SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2d57'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2d57 AQUAPORIN-4
(Rattus
norvegicus) 		3 / 3 THR A  39
LEU A  43
LEU A  50
 None
 0.55A 1mz9C-2d57A:
undetectable		 1mz9C-2d57A:
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_2
(PROTEASE)		 2d57 AQUAPORIN-4
(Rattus
norvegicus) 		4 / 6 ASN A 229
GLY A 209
PRO A 237
ILE A 232
 None
 0.85A 1n49D-2d57A:
undetectable		 1n49D-2d57A:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 2d57 AQUAPORIN-4
(Rattus
norvegicus) 		5 / 12 ILE A  81
ALA A  82
ILE A 199
HIS A 201
PHE A  48
 None
 1.08A 1y0xX-2d57A:
undetectable		 1y0xX-2d57A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H79_A_T3A1_1
(THRA PROTEIN)		 2d57 AQUAPORIN-4
(Rattus
norvegicus) 		5 / 12 ILE A  81
ALA A  82
ILE A 199
HIS A 201
PHE A  48
 None
 1.10A 2h79A-2d57A:
undetectable		 2h79A-2d57A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWS_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 2d57 AQUAPORIN-4
(Rattus
norvegicus) 		5 / 12 ILE A  81
ALA A  82
ILE A 199
HIS A 201
PHE A  48
 None
 1.05A 3gwsX-2d57A:
undetectable		 3gwsX-2d57A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_H_DHIH3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 2d57 AQUAPORIN-4
(Rattus
norvegicus) 		3 / 3 LEU A  66
TRP A  59
GLY A  60
 None
 0.74A 3l35A-2d57A:
undetectable
3l35H-2d57A:
undetectable		 3l35A-2d57A:
9.52
3l35H-2d57A:
4.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_K_DHIK3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 2d57 AQUAPORIN-4
(Rattus
norvegicus) 		3 / 3 LEU A  66
TRP A  59
GLY A  60
 None
 0.76A 3l35B-2d57A:
undetectable
3l35K-2d57A:
undetectable		 3l35B-2d57A:
9.52
3l35K-2d57A:
4.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_K_DHIK3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 2d57 AQUAPORIN-4
(Rattus
norvegicus) 		3 / 3 LEU A  66
TRP A  59
GLY A  61
 None
 0.79A 3l35B-2d57A:
undetectable
3l35K-2d57A:
undetectable		 3l35B-2d57A:
9.52
3l35K-2d57A:
4.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_A_BEZA1000_0
(BENZOATE-COENZYME A
LIGASE)		 2d57 AQUAPORIN-4
(Rattus
norvegicus) 		5 / 7 ALA A 215
ALA A 130
ILE A 128
GLY A 125
ILE A 127
 None
 0.94A 4eatA-2d57A:
undetectable		 4eatA-2d57A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_B_BEZB1000_0
(BENZOATE-COENZYME A
LIGASE)		 2d57 AQUAPORIN-4
(Rattus
norvegicus) 		5 / 9 ALA A 215
ALA A 130
ILE A 128
GLY A 125
ILE A 127
 None
 0.98A 4eatB-2d57A:
undetectable		 4eatB-2d57A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_C_NCTC501_1
(CYTOCHROME P450 2A6)		 2d57 AQUAPORIN-4
(Rattus
norvegicus) 		4 / 5 PHE A  48
PHE A  77
GLY A  54
THR A  56
 None
 1.03A 4ejjC-2d57A:
undetectable		 4ejjC-2d57A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 2d57 AQUAPORIN-4
(Rattus
norvegicus) 		5 / 12 ILE A  81
ALA A  82
ILE A 199
HIS A 201
PHE A  48
 None
 1.08A 4lnwA-2d57A:
undetectable		 4lnwA-2d57A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 2d57 AQUAPORIN-4
(Rattus
norvegicus) 		5 / 12 ILE A  81
ALA A  82
ILE A 199
HIS A 201
PHE A  48
 None
 1.09A 4lnxA-2d57A:
undetectable		 4lnxA-2d57A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 2d57 AQUAPORIN-4
(Rattus
norvegicus) 		4 / 5 PHE A 218
PRO A 220
VAL A 222
ALA A 126
 None
 1.28A 4z4cA-2d57A:
undetectable		 4z4cA-2d57A:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 2d57 AQUAPORIN-4
(Rattus
norvegicus) 		4 / 5 PHE A 218
PRO A 220
VAL A 222
ALA A 126
 None
 1.28A 4z4dA-2d57A:
undetectable		 4z4dA-2d57A:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 2d57 AQUAPORIN-4
(Rattus
norvegicus) 		4 / 5 PHE A 218
PRO A 220
VAL A 222
ALA A 126
 None
 1.27A 4z4eA-2d57A:
undetectable		 4z4eA-2d57A:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_0
(STIE PROTEIN)		 2d57 AQUAPORIN-4
(Rattus
norvegicus) 		5 / 12 GLY A 146
GLY A 144
ILE A 223
VAL A  53
LEU A 133
 None
 0.97A 6ectA-2d57A:
undetectable		 6ectA-2d57A:
22.32