SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2d5m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 2d5m FLAVOREDOXIN
(Desulfovibrio
vulgaris) 		5 / 12 ALA A  32
TYR A 171
VAL A 162
PHE A 114
GLY A  83
 FMN  A1001 (-3.8A)
None
None
None
FMN  A1001 (-3.2A)
 1.42A 2dcfA-2d5mA:
undetectable		 2dcfA-2d5mA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_A_017A201_1
(PROTEASE)		 2d5m FLAVOREDOXIN
(Desulfovibrio
vulgaris) 		5 / 12 GLY A  64
ALA A  65
GLY A 136
ILE A 123
VAL A 106
 None
 0.90A 3ucbA-2d5mA:
undetectable		 3ucbA-2d5mA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2d5m FLAVOREDOXIN
(Desulfovibrio
vulgaris) 		3 / 3 THR A  54
HIS A 124
LEU A 122
 FMN  A1001 (-4.0A)
None
None
 0.52A 5axdA-2d5mA:
undetectable		 5axdA-2d5mA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2d5m FLAVOREDOXIN
(Desulfovibrio
vulgaris) 		3 / 3 THR A  54
HIS A 124
LEU A 122
 FMN  A1001 (-4.0A)
None
None
 0.55A 5axdC-2d5mA:
undetectable		 5axdC-2d5mA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_BEZA401_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 2d5m FLAVOREDOXIN
(Desulfovibrio
vulgaris) 		5 / 9 LEU A  96
SER A  95
ILE A  30
PRO A 100
VAL A 111
 None
 1.28A 6ef6A-2d5mA:
undetectable		 6ef6A-2d5mA:
22.03