SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2d2r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4001_1
(SERUM ALBUMIN)		 2d2r UNDECAPRENYL
PYROPHOSPHATE
SYNTHASE
(Helicobacter
pylori) 		4 / 5 ARG A  26
LYS A  20
ALA A  19
GLY A  14
 None
 1.08A 1e7bA-2d2rA:
undetectable		 1e7bA-2d2rA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_0
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 2d2r UNDECAPRENYL
PYROPHOSPHATE
SYNTHASE
(Helicobacter
pylori) 		5 / 12 ALA A  56
PHE A  57
GLY A  98
ILE A  97
LEU A 178
 None
 1.21A 1kglA-2d2rA:
undetectable		 1kglA-2d2rA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_G_SAMG302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2d2r UNDECAPRENYL
PYROPHOSPHATE
SYNTHASE
(Helicobacter
pylori) 		5 / 12 GLY A 182
GLY A  14
ILE A 205
ASP A 209
LEU A 179
 None
 1.09A 3cjtG-2d2rA:
undetectable		 3cjtG-2d2rA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_1
(GLUCOCORTICOID
RECEPTOR)		 2d2r UNDECAPRENYL
PYROPHOSPHATE
SYNTHASE
(Helicobacter
pylori) 		5 / 12 LEU A 206
ASN A  15
GLY A  16
LEU A  21
THR A  36
 None
 1.47A 4p6xI-2d2rA:
undetectable		 4p6xI-2d2rA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNU_A_BEZA319_0
(SHKAI2IB)		 2d2r UNDECAPRENYL
PYROPHOSPHATE
SYNTHASE
(Helicobacter
pylori) 		4 / 5 GLN A 126
ILE A  92
ILE A  42
TYR A  87
 None
 1.29A 5dnuA-2d2rA:
undetectable		 5dnuA-2d2rA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNV_A_BEZA304_0
(SHKAI2IB)		 2d2r UNDECAPRENYL
PYROPHOSPHATE
SYNTHASE
(Helicobacter
pylori) 		4 / 5 GLN A 126
ILE A  92
ILE A  42
TYR A  87
 None
 1.26A 5dnvA-2d2rA:
2.5		 5dnvA-2d2rA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA503_1
(CYTOCHROME P450 2C9)		 2d2r UNDECAPRENYL
PYROPHOSPHATE
SYNTHASE
(Helicobacter
pylori) 		5 / 12 ASN A 217
LEU A 206
THR A 181
LEU A 179
PHE A 210
 None
 1.29A 5xxiA-2d2rA:
undetectable		 5xxiA-2d2rA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZSF_A_6T0A910_0
(TOLL-LIKE RECEPTOR 7)		 2d2r UNDECAPRENYL
PYROPHOSPHATE
SYNTHASE
(Helicobacter
pylori) 		4 / 7 THR A 118
LEU A 114
ILE A 111
THR A 110
 None
 1.03A 5zsfA-2d2rA:
undetectable
5zsfB-2d2rA:
undetectable		 5zsfA-2d2rA:
14.16
5zsfB-2d2rA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA605_0
(SERUM ALBUMIN)		 2d2r UNDECAPRENYL
PYROPHOSPHATE
SYNTHASE
(Helicobacter
pylori) 		4 / 8 HIS A  30
LYS A  32
GLY A  33
LEU A 206
 None
 0.61A 6mdqA-2d2rA:
undetectable		 6mdqA-2d2rA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NCS_A_ACTA303_0
(N-ACETYLNEURAMINIC
ACID (SIALIC ACID)
SYNTHETASE)		 2d2r UNDECAPRENYL
PYROPHOSPHATE
SYNTHASE
(Helicobacter
pylori) 		3 / 3 ILE A  40
THR A  41
PRO A 212
 None
 0.65A 6ncsA-2d2rA:
undetectable		 6ncsA-2d2rA:
24.40