SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2d89'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_B_STIB4_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2d89 EHBP1 PROTEIN
(Homo
sapiens) 		4 / 6 LEU A  54
VAL A 101
ILE A 108
ARG A  38
 None
 0.98A 1opjB-2d89A:
undetectable		 1opjB-2d89A:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2d89 EHBP1 PROTEIN
(Homo
sapiens) 		4 / 6 LEU A  54
VAL A 101
ILE A 108
ARG A  38
 None
 0.99A 2hyyA-2d89A:
undetectable		 2hyyA-2d89A:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1375_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 2d89 EHBP1 PROTEIN
(Homo
sapiens) 		3 / 3 LEU A 105
TYR A 104
GLN A 107
 None
 0.64A 2wekA-2d89A:
undetectable		 2wekA-2d89A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_1
(STRUCTURAL PROTEIN
VP3)		 2d89 EHBP1 PROTEIN
(Homo
sapiens) 		3 / 3 GLU A  67
ASP A  56
ASP A  74
 None
 0.70A 3jb2A-2d89A:
undetectable		 3jb2A-2d89A:
8.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_A_PAUA301_0
(TYPE III
PANTOTHENATE KINASE)		 2d89 EHBP1 PROTEIN
(Homo
sapiens) 		5 / 12 ASN A  39
GLY A  27
THR A  31
ILE A  30
THR A  22
 None
 1.17A 4o5fA-2d89A:
undetectable
4o5fB-2d89A:
undetectable		 4o5fA-2d89A:
19.71
4o5fB-2d89A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 2d89 EHBP1 PROTEIN
(Homo
sapiens) 		5 / 12 THR A  22
ASN A  39
GLY A  27
THR A  31
ILE A  30
 None
 1.13A 4o5fA-2d89A:
undetectable
4o5fB-2d89A:
undetectable		 4o5fA-2d89A:
19.71
4o5fB-2d89A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_A_PAUA302_0
(TYPE III
PANTOTHENATE KINASE)		 2d89 EHBP1 PROTEIN
(Homo
sapiens) 		5 / 12 ASN A  39
GLY A  27
THR A  31
ILE A  30
THR A  22
 None
 1.16A 5b8hA-2d89A:
undetectable
5b8hB-2d89A:
undetectable		 5b8hA-2d89A:
18.56
5b8hB-2d89A:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 2d89 EHBP1 PROTEIN
(Homo
sapiens) 		5 / 12 THR A  22
ASN A  39
GLY A  27
THR A  31
ILE A  30
 None
 1.15A 5b8hA-2d89A:
undetectable
5b8hB-2d89A:
undetectable		 5b8hA-2d89A:
18.56
5b8hB-2d89A:
18.56