAIN
(Oligobrachia
mashikoi) 		5 / 12 TRP B  32
ILE B 140
LEU B  86
SER B  92
ASP B  71
 None
None
MMC  B1500 ( 4.5A)
None
None
 1.26A 2iyfB-2d2nB:
undetectable		 2iyfB-2d2nB:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V35_A_NTIA317_1
(ALDOSE REDUCTASE)		 2d2n GIANT HEMOGLOBIN,
A2(A5) GLOBIN CHAIN
(Oligobrachia
mashikoi) 		4 / 8 TRP B  32
HIS B  62
PHE B 107
PRO B 100
 None
HEM  B 200 ( 4.1A)
HEM  B 200 (-3.7A)
None
 1.32A 3v35A-2d2nB:
undetectable		 3v35A-2d2nB:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 2d2n GIANT HEMOGLOBIN,
A1(B) GLOBIN CHAIN
(Oligobrachia
mashikoi) 		4 / 8 LEU A  70
VAL A 115
TYR A 131
LEU A  31
 HEM  A 200 ( 4.6A)
None
None
None
 0.98A 3v81C-2d2nA:
undetectable		 3v81C-2d2nA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3Q_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 2d2n GIANT HEMOGLOBIN,
A1(B) GLOBIN CHAIN
(Oligobrachia
mashikoi) 		4 / 7 LEU A  70
VAL A 115
TYR A 131
LEU A  31
 HEM  A 200 ( 4.6A)
None
None
None
 0.93A 4b3qA-2d2nA:
undetectable		 4b3qA-2d2nA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PUO_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 2d2n GIANT HEMOGLOBIN,
A1(B) GLOBIN CHAIN
(Oligobrachia
mashikoi) 		4 / 8 LEU A  70
VAL A 115
TYR A 131
LEU A  31
 HEM  A 200 ( 4.6A)
None
None
None
 0.97A 4puoC-2d2nA:
undetectable		 4puoC-2d2nA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 2d2n GIANT HEMOGLOBIN,
A1(B) GLOBIN CHAIN
(Oligobrachia
mashikoi) 		4 / 8 LEU A  70
VAL A 115
TYR A 131
LEU A  31
 HEM  A 200 ( 4.6A)
None
None
None
 0.89A 4pwdA-2d2nA:
undetectable		 4pwdA-2d2nA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 2d2n GIANT HEMOGLOBIN,
A1(B) GLOBIN CHAIN
(Oligobrachia
mashikoi) 		4 / 8 LEU A  70
VAL A 115
TYR A 131
LEU A  31
 HEM  A 200 ( 4.6A)
None
None
None
 0.98A 4pwdC-2d2nA:
undetectable		 4pwdC-2d2nA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0B_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 2d2n GIANT HEMOGLOBIN,
A1(B) GLOBIN CHAIN
(Oligobrachia
mashikoi) 		4 / 8 LEU A  70
VAL A 115
TYR A 131
LEU A  31
 HEM  A 200 ( 4.6A)
None
None
None
 0.92A 4q0bA-2d2nA:
undetectable		 4q0bA-2d2nA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_A_3CJA607_1
(LACTOPEROXIDASE)		 2d2n GIANT HEMOGLOBIN,
A2(A5) GLOBIN CHAIN
GIANT HEMOGLOBIN,
B2(C) GLOBIN CHAIN
(Oligobrachia
mashikoi) 		3 / 3 GLN C  97
HIS C  93
ARG B  65
 HEM  C 200 ( 3.5A)
HEM  B 200 (-4.2A)
HEM  B 200 (-4.0A)
 1.17A 4qyqA-2d2nC:
undetectable		 4qyqA-2d2nC:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_B_3CJB607_1
(LACTOPEROXIDASE)		 2d2n GIANT HEMOGLOBIN,
A2(A5) GLOBIN CHAIN
GIANT HEMOGLOBIN,
B2(C) GLOBIN CHAIN
(Oligobrachia
mashikoi) 		3 / 3 GLN C  97
HIS C  93
ARG B  65
 HEM  C 200 ( 3.5A)
HEM  B 200 (-4.2A)
HEM  B 200 (-4.0A)
 1.20A 4qyqB-2d2nC:
undetectable		 4qyqB-2d2nC:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MXB_A_ML1A222_1
(CLASS 10 PLANT
PATHOGENESIS-RELATED
PROTEIN)		 2d2n GIANT HEMOGLOBIN,
A2(A5) GLOBIN CHAIN
(Oligobrachia
mashikoi) 		5 / 10 LEU B   9
ARG B 122
GLY B 120
ALA B 121
PHE B 124
 None
 1.06A 5mxbA-2d2nB:
undetectable		 5mxbA-2d2nB:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODH_G_ACTG710_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 2d2n GIANT HEMOGLOBIN,
A2(A5) GLOBIN CHAIN
(Oligobrachia
mashikoi) 		4 / 4 ARG B  97
ILE B  99
TYR B 104
ILE B 140
 HEM  B 200 (-4.1A)
HEM  B 200 (-3.7A)
HEM  B 200 (-3.4A)
None
 1.36A 5odhG-2d2nB:
undetectable		 5odhG-2d2nB:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_0
(REGULATORY PROTEIN
TETR)		 2d2n GIANT HEMOGLOBIN,
A1(B) GLOBIN CHAIN
(Oligobrachia
mashikoi) 		5 / 12 ALA A 135
LEU A  73
ILE A  74
VAL A 111
TYR A  18
 None
 1.26A 5vlmE-2d2nA:
undetectable		 5vlmE-2d2nA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_1
(CYTOCHROME P450 1A1)		 2d2n GIANT HEMOGLOBIN,
A2(A5) GLOBIN CHAIN
GIANT HEMOGLOBIN,
B2(C) GLOBIN CHAIN
(Oligobrachia
mashikoi;
Oligobrachia
mashikoi) 		3 / 3 SER C  25
SER B  76
ALA C  61
 None
 0.55A 6dwnC-2d2nC:
undetectable		 6dwnC-2d2nC:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA810_0
(GEPHYRIN)		 2d2n GIANT HEMOGLOBIN,
B2(C) GLOBIN CHAIN
(Oligobrachia
mashikoi) 		3 / 3 LEU C  39
SER C  41
PHE C  40
 None
 0.59A 6fgcA-2d2nC:
undetectable		 6fgcA-2d2nC:
16.67