SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2d2z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_C_CCSC47_0
(GLUTATHIONE
S-TRANSFERASE)		 2d2z CHLORIDE
INTRACELLULAR
CHANNEL PROTEIN 4
(Homo
sapiens) 		4 / 6 LEU A  99
GLY A  49
LYS A 103
TYR A 104
 None
 1.18A 1gtiC-2d2zA:
13.8		 1gtiC-2d2zA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_F_CCSF47_0
(GLUTATHIONE
S-TRANSFERASE)		 2d2z CHLORIDE
INTRACELLULAR
CHANNEL PROTEIN 4
(Homo
sapiens) 		4 / 5 LEU A  99
GLY A  49
LYS A 103
TYR A 104
 None
 1.18A 1gtiF-2d2zA:
13.6		 1gtiF-2d2zA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_B_T44B128_1
(TRANSTHYRETIN)		 2d2z CHLORIDE
INTRACELLULAR
CHANNEL PROTEIN 4
(Homo
sapiens) 		4 / 6 LEU A 191
ALA A 187
LEU A 192
THR A 185
 None
 1.06A 2roxB-2d2zA:
undetectable		 2roxB-2d2zA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I89_A_1FLA201_1
(TRANSTHYRETIN)		 2d2z CHLORIDE
INTRACELLULAR
CHANNEL PROTEIN 4
(Homo
sapiens) 		4 / 6 LEU A 191
ALA A 187
LEU A 192
THR A 185
 None
 1.06A 4i89A-2d2zA:
undetectable		 4i89A-2d2zA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2d2z CHLORIDE
INTRACELLULAR
CHANNEL PROTEIN 4
(Homo
sapiens) 		4 / 6 ILE A 121
PHE A 125
ILE A 217
LEU A 191
 None
 0.75A 4o8fB-2d2zA:
undetectable		 4o8fB-2d2zA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA5_A_ZMRA501_1
(NEURAMINIDASE)		 2d2z CHLORIDE
INTRACELLULAR
CHANNEL PROTEIN 4
(Homo
sapiens) 		5 / 12 GLU A  93
ALA A 187
GLU A  92
ARG A  40
ASN A 190
 None
 1.50A 4wa5A-2d2zA:
undetectable		 4wa5A-2d2zA:
21.18