SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2d3l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA1001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		 2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE
(Bacillus
sp.
707) 		6 / 12 TYR A  58
LEU A 201
ASP A 236
ALA A 237
HIS A 332
ASP A 333
 GLC  A 605 (-4.8A)
None
None
None
None
GLC  A 605 (-3.5A)
 0.67A 1dedA-2d3lA:
26.2		 1dedA-2d3lA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_B_QPSB1501_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		 2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE
(Bacillus
sp.
707) 		7 / 12 TYR A  58
ARG A 234
ASP A 236
ALA A 237
GLU A 266
HIS A 332
ASP A 333
 GLC  A 605 (-4.8A)
None
None
None
None
None
GLC  A 605 (-3.5A)
 0.70A 1dedB-2d3lA:
24.0		 1dedB-2d3lA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_A_IBPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE
(Bacillus
sp.
707) 		5 / 9 VAL A  42
LEU A  34
ALA A  88
SER A  91
LEU A  92
 None
 1.05A 1eqgA-2d3lA:
undetectable		 1eqgA-2d3lA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_B_IBPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE
(Bacillus
sp.
707) 		5 / 11 VAL A  42
LEU A  34
ALA A  88
SER A  91
LEU A  92
 None
 1.06A 1eqgB-2d3lA:
undetectable		 1eqgB-2d3lA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GAH_A_ACRA497_2
(GLUCOAMYLASE-471)		 2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE
(Bacillus
sp.
707) 		4 / 6 ALA A 300
TRP A 413
ARG A 359
LEU A 297
 None
 1.06A 1gahA-2d3lA:
undetectable		 1gahA-2d3lA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_1
(ALPHA-AMYLASE)		 2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE
(Bacillus
sp.
707) 		5 / 12 TRP A  15
HIS A 107
ALA A 237
GLU A 266
ASP A 333
 None
None
None
None
GLC  A 605 (-3.5A)
 0.68A 1kxhA-2d3lA:
28.7		 1kxhA-2d3lA:
26.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MXD_A_ACRA735_1
(ALPHA AMYLASE)		 2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE
(Bacillus
sp.
707) 		10 / 12 TRP A  15
TYR A  58
HIS A 107
ARG A 234
ASP A 236
LYS A 239
GLU A 266
TRP A 268
HIS A 332
ASP A 333
 None
GLC  A 605 (-4.8A)
None
None
None
None
None
None
None
GLC  A 605 (-3.5A)
 0.90A 1mxdA-2d3lA:
39.8		 1mxdA-2d3lA:
30.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MXG_A_ACRA444_1
(ALPHA AMYLASE)		 2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE
(Bacillus
sp.
707) 		4 / 7 TYR A  16
TRP A  15
TYR A  58
GLY A  50
 None
None
GLC  A 605 (-4.8A)
None
 1.36A 1mxgA-2d3lA:
39.8		 1mxgA-2d3lA:
30.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_A_IPHA6012_0
(PHENOL
2-MONOOXYGENASE)		 2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE
(Bacillus
sp.
707) 		5 / 10 ASP A  55
GLY A  57
VAL A  56
MET A 202
TYR A 203
 GLC  A 605 ( 4.7A)
None
None
GLC  A 605 ( 3.5A)
GLC  A 603 (-4.0A)
 1.46A 1pn0A-2d3lA:
undetectable		 1pn0A-2d3lA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_B_IPHB6022_0
(PHENOL
2-MONOOXYGENASE)		 2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE
(Bacillus
sp.
707) 		5 / 10 ASP A  55
GLY A  57
VAL A  56
MET A 202
TYR A 203
 GLC  A 605 ( 4.7A)
None
None
GLC  A 605 ( 3.5A)
GLC  A 603 (-4.0A)
 1.46A 1pn0B-2d3lA:
undetectable		 1pn0B-2d3lA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_C_IPHC6032_0
(PHENOL
2-MONOOXYGENASE)		 2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE
(Bacillus
sp.
707) 		5 / 10 ASP A  55
GLY A  57
VAL A  56
MET A 202
TYR A 203
 GLC  A 605 ( 4.7A)
None
None
GLC  A 605 ( 3.5A)
GLC  A 603 (-4.0A)
 1.44A 1pn0C-2d3lA:
undetectable		 1pn0C-2d3lA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_D_IPHD6042_0
(PHENOL
2-MONOOXYGENASE)		 2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE
(Bacillus
sp.
707) 		5 / 10 ASP A  55
GLY A  57
VAL A  56
MET A 202
TYR A 203
 GLC  A 605 ( 4.7A)
None
None
GLC  A 605 ( 3.5A)
GLC  A 603 (-4.0A)
 1.43A 1pn0D-2d3lA:
undetectable		 1pn0D-2d3lA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE
(Bacillus
sp.
707) 		3 / 3 ILE A 429
ILE A 410
THR A 414
 None
 0.63A 1rg7A-2d3lA:
undetectable		 1rg7A-2d3lA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA501_1
(YKOF)		 2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE
(Bacillus
sp.
707) 		4 / 8 PHE A 313
LEU A 405
ILE A 410
ILE A 411
 None
 0.92A 1sbrA-2d3lA:
undetectable		 1sbrA-2d3lA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_1
(THYMIDYLATE SYNTHASE)		 2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE
(Bacillus
sp.
707) 		5 / 12 SER A 287
TRP A 249
GLY A 232
PHE A 262
VAL A 103
 GLC  A 632 ( 4.2A)
None
None
GLC  A 632 (-4.1A)
None
 1.35A 2kceA-2d3lA:
undetectable		 2kceA-2d3lA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OWC_A_ACRA600_1
(4-ALPHA-GLUCANOTRANS
FERASE)		 2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE
(Bacillus
sp.
707) 		5 / 11 TYR A  58
ASP A 236
HIS A 332
ASP A 333
TRP A  15
 GLC  A 605 (-4.8A)
None
None
GLC  A 605 (-3.5A)
None
 0.93A 2owcA-2d3lA:
15.3		 2owcA-2d3lA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OWW_A_ACRA600_1
(4-ALPHA-GLUCANOTRANS
FERASE)		 2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE
(Bacillus
sp.
707) 		5 / 11 TYR A  58
ASP A 236
HIS A 332
ASP A 333
TRP A  15
 GLC  A 605 (-4.8A)
None
None
GLC  A 605 (-3.5A)
None
 0.95A 2owwA-2d3lA:
15.3		 2owwA-2d3lA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7L_A_TESA155_1
(ANDROGEN RECEPTOR)		 2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE
(Bacillus
sp.
707) 		5 / 12 ASN A 226
LEU A 228
GLY A 229
MET A 261
THR A 257
 None
 1.33A 2q7lA-2d3lA:
undetectable		 2q7lA-2d3lA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		 2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE
(Bacillus
sp.
707) 		3 / 3 ASN A  54
ASN A  19
ARG A  76
 None
 0.91A 2rlcA-2d3lA:
undetectable		 2rlcA-2d3lA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YHD_A_TESA1920_1
(ANDROGEN RECEPTOR)		 2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE
(Bacillus
sp.
707) 		5 / 12 ASN A 226
LEU A 228
GLY A 229
MET A 261
THR A 257
 None
 1.35A 2yhdA-2d3lA:
undetectable		 2yhdA-2d3lA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_A_ACRA5044_1
(GLUCOSYLTRANSFERASE-
SI)		 2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE
(Bacillus
sp.
707) 		7 / 12 LEU A 201
ARG A 234
ASP A 236
ALA A 237
GLU A 266
HIS A 332
ASP A 333
 None
None
None
None
None
None
GLC  A 605 (-3.5A)
 0.63A 3aicA-2d3lA:
11.6		 3aicA-2d3lA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_B_ACRB5044_1
(GLUCOSYLTRANSFERASE-
SI)		 2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE
(Bacillus
sp.
707) 		7 / 12 LEU A 201
ARG A 234
ASP A 236
ALA A 237
GLU A 266
HIS A 332
ASP A 333
 None
None
None
None
None
None
GLC  A 605 (-3.5A)
 0.62A 3aicB-2d3lA:
7.1		 3aicB-2d3lA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_C_ACRC5044_1
(GLUCOSYLTRANSFERASE-
SI)		 2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE
(Bacillus
sp.
707) 		7 / 12 ARG A 234
ASP A 236
ALA A 237
GLU A 266
HIS A 332
ASP A 333
TYR A  58
 None
None
None
None
None
GLC  A 605 (-3.5A)
GLC  A 605 (-4.8A)
 0.63A 3aicC-2d3lA:
11.7		 3aicC-2d3lA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_D_ACRD5044_1
(GLUCOSYLTRANSFERASE-
SI)		 2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE
(Bacillus
sp.
707) 		7 / 12 LEU A 201
ARG A 234
ASP A 236
ALA A 237
GLU A 266
HIS A 332
ASP A 333
 None
None
None
None
None
None
GLC  A 605 (-3.5A)
 0.68A 3aicD-2d3lA:
11.7		 3aicD-2d3lA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_E_ACRE5044_1
(GLUCOSYLTRANSFERASE-
SI)		 2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE
(Bacillus
sp.
707) 		7 / 12 LEU A 201
ARG A 234
ASP A 236
ALA A 237
GLU A 266
HIS A 332
ASP A 333
 None
None
None
None
None
None
GLC  A 605 (-3.5A)
 0.67A 3aicE-2d3lA:
11.8		 3aicE-2d3lA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_F_ACRF5044_1
(GLUCOSYLTRANSFERASE-
SI)		 2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE
(Bacillus
sp.
707) 		7 / 12 LEU A 201
ARG A 234
ASP A 236
ALA A 237
GLU A 266
HIS A 332
ASP A 333
 None
None
None
None
None
None
GLC  A 605 (-3.5A)
 0.65A 3aicF-2d3lA:
11.6		 3aicF-2d3lA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_G_ACRG5044_1
(GLUCOSYLTRANSFERASE-
SI)		 2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE
(Bacillus
sp.
707) 		7 / 12 LEU A 201
ARG A 234
ASP A 236
ALA A 237
GLU A 266
HIS A 332
ASP A 333
 None
None
None
None
None
None
GLC  A 605 (-3.5A)
 0.60A 3aicG-2d3lA:
11.7		 3aicG-2d3lA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_H_ACRH5044_1
(GLUCOSYLTRANSFERASE-
SI)		 2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE
(Bacillus
sp.
707) 		7 / 12 LEU A 201
ARG A 234
ASP A 236
ALA A 237
GLU A 266
HIS A 332
ASP A 333
 None
None
None
None
None
None
GLC  A 605 (-3.5A)
 0.71A 3aicH-2d3lA:
11.7		 3aicH-2d3lA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJ8_C_SPMC500_1
(DIAMINE
ACETYLTRANSFERASE 1)		 2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE
(Bacillus
sp.
707) 		4 / 6 ASP A 308
LEU A 405
ASP A 432
LEU A 351
 None
None
CA  A 503 (-2.3A)
None
 1.27A 3bj8C-2d3lA:
undetectable
3bj8D-2d3lA:
undetectable		 3bj8C-2d3lA:
16.87
3bj8D-2d3lA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE
(Bacillus
sp.
707) 		3 / 3 GLY A 425
GLY A 399
GLY A 417
 None
 0.42A 3bogC-2d3lA:
undetectable		 3bogC-2d3lA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL5_B_1UNB201_1
(PROTEASE)		 2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE
(Bacillus
sp.
707) 		5 / 10 LEU A 293
ALA A 352
ILE A 386
PRO A 364
THR A 327
 None
 1.03A 3el5A-2d3lA:
undetectable		 3el5A-2d3lA:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE
(Bacillus
sp.
707) 		5 / 12 ASN A  95
ILE A  97
ALA A  88
VAL A  42
VAL A  99
 None
 0.96A 3rukB-2d3lA:
undetectable		 3rukB-2d3lA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_1
(METHYLTRANSFERASE
WBDD)		 2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE
(Bacillus
sp.
707) 		3 / 3 GLN A 319
ASP A 403
GLN A 401
 None
 0.85A 4aztA-2d3lA:
undetectable		 4aztA-2d3lA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7N_A_ZMRA601_2
(NEURAMINIDASE)		 2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE
(Bacillus
sp.
707) 		3 / 3 ARG A 359
ARG A 415
TRP A 413
 None
 1.11A 4b7nA-2d3lA:
undetectable		 4b7nA-2d3lA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_C_ZMRC1470_2
(NEURAMINIDASE)		 2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE
(Bacillus
sp.
707) 		3 / 3 ARG A 359
ARG A 415
TRP A 413
 None
 1.20A 4cpzC-2d3lA:
undetectable		 4cpzC-2d3lA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_E_ZMRE1471_2
(NEURAMINIDASE)		 2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE
(Bacillus
sp.
707) 		3 / 3 ARG A 359
ARG A 415
TRP A 413
 None
 1.18A 4cpzE-2d3lA:
undetectable		 4cpzE-2d3lA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_F_ZMRF1470_2
(NEURAMINIDASE)		 2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE
(Bacillus
sp.
707) 		3 / 3 ARG A 359
ARG A 415
TRP A 413
 None
 1.11A 4cpzF-2d3lA:
undetectable		 4cpzF-2d3lA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_G_ZMRG1471_2
(NEURAMINIDASE)		 2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE
(Bacillus
sp.
707) 		3 / 3 ARG A 359
ARG A 415
TRP A 413
 None
 1.15A 4cpzG-2d3lA:
undetectable		 4cpzG-2d3lA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_H_ZMRH1470_2
(NEURAMINIDASE)		 2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE
(Bacillus
sp.
707) 		3 / 3 ARG A 359
ARG A 415
TRP A 413
 None
 1.13A 4cpzH-2d3lA:
undetectable		 4cpzH-2d3lA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA2)		 2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE
(Bacillus
sp.
707) 		4 / 6 SER A 365
GLY A 232
ASP A 231
GLY A 101
 None
 1.00A 4koeA-2d3lA:
undetectable
4koeB-2d3lA:
undetectable
4koeC-2d3lA:
undetectable		 4koeA-2d3lA:
20.41
4koeB-2d3lA:
20.41
4koeC-2d3lA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE
(Bacillus
sp.
707) 		5 / 12 ASN A  95
ILE A  97
ALA A  88
VAL A  42
VAL A  99
 None
 0.98A 4nkvA-2d3lA:
undetectable		 4nkvA-2d3lA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE
(Bacillus
sp.
707) 		5 / 12 ASN A  95
ILE A  97
ALA A  88
VAL A  42
VAL A  99
 None
 0.98A 4nkvB-2d3lA:
undetectable		 4nkvB-2d3lA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE
(Bacillus
sp.
707) 		5 / 12 ASN A  95
ILE A  97
ALA A  88
VAL A  42
VAL A  99
 None
 0.99A 4nkvC-2d3lA:
undetectable		 4nkvC-2d3lA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE
(Bacillus
sp.
707) 		5 / 12 ASN A  95
ILE A  97
ALA A  88
VAL A  42
VAL A  99
 None
 0.97A 4nkvD-2d3lA:
undetectable		 4nkvD-2d3lA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE
(Bacillus
sp.
707) 		4 / 6 GLY A 232
ASP A 231
GLY A 101
SER A 365
 None
 0.96A 4z53A-2d3lA:
0.0
4z53B-2d3lA:
0.0		 4z53A-2d3lA:
19.95
4z53B-2d3lA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE
(Bacillus
sp.
707) 		4 / 7 GLY A 232
ASP A 231
GLY A 101
SER A 365
 None
 0.95A 4z53A-2d3lA:
undetectable
4z53B-2d3lA:
undetectable		 4z53A-2d3lA:
19.95
4z53B-2d3lA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSY_B_ACRB601_1
(4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC)		 2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE
(Bacillus
sp.
707) 		5 / 12 ARG A 234
ASP A 236
GLU A 266
HIS A 332
ASP A 333
 None
None
None
None
GLC  A 605 (-3.5A)
 0.58A 5csyB-2d3lA:
5.3		 5csyB-2d3lA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CU6_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE
(Bacillus
sp.
707) 		4 / 6 VAL A 288
ASP A 290
PRO A 292
ALA A 325
 None
 0.92A 5cu6A-2d3lA:
undetectable		 5cu6A-2d3lA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CVT_B_ACTB200_0
(N5-CARBOXYAMINOIMIDA
ZOLE RIBONUCLEOTIDE
MUTASE)		 2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE
(Bacillus
sp.
707) 		3 / 3 ASN A   6
ALA A 397
ARG A 415
 None
 0.78A 5cvtB-2d3lA:
undetectable		 5cvtB-2d3lA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5H_C_ACTC1743_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SUBUNIT
PUTATIVE XANTHINE
DEHYDROGENASE YAGT
IRON-SULFUR-BINDING
SUBUNIT)		 2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE
(Bacillus
sp.
707) 		4 / 5 LYS A 349
ASP A 370
PHE A 343
PRO A 380
 None
 1.38A 5g5hA-2d3lA:
0.0
5g5hC-2d3lA:
0.0		 5g5hA-2d3lA:
19.65
5g5hC-2d3lA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_B_RBFB201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE
(Bacillus
sp.
707) 		5 / 12 GLY A  96
ASN A  94
ALA A  88
VAL A  42
ASN A  28
 None
 1.40A 5kbwB-2d3lA:
undetectable		 5kbwB-2d3lA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE
(Bacillus
sp.
707) 		4 / 7 LEU A 405
ILE A 389
THR A 358
MET A 430
 None
 1.18A 5ljcA-2d3lA:
undetectable		 5ljcA-2d3lA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N9X_A_THRA601_0
(ADENYLATION DOMAIN)		 2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE
(Bacillus
sp.
707) 		4 / 7 ASP A  62
PHE A  69
GLY A 149
HIS A 152
 None
 1.02A 5n9xA-2d3lA:
undetectable		 5n9xA-2d3lA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TQR_B_SAMB8009_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2, POLYCOMB
PROTEIN SUZ12)		 2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE
(Bacillus
sp.
707) 		5 / 10 TYR A 371
VAL A  42
TYR A  12
TYR A 372
HIS A 332
 None
 1.41A 5tqrB-2d3lA:
undetectable		 5tqrB-2d3lA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YSI_A_NCAA1001_0
(UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA)		 2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE
(Bacillus
sp.
707) 		4 / 6 GLY A 470
THR A 414
VAL A 442
TRP A 451
 None
 1.22A 5ysiA-2d3lA:
undetectable		 5ysiA-2d3lA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA605_0
(ALPHA-AMYLASE)		 2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE
(Bacillus
sp.
707) 		7 / 8 TYR A 160
GLY A 182
LYS A 185
ASP A 207
ASP A 209
HIS A 210
PRO A 211
 GLC  A 621 (-4.0A)
None
None
CA  A 501 (-2.9A)
CA  A 501 (-3.4A)
None
None
 0.64A 6ag0A-2d3lA:
59.6		 6ag0A-2d3lA:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA606_0
(ALPHA-AMYLASE)		 2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE
(Bacillus
sp.
707) 		6 / 7 GLY A 304
GLY A 305
TRP A 347
GLY A 433
GLY A 476
GLY A 477
 None
CA  A 503 (-4.1A)
None
None
None
None
 0.39A 6ag0A-2d3lA:
59.6		 6ag0A-2d3lA:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA608_0
(ALPHA-AMYLASE)		 2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE
(Bacillus
sp.
707) 		5 / 6 GLY A   7
THR A  40
GLN A  98
TYR A 100
TYR A 363
 GLC  A 632 (-3.6A)
GLC  A 631 (-3.8A)
GLC  A 631 (-3.4A)
None
GLC  A 632 (-3.8A)
 0.32A 6ag0A-2d3lA:
55.4		 6ag0A-2d3lA:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA609_0
(ALPHA-AMYLASE)		 2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE
(Bacillus
sp.
707) 		7 / 7 LYS A  72
GLY A 110
TRP A 140
ASP A 166
TRP A 167
MET A 202
TYR A 203
 GLC  A 601 (-3.0A)
GLC  A 602 ( 3.2A)
GLC  A 602 ( 3.7A)
GLC  A 603 (-2.8A)
GLC  A 602 ( 4.8A)
GLC  A 605 ( 3.5A)
GLC  A 603 (-4.0A)
 0.33A 6ag0A-2d3lA:
59.6		 6ag0A-2d3lA:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA610_0
(ALPHA-AMYLASE)		 2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE
(Bacillus
sp.
707) 		12 / 12 TRP A  15
TYR A  58
HIS A 107
GLU A 194
TYR A 198
LEU A 201
MET A 202
ASP A 236
LYS A 239
HIS A 240
HIS A 332
ASP A 333
 None
GLC  A 605 (-4.8A)
None
None
None
None
GLC  A 605 ( 3.5A)
None
None
None
None
GLC  A 605 (-3.5A)
 0.37A 6ag0A-2d3lA:
59.6		 6ag0A-2d3lA:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC605_0
(ALPHA-AMYLASE)		 2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE
(Bacillus
sp.
707) 		7 / 8 TYR A 160
GLY A 182
LYS A 185
ASP A 207
ASP A 209
HIS A 210
PRO A 211
 GLC  A 621 (-4.0A)
None
None
CA  A 501 (-2.9A)
CA  A 501 (-3.4A)
None
None
 0.65A 6ag0C-2d3lA:
59.6		 6ag0C-2d3lA:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC606_0
(ALPHA-AMYLASE)		 2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE
(Bacillus
sp.
707) 		5 / 6 GLY A   7
THR A  40
GLN A  98
TYR A 100
TYR A 363
 GLC  A 632 (-3.6A)
GLC  A 631 (-3.8A)
GLC  A 631 (-3.4A)
None
GLC  A 632 (-3.8A)
 0.29A 6ag0C-2d3lA:
59.6		 6ag0C-2d3lA:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC607_0
(ALPHA-AMYLASE)		 2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE
(Bacillus
sp.
707) 		4 / 6 GLY A 304
TRP A 347
GLY A 433
GLY A 477
 None
 0.35A 6ag0C-2d3lA:
59.6		 6ag0C-2d3lA:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC608_0
(ALPHA-AMYLASE)		 2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE
(Bacillus
sp.
707) 		10 / 12 TRP A  15
GLU A 194
TYR A 198
LEU A 201
MET A 202
ASP A 236
LYS A 239
HIS A 240
HIS A 332
ASP A 333
 None
None
None
None
GLC  A 605 ( 3.5A)
None
None
None
None
GLC  A 605 (-3.5A)
 0.39A 6ag0C-2d3lA:
59.6		 6ag0C-2d3lA:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC608_0
(ALPHA-AMYLASE)		 2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE
(Bacillus
sp.
707) 		7 / 12 TRP A  15
LEU A 201
ASP A 236
HIS A 240
TYR A 295
HIS A 332
ASP A 333
 None
None
None
None
None
None
GLC  A 605 (-3.5A)
 0.82A 6ag0C-2d3lA:
59.6		 6ag0C-2d3lA:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC608_1
(ALPHA-AMYLASE)		 2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE
(Bacillus
sp.
707) 		3 / 3 TYR A  58
ALA A 339
LEU A 340
 GLC  A 605 (-4.8A)
GLC  A 605 ( 4.0A)
None
 0.39A 6ag0C-2d3lA:
59.6		 6ag0C-2d3lA:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC609_0
(ALPHA-AMYLASE)		 2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE
(Bacillus
sp.
707) 		7 / 7 LYS A  72
GLY A 110
TRP A 140
ASP A 166
TRP A 167
MET A 202
TYR A 203
 GLC  A 601 (-3.0A)
GLC  A 602 ( 3.2A)
GLC  A 602 ( 3.7A)
GLC  A 603 (-2.8A)
GLC  A 602 ( 4.8A)
GLC  A 605 ( 3.5A)
GLC  A 603 (-4.0A)
 0.36A 6ag0C-2d3lA:
59.6		 6ag0C-2d3lA:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE
(Bacillus
sp.
707) 		4 / 8 ARG A 234
VAL A 213
ARG A 148
GLN A  71
 None
 1.19A 6fbvD-2d3lA:
undetectable		 6fbvD-2d3lA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_B_LLLB301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE
(Bacillus
sp.
707) 		4 / 7 TYR A  16
GLU A 338
ASP A 333
GLU A 266
 None
None
GLC  A 605 (-3.5A)
None
 1.12A 6mn5B-2d3lA:
undetectable		 6mn5B-2d3lA:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_C_LLLC301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE
(Bacillus
sp.
707) 		4 / 6 TYR A  16
GLU A 338
ASP A 333
GLU A 266
 None
None
GLC  A 605 (-3.5A)
None
 1.11A 6mn5C-2d3lA:
undetectable		 6mn5C-2d3lA:
12.34