SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2d5i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S19_A_MC9A500_0
(VITAMIN D3 RECEPTOR)		 2d5i AZO REDUCTASE
(Escherichia
coli) 		5 / 12 LEU A 104
LEU A 110
VAL A 111
ILE A  80
LEU A   4
 None
 1.14A 1s19A-2d5iA:
undetectable		 1s19A-2d5iA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		 2d5i AZO REDUCTASE
(Escherichia
coli) 		5 / 11 LEU A   6
GLN A 103
ILE A  91
PHE A 108
LEU A 156
 None
 1.28A 2q6hA-2d5iA:
undetectable		 2q6hA-2d5iA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2d5i AZO REDUCTASE
(Escherichia
coli) 		3 / 3 GLY A 127
GLY A 161
GLY A 164
 None
 0.41A 3bogC-2d5iA:
undetectable		 3bogC-2d5iA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2d5i AZO REDUCTASE
(Escherichia
coli) 		3 / 3 GLY A 127
GLY A 161
GLY A 164
 None
 0.32A 3bogD-2d5iA:
undetectable		 3bogD-2d5iA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_1
(CYTOCHROME P450 3A4)		 2d5i AZO REDUCTASE
(Escherichia
coli) 		5 / 12 LEU A   4
ILE A  91
ALA A 134
ILE A 197
ALA A 193
 None
 1.20A 3nxuB-2d5iA:
undetectable		 3nxuB-2d5iA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_1
(ENDOTHIAPEPSIN)		 2d5i AZO REDUCTASE
(Escherichia
coli) 		5 / 10 ILE A 100
ALA A  93
LEU A 160
ILE A 197
THR A 138
 None
 1.21A 3prsA-2d5iA:
undetectable		 3prsA-2d5iA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_A_NCAA300_0
(PROTOGLOBIN)		 2d5i AZO REDUCTASE
(Escherichia
coli) 		4 / 7 TYR A 155
VAL A 152
PHE A 108
ILE A  91
 GOL  A 202 (-4.4A)
GOL  A 202 (-4.5A)
None
None
 0.79A 3zjqA-2d5iA:
undetectable		 3zjqA-2d5iA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_B_NCAB300_0
(PROTOGLOBIN)		 2d5i AZO REDUCTASE
(Escherichia
coli) 		4 / 7 TYR A 155
VAL A 152
PHE A 108
ILE A  91
 GOL  A 202 (-4.4A)
GOL  A 202 (-4.5A)
None
None
 0.80A 3zjqB-2d5iA:
undetectable		 3zjqB-2d5iA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA510_1
(PROTON-GATED ION
CHANNEL)		 2d5i AZO REDUCTASE
(Escherichia
coli) 		5 / 9 ILE A  91
ALA A 134
ILE A  89
ILE A 163
LEU A  83
 None
 0.83A 5mvmA-2d5iA:
undetectable
5mvmE-2d5iA:
undetectable		 5mvmA-2d5iA:
17.33
5mvmE-2d5iA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 2d5i AZO REDUCTASE
(Escherichia
coli) 		5 / 10 ILE A 163
LEU A  83
ILE A  91
ALA A 134
ILE A  89
 None
 0.87A 5mvmD-2d5iA:
undetectable
5mvmE-2d5iA:
undetectable		 5mvmD-2d5iA:
17.33
5mvmE-2d5iA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODC_A_ACTA703_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 2d5i AZO REDUCTASE
(Escherichia
coli) 		4 / 4 GLN A  16
GLN A 187
PRO A 180
ALA A 184
 None
 1.28A 5odcA-2d5iA:
2.6
5odcG-2d5iA:
2.2		 5odcA-2d5iA:
15.77
5odcG-2d5iA:
15.77