SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2d5r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_A_CCSA47_0
(GLUTATHIONE
S-TRANSFERASE)		 2d5r CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 7
(Homo
sapiens) 		4 / 7 TRP A 153
LEU A 165
LEU A 139
LEU A  79
 None
 0.86A 1gtiA-2d5rA:
undetectable		 1gtiA-2d5rA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_2
(LIVER
CARBOXYLESTERASE I)		 2d5r TOB1 PROTEIN
(Homo
sapiens) 		3 / 3 PHE B  35
LEU B 114
LEU B 110
 None
 0.60A 1mx1E-2d5rB:
undetectable		 1mx1E-2d5rB:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_1
(ESTROGEN RECEPTOR
BETA)		 2d5r CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 7
(Homo
sapiens) 		5 / 12 LEU A 233
THR A 234
ALA A 237
LEU A 216
GLY A 207
 None
 0.90A 1qknA-2d5rA:
undetectable		 1qknA-2d5rA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_C_H4BC1290_1
(PTERIDINE REDUCTASE
1)		 2d5r CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 7
(Homo
sapiens) 		4 / 8 PHE A 189
LEU A 169
LEU A  77
LEU A  79
 None
 0.99A 2bfpC-2d5rA:
undetectable		 2bfpC-2d5rA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UVN_B_ECNB1406_1
(CYTOCHROME P450 130)		 2d5r CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 7
(Homo
sapiens) 		5 / 11 ASP A 161
MET A 236
THR A  80
GLY A 228
LEU A 209
 None
 1.29A 2uvnB-2d5rA:
undetectable		 2uvnB-2d5rA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)		 2d5r CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 7
(Homo
sapiens) 		4 / 7 LEU A 174
GLU A 177
LEU A 179
TYR A 160
 None
 1.11A 2w8yA-2d5rA:
undetectable		 2w8yA-2d5rA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_C_NILC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2d5r CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 7
(Homo
sapiens) 		5 / 9 LEU A  65
TYR A 160
VAL A  69
ILE A 168
PHE A  43
 None
 1.43A 3cs9C-2d5rA:
undetectable		 3cs9C-2d5rA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_A_H3PA552_1
(GLUTAMATE
DEHYDROGENASE)		 2d5r CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 7
(Homo
sapiens) 		4 / 6 ILE A 250
LYS A 152
ILE A 192
HIS A 258
 None
 1.21A 3eteA-2d5rA:
undetectable
3eteE-2d5rA:
undetectable		 3eteA-2d5rA:
19.60
3eteE-2d5rA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3004_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2d5r CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 7
(Homo
sapiens) 		4 / 5 ILE A 166
PHE A 181
ASP A 180
GLU A 183
 None
 1.15A 3kp6A-2d5rA:
0.0
3kp6B-2d5rA:
undetectable		 3kp6A-2d5rA:
21.74
3kp6B-2d5rA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA193_1
(DIHYDROFOLATE
REDUCTASE)		 2d5r CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 7
(Homo
sapiens) 		4 / 5 ASP A  70
LEU A 174
ILE A  74
PHE A  43
 None
 1.24A 3s3vA-2d5rA:
undetectable		 3s3vA-2d5rA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_A_9PLA501_1
(CYTOCHROME P450 2A6)		 2d5r CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 7
(Homo
sapiens) 		5 / 10 PHE A 188
PHE A 189
ALA A 137
THR A 133
ILE A  74
 None
 1.41A 3t3qA-2d5rA:
undetectable		 3t3qA-2d5rA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_B_9PLB501_1
(CYTOCHROME P450 2A6)		 2d5r CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 7
(Homo
sapiens) 		5 / 10 PHE A 188
PHE A 189
ALA A 137
THR A 133
ILE A  74
 None
 1.41A 3t3qB-2d5rA:
undetectable		 3t3qB-2d5rA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_C_9PLC501_1
(CYTOCHROME P450 2A6)		 2d5r CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 7
(Homo
sapiens) 		5 / 10 PHE A 188
PHE A 189
ALA A 137
THR A 133
ILE A  74
 None
 1.41A 3t3qC-2d5rA:
undetectable		 3t3qC-2d5rA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_D_9PLD501_1
(CYTOCHROME P450 2A6)		 2d5r CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 7
(Homo
sapiens) 		5 / 10 PHE A 188
PHE A 189
ALA A 137
THR A 133
ILE A  74
 None
 1.41A 3t3qD-2d5rA:
undetectable		 3t3qD-2d5rA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_2
(ADENOSINE KINASE,
PUTATIVE)		 2d5r CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 7
(Homo
sapiens) 		4 / 5 LEU A 259
GLY A 159
MET A  39
PHE A 189
 None
 1.22A 3uq6B-2d5rA:
undetectable		 3uq6B-2d5rA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYK_B_IMNB300_1
(LACTOYLGLUTATHIONE
LYASE)		 2d5r CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 7
(Homo
sapiens) 		5 / 12 PHE A 136
LEU A 140
PHE A 189
GLY A 228
PHE A  81
 None
 0.99A 4kykA-2d5rA:
1.2
4kykB-2d5rA:
1.3		 4kykA-2d5rA:
20.00
4kykB-2d5rA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_A_SAMA301_0
(PUTATIVE RNA
METHYLASE)		 2d5r CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 7
(Homo
sapiens) 		5 / 12 GLY A 159
HIS A 157
ASP A 194
ILE A 166
LEU A  65
 None
 1.34A 4pooA-2d5rA:
undetectable		 4pooA-2d5rA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_A_ADNA2414_1
(RNA-DIRECTED RNA
POLYMERASE L)		 2d5r CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 7
TOB1 PROTEIN
(Homo
sapiens) 		4 / 6 GLU A 247
PHE A 246
PHE A 245
TYR B  74
 None
 1.33A 4uciA-2d5rA:
undetectable		 4uciA-2d5rA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_ADNB2415_1
(RNA-DIRECTED RNA
POLYMERASE L)		 2d5r CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 7
TOB1 PROTEIN
(Homo
sapiens) 		4 / 7 GLU A 247
PHE A 246
PHE A 245
TYR B  74
 None
 1.30A 4uciB-2d5rA:
undetectable		 4uciB-2d5rA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 2d5r CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 7
(Homo
sapiens) 		5 / 12 ASN A  83
ILE A  12
ILE A 221
SER A 229
GLN A 224
 None
 1.41A 4xueA-2d5rA:
undetectable		 4xueA-2d5rA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y4D_A_CFFA411_1
(ENDOTHIAPEPSIN)		 2d5r CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 7
(Homo
sapiens) 		4 / 6 ASP A  70
LEU A  65
ILE A 184
PHE A 181
 None
 1.06A 4y4dA-2d5rA:
undetectable		 4y4dA-2d5rA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_A_ACTA403_0
(D-ALANINE--D-ALANINE
LIGASE)		 2d5r CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 7
(Homo
sapiens) 		4 / 6 LYS A  11
GLY A 222
SER A 229
LEU A 232
 None
 1.19A 5bphA-2d5rA:
undetectable		 5bphA-2d5rA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_C_ACTC403_0
(D-ALANINE--D-ALANINE
LIGASE)		 2d5r CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 7
(Homo
sapiens) 		4 / 4 TYR A  88
GLY A 228
SER A 231
LEU A 232
 None
 1.41A 5bphC-2d5rA:
undetectable		 5bphC-2d5rA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_D_ACTD403_0
(D-ALANINE--D-ALANINE
LIGASE)		 2d5r CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 7
(Homo
sapiens) 		4 / 6 LYS A  11
GLY A 222
SER A 229
LEU A 232
 None
 1.21A 5bphD-2d5rA:
undetectable		 5bphD-2d5rA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KI6_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 2d5r CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 7
(Homo
sapiens) 		4 / 5 CYH A  67
GLN A  63
PRO A  50
ILE A  51
 None
 1.36A 5ki6A-2d5rA:
undetectable		 5ki6A-2d5rA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJY_A_BEZA304_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 2d5r CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 7
TOB1 PROTEIN
(Homo
sapiens;
Homo
sapiens) 		3 / 3 MET B  25
GLU A 247
ARG B  80
 None
 0.96A 5tjyA-2d5rB:
undetectable		 5tjyA-2d5rB:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_D_HISD402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 2d5r CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 7
(Homo
sapiens) 		4 / 8 GLY A  78
LEU A  79
VAL A  15
LEU A 140
 None
 0.76A 6czmD-2d5rA:
undetectable
6czmF-2d5rA:
undetectable		 6czmD-2d5rA:
22.10
6czmF-2d5rA:
22.10