SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2d7s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_A_ADNA601_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 2d7s RNA-DEPENDENT RNA
POLYMERASE
(Foot-and-mouth
disease
virus) 		4 / 5 THR A 303
THR A 281
HIS A 283
HIS A 188
 None
 1.47A 1d4fA-2d7sA:
undetectable		 1d4fA-2d7sA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_D_ADND604_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 2d7s RNA-DEPENDENT RNA
POLYMERASE
(Foot-and-mouth
disease
virus) 		4 / 5 THR A 303
THR A 281
HIS A 283
HIS A 188
 None
 1.41A 1d4fD-2d7sA:
undetectable		 1d4fD-2d7sA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DIT_P_2PPP1_1
(ALPHA-THROMBIN
PEPTIDE INHIBITOR
CVS995)		 2d7s RNA-DEPENDENT RNA
POLYMERASE
(Foot-and-mouth
disease
virus) 		4 / 6 LEU A 386
ILE A 334
ASP A 222
PRO A 219
 None
 1.18A 1ditH-2d7sA:
undetectable
1ditP-2d7sA:
undetectable		 1ditH-2d7sA:
18.60
1ditP-2d7sA:
3.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GEB_A_CAMA418_0
(CYTOCHROME P450-CAM)		 2d7s RNA-DEPENDENT RNA
POLYMERASE
(Foot-and-mouth
disease
virus) 		5 / 9 TYR A 331
LEU A 319
ILE A 364
VAL A 239
ILE A 340
 None
 1.40A 1gebA-2d7sA:
undetectable		 1gebA-2d7sA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_A_D16A414_1
(THYMIDYLATE SYNTHASE)		 2d7s RNA-DEPENDENT RNA
POLYMERASE
(Foot-and-mouth
disease
virus) 		5 / 12 PHE A 226
ILE A 334
ASN A 311
ASP A 238
PHE A 230
 None
 1.16A 1hvyA-2d7sA:
undetectable		 1hvyA-2d7sA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA502_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2d7s RNA-DEPENDENT RNA
POLYMERASE
(Foot-and-mouth
disease
virus) 		4 / 6 ASN A 311
ASN A 312
ILE A 334
GLY A 212
 None
 0.97A 1oniA-2d7sA:
undetectable
1oniB-2d7sA:
undetectable		 1oniA-2d7sA:
14.98
1oniB-2d7sA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD508_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2d7s RNA-DEPENDENT RNA
POLYMERASE
(Foot-and-mouth
disease
virus) 		4 / 6 ASN A 311
ASN A 312
ILE A 334
GLY A 212
 None
 0.96A 1oniD-2d7sA:
undetectable
1oniF-2d7sA:
undetectable		 1oniD-2d7sA:
14.98
1oniF-2d7sA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2d7s RNA-DEPENDENT RNA
POLYMERASE
(Foot-and-mouth
disease
virus) 		5 / 12 THR A 308
SER A 335
PHE A 199
LEU A  89
VAL A  88
 None
 1.38A 1q23C-2d7sA:
undetectable		 1q23C-2d7sA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2d7s RNA-DEPENDENT RNA
POLYMERASE
(Foot-and-mouth
disease
virus) 		5 / 10 THR A 308
SER A 335
PHE A 199
LEU A  89
VAL A  88
 None
 1.41A 1q23E-2d7sA:
undetectable		 1q23E-2d7sA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2d7s RNA-DEPENDENT RNA
POLYMERASE
(Foot-and-mouth
disease
virus) 		5 / 11 THR A 308
SER A 335
PHE A 199
LEU A  89
VAL A  88
 None
 1.39A 1q23I-2d7sA:
undetectable		 1q23I-2d7sA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2d7s RNA-DEPENDENT RNA
POLYMERASE
(Foot-and-mouth
disease
virus) 		5 / 10 THR A 308
SER A 335
PHE A 199
LEU A  89
VAL A  88
 None
 1.39A 1q23K-2d7sA:
undetectable		 1q23K-2d7sA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2d7s RNA-DEPENDENT RNA
POLYMERASE
(Foot-and-mouth
disease
virus) 		5 / 9 PHE A 265
PHE A 199
PHE A 267
PHE A  74
LEU A  85
 None
 1.35A 1wrkA-2d7sA:
0.2
1wrkB-2d7sA:
undetectable		 1wrkA-2d7sA:
14.33
1wrkB-2d7sA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 2d7s RNA-DEPENDENT RNA
POLYMERASE
(Foot-and-mouth
disease
virus) 		4 / 6 PHE A 257
GLY A 295
GLY A 294
ASN A 280
 None
 0.87A 2qr2A-2d7sA:
undetectable
2qr2B-2d7sA:
undetectable		 2qr2A-2d7sA:
19.46
2qr2B-2d7sA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_A_MIYA2001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2d7s RNA-DEPENDENT RNA
POLYMERASE
(Foot-and-mouth
disease
virus) 		4 / 8 PHE A 199
GLY A 197
GLU A 100
ALA A 302
 None
 0.93A 3aodA-2d7sA:
1.8		 3aodA-2d7sA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_C_ADNC438_2
(ADENOSYLHOMOCYSTEINA
SE)		 2d7s RNA-DEPENDENT RNA
POLYMERASE
(Foot-and-mouth
disease
virus) 		4 / 5 THR A 303
THR A 281
HIS A 283
HIS A 188
 None
 1.46A 3g1uC-2d7sA:
undetectable		 3g1uC-2d7sA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL201_1
(PROTEIN S100-A4)		 2d7s RNA-DEPENDENT RNA
POLYMERASE
(Foot-and-mouth
disease
virus) 		4 / 7 GLY A 208
PHE A 265
PHE A 267
PHE A 199
 None
 1.09A 3ko0L-2d7sA:
undetectable
3ko0N-2d7sA:
undetectable		 3ko0L-2d7sA:
12.39
3ko0N-2d7sA:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS201_1
(PROTEIN S100-A4)		 2d7s RNA-DEPENDENT RNA
POLYMERASE
(Foot-and-mouth
disease
virus) 		4 / 7 PHE A 199
GLY A 208
PHE A 265
PHE A 267
 None
 1.10A 3ko0K-2d7sA:
undetectable
3ko0S-2d7sA:
undetectable		 3ko0K-2d7sA:
12.39
3ko0S-2d7sA:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NAI_B_URFB521_1
(RNA DEPENDENT RNA
POLYMERASE)		 2d7s RNA-DEPENDENT RNA
POLYMERASE
(Foot-and-mouth
disease
virus) 		4 / 4 ARG A 179
ASP A 240
ASP A 338
ASP A 339
 None
 0.90A 3naiB-2d7sA:
32.8		 3naiB-2d7sA:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_A_RBVA601_1
(RNA POLYMERASE)		 2d7s RNA-DEPENDENT RNA
POLYMERASE
(Foot-and-mouth
disease
virus) 		7 / 9 ASP A 245
SER A 298
ASN A 307
TYR A 336
GLY A 337
ASP A 338
ASP A 339
 None
 0.89A 3sfuA-2d7sA:
32.1		 3sfuA-2d7sA:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_B_RBVB601_1
(RNA POLYMERASE)		 2d7s RNA-DEPENDENT RNA
POLYMERASE
(Foot-and-mouth
disease
virus) 		7 / 9 ASP A 245
ASN A 307
TYR A 336
GLY A 337
ASP A 338
ASP A 339
LEU A 386
 None
 0.63A 3sfuB-2d7sA:
32.1		 3sfuB-2d7sA:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_B_RBVB601_1
(RNA POLYMERASE)		 2d7s RNA-DEPENDENT RNA
POLYMERASE
VPG1 PROTEIN
(Foot-and-mouth
disease
virus) 		5 / 9 THR A 308
ASN A 307
GLY A 337
LEU A 386
ARG B1011
 None
 1.14A 3sfuB-2d7sA:
32.1		 3sfuB-2d7sA:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		 2d7s RNA-DEPENDENT RNA
POLYMERASE
(Foot-and-mouth
disease
virus) 		5 / 11 ASP A 245
THR A 303
ASN A 307
GLY A 337
ASP A 338
 None
 0.92A 3sfuC-2d7sA:
32.2		 3sfuC-2d7sA:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		 2d7s RNA-DEPENDENT RNA
POLYMERASE
(Foot-and-mouth
disease
virus) 		6 / 11 LYS A 164
ARG A 179
ASP A 245
ASN A 307
GLY A 337
ASP A 338
 None
 0.80A 3sfuC-2d7sA:
32.2		 3sfuC-2d7sA:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		 2d7s RNA-DEPENDENT RNA
POLYMERASE
(Foot-and-mouth
disease
virus) 		5 / 11 LYS A 164
ASP A 245
THR A 303
ASN A 307
ASP A 338
 None
 1.39A 3sfuC-2d7sA:
32.2		 3sfuC-2d7sA:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_A_IL2A901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 2d7s RNA-DEPENDENT RNA
POLYMERASE
(Foot-and-mouth
disease
virus) 		5 / 12 LEU A  85
PHE A 257
THR A 192
HIS A 188
ILE A 189
 None
 1.28A 3sp9A-2d7sA:
undetectable		 3sp9A-2d7sA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_B_IL2B901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 2d7s RNA-DEPENDENT RNA
POLYMERASE
(Foot-and-mouth
disease
virus) 		5 / 12 LEU A  85
PHE A 257
THR A 192
HIS A 188
ILE A 189
 None
 1.27A 3sp9B-2d7sA:
undetectable		 3sp9B-2d7sA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 2d7s RNA-DEPENDENT RNA
POLYMERASE
(Foot-and-mouth
disease
virus) 		3 / 3 ASN A 247
PHE A 357
TYR A 317
 None
 0.87A 4u15A-2d7sA:
undetectable		 4u15A-2d7sA:
24.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WZM_A_ACTA503_0
(RNA DEPENDENT RNA
POLYMERASE)		 2d7s RNA-DEPENDENT RNA
POLYMERASE
(Foot-and-mouth
disease
virus) 		4 / 4 ASP A 238
ASP A 240
ASP A 339
ALA A 367
 None
 0.54A 4wzmA-2d7sA:
56.2		 4wzmA-2d7sA:
99.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2d7s RNA-DEPENDENT RNA
POLYMERASE
(Foot-and-mouth
disease
virus) 		3 / 3 PHE A 199
ILE A 305
ASP A 109
 None
 0.75A 5cswB-2d7sA:
undetectable		 5cswB-2d7sA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DX3_A_ESTA601_1
(ESTROGEN RECEPTOR)		 2d7s RNA-DEPENDENT RNA
POLYMERASE
(Foot-and-mouth
disease
virus) 		5 / 10 LEU A 108
ALA A 201
GLY A  90
HIS A  86
LEU A  89
 None
 1.41A 5dx3A-2d7sA:
undetectable		 5dx3A-2d7sA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2d7s RNA-DEPENDENT RNA
POLYMERASE
(Foot-and-mouth
disease
virus) 		5 / 12 LEU A 442
ALA A 410
VAL A 427
GLY A 429
ALA A 428
 None
 1.08A 5kirA-2d7sA:
undetectable		 5kirA-2d7sA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB307_0
(WELO5)		 2d7s RNA-DEPENDENT RNA
POLYMERASE
(Foot-and-mouth
disease
virus) 		3 / 3 GLU A 286
HIS A  14
VAL A  15
 None
 0.92A 5trqB-2d7sA:
undetectable		 5trqB-2d7sA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2d7s RNA-DEPENDENT RNA
POLYMERASE
(Foot-and-mouth
disease
virus) 		3 / 3 ASN A 206
VAL A 260
HIS A  86
 None
 0.74A 6a5yD-2d7sA:
undetectable		 6a5yD-2d7sA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_B_9SCB601_1
(SERUM ALBUMIN)		 2d7s RNA-DEPENDENT RNA
POLYMERASE
(Foot-and-mouth
disease
virus) 		4 / 6 PHE A 261
TYR A  81
LEU A  89
SER A 213
 None
 1.17A 6a7pB-2d7sA:
undetectable		 6a7pB-2d7sA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_0
(CYTOCHROME P450 1A1)		 2d7s RNA-DEPENDENT RNA
POLYMERASE
(Foot-and-mouth
disease
virus) 		5 / 12 ILE A 309
SER A 213
PHE A 199
ILE A 211
LEU A  89
 None
 1.04A 6dwnC-2d7sA:
undetectable		 6dwnC-2d7sA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_D_AQ4D602_0
(CYTOCHROME P450 1A1)		 2d7s RNA-DEPENDENT RNA
POLYMERASE
(Foot-and-mouth
disease
virus) 		5 / 12 ILE A 309
SER A 213
PHE A 199
ILE A 211
LEU A  89
 None
 1.04A 6dwnD-2d7sA:
undetectable		 6dwnD-2d7sA:
11.19