SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2d4x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_A_TESA325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 2d4x FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 3
(Salmonella
enterica) 		4 / 7 LEU A 250
HIS A 174
THR A  84
ASN A 242
 None
 1.38A 1afsA-2d4xA:
undetectable		 1afsA-2d4xA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_B_TESB325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 2d4x FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 3
(Salmonella
enterica) 		4 / 7 LEU A 250
HIS A 174
THR A  84
ASN A 242
 None
 1.37A 1afsB-2d4xA:
undetectable		 1afsB-2d4xA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_2
(LIVER
CARBOXYLESTERASE I)		 2d4x FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 3
(Salmonella
enterica) 		3 / 3 PHE A 136
LEU A  80
LEU A 250
 None
 0.58A 1mx1E-2d4xA:
undetectable		 1mx1E-2d4xA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9H_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE)		 2d4x FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 3
(Salmonella
enterica) 		5 / 10 LEU A 121
ALA A 125
LEU A  80
VAL A  83
SER A 182
 None
 1.12A 2w9hA-2d4xA:
undetectable		 2w9hA-2d4xA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_B_CHDB2_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2d4x FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 3
(Salmonella
enterica) 		3 / 3 LEU A 121
LEU A 124
ARG A 247
 None
 0.65A 3hcnB-2d4xA:
undetectable		 3hcnB-2d4xA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LB3_A_4CHA191_0
(DEHALOPEROXIDASE A)		 2d4x FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 3
(Salmonella
enterica) 		4 / 6 PHE A 180
PHE A 136
HIS A 174
VAL A 243
 None
 1.26A 3lb3A-2d4xA:
undetectable		 3lb3A-2d4xA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_D_T1CD401_1
(TETX2 PROTEIN)		 2d4x FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 3
(Salmonella
enterica) 		5 / 10 ASP A 147
HIS A 154
GLN A 115
GLY A 116
GLY A 151
 None
 1.39A 3v3oD-2d4xA:
undetectable		 3v3oD-2d4xA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA303_1
(CHITOSANASE)		 2d4x FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 3
(Salmonella
enterica) 		4 / 6 ILE A 208
ASP A 205
ARG A 118
GLY A 116
 None
 1.08A 4oltA-2d4xA:
undetectable		 4oltA-2d4xA:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_0
(HYDG PROTEIN)		 2d4x FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 3
(Salmonella
enterica) 		5 / 12 VAL A  83
LEU A 250
LYS A  72
ALA A 144
PHE A 146
 None
 1.42A 4rtbA-2d4xA:
undetectable		 4rtbA-2d4xA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_2
(PROTEIN CYP51)		 2d4x FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 3
(Salmonella
enterica) 		4 / 7 VAL A 160
LEU A 244
PHE A 136
LEU A  80
 None
 1.02A 6aycA-2d4xA:
1.4		 6aycA-2d4xA:
16.12