SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2d4p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		 2d4p HYPOTHETICAL PROTEIN
TTHA1254
(Thermus
thermophilus) 		4 / 8 GLU A  69
LEU A 106
ALA A 109
LEU A 110
 None
 0.64A 1hwiB-2d4pA:
undetectable		 1hwiB-2d4pA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		 2d4p HYPOTHETICAL PROTEIN
TTHA1254
(Thermus
thermophilus) 		4 / 8 GLU A  69
LEU A 106
ALA A 109
LEU A 110
 None
 0.70A 1hwiD-2d4pA:
undetectable		 1hwiD-2d4pA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		 2d4p HYPOTHETICAL PROTEIN
TTHA1254
(Thermus
thermophilus) 		4 / 8 GLU A  69
LEU A 106
ALA A 109
LEU A 110
 None
 0.70A 1hwiC-2d4pA:
undetectable		 1hwiC-2d4pA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IWH_A_PEMA501_1
(HEMOGLOBIN ALPHA
CHAIN)		 2d4p HYPOTHETICAL PROTEIN
TTHA1254
(Thermus
thermophilus) 		4 / 6 ALA A  82
LYS A  85
ASP A  89
ALA A  90
 None
 0.31A 1iwhA-2d4pA:
undetectable		 1iwhA-2d4pA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N3Z_A_ADNA126_1
(RIBONUCLEASE,
SEMINAL)		 2d4p HYPOTHETICAL PROTEIN
TTHA1254
(Thermus
thermophilus) 		5 / 9 ALA A  82
LYS A  85
ALA A  52
VAL A  83
HIS A  36
 None
 1.34A 1n3zA-2d4pA:
undetectable		 1n3zA-2d4pA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_C_STRC3001_1
(MINERALOCORTICOID
RECEPTOR)		 2d4p HYPOTHETICAL PROTEIN
TTHA1254
(Thermus
thermophilus) 		5 / 12 LEU A  11
LEU A  14
ASN A  15
LEU A  17
ALA A  18
 None
 0.97A 1ya3C-2d4pA:
undetectable		 1ya3C-2d4pA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		 2d4p HYPOTHETICAL PROTEIN
TTHA1254
(Thermus
thermophilus) 		5 / 12 THR A  66
VAL A  23
LEU A  76
ALA A  50
SER A  37
 None
 1.15A 3d91B-2d4pA:
undetectable		 3d91B-2d4pA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_A_URFA2001_1
(URIDINE
PHOSPHORYLASE)		 2d4p HYPOTHETICAL PROTEIN
TTHA1254
(Thermus
thermophilus) 		5 / 10 GLY A  78
GLU A  74
LEU A  79
LEU A  80
ILE A  68
 None
 1.35A 3kvrA-2d4pA:
undetectable		 3kvrA-2d4pA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 2d4p HYPOTHETICAL PROTEIN
TTHA1254
(Thermus
thermophilus) 		5 / 10 GLY A  78
GLU A  74
LEU A  79
LEU A  80
ILE A  68
 None
 1.33A 3kvrB-2d4pA:
undetectable		 3kvrB-2d4pA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_A_URFA400_1
(URIDINE
PHOSPHORYLASE 1)		 2d4p HYPOTHETICAL PROTEIN
TTHA1254
(Thermus
thermophilus) 		5 / 9 GLY A  70
ARG A 103
LEU A  79
LEU A  76
ILE A  68
 None
 1.35A 3nbqA-2d4pA:
undetectable		 3nbqA-2d4pA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_D_URFD400_1
(URIDINE
PHOSPHORYLASE 1)		 2d4p HYPOTHETICAL PROTEIN
TTHA1254
(Thermus
thermophilus) 		5 / 9 GLY A  70
ARG A 103
LEU A  79
LEU A  76
ILE A  68
 None
 1.28A 3nbqD-2d4pA:
undetectable		 3nbqD-2d4pA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_B_QPSB951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		 2d4p HYPOTHETICAL PROTEIN
TTHA1254
(Thermus
thermophilus) 		4 / 8 ARG A  16
GLU A  45
GLU A  41
ARG A   4
 None
 1.08A 4bqfB-2d4pA:
undetectable		 4bqfB-2d4pA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FN9_A_STRA301_1
(STEROID RECEPTOR 2)		 2d4p HYPOTHETICAL PROTEIN
TTHA1254
(Thermus
thermophilus) 		5 / 12 LEU A  11
LEU A  14
ASN A  15
LEU A  17
ALA A  18
 None
 0.93A 4fn9A-2d4pA:
undetectable		 4fn9A-2d4pA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_1
(ANCESTRAL STEROID
RECEPTOR 2)		 2d4p HYPOTHETICAL PROTEIN
TTHA1254
(Thermus
thermophilus) 		5 / 12 LEU A  11
LEU A  14
ASN A  15
LEU A  17
ALA A  18
 None
 0.98A 4ltwA-2d4pA:
undetectable		 4ltwA-2d4pA:
20.46