SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2d3r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_B_VIBB501_1
(THIAMIN
PYROPHOSPHOKINASE)		 2d3r LECTIN ALPHA CHAIN
(Cratylia
argentea) 		4 / 7 ASP A 207
SER A 166
SER A 168
ASN A 167
 None
 1.18A 1ig3A-2d3rA:
2.7
1ig3B-2d3rA:
2.8		 1ig3A-2d3rA:
22.79
1ig3B-2d3rA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R5L_A_VIVA301_0
(PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN))		 2d3r LECTIN ALPHA CHAIN
(Cratylia
argentea) 		5 / 12 TRP A  40
VAL A  65
ILE A 213
VAL A  91
ILE A 106
 None
 1.28A 1r5lA-2d3rA:
undetectable		 1r5lA-2d3rA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_C_8MOC501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 2d3r LECTIN ALPHA CHAIN
(Cratylia
argentea) 		5 / 10 VAL A  79
ILE A  27
ILE A 213
LEU A  81
PHE A 190
 None
 1.12A 1z11C-2d3rA:
undetectable		 1z11C-2d3rA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1414_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 2d3r LECTIN ALPHA CHAIN
(Cratylia
argentea) 		4 / 8 LEU A 156
ILE A 209
LEU A  93
LEU A 154
 None
 0.68A 2xfhA-2d3rA:
undetectable		 2xfhA-2d3rA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECLA600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2d3r LECTIN ALPHA CHAIN
(Cratylia
argentea) 		4 / 8 LEU A 229
GLY A 144
ALA A 146
ILE A 106
 None
 0.81A 3jusA-2d3rA:
undetectable		 3jusA-2d3rA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2d3r LECTIN ALPHA CHAIN
(Cratylia
argentea) 		4 / 8 LEU A 229
GLY A 144
ALA A 146
ILE A 106
 None
 0.81A 3jusA-2d3rA:
undetectable		 3jusA-2d3rA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECLB600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2d3r LECTIN ALPHA CHAIN
(Cratylia
argentea) 		4 / 8 LEU A 229
GLY A 144
ALA A 146
ILE A 106
 None
 0.84A 3jusB-2d3rA:
undetectable		 3jusB-2d3rA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG801_0
(GLUTAMATE RECEPTOR 2)		 2d3r LECTIN ALPHA CHAIN
(Cratylia
argentea) 		3 / 3 PRO A 164
SER A 200
ASN A 104
 None
 0.86A 3lslG-2d3rA:
undetectable		 3lslG-2d3rA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_D_URFD400_1
(URIDINE
PHOSPHORYLASE 1)		 2d3r LECTIN ALPHA CHAIN
(Cratylia
argentea) 		5 / 9 GLY A 226
LEU A 229
LEU A 228
ARG A 227
ILE A  32
 None
 1.45A 3nbqD-2d3rA:
undetectable		 3nbqD-2d3rA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA2)		 2d3r LECTIN ALPHA CHAIN
(Cratylia
argentea) 		4 / 6 SER A 218
ARG A 171
GLY A 225
GLY A 223
 None
 1.00A 4koeA-2d3rA:
undetectable
4koeB-2d3rA:
undetectable
4koeC-2d3rA:
undetectable		 4koeA-2d3rA:
17.55
4koeB-2d3rA:
17.55
4koeC-2d3rA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA4)		 2d3r LECTIN ALPHA CHAIN
(Cratylia
argentea) 		4 / 7 ARG A 171
SER A 218
GLY A 225
GLY A 223
 None
 0.96A 4koeA-2d3rA:
undetectable
4koeB-2d3rA:
undetectable
4koeD-2d3rA:
undetectable		 4koeA-2d3rA:
17.55
4koeB-2d3rA:
17.55
4koeD-2d3rA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_B_SAMB301_0
(PUTATIVE RNA
METHYLASE)		 2d3r LECTIN ALPHA CHAIN
(Cratylia
argentea) 		5 / 12 THR A  97
GLY A 226
ASP A 207
ASN A 167
SER A 200
 None
 1.00A 4pooB-2d3rA:
undetectable		 4pooB-2d3rA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		 2d3r LECTIN ALPHA CHAIN
(Cratylia
argentea) 		4 / 7 SER A 218
ASP A   2
PHE A 232
SER A  94
 None
 1.17A 5l1fC-2d3rA:
undetectable		 5l1fC-2d3rA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		 2d3r LECTIN ALPHA CHAIN
(Cratylia
argentea) 		4 / 8 THR A 195
SER A 108
THR A 193
SER A 110
 None
 1.02A 5l4eA-2d3rA:
undetectable
5l4eB-2d3rA:
undetectable
5l4eC-2d3rA:
undetectable
5l4eD-2d3rA:
undetectable
5l4eE-2d3rA:
undetectable		 5l4eA-2d3rA:
23.33
5l4eB-2d3rA:
23.33
5l4eC-2d3rA:
23.33
5l4eD-2d3rA:
23.33
5l4eE-2d3rA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_G_ACTG702_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 2d3r LECTIN ALPHA CHAIN
(Cratylia
argentea) 		3 / 3 GLY A 208
THR A  97
ASN A 104
 None
 0.60A 5odiG-2d3rA:
undetectable		 5odiG-2d3rA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_B_ADNB502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 2d3r LECTIN ALPHA CHAIN
(Cratylia
argentea) 		4 / 4 GLU A 102
THR A 103
THR A 195
LEU A  93
 None
 1.44A 5v96B-2d3rA:
undetectable		 5v96B-2d3rA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_C_ADNC502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 2d3r LECTIN ALPHA CHAIN
(Cratylia
argentea) 		4 / 4 GLU A 102
THR A 103
THR A 195
LEU A  93
 None
 1.43A 5v96C-2d3rA:
undetectable		 5v96C-2d3rA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_D_CVID301_0
(REGULATORY PROTEIN
TETR)		 2d3r LECTIN ALPHA CHAIN
(Cratylia
argentea) 		5 / 12 ALA A 214
LEU A  81
VAL A 178
ASP A 191
PHE A 111
 None
 1.44A 5vlmD-2d3rA:
undetectable		 5vlmD-2d3rA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC608_1
(ALPHA-AMYLASE)		 2d3r LECTIN ALPHA CHAIN
(Cratylia
argentea) 		3 / 3 TYR A 175
ALA A 172
LEU A 142
 None
 0.69A 6ag0C-2d3rA:
undetectable		 6ag0C-2d3rA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_A_EU7A102_0
(MATRIX PROTEIN 2)		 2d3r LECTIN ALPHA CHAIN
(Cratylia
argentea) 		4 / 6 SER A 108
ALA A 192
SER A 110
ALA A  50
 None
 1.04A 6bocA-2d3rA:
undetectable
6bocB-2d3rA:
undetectable
6bocC-2d3rA:
undetectable
6bocD-2d3rA:
undetectable		 6bocA-2d3rA:
8.73
6bocB-2d3rA:
8.73
6bocC-2d3rA:
8.73
6bocD-2d3rA:
8.73