SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2d7u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_E_ACTE3005_0
(BETA-CARBONIC
ANHYDRASE)		 2d7u ADENYLOSUCCINATE
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 7 HIS A  43
GLY A 177
GLY A  35
GLN A 179
 None
 0.95A 1ekjE-2d7uA:
undetectable
1ekjF-2d7uA:
undetectable		 1ekjE-2d7uA:
20.82
1ekjF-2d7uA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 2d7u ADENYLOSUCCINATE
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 7 LEU A  69
ALA A  33
VAL A 175
VAL A 173
 None
 0.65A 1epbA-2d7uA:
undetectable		 1epbA-2d7uA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 2d7u ADENYLOSUCCINATE
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 7 LEU A 322
ALA A 281
VAL A 220
VAL A   6
 None
 0.65A 1epbA-2d7uA:
undetectable		 1epbA-2d7uA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 2d7u ADENYLOSUCCINATE
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 8 LEU A 322
ALA A 281
VAL A 220
VAL A   6
 None
 0.57A 1epbB-2d7uA:
undetectable		 1epbB-2d7uA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_A_KANA558_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 2d7u ADENYLOSUCCINATE
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 7 GLU A 311
GLU A 314
GLU A 310
GLU A 307
 None
 1.20A 1knyA-2d7uA:
undetectable
1knyB-2d7uA:
undetectable		 1knyA-2d7uA:
21.71
1knyB-2d7uA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEI_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 2d7u ADENYLOSUCCINATE
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 8 SER A 223
ILE A 323
GLU A  14
GLY A  15
 None
 0.87A 1meiA-2d7uA:
undetectable		 1meiA-2d7uA:
22.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MF1_A_ACTA458_0
(ADENYLOSUCCINATE
SYNTHETASE)		 2d7u ADENYLOSUCCINATE
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 4 GLY A  15
LYS A  16
GLY A  17
HIS A  43
 None
 0.23A 1mf1A-2d7uA:
42.7		 1mf1A-2d7uA:
31.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2d7u ADENYLOSUCCINATE
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A 174
GLY A  17
SER A  24
ASP A  13
ALA A  41
 None
 1.32A 2bm9B-2d7uA:
undetectable		 2bm9B-2d7uA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 2d7u ADENYLOSUCCINATE
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 7 ILE A 218
ARG A 336
LEU A 172
ASP A  27
 None
 1.06A 2qqcB-2d7uA:
undetectable
2qqcC-2d7uA:
undetectable		 2qqcB-2d7uA:
15.34
2qqcC-2d7uA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 2d7u ADENYLOSUCCINATE
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 7 LEU A 172
ASP A  27
ILE A 218
ARG A 336
 None
 1.07A 2qqcA-2d7uA:
undetectable
2qqcF-2d7uA:
undetectable		 2qqcA-2d7uA:
10.71
2qqcF-2d7uA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 2d7u ADENYLOSUCCINATE
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 7 LEU A 172
ASP A  27
ILE A 218
ARG A 336
 None
 1.04A 2qqcI-2d7uA:
undetectable
2qqcL-2d7uA:
undetectable		 2qqcI-2d7uA:
10.71
2qqcL-2d7uA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EBZ_B_017B201_1
(PROTEASE)		 2d7u ADENYLOSUCCINATE
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 11 LEU A  68
ASP A 100
ILE A  99
GLY A  38
ILE A  57
 None
 1.12A 3ebzA-2d7uA:
undetectable		 3ebzA-2d7uA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VNS_A_DVAA602_0
(NRPS ADENYLATION
PROTEIN CYTC1)		 2d7u ADENYLOSUCCINATE
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 7 PHE A 221
GLY A   8
THR A 226
LYS A  16
 None
 1.09A 3vnsA-2d7uA:
undetectable		 3vnsA-2d7uA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1475_0
(MJ0495-LIKE PROTEIN)		 2d7u ADENYLOSUCCINATE
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 8 ILE A  99
ASP A 100
ILE A  70
SER A 129
GLY A  38
 None
 1.31A 4ac9C-2d7uA:
6.3		 4ac9C-2d7uA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2d7u ADENYLOSUCCINATE
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 5 ARG A 213
VAL A 173
LEU A 172
SER A 171
 None
 1.12A 4e1gA-2d7uA:
undetectable		 4e1gA-2d7uA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_2
(HIV-1 PROTEASE)		 2d7u ADENYLOSUCCINATE
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 8 ARG A  55
GLY A 132
ALA A 134
ASP A 137
PRO A  78
 None
 1.47A 4eyrB-2d7uA:
undetectable		 4eyrB-2d7uA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 2d7u ADENYLOSUCCINATE
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 8 ASP A  77
GLU A 108
VAL A 253
ARG A  55
 None
 1.12A 4lnwA-2d7uA:
undetectable		 4lnwA-2d7uA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 2d7u ADENYLOSUCCINATE
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 6 SER A 271
GLY A 177
THR A  59
GLU A 176
 None
 1.10A 5btaA-2d7uA:
undetectable
5btaB-2d7uA:
undetectable
5btaC-2d7uA:
undetectable		 5btaA-2d7uA:
21.29
5btaB-2d7uA:
22.92
5btaC-2d7uA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 2d7u ADENYLOSUCCINATE
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 6 SER A 271
GLY A 177
THR A  59
GLU A 176
 None
 1.09A 5btcA-2d7uA:
undetectable
5btcB-2d7uA:
undetectable
5btcC-2d7uA:
undetectable		 5btcA-2d7uA:
21.29
5btcB-2d7uA:
22.92
5btcC-2d7uA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 2d7u ADENYLOSUCCINATE
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 7 SER A 271
GLY A 177
THR A  59
GLU A 176
 None
 1.11A 5btfA-2d7uA:
undetectable
5btfC-2d7uA:
undetectable
5btfD-2d7uA:
undetectable		 5btfA-2d7uA:
21.29
5btfC-2d7uA:
21.29
5btfD-2d7uA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 2d7u ADENYLOSUCCINATE
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 5 SER A 195
GLY A  35
THR A  59
GLU A 176
 None
 1.17A 5btiA-2d7uA:
undetectable
5btiB-2d7uA:
undetectable		 5btiA-2d7uA:
21.29
5btiB-2d7uA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 2d7u ADENYLOSUCCINATE
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 5 SER A 271
GLY A 177
THR A  59
GLU A 176
 None
 1.08A 5btiA-2d7uA:
undetectable
5btiB-2d7uA:
undetectable		 5btiA-2d7uA:
21.29
5btiB-2d7uA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 2d7u ADENYLOSUCCINATE
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 5 SER A 195
GLY A  35
THR A  59
GLU A 176
 None
 1.18A 5btiC-2d7uA:
undetectable
5btiD-2d7uA:
undetectable		 5btiC-2d7uA:
21.29
5btiD-2d7uA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 2d7u ADENYLOSUCCINATE
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 5 SER A 271
GLY A 177
THR A  59
GLU A 176
 None
 1.10A 5btiC-2d7uA:
undetectable
5btiD-2d7uA:
undetectable		 5btiC-2d7uA:
21.29
5btiD-2d7uA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_D_HISD402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 2d7u ADENYLOSUCCINATE
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 8 GLY A  17
VAL A   4
VAL A 220
LEU A 174
 None
 0.84A 6czmD-2d7uA:
undetectable
6czmF-2d7uA:
undetectable		 6czmD-2d7uA:
22.19
6czmF-2d7uA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_F_HISF402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 2d7u ADENYLOSUCCINATE
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 10 VAL A  20
VAL A 220
LEU A  23
GLY A 321
LEU A 322
 None
 1.31A 6czmE-2d7uA:
undetectable
6czmF-2d7uA:
undetectable		 6czmE-2d7uA:
22.19
6czmF-2d7uA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_H_PCFH604_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 2d7u ADENYLOSUCCINATE
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 8 GLY A 326
GLY A  15
SER A  18
ALA A  21
 None
 0.42A 6hu9H-2d7uA:
undetectable
6hu9e-2d7uA:
undetectable		 6hu9H-2d7uA:
12.23
6hu9e-2d7uA:
16.82