SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2d7i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_2
(BETA-LACTAMASE
CTX-M-9)		 2d7i POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 10
(Homo
sapiens) 		4 / 5 CYH A 263
PRO A 364
THR A 147
THR A 234
 None
 1.39A 1ymxB-2d7iA:
undetectable		 1ymxB-2d7iA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_A_THRA401_0
(ASPARTOKINASE)		 2d7i POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 10
(Homo
sapiens) 		4 / 8 GLY A 343
GLU A 345
THR A 220
ILE A 341
 NGA  A 702 (-3.4A)
NGA  A 702 (-2.9A)
UDP  A 705 ( 3.9A)
UDP  A 705 (-4.3A)
 0.86A 2dtjA-2d7iA:
undetectable
2dtjB-2d7iA:
undetectable		 2dtjA-2d7iA:
16.13
2dtjB-2d7iA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		 2d7i POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 10
(Homo
sapiens) 		3 / 3 LEU A 555
LEU A 485
PHE A 589
 None
 0.59A 2pgrA-2d7iA:
undetectable		 2pgrA-2d7iA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_A_BEZA1222_0
(PEROXIREDOXIN 6)		 2d7i POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 10
(Homo
sapiens) 		4 / 8 PRO A 558
VAL A 559
SER A 560
ALA A 526
 None
 0.71A 2v32A-2d7iA:
2.2
2v32B-2d7iA:
2.3		 2v32A-2d7iA:
18.00
2v32B-2d7iA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_B_BEZB1220_0
(PEROXIREDOXIN 6)		 2d7i POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 10
(Homo
sapiens) 		4 / 8 PRO A 558
VAL A 559
SER A 560
ALA A 526
 None
 0.76A 2v32A-2d7iA:
2.2
2v32B-2d7iA:
2.2		 2v32A-2d7iA:
18.00
2v32B-2d7iA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_G_BEZG1222_0
(PEROXIREDOXIN 6.)		 2d7i POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 10
(Homo
sapiens) 		4 / 8 PRO A 558
VAL A 559
SER A 560
ALA A 526
 None
 0.74A 2v41G-2d7iA:
2.2
2v41H-2d7iA:
2.3		 2v41G-2d7iA:
18.00
2v41H-2d7iA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKK_E_MFXE1100_1
(TOPOISOMERASE IV
DNA)		 2d7i POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 10
(Homo
sapiens) 		3 / 3 ARG A 221
GLU A 340
SER A 238
 NGA  A 702 (-3.6A)
None
UDP  A 705 (-2.8A)
 0.94A 2xkkA-2d7iA:
1.7
2xkkC-2d7iA:
undetectable		 2xkkA-2d7iA:
20.46
2xkkC-2d7iA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_B_VDYB6178_1
(VITAMIN D
HYDROXYLASE)		 2d7i POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 10
(Homo
sapiens) 		5 / 12 THR A 164
ILE A 149
VAL A 262
PRO A 264
LEU A 250
 None
 1.41A 3a51B-2d7iA:
undetectable		 3a51B-2d7iA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_1
(HIV-1 PROTEASE)		 2d7i POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 10
(Homo
sapiens) 		5 / 12 GLY A 319
ALA A 318
VAL A 262
VAL A 368
ILE A 266
 NGA  A 702 (-3.7A)
NGA  A 702 (-3.0A)
None
None
NGA  A 702 ( 4.6A)
 0.98A 3cyxA-2d7iA:
undetectable		 3cyxA-2d7iA:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB303_0
(DISULFIDE
INTERCHANGE PROTEIN)		 2d7i POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 10
(Homo
sapiens) 		4 / 4 LEU A 247
ALA A 323
VAL A 262
PRO A 264
 None
 1.00A 3gv1B-2d7iA:
undetectable		 3gv1B-2d7iA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 2d7i POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 10
(Homo
sapiens) 		3 / 3 ARG A 189
ASP A 184
ASP A 188
 None
 0.93A 3jb2A-2d7iA:
2.1		 3jb2A-2d7iA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 2d7i POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 10
(Homo
sapiens) 		3 / 3 ARG A 189
ASP A 184
ASP A 188
 None
 0.94A 3jb3A-2d7iA:
undetectable		 3jb3A-2d7iA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OEZ_A_STIA601_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2d7i POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 10
(Homo
sapiens) 		4 / 5 LYS A 352
ILE A 349
MET A 439
ARG A 388
 None
 1.43A 3oezA-2d7iA:
undetectable		 3oezA-2d7iA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_B_478B200_1
(HIV-1 PROTEASE)		 2d7i POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 10
(Homo
sapiens) 		5 / 9 GLY A 319
ALA A 318
VAL A 262
VAL A 368
ILE A 266
 NGA  A 702 (-3.7A)
NGA  A 702 (-3.0A)
None
None
NGA  A 702 ( 4.6A)
 0.90A 3oxvA-2d7iA:
undetectable		 3oxvA-2d7iA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_C_DR7C100_1
(HIV-1 PROTEASE)		 2d7i POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 10
(Homo
sapiens) 		5 / 12 GLY A 319
ALA A 318
VAL A 262
VAL A 368
ILE A 266
 NGA  A 702 (-3.7A)
NGA  A 702 (-3.0A)
None
None
NGA  A 702 ( 4.6A)
 1.00A 3oxxC-2d7iA:
undetectable		 3oxxC-2d7iA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT7_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 2d7i POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 10
(Homo
sapiens) 		5 / 12 TYR A 276
VAL A 168
SER A 167
ARG A 171
LEU A 251
 None
 1.40A 3vt7A-2d7iA:
undetectable		 3vt7A-2d7iA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_C_ACTC1113_0
(BLR5658 PROTEIN)		 2d7i POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 10
(Homo
sapiens) 		4 / 4 ASN A 146
ALA A 178
GLY A 230
THR A 229
 NAG  A 704 (-2.3A)
NAG  A 704 (-3.3A)
NAG  A 704 ( 4.9A)
NAG  A 704 ( 4.8A)
 1.05A 4bboC-2d7iA:
undetectable		 4bboC-2d7iA:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_A_CLQA303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2d7i POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 10
(Homo
sapiens) 		5 / 12 GLY A 112
TYR A 375
GLU A 156
ILE A 371
ILE A 115
 None
None
UDP  A 705 (-3.6A)
None
None
 1.18A 4fglA-2d7iA:
undetectable
4fglB-2d7iA:
undetectable		 4fglA-2d7iA:
16.19
4fglB-2d7iA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_A_SUZA201_1
(TRANSTHYRETIN)		 2d7i POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 10
(Homo
sapiens) 		4 / 7 LEU A 250
LEU A 247
SER A 172
SER A 167
 None
 1.12A 4iklA-2d7iA:
undetectable
4iklB-2d7iA:
undetectable		 4iklA-2d7iA:
12.48
4iklB-2d7iA:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVO_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2d7i POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 10
(Homo
sapiens) 		3 / 3 ARG A 285
VAL A 316
TRP A 354
 None
 1.26A 5fvoA-2d7iA:
undetectable		 5fvoA-2d7iA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_B_9SCB601_0
(SERUM ALBUMIN)		 2d7i POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 10
(Homo
sapiens) 		5 / 12 ILE A 349
VAL A 206
VAL A 324
ARG A 221
LEU A 182
 None
None
None
NGA  A 702 (-3.6A)
None
 1.17A 6a7pB-2d7iA:
undetectable		 6a7pB-2d7iA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWT_D_BEZD202_0
(PR 10 PROTEIN)		 2d7i POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 10
(Homo
sapiens) 		3 / 3 PHE A 449
ASP A 289
LYS A 295
 None
 0.88A 6awtD-2d7iA:
undetectable		 6awtD-2d7iA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 2d7i POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 10
(Homo
sapiens) 		5 / 12 ASN A 245
PRO A 173
VAL A 177
THR A 234
ILE A 149
 None
 1.43A 6j20A-2d7iA:
undetectable		 6j20A-2d7iA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 2d7i POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 10
(Homo
sapiens) 		3 / 3 ASN A 243
PRO A 128
GLN A  92
 None
 0.80A 6jnhA-2d7iA:
4.9		 6jnhA-2d7iA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 2d7i POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 10
(Homo
sapiens) 		3 / 3 ASN A 243
PRO A 128
GLN A  92
 None
 0.80A 6jogA-2d7iA:
5.0		 6jogA-2d7iA:
13.96