SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2d7d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_A_SAMA200_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 2d7d UVRABC SYSTEM
PROTEIN B
(Bacillus
subtilis) 		5 / 11 GLU A 566
ARG A 569
GLU A 409
ALA A  40
LEU A  38
 None
 1.34A 1mjlA-2d7dA:
undetectable
1mjlB-2d7dA:
undetectable		 1mjlA-2d7dA:
10.69
1mjlB-2d7dA:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_B_URFB999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 2d7d UVRABC SYSTEM
PROTEIN B
(Bacillus
subtilis) 		5 / 7 ALA A  70
TYR A  74
ILE A 139
ILE A 138
PHE A  89
 None
 1.31A 1upfB-2d7dA:
2.9		 1upfB-2d7dA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 2d7d UVRABC SYSTEM
PROTEIN B
(Bacillus
subtilis) 		4 / 7 ILE A 442
LEU A 520
ILE A 427
ASP A 433
 None
 0.83A 1uwjA-2d7dA:
undetectable		 1uwjA-2d7dA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 2d7d UVRABC SYSTEM
PROTEIN B
(Bacillus
subtilis) 		3 / 3 PHE A 351
ARG A 367
ASN A 374
 None
 0.90A 1xzxX-2d7dA:
undetectable		 1xzxX-2d7dA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1502_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 2d7d UVRABC SYSTEM
PROTEIN B
(Bacillus
subtilis) 		4 / 5 PRO A 376
GLY A 353
ASN A 352
GLY A 349
 None
 0.96A 1zlqA-2d7dA:
0.6		 1zlqA-2d7dA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_B_EV1B1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 2d7d UVRABC SYSTEM
PROTEIN B
(Bacillus
subtilis) 		4 / 8 LEU A 176
VAL A 241
ILE A 221
PHE A 216
 None
 0.79A 2weyB-2d7dA:
2.4		 2weyB-2d7dA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 2d7d UVRABC SYSTEM
PROTEIN B
(Bacillus
subtilis) 		4 / 4 TYR A 328
LEU A 326
LEU A 325
HIS A 248
 None
 1.24A 2x7hB-2d7dA:
2.9		 2x7hB-2d7dA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 2d7d UVRABC SYSTEM
PROTEIN B
(Bacillus
subtilis) 		3 / 3 ARG A 183
ASP A 198
ASN A 170
 None
 0.89A 2zzmA-2d7dA:
3.8		 2zzmA-2d7dA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CV9_A_VDXA501_1
(CYTOCHROME P450-SU1)		 2d7d UVRABC SYSTEM
PROTEIN B
(Bacillus
subtilis) 		5 / 9 THR A 537
VAL A 514
ARG A 447
ILE A 438
ILE A 519
 None
 1.20A 3cv9A-2d7dA:
undetectable		 3cv9A-2d7dA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 2d7d UVRABC SYSTEM
PROTEIN B
(Bacillus
subtilis) 		3 / 3 SER A 128
GLU A 226
ASP A 228
 None
 0.82A 3dmhA-2d7dA:
5.2		 3dmhA-2d7dA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL9_A_DR7A100_1
(PROTEASE)		 2d7d UVRABC SYSTEM
PROTEIN B
(Bacillus
subtilis) 		4 / 8 ALA A 371
GLY A 305
ILE A 306
THR A 290
 None
 0.84A 3el9A-2d7dA:
undetectable		 3el9A-2d7dA:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_A_LEIA16_0
(COIL SER L16D-PEN)		 2d7d UVRABC SYSTEM
PROTEIN B
(Bacillus
subtilis) 		4 / 6 GLN A 288
LEU A 286
GLU A 287
LEU A 271
 None
 0.87A 3h5gA-2d7dA:
undetectable
3h5gC-2d7dA:
undetectable		 3h5gA-2d7dA:
4.29
3h5gC-2d7dA:
4.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_A_BCZA468_1
(NEURAMINIDASE)		 2d7d UVRABC SYSTEM
PROTEIN B
(Bacillus
subtilis) 		3 / 3 ASP A 373
ARG A 311
ARG A 378
 None
 0.96A 3k37A-2d7dA:
undetectable		 3k37A-2d7dA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_1
(ENDOTHIAPEPSIN)		 2d7d UVRABC SYSTEM
PROTEIN B
(Bacillus
subtilis) 		5 / 10 ILE A 138
ALA A 126
LEU A 148
THR A 314
ILE A 179
 None
 1.07A 3prsA-2d7dA:
undetectable		 3prsA-2d7dA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA1_1
(CYTOCHROME P450 2D6)		 2d7d UVRABC SYSTEM
PROTEIN B
(Bacillus
subtilis) 		5 / 12 LEU A 528
PHE A 527
GLY A 501
LEU A 475
SER A 477
 None
 1.21A 3tbgA-2d7dA:
undetectable		 3tbgA-2d7dA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC1_1
(CYTOCHROME P450 2D6)		 2d7d UVRABC SYSTEM
PROTEIN B
(Bacillus
subtilis) 		5 / 12 LEU A 528
PHE A 527
GLY A 501
LEU A 475
SER A 477
 None
 1.18A 3tbgC-2d7dA:
undetectable		 3tbgC-2d7dA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		 2d7d UVRABC SYSTEM
PROTEIN B
(Bacillus
subtilis) 		4 / 8 ILE A 335
PHE A 333
GLU A 381
VAL A 347
 None
 0.73A 3ua5A-2d7dA:
undetectable		 3ua5A-2d7dA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_C_ACTC502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2d7d UVRABC SYSTEM
PROTEIN B
(Bacillus
subtilis) 		3 / 3 PRO A 426
ASP A 554
GLU A 428
 None
 0.88A 3v4tC-2d7dA:
1.7		 3v4tC-2d7dA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2d7d UVRABC SYSTEM
PROTEIN B
(Bacillus
subtilis) 		4 / 6 LEU A  61
PHE A 329
LEU A 325
PHE A  89
 None
 1.01A 3wg7P-2d7dA:
undetectable
3wg7W-2d7dA:
undetectable		 3wg7P-2d7dA:
15.51
3wg7W-2d7dA:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUB_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 2d7d UVRABC SYSTEM
PROTEIN B
(Bacillus
subtilis) 		3 / 3 TYR A  92
ARG A 190
HIS A 124
 None
 1.17A 4fubA-2d7dA:
undetectable		 4fubA-2d7dA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K39_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 2d7d UVRABC SYSTEM
PROTEIN B
(Bacillus
subtilis) 		5 / 12 PHE A 379
ASN A 388
LEU A  61
VAL A 337
ILE A  63
 None
 1.38A 4k39A-2d7dA:
undetectable		 4k39A-2d7dA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR4_C_AICC401_1
(OUTER MEMBRANE
PROTEIN F)		 2d7d UVRABC SYSTEM
PROTEIN B
(Bacillus
subtilis) 		4 / 8 ARG A 570
ASP A 510
GLU A 339
ARG A 413
 None
 1.39A 4kr4C-2d7dA:
undetectable		 4kr4C-2d7dA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2d7d UVRABC SYSTEM
PROTEIN B
(Bacillus
subtilis) 		6 / 9 THR A 557
ALA A 563
ILE A 538
VAL A 549
ALA A 522
ILE A 519
 None
 1.35A 4lbgB-2d7dA:
undetectable		 4lbgB-2d7dA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_B_RTLB201_0
(RETINOL-BINDING
PROTEIN 2)		 2d7d UVRABC SYSTEM
PROTEIN B
(Bacillus
subtilis) 		5 / 12 ILE A 511
THR A 462
ARG A 447
LEU A 491
LEU A 504
 None
 1.21A 4qynB-2d7dA:
undetectable		 4qynB-2d7dA:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 2d7d UVRABC SYSTEM
PROTEIN B
(Bacillus
subtilis) 		5 / 12 ILE A 511
THR A 462
ARG A 447
LEU A 491
LEU A 504
 None
 1.19A 4qzuA-2d7dA:
2.8		 4qzuA-2d7dA:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1344_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2d7d UVRABC SYSTEM
PROTEIN B
(Bacillus
subtilis) 		4 / 5 GLU A 118
LYS A 121
ASP A 208
HIS A 210
 None
 1.37A 5a06A-2d7dA:
0.7		 5a06A-2d7dA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FQD_E_LVYE1438_1
(PROTEIN CEREBLON
CASEIN KINASE I
ISOFORM ALPHA)		 2d7d UVRABC SYSTEM
PROTEIN B
(Bacillus
subtilis) 		5 / 12 GLU A 531
SER A 533
PHE A 527
ILE A 401
GLY A 397
 None
 1.12A 5fqdE-2d7dA:
0.0
5fqdF-2d7dA:
0.0		 5fqdE-2d7dA:
21.26
5fqdF-2d7dA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9Y_A_1N1A1001_2
(EPHRIN TYPE-A
RECEPTOR 2)		 2d7d UVRABC SYSTEM
PROTEIN B
(Bacillus
subtilis) 		3 / 3 ILE A 431
ILE A 468
MET A 457
 None
 0.64A 5i9yA-2d7dA:
undetectable		 5i9yA-2d7dA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_B_ACTB401_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT
N6-ADENOSINE-METHYLT
RANSFERASE SUBUNIT
METTL14)		 2d7d UVRABC SYSTEM
PROTEIN B
(Bacillus
subtilis) 		4 / 6 GLU A 513
LEU A 493
ARG A 447
ARG A 492
 None
 1.24A 5l6eA-2d7dA:
undetectable
5l6eB-2d7dA:
undetectable		 5l6eA-2d7dA:
15.77
5l6eB-2d7dA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_B_6V8B304_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		 2d7d UVRABC SYSTEM
PROTEIN B
(Bacillus
subtilis) 		5 / 12 TYR A 552
THR A 451
ALA A 518
SER A 530
ALA A 522
 None
 1.19A 5lf7V-2d7dA:
undetectable
5lf7b-2d7dA:
undetectable		 5lf7V-2d7dA:
17.83
5lf7b-2d7dA:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_N_6V8N305_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		 2d7d UVRABC SYSTEM
PROTEIN B
(Bacillus
subtilis) 		5 / 12 TYR A 552
THR A 451
ALA A 518
SER A 530
ALA A 522
 None
 1.20A 5lf7H-2d7dA:
undetectable
5lf7N-2d7dA:
undetectable		 5lf7H-2d7dA:
17.83
5lf7N-2d7dA:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_C_SAMC501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 2d7d UVRABC SYSTEM
PROTEIN B
(Bacillus
subtilis) 		4 / 7 GLY A 349
GLY A 353
SER A 143
LEU A 377
 None
 0.73A 5o96C-2d7dA:
undetectable		 5o96C-2d7dA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2d7d UVRABC SYSTEM
PROTEIN B
(Bacillus
subtilis) 		5 / 12 GLY A 429
VAL A 448
LEU A 516
GLY A 436
ILE A 435
 None
 1.11A 5vooE-2d7dA:
3.1		 5vooE-2d7dA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_F_C2FF3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2d7d UVRABC SYSTEM
PROTEIN B
(Bacillus
subtilis) 		5 / 12 GLY A 429
VAL A 448
LEU A 516
GLY A 436
ILE A 435
 None
 1.14A 5vooF-2d7dA:
2.0		 5vooF-2d7dA:
19.91