SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2d5w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)
2d5w PEPTIDE ABC
TRANSPORTER,
PEPTIDE-BINDING
PROTEIN

(Thermus
thermophilus)
3 / 3 THR A 255
LEU A 259
VAL A 262
None
0.46A 1mz9E-2d5wA:
undetectable
1mz9E-2d5wA:
6.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_A_DVAA8_0
(GRAMICIDIN A)
2d5w PEPTIDE ABC
TRANSPORTER,
PEPTIDE-BINDING
PROTEIN

(Thermus
thermophilus)
4 / 4 GLY A 588
VAL A 590
TRP A 584
GLY A 583
None
1.30A 1ng8A-2d5wA:
undetectable
1ng8A-2d5wA:
3.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_B_DVAB8_0
(GRAMICIDIN A)
2d5w PEPTIDE ABC
TRANSPORTER,
PEPTIDE-BINDING
PROTEIN

(Thermus
thermophilus)
4 / 4 GLY A 588
VAL A 590
TRP A 584
GLY A 583
None
1.30A 1ng8B-2d5wA:
undetectable
1ng8B-2d5wA:
3.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)
2d5w PEPTIDE ABC
TRANSPORTER,
PEPTIDE-BINDING
PROTEIN

(Thermus
thermophilus)
4 / 8 ARG A 550
GLN A 279
PHE A 277
ASN A 552
None
1.24A 1p6kA-2d5wA:
undetectable
1p6kA-2d5wA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)
2d5w PEPTIDE ABC
TRANSPORTER,
PEPTIDE-BINDING
PROTEIN

(Thermus
thermophilus)
4 / 5 GLY A 280
GLN A 279
VAL A 262
SER A 274
None
1.39A 1p6kB-2d5wA:
undetectable
1p6kB-2d5wA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)
2d5w PEPTIDE ABC
TRANSPORTER,
PEPTIDE-BINDING
PROTEIN

(Thermus
thermophilus)
4 / 8 ARG A 550
GLN A 279
PHE A 277
ASN A 552
None
1.23A 1rs6A-2d5wA:
undetectable
1rs6A-2d5wA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)
2d5w PEPTIDE ABC
TRANSPORTER,
PEPTIDE-BINDING
PROTEIN

(Thermus
thermophilus)
4 / 5 GLY A 280
GLN A 279
VAL A 262
SER A 274
None
1.43A 1rs6B-2d5wA:
undetectable
1rs6B-2d5wA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_J_CHDJ3060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)
2d5w PEPTIDE ABC
TRANSPORTER,
PEPTIDE-BINDING
PROTEIN

(Thermus
thermophilus)
4 / 7 ILE A  36
ARG A  17
THR A 198
LEU A 202
None
0.94A 1v55A-2d5wA:
1.6
1v55J-2d5wA:
undetectable
1v55A-2d5wA:
20.31
1v55J-2d5wA:
7.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_A_SAMA301_0
(RRNA
METHYLTRANSFERASE)
2d5w PEPTIDE ABC
TRANSPORTER,
PEPTIDE-BINDING
PROTEIN

(Thermus
thermophilus)
5 / 11 GLY A 573
GLY A 570
ILE A  32
ALA A  31
ARG A  25
None
1.03A 1x7pA-2d5wA:
undetectable
1x7pB-2d5wA:
undetectable
1x7pA-2d5wA:
19.34
1x7pB-2d5wA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_B_SAMB302_0
(RRNA
METHYLTRANSFERASE)
2d5w PEPTIDE ABC
TRANSPORTER,
PEPTIDE-BINDING
PROTEIN

(Thermus
thermophilus)
5 / 10 ARG A  25
GLY A 573
GLY A 570
ILE A  32
ALA A  31
None
1.15A 1x7pA-2d5wA:
undetectable
1x7pB-2d5wA:
undetectable
1x7pA-2d5wA:
19.34
1x7pB-2d5wA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)
2d5w PEPTIDE ABC
TRANSPORTER,
PEPTIDE-BINDING
PROTEIN

(Thermus
thermophilus)
4 / 8 ARG A 550
GLN A 279
PHE A 277
ASN A 552
None
1.23A 1zzqA-2d5wA:
undetectable
1zzqA-2d5wA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)
2d5w PEPTIDE ABC
TRANSPORTER,
PEPTIDE-BINDING
PROTEIN

(Thermus
thermophilus)
4 / 5 GLY A 280
GLN A 279
VAL A 262
SER A 274
None
1.39A 1zzuB-2d5wA:
undetectable
1zzuB-2d5wA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EFJ_A_37TA502_1
(3,7-DIMETHYLXANTHINE
METHYLTRANSFERASE)
2d5w PEPTIDE ABC
TRANSPORTER,
PEPTIDE-BINDING
PROTEIN

(Thermus
thermophilus)
5 / 12 LEU A 258
ILE A  32
SER A 271
ILE A  36
ILE A  10
None
1.48A 2efjA-2d5wA:
undetectable
2efjA-2d5wA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)
2d5w PEPTIDE ABC
TRANSPORTER,
PEPTIDE-BINDING
PROTEIN

(Thermus
thermophilus)
4 / 7 TYR A 563
GLY A 576
TYR A 249
ASN A 578
None
1.06A 2g70B-2d5wA:
undetectable
2g70B-2d5wA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)
2d5w PEPTIDE ABC
TRANSPORTER,
PEPTIDE-BINDING
PROTEIN

(Thermus
thermophilus)
4 / 7 TYR A 563
GLY A 576
TYR A 249
ASN A 578
None
1.02A 2g72B-2d5wA:
undetectable
2g72B-2d5wA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACHB603_0
(ACETYLCHOLINESTERASE)
2d5w PEPTIDE ABC
TRANSPORTER,
PEPTIDE-BINDING
PROTEIN

(Thermus
thermophilus)
4 / 7 TYR A 572
TYR A 146
GLU A 474
GLY A 476
None
1.10A 2ha4B-2d5wA:
undetectable
2ha4B-2d5wA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_B_ACTB501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)
2d5w PEPTIDE ABC
TRANSPORTER,
PEPTIDE-BINDING
PROTEIN

(Thermus
thermophilus)
4 / 6 ASP A  84
VAL A 129
ARG A 130
ILE A 140
None
1.22A 2yfbB-2d5wA:
undetectable
2yfbB-2d5wA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_B_SAMB402_0
(UNCHARACTERIZED
PROTEIN MJ0883)
2d5w PEPTIDE ABC
TRANSPORTER,
PEPTIDE-BINDING
PROTEIN

(Thermus
thermophilus)
5 / 12 TYR A 209
LEU A  19
PHE A 213
GLY A 211
ASN A 231
None
1.38A 2zznB-2d5wA:
undetectable
2zznB-2d5wA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_W_CHDW1059_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)
2d5w PEPTIDE ABC
TRANSPORTER,
PEPTIDE-BINDING
PROTEIN

(Thermus
thermophilus)
5 / 8 ILE A  36
LEU A  40
ARG A  17
THR A 198
LEU A 202
None
1.23A 3asoN-2d5wA:
1.5
3asoW-2d5wA:
undetectable
3asoN-2d5wA:
20.31
3asoW-2d5wA:
7.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_B_BEZB261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)
2d5w PEPTIDE ABC
TRANSPORTER,
PEPTIDE-BINDING
PROTEIN

(Thermus
thermophilus)
4 / 8 HIS A 305
ILE A 503
TRP A 460
PHE A 464
None
1.46A 3ccfB-2d5wA:
undetectable
3ccfB-2d5wA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_A_BCZA468_0
(NEURAMINIDASE)
2d5w PEPTIDE ABC
TRANSPORTER,
PEPTIDE-BINDING
PROTEIN

(Thermus
thermophilus)
5 / 12 ARG A 550
GLU A 304
LEU A 547
GLU A 465
GLU A 419
None
1.35A 3k37A-2d5wA:
undetectable
3k37A-2d5wA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_A_BCZA1001_0
(NEURAMINIDASE)
2d5w PEPTIDE ABC
TRANSPORTER,
PEPTIDE-BINDING
PROTEIN

(Thermus
thermophilus)
5 / 12 ARG A 550
GLU A 304
LEU A 547
GLU A 465
GLU A 419
None
1.25A 3k39A-2d5wA:
undetectable
3k39A-2d5wA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_C_BCZC1001_0
(NEURAMINIDASE)
2d5w PEPTIDE ABC
TRANSPORTER,
PEPTIDE-BINDING
PROTEIN

(Thermus
thermophilus)
5 / 12 ARG A 550
GLU A 304
LEU A 547
GLU A 465
GLU A 419
None
1.26A 3k39C-2d5wA:
undetectable
3k39C-2d5wA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_E_BCZE1001_0
(NEURAMINIDASE)
2d5w PEPTIDE ABC
TRANSPORTER,
PEPTIDE-BINDING
PROTEIN

(Thermus
thermophilus)
5 / 12 ARG A 550
GLU A 304
LEU A 547
GLU A 465
GLU A 419
None
1.26A 3k39E-2d5wA:
undetectable
3k39E-2d5wA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_F_BCZF1001_0
(NEURAMINIDASE)
2d5w PEPTIDE ABC
TRANSPORTER,
PEPTIDE-BINDING
PROTEIN

(Thermus
thermophilus)
5 / 12 ARG A 550
GLU A 304
LEU A 547
GLU A 465
GLU A 419
None
1.28A 3k39F-2d5wA:
undetectable
3k39F-2d5wA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_G_BCZG1001_0
(NEURAMINIDASE)
2d5w PEPTIDE ABC
TRANSPORTER,
PEPTIDE-BINDING
PROTEIN

(Thermus
thermophilus)
5 / 12 ARG A 550
GLU A 304
LEU A 547
GLU A 465
GLU A 419
None
1.26A 3k39G-2d5wA:
undetectable
3k39G-2d5wA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_H_BCZH1001_0
(NEURAMINIDASE)
2d5w PEPTIDE ABC
TRANSPORTER,
PEPTIDE-BINDING
PROTEIN

(Thermus
thermophilus)
5 / 12 ARG A 550
GLU A 304
LEU A 547
GLU A 465
GLU A 419
None
1.27A 3k39H-2d5wA:
undetectable
3k39H-2d5wA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_I_BCZI1001_0
(NEURAMINIDASE)
2d5w PEPTIDE ABC
TRANSPORTER,
PEPTIDE-BINDING
PROTEIN

(Thermus
thermophilus)
5 / 12 ARG A 550
GLU A 304
LEU A 547
GLU A 465
GLU A 419
None
1.26A 3k39I-2d5wA:
undetectable
3k39I-2d5wA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_J_BCZJ1001_0
(NEURAMINIDASE)
2d5w PEPTIDE ABC
TRANSPORTER,
PEPTIDE-BINDING
PROTEIN

(Thermus
thermophilus)
5 / 12 ARG A 550
GLU A 304
LEU A 547
GLU A 465
GLU A 419
None
1.25A 3k39J-2d5wA:
undetectable
3k39J-2d5wA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_K_BCZK1001_0
(NEURAMINIDASE)
2d5w PEPTIDE ABC
TRANSPORTER,
PEPTIDE-BINDING
PROTEIN

(Thermus
thermophilus)
5 / 12 ARG A 550
GLU A 304
LEU A 547
GLU A 465
GLU A 419
None
1.26A 3k39K-2d5wA:
undetectable
3k39K-2d5wA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_L_BCZL1001_0
(NEURAMINIDASE)
2d5w PEPTIDE ABC
TRANSPORTER,
PEPTIDE-BINDING
PROTEIN

(Thermus
thermophilus)
5 / 12 ARG A 550
GLU A 304
LEU A 547
GLU A 465
GLU A 419
None
1.26A 3k39L-2d5wA:
undetectable
3k39L-2d5wA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_M_BCZM1001_0
(NEURAMINIDASE)
2d5w PEPTIDE ABC
TRANSPORTER,
PEPTIDE-BINDING
PROTEIN

(Thermus
thermophilus)
5 / 12 ARG A 550
GLU A 304
LEU A 547
GLU A 465
GLU A 419
None
1.26A 3k39M-2d5wA:
undetectable
3k39M-2d5wA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_O_BCZO1001_0
(NEURAMINIDASE)
2d5w PEPTIDE ABC
TRANSPORTER,
PEPTIDE-BINDING
PROTEIN

(Thermus
thermophilus)
5 / 12 ARG A 550
GLU A 304
LEU A 547
GLU A 465
GLU A 419
None
1.26A 3k39O-2d5wA:
undetectable
3k39O-2d5wA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)
2d5w PEPTIDE ABC
TRANSPORTER,
PEPTIDE-BINDING
PROTEIN

(Thermus
thermophilus)
5 / 12 ILE A 331
THR A 327
ILE A 306
ASN A 309
ILE A 308
None
1.19A 3kpdB-2d5wA:
undetectable
3kpdB-2d5wA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R55_A_PZAA598_0
(LACTOPEROXIDASE)
2d5w PEPTIDE ABC
TRANSPORTER,
PEPTIDE-BINDING
PROTEIN

(Thermus
thermophilus)
3 / 3 GLU A 474
PHE A 531
GLN A 480
None
0.78A 3r55A-2d5wA:
undetectable
3r55A-2d5wA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TF1_A_ACTA191_0
(METHYL-ACCEPTING
CHEMOTAXIS PROTEIN)
2d5w PEPTIDE ABC
TRANSPORTER,
PEPTIDE-BINDING
PROTEIN

(Thermus
thermophilus)
4 / 5 THR A 327
ILE A 331
PHE A 405
LEU A 322
None
1.19A 3tf1A-2d5wA:
undetectable
3tf1A-2d5wA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
2d5w PEPTIDE ABC
TRANSPORTER,
PEPTIDE-BINDING
PROTEIN

(Thermus
thermophilus)
4 / 6 ILE A  36
ARG A  17
THR A 198
LEU A 202
None
0.92A 3wg7N-2d5wA:
0.0
3wg7W-2d5wA:
undetectable
3wg7N-2d5wA:
20.31
3wg7W-2d5wA:
7.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)
2d5w PEPTIDE ABC
TRANSPORTER,
PEPTIDE-BINDING
PROTEIN

(Thermus
thermophilus)
4 / 6 ALA A 357
ALA A 352
PRO A 546
THR A 354
None
1.09A 4dtzB-2d5wA:
undetectable
4dtzB-2d5wA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIS_A_DAHA24_1
(POLYSACCHARIDE
MONOOXYGENASE-3)
2d5w PEPTIDE ABC
TRANSPORTER,
PEPTIDE-BINDING
PROTEIN

(Thermus
thermophilus)
4 / 5 TYR A 498
PRO A 117
ASN A 496
PRO A 121
None
1.41A 4eisA-2d5wA:
0.0
4eisB-2d5wA:
undetectable
4eisA-2d5wA:
16.67
4eisB-2d5wA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIM_A_CELA711_1
(LACTOTRANSFERRIN)
2d5w PEPTIDE ABC
TRANSPORTER,
PEPTIDE-BINDING
PROTEIN

(Thermus
thermophilus)
5 / 9 GLY A 151
GLU A  35
TYR A 572
GLY A 573
TYR A 568
None
1.32A 4fimA-2d5wA:
undetectable
4fimA-2d5wA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)
2d5w PEPTIDE ABC
TRANSPORTER,
PEPTIDE-BINDING
PROTEIN

(Thermus
thermophilus)
4 / 7 ASN A 508
GLU A 510
GLU A 541
GLU A 540
None
1.35A 4mj8C-2d5wA:
undetectable
4mj8C-2d5wA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)
2d5w PEPTIDE ABC
TRANSPORTER,
PEPTIDE-BINDING
PROTEIN

(Thermus
thermophilus)
4 / 5 ASN A 502
PRO A 492
GLY A 505
ASP A 179
None
1.13A 4n48B-2d5wA:
undetectable
4n48B-2d5wA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_LZUA3008_1
(ALDEHYDE OXIDASE)
2d5w PEPTIDE ABC
TRANSPORTER,
PEPTIDE-BINDING
PROTEIN

(Thermus
thermophilus)
4 / 8 ASP A  90
ARG A  88
PRO A  98
TRP A  93
None
1.06A 4uhxA-2d5wA:
undetectable
4uhxA-2d5wA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_RTZA3009_1
(ALDEHYDE OXIDASE)
2d5w PEPTIDE ABC
TRANSPORTER,
PEPTIDE-BINDING
PROTEIN

(Thermus
thermophilus)
4 / 8 ASP A  90
ARG A  88
PRO A  98
TRP A  93
None
1.06A 4uhxA-2d5wA:
undetectable
4uhxA-2d5wA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA502_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
2d5w PEPTIDE ABC
TRANSPORTER,
PEPTIDE-BINDING
PROTEIN

(Thermus
thermophilus)
4 / 7 ILE A  36
ARG A 250
LEU A 258
ILE A  10
None
0.98A 4xumA-2d5wA:
undetectable
4xumA-2d5wA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
2d5w PEPTIDE ABC
TRANSPORTER,
PEPTIDE-BINDING
PROTEIN

(Thermus
thermophilus)
4 / 7 ILE A  36
ARG A  17
THR A 198
LEU A 202
None
0.92A 5b1bN-2d5wA:
2.3
5b1bW-2d5wA:
undetectable
5b1bN-2d5wA:
20.31
5b1bW-2d5wA:
7.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_F_RBFF201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)
2d5w PEPTIDE ABC
TRANSPORTER,
PEPTIDE-BINDING
PROTEIN

(Thermus
thermophilus)
4 / 7 LEU A  19
VAL A 273
GLU A  35
SER A 271
None
1.30A 5umwA-2d5wA:
2.7
5umwF-2d5wA:
1.2
5umwA-2d5wA:
7.36
5umwF-2d5wA:
7.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
2d5w PEPTIDE ABC
TRANSPORTER,
PEPTIDE-BINDING
PROTEIN

(Thermus
thermophilus)
4 / 6 ILE A  36
ARG A  17
THR A 198
LEU A 202
None
1.00A 5z86N-2d5wA:
undetectable
5z86W-2d5wA:
undetectable
5z86N-2d5wA:
20.31
5z86W-2d5wA:
7.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
2d5w PEPTIDE ABC
TRANSPORTER,
PEPTIDE-BINDING
PROTEIN

(Thermus
thermophilus)
4 / 6 ILE A  36
ARG A  17
THR A 198
LEU A 202
None
1.01A 5zcoN-2d5wA:
undetectable
5zcoW-2d5wA:
undetectable
5zcoN-2d5wA:
20.31
5zcoW-2d5wA:
7.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXM_A_SAMA402_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)
2d5w PEPTIDE ABC
TRANSPORTER,
PEPTIDE-BINDING
PROTEIN

(Thermus
thermophilus)
5 / 12 GLY A 291
SER A 282
LEU A 275
ILE A 295
ASP A 294
None
1.08A 6bxmA-2d5wA:
2.6
6bxmA-2d5wA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
2d5w PEPTIDE ABC
TRANSPORTER,
PEPTIDE-BINDING
PROTEIN

(Thermus
thermophilus)
3 / 3 ARG A 418
PHE A 549
PHE A 466
None
0.70A 6nknC-2d5wA:
undetectable
6nknJ-2d5wA:
undetectable
6nknC-2d5wA:
17.89
6nknJ-2d5wA:
7.26