SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2d5a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZQ9_A_CLSA11_1
(BETA-LACTAMASE
TOHO-1)		 2d5a HYPOTHETICAL PROTEIN
PH1109
(Pyrococcus
horikoshii) 		4 / 4 GLU A 136
ARG A 131
ASN A 130
ASP A   8
 None
 1.48A 2zq9A-2d5aA:
undetectable		 2zq9A-2d5aA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNO_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 2d5a HYPOTHETICAL PROTEIN
PH1109
(Pyrococcus
horikoshii) 		5 / 12 GLY A  29
VAL A  41
MET A 133
LEU A  45
ILE A  78
 COA  A 200 (-3.4A)
None
None
None
None
 1.27A 3mnoA-2d5aA:
undetectable		 3mnoA-2d5aA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNP_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 2d5a HYPOTHETICAL PROTEIN
PH1109
(Pyrococcus
horikoshii) 		5 / 12 GLY A  29
VAL A  41
MET A 133
LEU A  45
ILE A  78
 COA  A 200 (-3.4A)
None
None
None
None
 1.27A 3mnpA-2d5aA:
undetectable		 3mnpA-2d5aA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWX_A_ZMRA513_2
(NEURAMINIDASE)		 2d5a HYPOTHETICAL PROTEIN
PH1109
(Pyrococcus
horikoshii) 		3 / 3 ARG A 131
TRP A 106
ILE A  15
 None
 1.03A 4mwxA-2d5aA:
undetectable		 4mwxA-2d5aA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSP_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 2d5a HYPOTHETICAL PROTEIN
PH1109
(Pyrococcus
horikoshii) 		5 / 7 TYR A  93
VAL A  71
ILE A  78
VAL A  28
ALA A  26
 COA  A 200 (-4.5A)
None
None
None
None
 1.15A 5ospA-2d5aA:
undetectable		 5ospA-2d5aA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_A_SALA201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 2d5a HYPOTHETICAL PROTEIN
PH1109
(Pyrococcus
horikoshii) 		4 / 5 VAL A 128
ARG A 131
PRO A   6
GLY A   9
 None
 1.37A 5x80A-2d5aA:
undetectable
5x80B-2d5aA:
undetectable		 5x80A-2d5aA:
21.84
5x80B-2d5aA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_D_SALD201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 2d5a HYPOTHETICAL PROTEIN
PH1109
(Pyrococcus
horikoshii) 		4 / 5 PRO A   6
GLY A   9
VAL A 128
ARG A 131
 None
 1.36A 5x80C-2d5aA:
undetectable
5x80D-2d5aA:
undetectable		 5x80C-2d5aA:
21.84
5x80D-2d5aA:
21.84