SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2d62'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_B_CCSB417_0
(ESTROGEN RECEPTOR)		 2d62 MULTIPLE
SUGAR-BINDING
TRANSPORT
ATP-BINDING PROTEIN
(Pyrococcus
horikoshii) 		4 / 6 PRO A 115
GLN A 117
LYS A 121
VAL A 123
 None
 1.29A 1l2iB-2d62A:
undetectable		 1l2iB-2d62A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVT_A_PRLA311_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 2d62 MULTIPLE
SUGAR-BINDING
TRANSPORT
ATP-BINDING PROTEIN
(Pyrococcus
horikoshii) 		4 / 8 LEU A 278
GLU A 281
THR A 370
ILE A 365
 None
 1.05A 1qvtA-2d62A:
undetectable		 1qvtA-2d62A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_A_URFA999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 2d62 MULTIPLE
SUGAR-BINDING
TRANSPORT
ATP-BINDING PROTEIN
(Pyrococcus
horikoshii) 		4 / 5 ALA A 127
TYR A 102
ILE A 105
ASP A 120
 None
 1.19A 1upfA-2d62A:
undetectable		 1upfA-2d62A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_C_URFC999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 2d62 MULTIPLE
SUGAR-BINDING
TRANSPORT
ATP-BINDING PROTEIN
(Pyrococcus
horikoshii) 		4 / 5 ALA A 127
TYR A 102
ILE A 105
ASP A 120
 None
 0.95A 1upfC-2d62A:
undetectable		 1upfC-2d62A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VIF_A_FOLA1_0
(DIHYDROFOLATE
REDUCTASE)		 2d62 MULTIPLE
SUGAR-BINDING
TRANSPORT
ATP-BINDING PROTEIN
(Pyrococcus
horikoshii) 		3 / 3 GLN A  62
ILE A  63
TYR A  64
 None
 0.74A 1vifA-2d62A:
undetectable		 1vifA-2d62A:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		 2d62 MULTIPLE
SUGAR-BINDING
TRANSPORT
ATP-BINDING PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 ARG A 182
ILE A 243
GLY A 225
ALA A 206
VAL A 204
 None
 1.01A 2oc8A-2d62A:
undetectable		 2oc8A-2d62A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_FFOB505_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2d62 MULTIPLE
SUGAR-BINDING
TRANSPORT
ATP-BINDING PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 GLY A  44
LEU A   9
VAL A   7
ALA A  21
GLY A  54
 POP  A1293 (-3.1A)
None
None
None
None
 1.01A 2vmyA-2d62A:
undetectable		 2vmyA-2d62A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZB7_A_NCAA901_0
(PROSTAGLANDIN
REDUCTASE 2)		 2d62 MULTIPLE
SUGAR-BINDING
TRANSPORT
ATP-BINDING PROTEIN
(Pyrococcus
horikoshii) 		4 / 5 ILE A 197
MET A 216
LEU A   9
LEU A  27
 None
 0.88A 2zb7A-2d62A:
undetectable		 2zb7A-2d62A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_1
(PUTATIVE
MODIFICATION
METHYLASE)		 2d62 MULTIPLE
SUGAR-BINDING
TRANSPORT
ATP-BINDING PROTEIN
(Pyrococcus
horikoshii) 		3 / 3 ASP A 167
THR A  59
GLU A  56
 None
 0.74A 2zifB-2d62A:
2.4		 2zifB-2d62A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_B_ACTB4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 2d62 MULTIPLE
SUGAR-BINDING
TRANSPORT
ATP-BINDING PROTEIN
(Pyrococcus
horikoshii) 		3 / 3 GLY A  42
GLY A  44
THR A  46
 POP  A1293 (-3.2A)
POP  A1293 (-3.1A)
POP  A1293 (-3.9A)
 0.46A 3si7B-2d62A:
15.4		 3si7B-2d62A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_2
(HISTONE DEACETYLASE
8)		 2d62 MULTIPLE
SUGAR-BINDING
TRANSPORT
ATP-BINDING PROTEIN
(Pyrococcus
horikoshii) 		3 / 3 PRO A  97
MET A  99
TYR A  96
 None
SO4  A1005 ( 3.8A)
None
 0.99A 4qa2B-2d62A:
2.8		 4qa2B-2d62A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		 2d62 MULTIPLE
SUGAR-BINDING
TRANSPORT
ATP-BINDING PROTEIN
(Pyrococcus
horikoshii) 		4 / 6 VAL A 313
LEU A 251
ILE A 336
ALA A 340
 None
 0.76A 4zf8A-2d62A:
undetectable		 4zf8A-2d62A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_1
(CYP51 VARIANT1)		 2d62 MULTIPLE
SUGAR-BINDING
TRANSPORT
ATP-BINDING PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 GLY A 291
LEU A 331
PHE A 342
THR A 303
PHE A 266
 None
 1.23A 5fsaB-2d62A:
undetectable		 5fsaB-2d62A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUM_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 2d62 MULTIPLE
SUGAR-BINDING
TRANSPORT
ATP-BINDING PROTEIN
(Pyrococcus
horikoshii) 		5 / 8 VAL A  86
ILE A  52
LEU A 165
ILE A 197
ILE A  29
 None
 1.38A 5numA-2d62A:
undetectable		 5numA-2d62A:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_D_HISD402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 2d62 MULTIPLE
SUGAR-BINDING
TRANSPORT
ATP-BINDING PROTEIN
(Pyrococcus
horikoshii) 		4 / 8 GLY A 154
VAL A 194
VAL A  89
LEU A 192
 None
 0.60A 6czmD-2d62A:
undetectable
6czmF-2d62A:
undetectable		 6czmD-2d62A:
22.66
6czmF-2d62A:
22.66