SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2d42'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_O_CHDO3085_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE II
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIA-HEART)		 2d42 NON-TOXIC CRYSTAL
PROTEIN
(Bacillus
thuringiensis) 		5 / 11 GLY A  93
GLY A 123
GLN A  89
THR A 228
THR A 168
 None
 1.26A 1v54G-2d42A:
0.0
1v54N-2d42A:
undetectable
1v54O-2d42A:
0.0		 1v54G-2d42A:
14.80
1v54N-2d42A:
20.24
1v54O-2d42A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_O_CHDO3085_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE II
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIA-HEART)		 2d42 NON-TOXIC CRYSTAL
PROTEIN
(Bacillus
thuringiensis) 		5 / 11 GLY A  93
GLY A 123
GLN A  89
THR A 228
THR A 168
 None
 1.27A 1v55G-2d42A:
0.0
1v55N-2d42A:
undetectable
1v55O-2d42A:
0.0		 1v55G-2d42A:
14.80
1v55N-2d42A:
20.24
1v55O-2d42A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_A_ACTA1107_0
(C5A PEPTIDASE)		 2d42 NON-TOXIC CRYSTAL
PROTEIN
(Bacillus
thuringiensis) 		4 / 5 LEU A  41
GLY A  40
ILE A  38
PHE A 223
 None
 0.89A 1xf1A-2d42A:
undetectable		 1xf1A-2d42A:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AKE_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2d42 NON-TOXIC CRYSTAL
PROTEIN
(Bacillus
thuringiensis) 		5 / 12 THR A 228
GLY A 227
GLY A 225
ILE A 229
PHE A 121
 None
 1.10A 2akeA-2d42A:
undetectable		 2akeA-2d42A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_3
(POL POLYPROTEIN)		 2d42 NON-TOXIC CRYSTAL
PROTEIN
(Bacillus
thuringiensis) 		5 / 12 GLY A  97
ALA A  96
VAL A 174
ILE A   3
ILE A  38
 None
 0.86A 2avvB-2d42A:
undetectable		 2avvB-2d42A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA601_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2d42 NON-TOXIC CRYSTAL
PROTEIN
(Bacillus
thuringiensis) 		5 / 12 THR A 228
GLY A 227
GLY A 225
ILE A 229
PHE A 121
 None
 1.12A 2azxA-2d42A:
undetectable		 2azxA-2d42A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_B_TRPB603_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2d42 NON-TOXIC CRYSTAL
PROTEIN
(Bacillus
thuringiensis) 		5 / 12 THR A 228
GLY A 227
GLY A 225
ILE A 229
PHE A 121
 None
 1.14A 2azxB-2d42A:
undetectable		 2azxB-2d42A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_O_CHDO229_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 2d42 NON-TOXIC CRYSTAL
PROTEIN
(Bacillus
thuringiensis) 		5 / 11 GLY A  93
GLY A 123
GLN A  89
THR A 228
THR A 168
 None
 1.26A 2dyrG-2d42A:
0.0
2dyrN-2d42A:
undetectable
2dyrO-2d42A:
0.0		 2dyrG-2d42A:
14.80
2dyrN-2d42A:
20.24
2dyrO-2d42A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_O_CHDO229_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 2d42 NON-TOXIC CRYSTAL
PROTEIN
(Bacillus
thuringiensis) 		5 / 11 GLY A  93
GLY A 123
GLN A  89
THR A 228
THR A 168
 None
 1.26A 2eijG-2d42A:
0.0
2eijN-2d42A:
undetectable
2eijO-2d42A:
0.0		 2eijG-2d42A:
14.80
2eijN-2d42A:
20.24
2eijO-2d42A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_O_CHDO229_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 2d42 NON-TOXIC CRYSTAL
PROTEIN
(Bacillus
thuringiensis) 		5 / 11 GLY A  93
GLY A 123
GLN A  89
THR A 228
THR A 168
 None
 1.25A 2eikG-2d42A:
0.0
2eikN-2d42A:
undetectable
2eikO-2d42A:
0.0		 2eikG-2d42A:
14.80
2eikN-2d42A:
20.24
2eikO-2d42A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_O_CHDO229_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 2d42 NON-TOXIC CRYSTAL
PROTEIN
(Bacillus
thuringiensis) 		5 / 11 GLY A  93
GLY A 123
GLN A  89
THR A 228
THR A 168
 None
 1.25A 2eilG-2d42A:
0.0
2eilN-2d42A:
undetectable
2eilO-2d42A:
0.0		 2eilG-2d42A:
14.80
2eilN-2d42A:
20.24
2eilO-2d42A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_N_CHDN1604_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 2d42 NON-TOXIC CRYSTAL
PROTEIN
(Bacillus
thuringiensis) 		5 / 11 GLY A  93
GLY A 123
GLN A  89
THR A 228
THR A 168
 None
 1.24A 2eimG-2d42A:
0.0
2eimN-2d42A:
0.0
2eimO-2d42A:
0.0		 2eimG-2d42A:
14.80
2eimN-2d42A:
20.24
2eimO-2d42A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_G_CHDG86_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 6A2
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 2d42 NON-TOXIC CRYSTAL
PROTEIN
(Bacillus
thuringiensis) 		5 / 11 GLY A  93
GLY A 123
GLN A  89
THR A 228
THR A 168
 None
 1.29A 2zxwG-2d42A:
0.0
2zxwN-2d42A:
undetectable
2zxwO-2d42A:
0.0		 2zxwG-2d42A:
14.80
2zxwN-2d42A:
20.24
2zxwO-2d42A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_O_CHDO229_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 2d42 NON-TOXIC CRYSTAL
PROTEIN
(Bacillus
thuringiensis) 		5 / 11 GLY A  93
GLY A 123
GLN A  89
THR A 228
THR A 168
 None
 1.29A 3ag1G-2d42A:
0.0
3ag1N-2d42A:
undetectable
3ag1O-2d42A:
0.0		 3ag1G-2d42A:
14.80
3ag1N-2d42A:
20.24
3ag1O-2d42A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_B_CHDB1085_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 2d42 NON-TOXIC CRYSTAL
PROTEIN
(Bacillus
thuringiensis) 		5 / 11 GLY A 123
GLN A  89
THR A 228
THR A 168
GLY A  93
 None
 1.29A 3asoA-2d42A:
undetectable
3asoB-2d42A:
0.0
3asoT-2d42A:
0.0		 3asoA-2d42A:
20.24
3asoB-2d42A:
22.30
3asoT-2d42A:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 2d42 NON-TOXIC CRYSTAL
PROTEIN
(Bacillus
thuringiensis) 		5 / 12 ILE A 200
ALA A 221
THR A  90
LEU A   6
LEU A  41
 None
 1.06A 4qynA-2d42A:
undetectable		 4qynA-2d42A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 2d42 NON-TOXIC CRYSTAL
PROTEIN
(Bacillus
thuringiensis) 		5 / 12 ILE A 200
ALA A 221
THR A  90
LEU A   6
LEU A  41
 None
 1.01A 4qzuC-2d42A:
undetectable		 4qzuC-2d42A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UY8_7_TRP71002_0
(TRYPTOPHANASE)		 2d42 NON-TOXIC CRYSTAL
PROTEIN
(Bacillus
thuringiensis) 		4 / 4 ILE A 100
ASN A  99
ILE A   3
VAL A  94
 None
 1.17A 4uy87-2d42A:
undetectable		 4uy87-2d42A:
6.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WS0_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 2d42 NON-TOXIC CRYSTAL
PROTEIN
(Bacillus
thuringiensis) 		4 / 7 GLY A 234
GLN A 161
TYR A 157
PHE A 139
 None
 0.96A 4ws0A-2d42A:
undetectable		 4ws0A-2d42A:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_C_ACTC1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 2d42 NON-TOXIC CRYSTAL
PROTEIN
(Bacillus
thuringiensis) 		3 / 3 TYR A 222
THR A 224
THR A 213
 None
 0.78A 5aoxB-2d42A:
undetectable		 5aoxB-2d42A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_F_ACTF1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 2d42 NON-TOXIC CRYSTAL
PROTEIN
(Bacillus
thuringiensis) 		3 / 3 TYR A 222
THR A 224
THR A 213
 None
 0.81A 5aoxE-2d42A:
undetectable		 5aoxE-2d42A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_1
(CDL2.3A)		 2d42 NON-TOXIC CRYSTAL
PROTEIN
(Bacillus
thuringiensis) 		5 / 12 LEU A 108
PHE A 164
LEU A 133
THR A 168
ALA A  43
 None
 1.19A 5ieoA-2d42A:
undetectable		 5ieoA-2d42A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_1
(CDL2.3B)		 2d42 NON-TOXIC CRYSTAL
PROTEIN
(Bacillus
thuringiensis) 		5 / 12 LEU A 108
PHE A 164
LEU A 133
THR A 168
ALA A  43
 None
 1.21A 5iepA-2d42A:
0.8		 5iepA-2d42A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T2Z_B_017B201_2
(PROTEASE)		 2d42 NON-TOXIC CRYSTAL
PROTEIN
(Bacillus
thuringiensis) 		5 / 12 GLY A  97
ALA A  96
VAL A 174
ILE A   3
ILE A  38
 None
 0.80A 5t2zB-2d42A:
undetectable		 5t2zB-2d42A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_A_08JA602_1
(CYTOCHROME P450 3A4)		 2d42 NON-TOXIC CRYSTAL
PROTEIN
(Bacillus
thuringiensis) 		4 / 7 LEU A  41
ALA A 124
THR A  90
LEU A 170
 None
 0.96A 5te8A-2d42A:
undetectable		 5te8A-2d42A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_C_08JC602_1
(CYTOCHROME P450 3A4)		 2d42 NON-TOXIC CRYSTAL
PROTEIN
(Bacillus
thuringiensis) 		4 / 7 LEU A  41
ALA A 124
THR A  90
LEU A 170
 None
 0.98A 5te8C-2d42A:
undetectable		 5te8C-2d42A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_B_CHDB301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 2d42 NON-TOXIC CRYSTAL
PROTEIN
(Bacillus
thuringiensis) 		5 / 11 GLY A  93
GLY A 123
GLN A  89
THR A 228
THR A 168
 None
 1.20A 5w97G-2d42A:
0.0
5w97a-2d42A:
undetectable
5w97b-2d42A:
0.0		 5w97G-2d42A:
14.80
5w97a-2d42A:
20.24
5w97b-2d42A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA502_1
(CYTOCHROME P450 2C9)		 2d42 NON-TOXIC CRYSTAL
PROTEIN
(Bacillus
thuringiensis) 		5 / 12 ALA A 221
LEU A 204
GLY A 225
THR A  90
LEU A  41
 None
 1.05A 5x24A-2d42A:
undetectable		 5x24A-2d42A:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YN6_A_SAMA401_0
(NSP16 PROTEIN)		 2d42 NON-TOXIC CRYSTAL
PROTEIN
(Bacillus
thuringiensis) 		5 / 12 GLY A  93
PRO A 210
GLY A 211
ASN A   5
ASP A  92
 None
 1.24A 5yn6A-2d42A:
undetectable		 5yn6A-2d42A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNI_A_SAMA401_0
(NSP16 PROTEIN)		 2d42 NON-TOXIC CRYSTAL
PROTEIN
(Bacillus
thuringiensis) 		5 / 12 GLY A  93
PRO A 210
GLY A 211
ASN A   5
ASP A  92
 None
 1.28A 5yniA-2d42A:
undetectable		 5yniA-2d42A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNM_A_SAMA401_0
(NSP16 PROTEIN)		 2d42 NON-TOXIC CRYSTAL
PROTEIN
(Bacillus
thuringiensis) 		5 / 12 GLY A  93
PRO A 210
GLY A 211
ASN A   5
ASP A  92
 None
 1.23A 5ynmA-2d42A:
undetectable		 5ynmA-2d42A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIL_B_TPVB201_1
(HIV-1 PROTEASE)		 2d42 NON-TOXIC CRYSTAL
PROTEIN
(Bacillus
thuringiensis) 		5 / 12 GLY A  97
ALA A  96
VAL A 174
ILE A   3
ILE A  38
 None
 0.83A 6dilB-2d42A:
undetectable		 6dilB-2d42A:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_G_CHDG104_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 2d42 NON-TOXIC CRYSTAL
PROTEIN
(Bacillus
thuringiensis) 		5 / 10 GLY A  93
GLY A 123
GLN A  89
THR A 228
THR A 168
 None
 1.32A 6nmfG-2d42A:
0.0
6nmfN-2d42A:
undetectable
6nmfO-2d42A:
0.0		 6nmfG-2d42A:
14.80
6nmfN-2d42A:
20.24
6nmfO-2d42A:
22.30