SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2d4y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_A_DVAA8_0
(ACTINOMYCIN D)		 2d4y FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 1
(Salmonella
enterica) 		3 / 3 THR A 255
THR A 256
PRO A 247
 None
 0.85A 1a7yA-2d4yA:
undetectable		 1a7yA-2d4yA:
3.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_A_SAMA1401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 2d4y FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 1
(Salmonella
enterica) 		5 / 11 LEU A 458
GLY A 323
GLY A 315
ILE A 433
LEU A 139
 None
 1.14A 1p91A-2d4yA:
undetectable		 1p91A-2d4yA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFI_A_DVAA8_0
(ACTINOMYCIN X2)		 2d4y FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 1
(Salmonella
enterica) 		3 / 3 THR A 255
THR A 256
PRO A 247
 None
 0.84A 1qfiA-2d4yA:
undetectable		 1qfiA-2d4yA:
3.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAK_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 2d4y FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 1
(Salmonella
enterica) 		5 / 12 LEU A 279
GLY A 277
ILE A 161
GLY A 281
GLY A 280
 None
 0.86A 1uakA-2d4yA:
undetectable		 1uakA-2d4yA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2d4y FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 1
(Salmonella
enterica) 		4 / 5 PHE A 308
LEU A 132
PHE A 304
SER A 108
 None
 1.34A 1wrkB-2d4yA:
undetectable		 1wrkB-2d4yA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		 2d4y FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 1
(Salmonella
enterica) 		6 / 12 ILE A 133
ILE A 433
LEU A 119
THR A 118
LEU A 116
PHE A 112
 None
 0.92A 2bdmA-2d4yA:
0.6		 2bdmA-2d4yA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		 2d4y FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 1
(Salmonella
enterica) 		6 / 12 ILE A 133
ILE A 433
LEU A 119
THR A 118
LEU A 116
SER A 115
 None
 0.98A 2bdmA-2d4yA:
0.6		 2bdmA-2d4yA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		 2d4y FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 1
(Salmonella
enterica) 		5 / 12 PHE A 326
ILE A 433
LEU A 119
THR A 118
LEU A 116
 None
 1.01A 2bdmA-2d4yA:
0.6		 2bdmA-2d4yA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2d4y FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 1
(Salmonella
enterica) 		5 / 12 GLY A 455
LEU A 458
GLY A 323
ALA A 431
ASP A 451
 None
 1.04A 2bm9F-2d4yA:
undetectable		 2bm9F-2d4yA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_A_LDPA501_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 2d4y FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 1
(Salmonella
enterica) 		4 / 7 GLY A 134
PHE A 326
ILE A 433
PHE A 308
 None
 0.78A 2qmzA-2d4yA:
undetectable
2qmzB-2d4yA:
undetectable		 2qmzA-2d4yA:
17.83
2qmzB-2d4yA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A9E_B_REAB1_1
(RETINOIC ACID
RECEPTOR ALPHA)		 2d4y FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 1
(Salmonella
enterica) 		5 / 11 LEU A 461
PHE A 327
PHE A 112
VAL A 120
LEU A 119
 None
 1.12A 3a9eB-2d4yA:
undetectable		 3a9eB-2d4yA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_1
(PUTATIVE RRNA
METHYLASE)		 2d4y FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 1
(Salmonella
enterica) 		3 / 3 ASN A 158
ASP A 152
GLN A 148
 None
 0.77A 3eeyC-2d4yA:
undetectable		 3eeyC-2d4yA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_1
(PUTATIVE RRNA
METHYLASE)		 2d4y FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 1
(Salmonella
enterica) 		3 / 3 ASN A 158
ASP A 152
GLN A 148
 None
 0.77A 3eeyD-2d4yA:
undetectable		 3eeyD-2d4yA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_1
(PUTATIVE RRNA
METHYLASE)		 2d4y FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 1
(Salmonella
enterica) 		3 / 3 ASN A 158
ASP A 152
GLN A 148
 None
 0.76A 3eeyE-2d4yA:
undetectable		 3eeyE-2d4yA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2d4y FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 1
(Salmonella
enterica) 		5 / 12 GLY A 280
GLY A  76
ALA A  77
GLY A  83
LEU A  84
 None
 0.82A 3hs6B-2d4yA:
0.2		 3hs6B-2d4yA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2d4y FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 1
(Salmonella
enterica) 		5 / 12 GLY A 281
GLY A  76
ALA A  77
GLY A  83
LEU A  84
 None
 0.69A 3hs6B-2d4yA:
0.2		 3hs6B-2d4yA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QJ7_A_SPMA264_1
(THYMIDYLATE SYNTHASE)		 2d4y FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 1
(Salmonella
enterica) 		4 / 8 GLN A 142
LEU A  98
ASP A 100
SER A 102
 None
 1.00A 3qj7A-2d4yA:
undetectable
3qj7D-2d4yA:
undetectable		 3qj7A-2d4yA:
20.14
3qj7D-2d4yA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W37_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 2d4y FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 1
(Salmonella
enterica) 		5 / 12 ALA A 250
ASN A 337
ASP A 154
ASP A 291
ASP A 251
 None
 1.21A 3w37A-2d4yA:
undetectable		 3w37A-2d4yA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEL_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 2d4y FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 1
(Salmonella
enterica) 		5 / 12 ALA A 250
ASN A 337
ASP A 154
ASP A 291
ASP A 251
 None
 1.20A 3welA-2d4yA:
undetectable		 3welA-2d4yA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEM_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 2d4y FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 1
(Salmonella
enterica) 		5 / 12 ALA A 250
ASN A 337
ASP A 154
ASP A 291
ASP A 251
 None
 1.21A 3wemA-2d4yA:
undetectable		 3wemA-2d4yA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEN_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 2d4y FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 1
(Salmonella
enterica) 		5 / 12 ALA A 250
ASN A 337
ASP A 154
ASP A 291
ASP A 251
 None
 1.22A 3wenA-2d4yA:
undetectable		 3wenA-2d4yA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEO_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 2d4y FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 1
(Salmonella
enterica) 		5 / 12 ALA A 250
ASN A 337
ASP A 154
ASP A 291
ASP A 251
 None
 1.21A 3weoA-2d4yA:
undetectable		 3weoA-2d4yA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_C_ACTC1113_0
(BLR5658 PROTEIN)		 2d4y FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 1
(Salmonella
enterica) 		4 / 4 ASN A 454
ALA A 434
GLY A 315
THR A 313
 None
 1.04A 4bboC-2d4yA:
undetectable		 4bboC-2d4yA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_1
(METHYLTRANSFERASE
NSUN4)		 2d4y FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 1
(Salmonella
enterica) 		3 / 3 ASP A 291
ARG A 294
ASP A 251
 None
 0.76A 4fp9D-2d4yA:
undetectable		 4fp9D-2d4yA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_3
(HIV-1 PROTEASE)		 2d4y FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 1
(Salmonella
enterica) 		3 / 3 ASP A 199
LEU A 178
VAL A 218
 None
 0.71A 4jecB-2d4yA:
undetectable		 4jecB-2d4yA:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2d4y FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 1
(Salmonella
enterica) 		5 / 12 LEU A 132
PHE A 112
ILE A 433
GLY A 455
ALA A 307
 None
 0.85A 4nkxC-2d4yA:
undetectable		 4nkxC-2d4yA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2d4y FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 1
(Salmonella
enterica) 		5 / 12 LEU A 132
PHE A 112
ILE A 433
GLY A 455
ALA A 307
 None
 0.81A 4nkxD-2d4yA:
undetectable		 4nkxD-2d4yA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_2
(ANDROGEN RECEPTOR)		 2d4y FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 1
(Salmonella
enterica) 		4 / 7 ASN A 309
LEU A 116
LEU A 139
ILE A 433
 None
 0.96A 4okwA-2d4yA:
undetectable		 4okwA-2d4yA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 2d4y FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 1
(Salmonella
enterica) 		4 / 5 GLN A 110
LEU A 109
SER A 106
ASP A 475
 None
 1.35A 4qtuD-2d4yA:
undetectable		 4qtuD-2d4yA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 2d4y FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 1
(Salmonella
enterica) 		4 / 7 THR A 380
ALA A 377
THR A 360
ALA A 359
 None
 0.97A 4qw0K-2d4yA:
undetectable		 4qw0K-2d4yA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 2d4y FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 1
(Salmonella
enterica) 		4 / 7 THR A 380
ALA A 377
THR A 360
ALA A 359
 None
 0.97A 4qw0Y-2d4yA:
undetectable		 4qw0Y-2d4yA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 2d4y FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 1
(Salmonella
enterica) 		5 / 12 ALA A 303
ALA A 419
ILE A 420
LEU A 297
ALA A 478
 None
 1.10A 5bw4B-2d4yA:
undetectable		 5bw4B-2d4yA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 2d4y FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 1
(Salmonella
enterica) 		3 / 3 ASP A 180
ASN A 225
GLN A 219
 None
 0.77A 5k7uA-2d4yA:
undetectable		 5k7uA-2d4yA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 2d4y FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 1
(Salmonella
enterica) 		5 / 12 THR A  86
SER A  82
GLN A  80
GLY A 280
THR A 276
 None
 1.11A 5l66H-2d4yA:
undetectable
5l66I-2d4yA:
undetectable		 5l66H-2d4yA:
21.06
5l66I-2d4yA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 2d4y FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 1
(Salmonella
enterica) 		5 / 12 THR A  86
SER A  82
GLN A  80
GLY A 280
THR A 276
 None
 1.11A 5l66V-2d4yA:
undetectable
5l66W-2d4yA:
undetectable		 5l66V-2d4yA:
21.06
5l66W-2d4yA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2d4y FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 1
(Salmonella
enterica) 		4 / 5 GLY A  76
GLN A  78
VAL A 501
SER A  81
 None
 1.17A 5vunA-2d4yA:
undetectable		 5vunA-2d4yA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA503_1
(CYTOCHROME P450 2C9)		 2d4y FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 1
(Salmonella
enterica) 		4 / 5 GLY A 485
THR A 488
ASN A 486
LYS A 487
 None
 1.08A 5x23A-2d4yA:
undetectable		 5x23A-2d4yA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA502_1
(CYTOCHROME P450 2C9)		 2d4y FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 1
(Salmonella
enterica) 		4 / 6 GLY A 485
THR A 488
ASN A 486
LYS A 487
 None
 0.94A 5xxiA-2d4yA:
undetectable		 5xxiA-2d4yA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZHM_B_SAMB301_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 2d4y FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 1
(Salmonella
enterica) 		5 / 12 LEU A 279
GLY A 277
ILE A 161
GLY A 281
GLY A 280
 None
 0.84A 5zhmB-2d4yA:
undetectable		 5zhmB-2d4yA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B54_A_OAQA302_0
(SULFOTRANSFERASE)		 2d4y FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 1
(Salmonella
enterica) 		6 / 12 ILE A  94
LEU A 491
LEU A 150
PHE A 285
THR A 296
LEU A 297
 None
 1.43A 6b54A-2d4yA:
undetectable		 6b54A-2d4yA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GB9_A_ACTA508_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)		 2d4y FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 1
(Salmonella
enterica) 		3 / 3 VAL A 467
ALA A 476
GLN A 299
 None
 0.66A 6gb9A-2d4yA:
undetectable		 6gb9A-2d4yA:
23.28