SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2d58'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		 2d58 ALLOGRAFT
INFLAMMATORY FACTOR
1
(Homo
sapiens) 		5 / 11 PHE A  57
ILE A  65
LEU A  70
LEU A  77
VAL A  93
 None
 0.95A 1dtlA-2d58A:
9.3		 1dtlA-2d58A:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA156_1
(CALMODULIN)		 2d58 ALLOGRAFT
INFLAMMATORY FACTOR
1
(Homo
sapiens) 		5 / 8 ILE A  65
LEU A  70
ILE A  90
GLU A  92
VAL A  93
 None
 0.78A 1linA-2d58A:
9.5		 1linA-2d58A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA156_1
(CALMODULIN)		 2d58 ALLOGRAFT
INFLAMMATORY FACTOR
1
(Homo
sapiens) 		5 / 8 ILE A  65
LEU A  70
ILE A  90
VAL A  93
MET A 109
 None
 0.39A 1linA-2d58A:
9.5		 1linA-2d58A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT6_A_DESA129_1
(TRANSTHYRETIN)		 2d58 ALLOGRAFT
INFLAMMATORY FACTOR
1
(Homo
sapiens) 		4 / 4 LYS A  81
LEU A  89
LEU A  70
SER A  69
 None
 1.08A 1tt6A-2d58A:
undetectable		 1tt6A-2d58A:
19.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WRK_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2d58 ALLOGRAFT
INFLAMMATORY FACTOR
1
(Homo
sapiens) 		4 / 5 PHE A  57
LEU A  77
PHE A 106
MET A 110
 None
 1.17A 1wrkB-2d58A:
8.5		 1wrkB-2d58A:
32.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WRL_C_TFPC208_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2d58 ALLOGRAFT
INFLAMMATORY FACTOR
1
(Homo
sapiens) 		4 / 5 PHE A  57
LEU A  74
PHE A 106
MET A 110
 None
 1.25A 1wrlC-2d58A:
8.6		 1wrlC-2d58A:
32.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WRL_C_TFPC208_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2d58 ALLOGRAFT
INFLAMMATORY FACTOR
1
(Homo
sapiens) 		4 / 5 PHE A  57
LEU A  77
PHE A 106
MET A 110
 None
 1.13A 1wrlC-2d58A:
8.6		 1wrlC-2d58A:
32.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WRL_D_TFPD207_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2d58 ALLOGRAFT
INFLAMMATORY FACTOR
1
(Homo
sapiens) 		4 / 8 PHE A  50
LEU A  77
PHE A 106
MET A 110
 None
 0.79A 1wrlC-2d58A:
8.6
1wrlD-2d58A:
8.5		 1wrlC-2d58A:
32.46
1wrlD-2d58A:
32.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WRL_E_TFPE212_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2d58 ALLOGRAFT
INFLAMMATORY FACTOR
1
(Homo
sapiens) 		4 / 7 PHE A  50
LEU A  77
PHE A 106
MET A 110
 None
 0.64A 1wrlE-2d58A:
8.5		 1wrlE-2d58A:
32.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WRL_E_TFPE212_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2d58 ALLOGRAFT
INFLAMMATORY FACTOR
1
(Homo
sapiens) 		4 / 7 PHE A  57
LEU A  77
PHE A 106
MET A 110
 None
 1.17A 1wrlE-2d58A:
8.5		 1wrlE-2d58A:
32.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K7G_B_ACTB902_0
(3-HYDROXYPROLINE
DEHYDRATSE)		 2d58 ALLOGRAFT
INFLAMMATORY FACTOR
1
(Homo
sapiens) 		4 / 7 ASP A  64
PRO A 104
ASP A 105
SER A  95
 None
 1.05A 4k7gB-2d58A:
undetectable		 4k7gB-2d58A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2d58 ALLOGRAFT
INFLAMMATORY FACTOR
1
(Homo
sapiens) 		3 / 3 ASP A  25
LYS A  17
LEU A  59
 None
 0.95A 4ptjA-2d58A:
undetectable		 4ptjA-2d58A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_B_TFPB203_1
(CALMODULIN)		 2d58 ALLOGRAFT
INFLAMMATORY FACTOR
1
(Homo
sapiens) 		4 / 7 PHE A  57
LEU A  70
MET A 109
MET A 110
 None
 0.90A 4rjdB-2d58A:
8.5		 4rjdB-2d58A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2d58 ALLOGRAFT
INFLAMMATORY FACTOR
1
(Homo
sapiens) 		4 / 4 LEU A  70
ARG A  72
ILE A  65
PHE A  57
 None
 1.24A 5kirB-2d58A:
undetectable		 5kirB-2d58A:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEA_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 2d58 ALLOGRAFT
INFLAMMATORY FACTOR
1
(Homo
sapiens) 		4 / 5 LEU A 107
LYS A  51
LEU A  47
GLU A  48
 None
 1.25A 5weaA-2d58A:
undetectable		 5weaA-2d58A:
9.31