SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2d4a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_1
(TRANSTHYRETIN)		 2d4a MALATE DEHYDROGENASE
(Aeropyrum
pernix) 		4 / 7 LEU B  41
ALA B  44
SER B  59
SER B  57
 None
 1.03A 1dvxA-2d4aB:
undetectable		 1dvxA-2d4aB:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_C_TRPC81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2d4a MALATE DEHYDROGENASE
(Aeropyrum
pernix) 		5 / 10 ALA B 226
GLY B   6
THR B 115
THR B  74
ILE B   4
 None
 1.22A 1gtnB-2d4aB:
undetectable
1gtnC-2d4aB:
undetectable		 1gtnB-2d4aB:
15.15
1gtnC-2d4aB:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1503_0
(FERROCHELATASE)		 2d4a MALATE DEHYDROGENASE
(Aeropyrum
pernix) 		3 / 3 LEU B 302
PRO B 303
LEU B 306
 None
 0.46A 1hrkA-2d4aB:
3.7		 1hrkA-2d4aB:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_E_NCAE507_0
(NAD-DEPENDENT
DEACETYLASE 2)		 2d4a MALATE DEHYDROGENASE
(Aeropyrum
pernix) 		4 / 7 ILE B   2
LEU B  28
ILE B  54
ASP B  24
 None
 0.88A 1yc2E-2d4aB:
4.2		 1yc2E-2d4aB:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_A_CLMA1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 2d4a MALATE DEHYDROGENASE
(Aeropyrum
pernix) 		5 / 8 ALA B  15
LEU B 229
ILE B   2
VAL B 113
ILE B 114
 None
 1.32A 2uxpA-2d4aB:
undetectable		 2uxpA-2d4aB:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1498_1
(CYTOCHROME P450 3A4)		 2d4a MALATE DEHYDROGENASE
(Aeropyrum
pernix) 		5 / 11 SER B 221
ILE B 213
ALA B 209
THR B 206
MET B 171
 None
 1.39A 2v0mD-2d4aB:
undetectable		 2v0mD-2d4aB:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WM3_A_NFLA1301_1
(NMRA-LIKE FAMILY
DOMAIN CONTAINING
PROTEIN 1)		 2d4a MALATE DEHYDROGENASE
(Aeropyrum
pernix) 		4 / 6 LEU B  18
THR B  14
LEU B  28
ASP B  25
 None
 1.12A 2wm3A-2d4aB:
9.2		 2wm3A-2d4aB:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 2d4a MALATE DEHYDROGENASE
(Aeropyrum
pernix) 		6 / 12 THR B 232
ILE B 236
ALA B 265
GLY B 271
LEU B 278
PRO B 245
 None
 1.48A 2y7hB-2d4aB:
4.1		 2y7hB-2d4aB:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 2d4a MALATE DEHYDROGENASE
(Aeropyrum
pernix) 		6 / 12 THR B 232
ILE B 236
ALA B 265
GLY B 271
LEU B 278
PRO B 245
 None
 1.49A 2y7hC-2d4aB:
4.4		 2y7hC-2d4aB:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_2
(NEURAMINIDASE A)		 2d4a MALATE DEHYDROGENASE
(Aeropyrum
pernix) 		4 / 6 ASP B 258
ILE B 259
GLN B 293
GLU B 300
 None
 1.19A 2ya7C-2d4aB:
undetectable		 2ya7C-2d4aB:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B53_B_ACTB1445_0
(IG GAMMA-4 CHAIN C
REGION)		 2d4a MALATE DEHYDROGENASE
(Aeropyrum
pernix) 		3 / 3 GLU B 262
GLY B 170
SER B 247
 None
 0.66A 4b53B-2d4aB:
undetectable		 4b53B-2d4aB:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB8_A_DXCA75_0
(PPCA)		 2d4a MALATE DEHYDROGENASE
(Aeropyrum
pernix) 		4 / 8 ILE B 272
LEU B 248
ILE B 276
GLY B 142
 None
 0.80A 4hb8A-2d4aB:
undetectable		 4hb8A-2d4aB:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K7G_B_ACTB902_0
(3-HYDROXYPROLINE
DEHYDRATSE)		 2d4a MALATE DEHYDROGENASE
(Aeropyrum
pernix) 		4 / 7 ASP B 145
SER B 247
HIS B 172
SER B 141
 None
 1.13A 4k7gB-2d4aB:
undetectable		 4k7gB-2d4aB:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_B_9TPB601_1
(SERUM ALBUMIN)		 2d4a MALATE DEHYDROGENASE
(Aeropyrum
pernix) 		5 / 12 LEU B 229
ALA B 147
TYR B 246
ILE B 138
GLY B 271
 None
 1.11A 4l9qB-2d4aB:
undetectable		 4l9qB-2d4aB:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 2d4a MALATE DEHYDROGENASE
(Aeropyrum
pernix) 		5 / 12 ASP B 289
LEU B 250
PHE B 288
GLY B 170
ASP B 120
 None
 1.38A 4pevC-2d4aB:
5.3		 4pevC-2d4aB:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 2d4a MALATE DEHYDROGENASE
(Aeropyrum
pernix) 		5 / 12 ILE B   4
LEU B 229
SER B 220
GLY B   8
GLY B   6
 None
 1.10A 5l6eA-2d4aB:
undetectable		 5l6eA-2d4aB:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 2d4a MALATE DEHYDROGENASE
(Aeropyrum
pernix) 		4 / 6 LEU B 190
VAL B 185
LEU B 157
VAL B 164
 None
 0.98A 5x7zA-2d4aB:
undetectable		 5x7zA-2d4aB:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUP_B_DZPB502_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT BETA-3)		 2d4a MALATE DEHYDROGENASE
(Aeropyrum
pernix) 		5 / 11 ILE B  29
LEU B   5
THR B 115
THR B  14
LEU B  26
 None
 1.22A 6hupA-2d4aB:
undetectable
6hupB-2d4aB:
undetectable		 6hupA-2d4aB:
15.81
6hupB-2d4aB:
14.72