SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2d6y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 2d6y PUTATIVE TETR FAMILY
REGULATORY PROTEIN
(Streptomyces
coelicolor) 		4 / 8 LEU A  55
GLY A  53
PHE A  56
TYR A  46
 None
 0.83A 2tsrB-2d6yA:
undetectable		 2tsrB-2d6yA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_D_ADND301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 2d6y PUTATIVE TETR FAMILY
REGULATORY PROTEIN
(Streptomyces
coelicolor) 		5 / 10 ALA A 127
GLY A 131
LEU A 150
ASP A  76
ILE A  78
 None
 1.14A 3wdmD-2d6yA:
undetectable		 3wdmD-2d6yA:
26.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 2d6y PUTATIVE TETR FAMILY
REGULATORY PROTEIN
(Streptomyces
coelicolor) 		4 / 8 LEU A  55
GLY A  53
PHE A  56
TYR A  46
 None
 0.89A 4iqqD-2d6yA:
undetectable		 4iqqD-2d6yA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 2d6y PUTATIVE TETR FAMILY
REGULATORY PROTEIN
(Streptomyces
coelicolor) 		4 / 6 LEU A  55
GLY A  53
PHE A  56
TYR A  46
 None
 0.98A 5nooC-2d6yA:
undetectable		 5nooC-2d6yA:
21.50