SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2d3a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C8L_A_CFFA940_1
(PROTEIN (GLYCOGEN
PHOSPHORYLASE))		 2d3a GLUTAMINE SYNTHETASE
(Zea
mays) 		4 / 6 HIS A 280
ALA A 283
GLY A 285
TYR A 284
 None
 1.07A 1c8lA-2d3aA:
0.1		 1c8lA-2d3aA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GFZ_A_CFFA940_1
(GLYCOGEN
PHOSPHORYLASE)		 2d3a GLUTAMINE SYNTHETASE
(Zea
mays) 		4 / 6 HIS A 280
ALA A 283
GLY A 285
TYR A 284
 None
 1.09A 1gfzA-2d3aA:
undetectable		 1gfzA-2d3aA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JGS_A_SALA256_1
(MULTIPLE ANTIBIOTIC
RESISTANCE PROTEIN
MARR)		 2d3a GLUTAMINE SYNTHETASE
(Zea
mays) 		4 / 7 PRO A 124
VAL A 206
THR A 344
VAL A 119
 None
 0.99A 1jgsA-2d3aA:
undetectable		 1jgsA-2d3aA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_A_CFFA863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2d3a GLUTAMINE SYNTHETASE
(Zea
mays) 		4 / 6 HIS A 280
ALA A 283
GLY A 285
TYR A 284
 None
 1.07A 1l5qA-2d3aA:
undetectable		 1l5qA-2d3aA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_B_CFFB1863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2d3a GLUTAMINE SYNTHETASE
(Zea
mays) 		4 / 6 HIS A 280
ALA A 283
GLY A 285
TYR A 284
 None
 1.07A 1l5qB-2d3aA:
undetectable		 1l5qB-2d3aA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7X_A_CFFA863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2d3a GLUTAMINE SYNTHETASE
(Zea
mays) 		4 / 6 HIS A 280
ALA A 283
GLY A 285
TYR A 284
 None
 1.10A 1l7xA-2d3aA:
undetectable		 1l7xA-2d3aA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7X_B_CFFB1863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2d3a GLUTAMINE SYNTHETASE
(Zea
mays) 		4 / 6 HIS A 280
ALA A 283
GLY A 285
TYR A 284
 None
 1.11A 1l7xB-2d3aA:
undetectable		 1l7xB-2d3aA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGZ_D_COCD401_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2d3a GLUTAMINE SYNTHETASE
(Zea
mays) 		4 / 6 TYR A 108
TYR A  73
GLN A  62
ILE A 102
 None
 1.47A 2pgzD-2d3aA:
undetectable
2pgzE-2d3aA:
undetectable		 2pgzD-2d3aA:
20.41
2pgzE-2d3aA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZT7_A_GLYA1300_0
(GLYCYL-TRNA
SYNTHETASE)		 2d3a GLUTAMINE SYNTHETASE
(Zea
mays) 		4 / 7 ARG A 316
GLU A 129
TYR A 158
GLU A 199
 ADP  A6001 (-2.8A)
MN  A1002 ( 2.0A)
P3S  A5001 ( 4.9A)
MN  A1001 ( 2.5A)
 1.17A 2zt7A-2d3aA:
undetectable		 2zt7A-2d3aA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DD1_A_CFFA903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2d3a GLUTAMINE SYNTHETASE
(Zea
mays) 		4 / 6 HIS A 280
ALA A 283
GLY A 285
TYR A 284
 None
 1.07A 3dd1A-2d3aA:
undetectable		 3dd1A-2d3aA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DD1_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2d3a GLUTAMINE SYNTHETASE
(Zea
mays) 		4 / 6 HIS A 280
ALA A 283
GLY A 285
TYR A 284
 None
 1.06A 3dd1B-2d3aA:
undetectable		 3dd1B-2d3aA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDS_A_CFFA904_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2d3a GLUTAMINE SYNTHETASE
(Zea
mays) 		4 / 6 HIS A 280
ALA A 283
GLY A 285
TYR A 284
 None
 1.08A 3ddsA-2d3aA:
undetectable		 3ddsA-2d3aA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDS_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2d3a GLUTAMINE SYNTHETASE
(Zea
mays) 		4 / 6 HIS A 280
ALA A 283
GLY A 285
TYR A 284
 None
 1.07A 3ddsB-2d3aA:
undetectable		 3ddsB-2d3aA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDW_A_CFFA903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2d3a GLUTAMINE SYNTHETASE
(Zea
mays) 		4 / 6 HIS A 280
ALA A 283
GLY A 285
TYR A 284
 None
 1.07A 3ddwA-2d3aA:
0.6		 3ddwA-2d3aA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDW_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2d3a GLUTAMINE SYNTHETASE
(Zea
mays) 		4 / 6 HIS A 280
ALA A 283
GLY A 285
TYR A 284
 None
 1.06A 3ddwB-2d3aA:
undetectable		 3ddwB-2d3aA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_D_30BD500_1
(GENOME POLYPROTEIN)		 2d3a GLUTAMINE SYNTHETASE
(Zea
mays) 		5 / 12 GLN A  62
ASP A  93
GLY A  30
ARG A 107
ASP A 212
 None
 1.13A 3keeD-2d3aA:
undetectable		 3keeD-2d3aA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 2d3a GLUTAMINE SYNTHETASE
(Zea
mays) 		5 / 12 GLY A  61
GLY A  57
ILE A 102
VAL A  70
ASP A  32
 None
 1.14A 4a6eA-2d3aA:
undetectable		 4a6eA-2d3aA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 2d3a GLUTAMINE SYNTHETASE
(Zea
mays) 		3 / 3 HIS A 249
GLU A 192
ASN A 244
 MN  A1002 ( 3.5A)
MN  A1003 ( 3.0A)
P3S  A5001 ( 4.7A)
 1.04A 4bupB-2d3aA:
undetectable		 4bupB-2d3aA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_D_MIXD101_1
(DNA TOPOISOMERASE
2-BETA)		 2d3a GLUTAMINE SYNTHETASE
(Zea
mays) 		4 / 6 ARG A 316
GLY A 312
ASN A 244
GLU A 297
 ADP  A6001 (-2.8A)
None
P3S  A5001 ( 4.7A)
P3S  A5001 (-3.4A)
 1.17A 4g0vB-2d3aA:
1.9		 4g0vB-2d3aA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2d3a GLUTAMINE SYNTHETASE
(Zea
mays) 		5 / 12 ILE A 266
ARG A 332
PHE A 329
ILE A 347
LEU A 273
 None
P3S  A5001 ( 3.1A)
None
None
None
 1.03A 4m6kA-2d3aA:
undetectable		 4m6kA-2d3aA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2d3a GLUTAMINE SYNTHETASE
(Zea
mays) 		5 / 12 ILE A 208
VAL A 214
VAL A 216
SER A 210
ALA A 110
 None
 1.15A 5n0oA-2d3aA:
undetectable		 5n0oA-2d3aA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_D_CCSD14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2
PROGRAMMED CELL
DEATH 1 LIGAND 1)		 2d3a GLUTAMINE SYNTHETASE
(Zea
mays) 		5 / 12 LEU A 292
SER A 336
GLY A 247
GLY A 245
ARG A 290
 None
None
P3S  A5001 ( 4.1A)
P3S  A5001 (-4.3A)
None
 1.32A 5o4yD-2d3aA:
undetectable
5o4yE-2d3aA:
undetectable		 5o4yD-2d3aA:
2.82
5o4yE-2d3aA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 2d3a GLUTAMINE SYNTHETASE
(Zea
mays) 		3 / 3 HIS A 249
GLU A 192
ASN A 244
 MN  A1002 ( 3.5A)
MN  A1003 ( 3.0A)
P3S  A5001 ( 4.7A)
 1.01A 5wbvA-2d3aA:
undetectable		 5wbvA-2d3aA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 2d3a GLUTAMINE SYNTHETASE
(Zea
mays) 		3 / 3 HIS A 249
GLU A 192
ASN A 244
 MN  A1002 ( 3.5A)
MN  A1003 ( 3.0A)
P3S  A5001 ( 4.7A)
 1.01A 5wbvB-2d3aA:
undetectable		 5wbvB-2d3aA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_C_HFGC1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 2d3a GLUTAMINE SYNTHETASE
(Zea
mays) 		5 / 12 GLU A 122
VAL A 119
PRO A 124
PHE A 329
THR A 321
 None
 1.15A 5xipC-2d3aA:
undetectable		 5xipC-2d3aA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_D_HFGD1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 2d3a GLUTAMINE SYNTHETASE
(Zea
mays) 		5 / 12 GLU A 122
VAL A 119
PRO A 124
PHE A 329
THR A 321
 None
 1.07A 5xipD-2d3aA:
undetectable		 5xipD-2d3aA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_A_HFGA1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 2d3a GLUTAMINE SYNTHETASE
(Zea
mays) 		5 / 12 GLU A 122
VAL A 119
PRO A 124
PHE A 329
THR A 321
 None
 1.12A 5xiqA-2d3aA:
undetectable		 5xiqA-2d3aA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 2d3a GLUTAMINE SYNTHETASE
(Zea
mays) 		5 / 12 GLU A 122
VAL A 119
PRO A 124
PHE A 329
THR A 321
 None
 1.13A 5xiqB-2d3aA:
undetectable		 5xiqB-2d3aA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_C_HFGC1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 2d3a GLUTAMINE SYNTHETASE
(Zea
mays) 		5 / 12 GLU A 122
VAL A 119
PRO A 124
PHE A 329
THR A 321
 None
 1.10A 5xiqC-2d3aA:
undetectable		 5xiqC-2d3aA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 2d3a GLUTAMINE SYNTHETASE
(Zea
mays) 		5 / 12 GLU A 122
VAL A 119
PRO A 124
PHE A 329
THR A 321
 None
 1.11A 5xiqD-2d3aA:
undetectable		 5xiqD-2d3aA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)		 2d3a GLUTAMINE SYNTHETASE
(Zea
mays) 		5 / 10 GLU A 129
HIS A 249
ALA A 309
GLU A 297
ARG A 332
 MN  A1002 ( 2.0A)
MN  A1002 ( 3.5A)
None
P3S  A5001 (-3.4A)
P3S  A5001 ( 3.1A)
 1.17A 6bniA-2d3aA:
undetectable		 6bniA-2d3aA:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 2d3a GLUTAMINE SYNTHETASE
(Zea
mays) 		4 / 6 MET A 194
GLY A 144
TRP A 145
LEU A 135
 None
 0.85A 6fosA-2d3aA:
undetectable		 6fosA-2d3aA:
11.73