SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2d86'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		 2d86 VAV-3 PROTEIN
(Homo
sapiens) 		4 / 4 LEU A  18
PRO A 137
ILE A 116
LEU A 119
 None
 1.05A 1ya4B-2d86A:
undetectable		 1ya4B-2d86A:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		 2d86 VAV-3 PROTEIN
(Homo
sapiens) 		4 / 4 LEU A  18
PRO A 137
ILE A 116
LEU A 119
 None
 1.04A 1ya4C-2d86A:
undetectable		 1ya4C-2d86A:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX94_0
(PROTEIN S100-B)		 2d86 VAV-3 PROTEIN
(Homo
sapiens) 		3 / 3 PHE A  85
CYH A  89
PHE A  93
 None
 0.92A 3cr5X-2d86A:
1.1		 3cr5X-2d86A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 2d86 VAV-3 PROTEIN
(Homo
sapiens) 		4 / 6 PHE A  93
ILE A 127
ALA A 128
THR A 131
 None
 0.96A 3mdrA-2d86A:
undetectable		 3mdrA-2d86A:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 2d86 VAV-3 PROTEIN
(Homo
sapiens) 		4 / 6 PHE A  93
ILE A 127
ALA A 128
THR A 131
 None
 0.99A 3mdrB-2d86A:
undetectable		 3mdrB-2d86A:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTR_A_LQZA90_1
(LACTOTRANSFERRIN)		 2d86 VAV-3 PROTEIN
(Homo
sapiens) 		3 / 3 PRO A 126
THR A 125
LEU A  57
 None
 0.74A 3ttrA-2d86A:
undetectable		 3ttrA-2d86A:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CXV_A_0HKA501_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M1,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M1)		 2d86 VAV-3 PROTEIN
(Homo
sapiens) 		3 / 3 THR A  84
THR A  87
PHE A  93
 None
 0.86A 5cxvA-2d86A:
undetectable		 5cxvA-2d86A:
14.54