SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2d6f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZF_A_TMQA170_1
(DIHYDROFOLATE
REDUCTASE)		 2d6f GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT E
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 ALA C 300
LEU C 355
LEU C 342
PHE C 337
ALA C 371
 None
 1.08A 1bzfA-2d6fC:
undetectable		 1bzfA-2d6fC:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_2
(PROTEIN (HIV-1
PROTEASE))		 2d6f GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT E
(Methanothermobac
ter
thermautotrophic
us) 		4 / 8 LEU C  18
GLY C 205
ILE C 204
VAL C 213
 None
 0.72A 1d4sB-2d6fC:
undetectable		 1d4sB-2d6fC:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 2d6f GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 ILE A 143
VAL A 140
ALA A 159
ILE A  96
ILE A  95
 None
 1.01A 1epbA-2d6fA:
undetectable		 1epbA-2d6fA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_A_DVAA8_0
(MINI-GRAMICIDIN A)		 2d6f GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D
(Methanothermobac
ter
thermautotrophic
us) 		4 / 5 VAL A 394
TRP A 401
TRP A 153
ALA A 395
 None
 1.35A 1kqeA-2d6fA:
undetectable
1kqeE-2d6fA:
undetectable		 1kqeA-2d6fA:
2.27
1kqeE-2d6fA:
2.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_B_ADNB1246_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2d6f GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT E
(Methanothermobac
ter
thermautotrophic
us) 		4 / 8 ARG C 400
GLY C 321
GLU C 398
ILE C 310
 None
 0.90A 1pk7B-2d6fC:
undetectable		 1pk7B-2d6fC:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 2d6f GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT E
(Methanothermobac
ter
thermautotrophic
us) 		3 / 3 ILE C 207
ILE C 204
THR C 211
 None
 0.64A 1rg7A-2d6fC:
undetectable		 1rg7A-2d6fC:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U70_A_MTXA187_2
(DIHYDROFOLATE
REDUCTASE)		 2d6f GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D
(Methanothermobac
ter
thermautotrophic
us) 		4 / 4 SER A  94
ILE A  95
VAL A 198
THR A 183
 None
 1.15A 1u70A-2d6fA:
undetectable		 1u70A-2d6fA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_Q_TRPQ81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2d6f GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D
(Methanothermobac
ter
thermautotrophic
us) 		5 / 10 HIS A 175
ALA A 159
THR A  98
ILE A  96
THR A 183
 None
 1.26A 1utdQ-2d6fA:
undetectable
1utdR-2d6fA:
undetectable		 1utdQ-2d6fA:
12.81
1utdR-2d6fA:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_A_SAMA201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 2d6f GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 SER A 206
GLY A  99
ALA A 174
GLY A 201
ALA A 202
 None
 0.85A 2nyuA-2d6fA:
undetectable		 2nyuA-2d6fA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2d6f GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D
(Methanothermobac
ter
thermautotrophic
us) 		3 / 3 LEU A 269
PRO A 270
LEU A 282
 None
 0.63A 2po5B-2d6fA:
5.5		 2po5B-2d6fA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 2d6f GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D
(Methanothermobac
ter
thermautotrophic
us) 		3 / 3 ASP A 298
THR A 193
PRO A 194
 None
 0.66A 2pynB-2d6fA:
undetectable		 2pynB-2d6fA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q2H_B_ACTB501_0
(SECRETION CHAPERONE,
PHAGE-DISPLAY
DERIVED PEPTIDE)		 2d6f GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D
GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT E
(Methanothermobac
ter
thermautotrophic
us;
Methanothermobac
ter
thermautotrophic
us) 		3 / 3 ARG C  43
SER A 210
TYR C  71
 None
 0.85A 2q2hA-2d6fC:
undetectable
2q2hB-2d6fC:
undetectable		 2q2hA-2d6fC:
12.50
2q2hB-2d6fC:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_4
(PROTEASE RETROPEPSIN)		 2d6f GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D
(Methanothermobac
ter
thermautotrophic
us) 		3 / 3 ASP A 298
THR A 193
PRO A 194
 None
 0.66A 2q64B-2d6fA:
undetectable		 2q64B-2d6fA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 2d6f GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D
(Methanothermobac
ter
thermautotrophic
us) 		3 / 3 ASP A 298
THR A 193
PRO A 194
 None
 0.62A 2qakB-2d6fA:
undetectable		 2qakB-2d6fA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEO_A_LNRA200_1
(D7R4 PROTEIN)		 2d6f GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D
GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT E
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 ARG A 208
ILE A 106
TYR A 108
GLU C 423
ASP C  84
 None
 1.28A 2qeoA-2d6fA:
undetectable		 2qeoA-2d6fA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UYQ_A_SAMA1311_0
(HYPOTHETICAL PROTEIN
ML2640)		 2d6f GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT E
(Methanothermobac
ter
thermautotrophic
us) 		5 / 7 GLY C 129
VAL C 121
ASP C 159
LEU C 178
ARG C 177
 None
 1.42A 2uyqA-2d6fC:
undetectable		 2uyqA-2d6fC:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1359_1
(PROSTAGLANDIN
REDUCTASE 2)		 2d6f GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT E
(Methanothermobac
ter
thermautotrophic
us) 		4 / 6 THR C 167
GLU C 166
PHE C 173
ILE C 164
 None
 1.27A 2w98B-2d6fC:
undetectable		 2w98B-2d6fC:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		 2d6f GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D
(Methanothermobac
ter
thermautotrophic
us) 		3 / 3 SER A 184
THR A 156
PHE A 117
 None
 0.74A 2x91A-2d6fA:
undetectable		 2x91A-2d6fA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CWK_A_REAA300_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 2d6f GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT E
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 PHE C 306
LEU C 266
ALA C 391
ALA C 388
GLU C 274
 None
 1.24A 3cwkA-2d6fC:
undetectable		 3cwkA-2d6fC:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DYE_A_LNRA600_1
(D7 PROTEIN)		 2d6f GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT E
(Methanothermobac
ter
thermautotrophic
us) 		5 / 9 GLU C 323
ILE C 314
ARG C 255
GLU C 398
VAL C 234
 None
 1.24A 3dyeA-2d6fC:
0.0		 3dyeA-2d6fC:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_A_BCZA468_1
(NEURAMINIDASE)		 2d6f GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D
(Methanothermobac
ter
thermautotrophic
us) 		3 / 3 ASP A 388
ARG A 367
ARG A 413
 None
 1.01A 3k37A-2d6fA:
undetectable		 3k37A-2d6fA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_D_30BD500_1
(GENOME POLYPROTEIN)		 2d6f GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT E
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 GLN C 120
GLY C 128
ALA C 160
ALA C 161
ASP C 159
 None
 0.93A 3keeD-2d6fC:
undetectable		 3keeD-2d6fC:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_2
(PROTEASE)		 2d6f GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D
(Methanothermobac
ter
thermautotrophic
us) 		4 / 6 ILE A 347
ASP A 407
GLY A 354
VAL A 304
 None
 0.95A 3n3iA-2d6fA:
undetectable		 3n3iA-2d6fA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 2d6f GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT E
(Methanothermobac
ter
thermautotrophic
us) 		3 / 3 LYS C 237
ARG C 412
ASP C 159
 None
 1.35A 3o7wA-2d6fC:
undetectable		 3o7wA-2d6fC:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P73_A_ACTA275_0
(MHC RFP-Y CLASS I
ALPHA CHAIN)		 2d6f GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D
(Methanothermobac
ter
thermautotrophic
us) 		3 / 3 ILE A  96
VAL A 140
ARG A 138
 None
 0.76A 3p73A-2d6fA:
undetectable		 3p73A-2d6fA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UY4_A_PAUA302_0
(PANTOTHENATE
SYNTHETASE)		 2d6f GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D
(Methanothermobac
ter
thermautotrophic
us) 		4 / 8 ARG A 138
VAL A 171
VAL A 197
ASP A 166
 None
 0.88A 3uy4A-2d6fA:
undetectable		 3uy4A-2d6fA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2d6f GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT E
(Methanothermobac
ter
thermautotrophic
us) 		3 / 3 ARG C 165
GLU C 166
THR C 167
 None
 0.80A 3v4tA-2d6fC:
undetectable		 3v4tA-2d6fC:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2d6f GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT E
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 VAL C 200
ILE C 245
VAL C 239
ILE C 226
LEU C   8
 None
 1.21A 3w67D-2d6fC:
undetectable		 3w67D-2d6fC:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA802_1
(CATALASE-PEROXIDASE)		 2d6f GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D
(Methanothermobac
ter
thermautotrophic
us) 		4 / 8 LEU A 122
ILE A 217
ASN A 216
GLY A 201
 None
 0.89A 3wxoA-2d6fA:
undetectable		 3wxoA-2d6fA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_1
(METHYLTRANSFERASE
NSUN4)		 2d6f GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT E
(Methanothermobac
ter
thermautotrophic
us) 		3 / 3 ASP C 176
ARG C 174
ASP C 159
 None
 0.76A 4fp9A-2d6fC:
undetectable		 4fp9A-2d6fC:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2d6f GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT E
(Methanothermobac
ter
thermautotrophic
us) 		5 / 10 LEU C 106
LEU C 154
ILE C 204
THR C 133
VAL C 213
 None
 1.23A 4mk4A-2d6fC:
undetectable		 4mk4A-2d6fC:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 2d6f GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 ALA A 350
GLY A 348
THR A 342
GLY A 383
VAL A 384
 None
 0.77A 4o33A-2d6fA:
2.9		 4o33A-2d6fA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 2d6f GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 GLY A 348
THR A 342
LEU A 379
GLY A 383
VAL A 384
 None
 0.78A 4o33A-2d6fA:
2.9		 4o33A-2d6fA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 2d6f GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D
(Methanothermobac
ter
thermautotrophic
us) 		6 / 12 ALA A 350
GLY A 348
THR A 342
LEU A 379
GLY A 383
VAL A 384
 None
 0.70A 4o3fA-2d6fA:
2.9		 4o3fA-2d6fA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YBN_A_ACTA303_0
(FLAVIN-NUCLEOTIDE-BI
NDING PROTEIN)		 2d6f GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D
(Methanothermobac
ter
thermautotrophic
us) 		3 / 3 VAL A 397
TYR A 182
ALA A 185
 None
 0.55A 4ybnA-2d6fA:
0.0		 4ybnA-2d6fA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_A_AZMA303_1
(ALPHA-CARBONIC
ANHYDRASE)		 2d6f GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D
(Methanothermobac
ter
thermautotrophic
us) 		5 / 11 HIS A 175
VAL A 173
LEU A 187
THR A 183
ALA A 186
 None
 1.44A 4ygfA-2d6fA:
undetectable		 4ygfA-2d6fA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_C_AZMC303_1
(ALPHA-CARBONIC
ANHYDRASE)		 2d6f GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D
(Methanothermobac
ter
thermautotrophic
us) 		5 / 11 HIS A 175
VAL A 173
LEU A 187
THR A 183
ALA A 186
 None
 1.44A 4ygfC-2d6fA:
undetectable		 4ygfC-2d6fA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_G_AZMG303_1
(ALPHA-CARBONIC
ANHYDRASE)		 2d6f GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 HIS A 175
VAL A 173
LEU A 187
THR A 183
ALA A 186
 None
 1.47A 4ygfG-2d6fA:
undetectable		 4ygfG-2d6fA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_A_SAMA601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 2d6f GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT E
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 GLU C 250
LEU C 197
GLN C 195
VAL C 239
VAL C 236
 None
 1.15A 5dpdA-2d6fC:
undetectable		 5dpdA-2d6fC:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 2d6f GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 ILE A 331
LEU A 343
SER A 374
GLY A 337
GLY A 333
 None
 1.07A 5l6eA-2d6fA:
undetectable		 5l6eA-2d6fA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_C_SAMC501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 2d6f GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT E
(Methanothermobac
ter
thermautotrophic
us) 		5 / 7 LEU C 464
GLY C 459
SER C 466
THR C 487
ALA C 491
 G  E 953 ( 4.4A)
None
None
None
None
 1.45A 5o96C-2d6fC:
undetectable		 5o96C-2d6fC:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGJ_A_ACTA307_0
(CARBONIC ANHYDRASE
13)		 2d6f GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D
(Methanothermobac
ter
thermautotrophic
us) 		4 / 6 HIS A 175
VAL A 173
LEU A 187
THR A 183
 None
 1.26A 5ogjA-2d6fA:
undetectable		 5ogjA-2d6fA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGJ_B_ACTB305_0
(CARBONIC ANHYDRASE
13)		 2d6f GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D
(Methanothermobac
ter
thermautotrophic
us) 		4 / 6 HIS A 175
VAL A 173
LEU A 187
THR A 183
 None
 1.25A 5ogjB-2d6fA:
undetectable		 5ogjB-2d6fA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OHH_A_ACTA307_0
(CARBONIC ANHYDRASE
13)		 2d6f GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D
(Methanothermobac
ter
thermautotrophic
us) 		4 / 5 HIS A 175
VAL A 173
LEU A 187
THR A 183
 None
 1.25A 5ohhA-2d6fA:
undetectable		 5ohhA-2d6fA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OHH_B_ACTB311_0
(CARBONIC ANHYDRASE
13)		 2d6f GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D
(Methanothermobac
ter
thermautotrophic
us) 		4 / 6 HIS A 175
VAL A 173
LEU A 187
THR A 183
 None
 1.26A 5ohhB-2d6fA:
undetectable		 5ohhB-2d6fA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T2Z_B_017B201_2
(PROTEASE)		 2d6f GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D
(Methanothermobac
ter
thermautotrophic
us) 		6 / 12 ALA A 168
ASP A  92
ASP A 169
VAL A 195
ILE A  96
ILE A 164
 None
 1.37A 5t2zB-2d6fA:
undetectable		 5t2zB-2d6fA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_E_EZLE303_1
(ALPHA-CARBONIC
ANHYDRASE)		 2d6f GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D
(Methanothermobac
ter
thermautotrophic
us) 		5 / 9 HIS A 175
VAL A 173
LEU A 187
THR A 183
ALA A 186
 None
 1.48A 5tt3E-2d6fA:
undetectable		 5tt3E-2d6fA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_G_EZLG303_1
(ALPHA-CARBONIC
ANHYDRASE)		 2d6f GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D
(Methanothermobac
ter
thermautotrophic
us) 		5 / 9 HIS A 175
VAL A 173
LEU A 187
THR A 183
ALA A 186
 None
 1.50A 5tt3G-2d6fA:
undetectable		 5tt3G-2d6fA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U6M_B_SALB503_1
(UDP-GLYCOSYLTRANSFER
ASE 74F2)		 2d6f GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D
(Methanothermobac
ter
thermautotrophic
us) 		4 / 7 THR A 179
PHE A 199
MET A 148
THR A 156
 None
 1.19A 5u6mB-2d6fA:
3.2		 5u6mB-2d6fA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA613_1
(SERUM ALBUMIN)		 2d6f GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT E
(Methanothermobac
ter
thermautotrophic
us) 		4 / 8 ALA C 371
VAL C 370
THR C 376
GLY C 335
 None
 0.99A 5v0vA-2d6fC:
undetectable		 5v0vA-2d6fC:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_G_CHDG401_0
(BILE SALT HYDROLASE)		 2d6f GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT E
(Methanothermobac
ter
thermautotrophic
us) 		5 / 10 LEU C 142
ILE C  14
ASN C 107
LEU C 208
GLU C 143
 None
 1.00A 5y7pG-2d6fC:
undetectable		 5y7pG-2d6fC:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_G_CHDG401_0
(BILE SALT HYDROLASE)		 2d6f GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT E
(Methanothermobac
ter
thermautotrophic
us) 		5 / 10 LEU C 142
ILE C 185
LEU C 208
LEU C 443
GLU C 143
 None
 1.22A 5y7pG-2d6fC:
undetectable		 5y7pG-2d6fC:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 2d6f GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D
GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT E
(Methanothermobac
ter
thermautotrophic
us;
Methanothermobac
ter
thermautotrophic
us) 		3 / 3 ASP A 241
ARG C  43
ASP A 261
 None
 0.87A 5zvgA-2d6fA:
undetectable		 5zvgA-2d6fA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 2d6f GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D
GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT E
(Methanothermobac
ter
thermautotrophic
us;
Methanothermobac
ter
thermautotrophic
us) 		3 / 3 ASP A 241
ARG C  43
ASP A 261
 None
 0.83A 5zvgB-2d6fA:
undetectable		 5zvgB-2d6fA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_0
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 2d6f GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT E
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 PRO C 396
ALA C 271
ALA C 391
ALA C 388
PHE C 306
 None
 0.98A 5zw4A-2d6fC:
undetectable		 5zw4A-2d6fC:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)		 2d6f GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D
(Methanothermobac
ter
thermautotrophic
us) 		5 / 9 ALA A 174
GLY A 176
ALA A 213
GLY A 201
SER A 206
 None
 1.06A 6bklE-2d6fA:
undetectable
6bklF-2d6fA:
undetectable
6bklG-2d6fA:
undetectable
6bklH-2d6fA:
undetectable		 6bklE-2d6fA:
5.79
6bklF-2d6fA:
5.79
6bklG-2d6fA:
5.79
6bklH-2d6fA:
5.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_1
(RIFAMPIN
MONOOXYGENASE)		 2d6f GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT E
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 GLY C 170
VAL C 171
THR C 127
GLY C 128
GLY C 129
 None
 1.05A 6brdB-2d6fC:
0.9		 6brdB-2d6fC:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA204_0
(N-ACETYLTRANSFERASE)		 2d6f GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D
(Methanothermobac
ter
thermautotrophic
us) 		4 / 5 LEU A 246
THR A 232
CYH A 234
THR A 200
 None
 1.04A 6gtqA-2d6fA:
undetectable		 6gtqA-2d6fA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_A_BEZA701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 2d6f GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT E
(Methanothermobac
ter
thermautotrophic
us) 		5 / 11 GLY C 134
LEU C  24
ALA C  95
PHE C 114
ALA C  99
 None
 1.26A 6qgbA-2d6fC:
undetectable		 6qgbA-2d6fC:
22.04